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Leonurine: A compound with the potential to prevent acute lung injury

  • Authors:
    • Guoying Zhang
    • Lanfei Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pain Rehabilitation, Qingdao Special Servicemen Recuperation Center of PLA Navy, Qingdao, Shandong 266071, P.R. China, Intensive Care Unit, Xinchang People's Hospital, Shaoxing, Zhejiang 312500, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 358
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    Published online on: March 29, 2022
       https://doi.org/10.3892/etm.2022.11285
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Abstract

Sepsis is an intense immune response to infection that contributes to the pathophysiological process of acute lung injury (ALI). Inflammation and oxidative stress serve an important role in the development of ALI. Leonurine (LEO) is a natural phenolic alkaloid extracted from Leonurus cardiaca, which possesses anti‑inflammatory and antioxidative properties. Therefore, the aim of the present study was to explore the effect of LEO on sepsis‑induced ALI and to investigate its underlying mechanism. MTT and Cell Counting Kit‑8 assays were performed to measure cell viability. The levels of reactive oxygen species, lactate dehydrogenase and malondialdehyde, as well as the activity of superoxidase dismutase, were quantified using commercial assay kits. The expression levels of specific inflammatory cytokines were measured by using ELISA. In addition, western blotting was employed to assess the expression levels of cytokines, including TNF‑α, IL‑6, nuclear factor erythroid 2‑related factor 2 (Nrf2) and heme oxygenase‑1. The findings demonstrated that LEO increased the viability of lipopolysaccharide (LPS)‑stimulated BEAS‑2B human lung epithelial cells in a dose‑dependent manner. Additionally, LEO suppressed LPS‑induced oxidative stress and inflammatory cytokine release in BEAS‑2B cells. Treatment with Nrf2 inhibitor reversed the effects of LEO treatment on LPS‑induced oxidative stress and inflammatory response in BEAS‑2B cells. Taken together, the data of the present study indicated that LEO attenuated LPS‑induced ALI through the inhibition of oxidative stress and inflammation regulated by the Nrf2 signaling pathway. Therefore, LEO may be a novel and effective agent for the prevention of sepsis‑induced ALI.
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1 

Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, Colombara DV, Ikuta KS, Kissoon N, Finfer S, et al: Global, regional, and national sepsis incidence and mortality, 1990-2017: Analysis for the global burden of disease study. Lancet. 395:200–211. 2020.PubMed/NCBI View Article : Google Scholar

2 

Wang YM, Ji R, Chen WW, Huang SW, Zheng YJ, Yang ZT, Qu HP, Chen H, Mao EQ, Chen Y and Chen EZ: Paclitaxel alleviated sepsis-induced acute lung injury by activating MUC1 and suppressing TLR-4/NF-κB pathway. Drug Des Devel Ther. 13:3391–3404. 2019.PubMed/NCBI View Article : Google Scholar

3 

Zhang H, Wang W, Fang H, Yang Y, Li X, He J, Jiang X, Wang W, Liu S, Hu J, et al: GSK-3β inhibition attenuates CLP-induced liver injury by reducing inflammation and hepatic cell apoptosis. Mediators Inflamm. 2014(629507)2014.PubMed/NCBI View Article : Google Scholar

4 

Zhang Z, Han N and Shen Y: S100A12 promotes inflammation and cell apoptosis in sepsis-induced ARDS via activation of NLRP3 inflammasome signaling. Mol Immunol. 122:38–48. 2020.PubMed/NCBI View Article : Google Scholar

5 

Kim WY and Hong SB: Sepsis and acute respiratory distress syndrome: Recent update. Tuberc Respir Dis (Seoul). 79:53–57. 2016.PubMed/NCBI View Article : Google Scholar

6 

Qiu N, Xu X and He Y: LncRNA TUG1 alleviates sepsis-induced acute lung injury by targeting miR-34b-5p/GAB1. BMC Pulm Med. 20(49)2020.PubMed/NCBI View Article : Google Scholar

7 

Fu H, Zhang J and Huang M: Topiroxostat ameliorates oxidative stress and inflammation in sepsis-induced lung injury. Z Naturforsch C J Biosci. 75:425–431. 2020.PubMed/NCBI View Article : Google Scholar

8 

Hu Q, Wang Q, Han C and Yang Y: Sufentanil attenuates inflammation and oxidative stress in sepsis-induced acute lung injury by downregulating KNG1 expression. Mol Med Rep. 22:4298–4306. 2020.PubMed/NCBI View Article : Google Scholar

9 

Xu W, Cui J, Zhou F, Bai M, Deng R and Wang W: Leonurine protects against dexamethasone-induced cytotoxicity in pancreatic β-cells via PI3K/Akt signaling pathway. Biochem Biophys Res Commun. 529:652–658. 2020.PubMed/NCBI View Article : Google Scholar

10 

Chen C, Zhu Z, Hu N, Liang X and Huang W: Leonurine hydrochloride suppresses inflammatory responses and ameliorates cartilage degradation in osteoarthritis via NF-κB signaling pathway. Inflammation. 43:146–154. 2020.PubMed/NCBI View Article : Google Scholar

11 

Ning K, Wang MJ, Lin G, Zhang YL, Li MY, Yang BF, Chen Y, Huang Y, Li ZM, Huang YJ, et al: eNOS-nitric oxide system contributes to a novel antiatherogenic effect of leonurine via inflammation inhibition and plaque stabilization. J Pharmacol Exp Ther. 373:463–475. 2020.PubMed/NCBI View Article : Google Scholar

12 

Li YY, Lin YK, Liu XH, Wang L, Yu M, Li DJ, Zhu YZ and Du MR: Leonurine: From gynecologic medicine to pleiotropic agent. Chin J Integr Med. 26:152–160. 2020.PubMed/NCBI View Article : Google Scholar

