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Saccharides from Arctium lappa L. root reduce platelet activation and thrombus formation in a laser injury thrombosis mouse model

  • Authors:
    • Yongjuan Ruan
    • Yanzhong Ding
    • Xiaowei Li
    • Chunyang Zhang
    • Mengyu Wang
    • Mengduan Liu
    • Lu Wang
    • Junhui Xing
    • Liang Hu
    • Xiaoyan Zhao
    • Zhongren Ding
    • Jianzeng Dong
    • Yangyang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Cardiovascular Center, Henan Key Laboratory of Hereditary Cardiovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Cardiology, Cardiovascular Center, Henan Key Laboratory of Hereditary Cardiovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of General Thoracic Surgery, Hami Central Hospital, Hami, Xinjiang 839000, P.R. China
    Copyright: © Ruan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 344
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    Published online on: March 22, 2022
       https://doi.org/10.3892/etm.2022.11274
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Abstract

Arctium lappa L., also known as burdock, is a popular medicinal plant in traditional Chinese medicine due to its potential therapeutic properties. Saccharides from Arctium lappa L. root (ALR‑S) have been extensively studied for their anti‑inflammatory and anti‑diabetes effects. Platelets play a pivotal role in thrombosis. The present study describes the effects of ALR‑S on platelet activation and thrombosis using a laser injury thrombosis in vivo model. The study also measured the effects of ALR‑S on platelet activation by analysing aggregation, ATP release, platelet spreading, adhesion and clot retraction in vitro. Specifically, the effects were ALR‑S concentration‑dependent inhibition of platelet aggregation and ATP release. Activated platelets pretreated with ALR‑S showed diminished CD62P expression levels and fibrinogen binding, as measured by flow cytometry. ALR‑S inhibited platelet spreading on fibrinogen and adhesion on collagen under shear. ALR‑S attenuated platelet activation by decreasing oxidative stress and thrombus formation. These results demonstrated the antiplatelet effects of ALR‑S, suggesting the antithrombotic and cardiovascular protective activities of ALR‑S as a functional food.
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Copy and paste a formatted citation
Spandidos Publications style
Ruan Y, Ding Y, Li X, Zhang C, Wang M, Liu M, Wang L, Xing J, Hu L, Zhao X, Zhao X, et al: Saccharides from <em>Arctium lappa</em> L. root reduce platelet activation and thrombus formation in a laser injury thrombosis mouse model. Exp Ther Med 23: 344, 2022.
APA
Ruan, Y., Ding, Y., Li, X., Zhang, C., Wang, M., Liu, M. ... Liu, Y. (2022). Saccharides from <em>Arctium lappa</em> L. root reduce platelet activation and thrombus formation in a laser injury thrombosis mouse model. Experimental and Therapeutic Medicine, 23, 344. https://doi.org/10.3892/etm.2022.11274
MLA
Ruan, Y., Ding, Y., Li, X., Zhang, C., Wang, M., Liu, M., Wang, L., Xing, J., Hu, L., Zhao, X., Ding, Z., Dong, J., Liu, Y."Saccharides from <em>Arctium lappa</em> L. root reduce platelet activation and thrombus formation in a laser injury thrombosis mouse model". Experimental and Therapeutic Medicine 23.5 (2022): 344.
Chicago
Ruan, Y., Ding, Y., Li, X., Zhang, C., Wang, M., Liu, M., Wang, L., Xing, J., Hu, L., Zhao, X., Ding, Z., Dong, J., Liu, Y."Saccharides from <em>Arctium lappa</em> L. root reduce platelet activation and thrombus formation in a laser injury thrombosis mouse model". Experimental and Therapeutic Medicine 23, no. 5 (2022): 344. https://doi.org/10.3892/etm.2022.11274
Copy and paste a formatted citation
x
Spandidos Publications style
Ruan Y, Ding Y, Li X, Zhang C, Wang M, Liu M, Wang L, Xing J, Hu L, Zhao X, Zhao X, et al: Saccharides from <em>Arctium lappa</em> L. root reduce platelet activation and thrombus formation in a laser injury thrombosis mouse model. Exp Ther Med 23: 344, 2022.
APA
Ruan, Y., Ding, Y., Li, X., Zhang, C., Wang, M., Liu, M. ... Liu, Y. (2022). Saccharides from <em>Arctium lappa</em> L. root reduce platelet activation and thrombus formation in a laser injury thrombosis mouse model. Experimental and Therapeutic Medicine, 23, 344. https://doi.org/10.3892/etm.2022.11274
MLA
Ruan, Y., Ding, Y., Li, X., Zhang, C., Wang, M., Liu, M., Wang, L., Xing, J., Hu, L., Zhao, X., Ding, Z., Dong, J., Liu, Y."Saccharides from <em>Arctium lappa</em> L. root reduce platelet activation and thrombus formation in a laser injury thrombosis mouse model". Experimental and Therapeutic Medicine 23.5 (2022): 344.
Chicago
Ruan, Y., Ding, Y., Li, X., Zhang, C., Wang, M., Liu, M., Wang, L., Xing, J., Hu, L., Zhao, X., Ding, Z., Dong, J., Liu, Y."Saccharides from <em>Arctium lappa</em> L. root reduce platelet activation and thrombus formation in a laser injury thrombosis mouse model". Experimental and Therapeutic Medicine 23, no. 5 (2022): 344. https://doi.org/10.3892/etm.2022.11274
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