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FOXA1 transcription activates TFF1 to reduce 6‑OHDA‑induced dopaminergic neuron damage

  • Authors:
    • Tingting Liang
    • Ping Zhao
    • Xiao Zhang
    • Xuedan Han
    • Bo Hong
    • Lingsheng Kong
    • Huanxian Chang
    • Liyan Liu
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The Affiliated Lianyungang Oriental Hospital of Xuzhou Medical University, Lianyungang, Jiangsu 222042, P.R. China
    Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 372
    |
    Published online on: April 5, 2022
       https://doi.org/10.3892/etm.2022.11299
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Abstract

Forkhead box A1 (FOXA1) plays an important role in the central nervous system, and its loss can lead to the downregulation of tyrosine hydroxylase, which directly affects the synthesis of dopamine, thus leading to Parkinson's disease (PD). The present study aimed to explore the specific role of FOXA1 in PD. Blood samples from patients with PD were collected to determine the expression levels of FOXA1 using reverse transcription‑quantitative PCR (RT‑qPCR). In addition, mouse dopaminergic neuron MES23.5 cells were induced with 6‑hydroxydopamine (6‑OHDA) to construct an in vitro PD model in order to study the effect of FOXA1 overexpression on cell inflammation, oxidative stress and apoptosis with RT‑qPCR, assay kits and TUNEL assays, respectively. Subsequently, the expression of FOXA1 was silenced to assess the effect on the downstream mechanism. The results revealed that the expression level of FOXA1 was downregulated in patients with PD, and FOXA1 overexpression attenuated 6‑OHDA‑induced inflammation, oxidative stress and apoptosis in MES23.5 cells. Furthermore, FOXA1 could bind to the trefoil factor 1 (TFF1) promoter, and the effects of FOXA1 overexpression on cells were reversed by TFF1 silencing, indicating that TFF1 mediated the mechanism of FOXA1 overexpression in MES23.5 cells. In conclusion, following FOXA1 transcription, TFF1 expression was activated, thereby relieving 6‑OHDA‑induced cell inflammation, oxidative stress and apoptosis. The present findings suggested that FOXA1 may serve as a target for the treatment of PD.
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1 

Balestrino R and Schapira AHV: Parkinson disease. Eur J Neurol. 27:27–42. 2020.PubMed/NCBI View Article : Google Scholar

2 

Salari S and Bagheri M: In vivo, in vitro and pharmacologic models of Parkinson's disease. Physiol Res. 68:17–24. 2019.PubMed/NCBI View Article : Google Scholar

3 

Armstrong MJ and Okun MS: Diagnosis and treatment of Parkinson disease: A review. JAMA. 323:548–560. 2020.PubMed/NCBI View Article : Google Scholar

4 

Aarsland D, Batzu L, Halliday GM, Geurtsen GJ, Ballard C, Ray Chaudhuri K and Weintraub D: Parkinson disease-associated cognitive impairment. Nat Rev Dis Primers. 7(47)2021.PubMed/NCBI View Article : Google Scholar

5 

López-Liria R, Parra-Egeda J, Vega-Ramírez FA, Aguilar-Parra JM, Trigueros-Ramos R, Morales-Gázquez MJ and Rocamora-Pérez P: Treatment of dysphagia in Parkinson's Disease: A systematic review. Int J Environ Res Public Health. 17(4104)2020.PubMed/NCBI View Article : Google Scholar

6 

Sodhi RK, Bansal Y, Singh R, Saroj P, Bhandari R, Kumar B and Kuhad A: IDO-1 inhibition protects against neuroinflammation, oxidative stress and mitochondrial dysfunction in 6-OHDA induced murine model of Parkinson's disease. Neurotoxicology. 84:184–197. 2021.PubMed/NCBI View Article : Google Scholar

7 

De Virgilio A, Greco A, Fabbrini G, Inghilleri M, Rizzo MI, Gallo A, Conte M, Rosato C, Ciniglio Appiani M and de Vincentiis M: Parkinson's disease: Autoimmunity and neuroinflammation. Autoimmun Rev. 15:1005–1011. 2016.PubMed/NCBI View Article : Google Scholar

8 

Xu X, Fu Z and Le W: Exercise and Parkinson's disease. Int Rev Neurobiol. 147:45–74. 2019.PubMed/NCBI View Article : Google Scholar

9 

Dunkley PR and Dickson PW: Tyrosine hydroxylase phosphorylation in vivo. J Neurochem. 149:706–728. 2019.PubMed/NCBI View Article : Google Scholar

10 

Yang X, Zhu Z, Ding X, Wang X, Cui G, Hua F and Xiang J: CaMKII inhibition ameliorated levodopa-induced dyskinesia by downregulating tyrosine hydroxylase activity in an experimental model of Parkinson's disease. Brain Res. 1687:66–73. 2018.PubMed/NCBI View Article : Google Scholar

11 

Pristerà A, Lin W, Kaufmann AK, Brimblecombe KR, Threlfell S, Dodson PD, Magill PJ, Fernandes C, Cragg SJ and Ang SL: Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice. Proc Natl Acad Sci USA. 112:E4929–E4938. 2015.PubMed/NCBI View Article : Google Scholar

12 

Horisawa K, Udono M, Ueno K, Ohkawa Y, Nagasaki M, Sekiya S and Suzuki A: The dynamics of transcriptional activation by hepatic reprogramming factors. Mol Cell. 79:660–676.e8. 2020.PubMed/NCBI View Article : Google Scholar

