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Regulation of apoptosis, autophagy and ferroptosis by non‑coding RNAs in metastatic non‑small cell lung cancer (Review)

  • Authors:
    • Lei Xu
    • Xin Huang
    • Yan Lou
    • Wei Xie
    • Hangyu Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Chengdu Seventh People's Hospital, Chengdu, Sichuan 610213, P.R. China, Department of Orthopedic Oncology, Spine Tumor Center, Changzheng Hospital, Naval Military Medical University, Shanghai 200003, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 352
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    Published online on: March 28, 2022
       https://doi.org/10.3892/etm.2022.11279
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Abstract

Non‑small cell lung cancer (NSCLC), a common type of cancer worldwide, is normally associated with a poor prognosis. It is difficult to treat successfully as it often metastasizes into brain or bone. Methods to facilitate the induction of effective programmed cell death (PCD) in NSCLC cells to reverse drug resistance, or to inhibit the invasion and migration of NSCLC cells, are currently under investigation. The present study summarized the regulatory functions of PCD, including apoptosis, autophagy and ferroptosis, in the context of NSCLC metastasis. It further summarized how regulatory agents, including long non‑coding RNAs, circular RNAs and microRNAs, regulate PCD during the metastasis of NSCLC and characterized new potential diagnostic biomarkers of NSCLC metastasis.
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Spandidos Publications style
Xu L, Huang X, Lou Y, Xie W and Zhao H: Regulation of apoptosis, autophagy and ferroptosis by non‑coding RNAs in metastatic non‑small cell lung cancer (Review). Exp Ther Med 23: 352, 2022.
APA
Xu, L., Huang, X., Lou, Y., Xie, W., & Zhao, H. (2022). Regulation of apoptosis, autophagy and ferroptosis by non‑coding RNAs in metastatic non‑small cell lung cancer (Review). Experimental and Therapeutic Medicine, 23, 352. https://doi.org/10.3892/etm.2022.11279
MLA
Xu, L., Huang, X., Lou, Y., Xie, W., Zhao, H."Regulation of apoptosis, autophagy and ferroptosis by non‑coding RNAs in metastatic non‑small cell lung cancer (Review)". Experimental and Therapeutic Medicine 23.5 (2022): 352.
Chicago
Xu, L., Huang, X., Lou, Y., Xie, W., Zhao, H."Regulation of apoptosis, autophagy and ferroptosis by non‑coding RNAs in metastatic non‑small cell lung cancer (Review)". Experimental and Therapeutic Medicine 23, no. 5 (2022): 352. https://doi.org/10.3892/etm.2022.11279
Copy and paste a formatted citation
x
Spandidos Publications style
Xu L, Huang X, Lou Y, Xie W and Zhao H: Regulation of apoptosis, autophagy and ferroptosis by non‑coding RNAs in metastatic non‑small cell lung cancer (Review). Exp Ther Med 23: 352, 2022.
APA
Xu, L., Huang, X., Lou, Y., Xie, W., & Zhao, H. (2022). Regulation of apoptosis, autophagy and ferroptosis by non‑coding RNAs in metastatic non‑small cell lung cancer (Review). Experimental and Therapeutic Medicine, 23, 352. https://doi.org/10.3892/etm.2022.11279
MLA
Xu, L., Huang, X., Lou, Y., Xie, W., Zhao, H."Regulation of apoptosis, autophagy and ferroptosis by non‑coding RNAs in metastatic non‑small cell lung cancer (Review)". Experimental and Therapeutic Medicine 23.5 (2022): 352.
Chicago
Xu, L., Huang, X., Lou, Y., Xie, W., Zhao, H."Regulation of apoptosis, autophagy and ferroptosis by non‑coding RNAs in metastatic non‑small cell lung cancer (Review)". Experimental and Therapeutic Medicine 23, no. 5 (2022): 352. https://doi.org/10.3892/etm.2022.11279
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