13 

Wang R, Li D, Ouyang J, Tian X, Zhao Y, Peng X, Li S, Yu G and Yang J: Leonurine alleviates LPS-induced myocarditis through suppressing the NF-кB signaling pathway. Toxicology. 422:1–13. 2019.PubMed/NCBI View Article : Google Scholar

14 

Xu D, Chen M, Ren X and Wu Y: Leonurine ameliorates LPS-induced acute kidney injury via suppressing ROS-mediated NF-κB signaling pathway. Fitoterapia. 97:148–155. 2014.PubMed/NCBI View Article : Google Scholar

15 

Xu T, Li X, Leng T, Zhuang T, Sun Y, Tang Y, Wang L, Yang M and Ji M: CYP2A13 acts as the main metabolic CYP450s enzyme for activating leonurine in human bronchial epithelial cells. Med Sci Monit. 26(e922149)2020.PubMed/NCBI View Article : Google Scholar

16 

Chen P, Chen F and Zhou BH: Leonurine ameliorates D-galactose-induced aging in mice through activation of the Nrf2 signalling pathway. Aging (Albany NY). 11:7339–7356. 2019.PubMed/NCBI View Article : Google Scholar

17 

Yuan CB, Tian L, Yang B and Zhou HY: Isoalantolactone protects LPS-induced acute lung injury through Nrf2 activation. Microb Pathog. 123:213–218. 2018.PubMed/NCBI View Article : Google Scholar

18 

Kumar P, Nagarajan A and Uchil PD: Analysis of cell viability by the MTT assay. Cold Spring Harb Protoc. 2018:2018.PubMed/NCBI View Article : Google Scholar

19 

Aziz M, Ode Y, Zhou M, Ochani M, Holodick NE, Rothstein TL and Wang P: B-1a cells protect mice from sepsis-induced acute lung injury. Mol Med. 24(26)2018.PubMed/NCBI View Article : Google Scholar

20 

Mokra D and Kosutova P: Biomarkers in acute lung injury. Respir Physiol Neurobiol. 209:52–58. 2015.PubMed/NCBI View Article : Google Scholar

21 

Crystal RG, Randell SH, Engelhardt JF, Voynow J and Sunday ME: Airway epithelial cells: Current concepts and challenges. Proc Am Thorac Soc. 5:772–777. 2008.PubMed/NCBI View Article : Google Scholar

22 

Lei J, Wei Y, Song P, Li Y, Zhang T, Feng Q and Xu G: Cordycepin inhibits LPS-induced acute lung injury by inhibiting inflammation and oxidative stress. Eur J Pharmacol. 818:110–114. 2018.PubMed/NCBI View Article : Google Scholar

23 

Chen TH and Wang JJ: Niacin pretreatment attenuates ischemia and reperfusion of pancreas-induced acute pancreatitis and remote lung injury through suppressing oxidative stress and inflammation and activation of SIRT1. Transplant Proc. 50:2860–2863. 2018.PubMed/NCBI View Article : Google Scholar

24 

Wang X, An X, Wang X, Hu X, Bi J, Tong L, Yang D, Song Y and Bai C: Peroxiredoxin 6 knockout aggravates cecal ligation and puncture-induced acute lung injury. Int Immunopharmacol. 68:252–258. 2019.PubMed/NCBI View Article : Google Scholar

25 

Butt Y, Kurdowska A and Allen TC: Acute lung injury: A clinical and molecular review. Arch Pathol Lab Med. 140:345–350. 2016.PubMed/NCBI View Article : Google Scholar

26 

Matzinger M, Fischhuber K and Heiss EH: Activation of Nrf2 signaling by natural products-can it alleviate diabetes? Biotechnol Adv. 36:1738–1767. 2018.PubMed/NCBI View Article : Google Scholar

27 

Pei X, Zhang XJ and Chen HM: Bardoxolone treatment alleviates lipopolysaccharide (LPS)-induced acute lung injury through suppressing inflammation and oxidative stress regulated by Nrf2 signaling. Biochem Biophys Res Commun. 516:270–277. 2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhang G and Wang L: Leonurine: A compound with the potential to prevent acute lung injury. Exp Ther Med 23: 358, 2022.
APA
Zhang, G., & Wang, L. (2022). Leonurine: A compound with the potential to prevent acute lung injury. Experimental and Therapeutic Medicine, 23, 358. https://doi.org/10.3892/etm.2022.11285
MLA
Zhang, G., Wang, L."Leonurine: A compound with the potential to prevent acute lung injury". Experimental and Therapeutic Medicine 23.5 (2022): 358.
Chicago
Zhang, G., Wang, L."Leonurine: A compound with the potential to prevent acute lung injury". Experimental and Therapeutic Medicine 23, no. 5 (2022): 358. https://doi.org/10.3892/etm.2022.11285
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang G and Wang L: Leonurine: A compound with the potential to prevent acute lung injury. Exp Ther Med 23: 358, 2022.
APA
Zhang, G., & Wang, L. (2022). Leonurine: A compound with the potential to prevent acute lung injury. Experimental and Therapeutic Medicine, 23, 358. https://doi.org/10.3892/etm.2022.11285
MLA
Zhang, G., Wang, L."Leonurine: A compound with the potential to prevent acute lung injury". Experimental and Therapeutic Medicine 23.5 (2022): 358.
Chicago
Zhang, G., Wang, L."Leonurine: A compound with the potential to prevent acute lung injury". Experimental and Therapeutic Medicine 23, no. 5 (2022): 358. https://doi.org/10.3892/etm.2022.11285
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