Open Access

Saccharides from Arctium lappa L. root reduce platelet activation and thrombus formation in a laser injury thrombosis mouse model

  • Authors:
    • Yongjuan Ruan
    • Yanzhong Ding
    • Xiaowei Li
    • Chunyang Zhang
    • Mengyu Wang
    • Mengduan Liu
    • Lu Wang
    • Junhui Xing
    • Liang Hu
    • Xiaoyan Zhao
    • Zhongren Ding
    • Jianzeng Dong
    • Yangyang Liu
  • View Affiliations

  • Published online on: March 22, 2022     https://doi.org/10.3892/etm.2022.11274
  • Article Number: 344
  • Copyright: © Ruan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Arctium lappa L., also known as burdock, is a popular medicinal plant in traditional Chinese medicine due to its potential therapeutic properties. Saccharides from Arctium lappa L. root (ALR‑S) have been extensively studied for their anti‑inflammatory and anti‑diabetes effects. Platelets play a pivotal role in thrombosis. The present study describes the effects of ALR‑S on platelet activation and thrombosis using a laser injury thrombosis in vivo model. The study also measured the effects of ALR‑S on platelet activation by analysing aggregation, ATP release, platelet spreading, adhesion and clot retraction in vitro. Specifically, the effects were ALR‑S concentration‑dependent inhibition of platelet aggregation and ATP release. Activated platelets pretreated with ALR‑S showed diminished CD62P expression levels and fibrinogen binding, as measured by flow cytometry. ALR‑S inhibited platelet spreading on fibrinogen and adhesion on collagen under shear. ALR‑S attenuated platelet activation by decreasing oxidative stress and thrombus formation. These results demonstrated the antiplatelet effects of ALR‑S, suggesting the antithrombotic and cardiovascular protective activities of ALR‑S as a functional food.
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May-2022
Volume 23 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Ruan Y, Ding Y, Li X, Zhang C, Wang M, Liu M, Wang L, Xing J, Hu L, Zhao X, Zhao X, et al: Saccharides from <em>Arctium lappa</em> L. root reduce platelet activation and thrombus formation in a laser injury thrombosis mouse model. Exp Ther Med 23: 344, 2022
APA
Ruan, Y., Ding, Y., Li, X., Zhang, C., Wang, M., Liu, M. ... Liu, Y. (2022). Saccharides from <em>Arctium lappa</em> L. root reduce platelet activation and thrombus formation in a laser injury thrombosis mouse model. Experimental and Therapeutic Medicine, 23, 344. https://doi.org/10.3892/etm.2022.11274
MLA
Ruan, Y., Ding, Y., Li, X., Zhang, C., Wang, M., Liu, M., Wang, L., Xing, J., Hu, L., Zhao, X., Ding, Z., Dong, J., Liu, Y."Saccharides from <em>Arctium lappa</em> L. root reduce platelet activation and thrombus formation in a laser injury thrombosis mouse model". Experimental and Therapeutic Medicine 23.5 (2022): 344.
Chicago
Ruan, Y., Ding, Y., Li, X., Zhang, C., Wang, M., Liu, M., Wang, L., Xing, J., Hu, L., Zhao, X., Ding, Z., Dong, J., Liu, Y."Saccharides from <em>Arctium lappa</em> L. root reduce platelet activation and thrombus formation in a laser injury thrombosis mouse model". Experimental and Therapeutic Medicine 23, no. 5 (2022): 344. https://doi.org/10.3892/etm.2022.11274