13 

Gredler ML, Patterson SE, Seifert AW and Cohn MJ: Foxa1 and Foxa2 orchestrate development of the urethral tube and division of the embryonic cloaca through an autoregulatory loop with Shh. Dev Biol. 465:23–30. 2020.PubMed/NCBI View Article : Google Scholar

14 

Ruiz i Altaba A, Palma V and Dahmane N: Hedgehog-Gli signalling and the growth of the brain. Nat Rev Neurosci. 3:24–33. 2002.PubMed/NCBI View Article : Google Scholar

15 

Yu Q, Chen J, Deng W, Cao X, Adu-Frimpong M, Yu J and Xu X: Neural differentiation of fibroblasts induced by intracellular co-delivery of Ascl1, Brn2 and FoxA1 via a non-viral vector of cationic polysaccharide. Biomed Mater. 13(015022)2017.PubMed/NCBI View Article : Google Scholar

16 

Tippabathani J, Nellore J, Radhakrishnan V, Banik S and Kapoor S: Identification of NURR1 (Exon 4) and FOXA1 (Exon 3) haplotypes associated with mRNA expression levels in peripheral blood lymphocytes of Parkinson's patients in small indian population. Parkinsons Dis. 2017(6025358)2017.PubMed/NCBI View Article : Google Scholar

17 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

18 

Jensen P, Heimberg M, Ducray AD, Widmer HR and Meyer M: Expression of trefoil factor 1 in the developing and adult rat ventral mesencephalon. PLoS One. 8(e76592)2013.PubMed/NCBI View Article : Google Scholar

19 

Chen Z and Trapp BD: Microglia and neuroprotection. J Neurochem. 136 (Suppl 1):S10–S17. 2016.PubMed/NCBI View Article : Google Scholar

20 

Puspita L, Chung SY and Shim JW: Oxidative stress and cellular pathologies in Parkinson's disease. Mol Brain. 10(53)2017.PubMed/NCBI View Article : Google Scholar

21 

Vivekanantham S, Shah S, Dewji R, Dewji A, Khatri C and Ologunde R: Neuroinflammation in Parkinson's disease: Role in neurodegeneration and tissue repair. Int J Neurosci. 125:717–725. 2015.PubMed/NCBI View Article : Google Scholar

22 

Pajares M, I Rojo A, Manda G, Boscá L and Cuadrado A: Inflammation in Parkinson's disease: Mechanisms and therapeutic implications. Cells. 9(1687)2020.PubMed/NCBI View Article : Google Scholar

23 

Feuerstein D, Backes H, Gramer M, Takagaki M, Gabel P, Kumagai T and Graf R: Regulation of cerebral metabolism during cortical spreading depression. J Cereb Blood Flow Metab. 36:1965–1977. 2016.PubMed/NCBI View Article : Google Scholar

24 

Deng H, Liu S, Pan D, Jia Y and Ma ZG: Myricetin reduces cytotoxicity by suppressing hepcidin expression in MES23.5 cells. Neural Regen Res. 16:1105–1110. 2021.PubMed/NCBI View Article : Google Scholar

25 

Taysi S, Tascan AS, Ugur MG and Demir M: Radicals, oxidative/nitrosative stress and preeclampsia. Mini Rev Med Chem. 19:178–193. 2019.PubMed/NCBI View Article : Google Scholar

26 

Islam MT: Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders. Neurol Res. 39:73–82. 2017.PubMed/NCBI View Article : Google Scholar

27 

Papavassiliou KA and Papavassiliou AG: Transcription factor drug targets. J Cell Biochem. 117:2693–2696. 2016.PubMed/NCBI View Article : Google Scholar

28 

Lambert M, Jambon S, Depauw S and David-Cordonnier MH: Targeting transcription factors for cancer treatment. Molecules. 23(1479)2018.PubMed/NCBI View Article : Google Scholar

29 

Lin W, Metzakopian E, Mavromatakis YE, Gao N, Balaskas N, Sasaki H, Briscoe J, Whitsett JA, Goulding M, Kaestner KH and Ang SL: Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development. Dev Biol. 333:386–396. 2009.PubMed/NCBI View Article : Google Scholar

30 

Ang SL: Foxa1 and Foxa2 transcription factors regulate differentiation of midbrain dopaminergic neurons. Adv Exp Med Biol. 651:58–65. 2009.PubMed/NCBI View Article : Google Scholar

31 

Clyne M and May FEB: The interaction of helicobacter pylori with TFF1 and its role in mediating the tropism of the bacteria within the stomach. Int J Mol Sci. 20(4400)2019.PubMed/NCBI View Article : Google Scholar

32 

Hu J, Shi Y, Wang C, Wan H, Wu D, Wang H and Peng X: Role of intestinal trefoil factor in protecting intestinal epithelial cells from burn-induced injury. Sci Rep. 8(3201)2018.PubMed/NCBI View Article : Google Scholar

33 

Soutto M, Chen Z, Bhat AA, Wang L, Zhu S, Gomaa A, Bates A, Bhat NS, Peng D, Belkhiri A, et al: Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia. Nat Commun. 10(3039)2019.PubMed/NCBI View Article : Google Scholar

34 

Yi J, Ren L, Li D, Wu J, Li W, Du G and Wang J: Trefoil factor 1 (TFF1) is a potential prognostic biomarker with functional significance in breast cancers. Biomed Pharmacother. 124(109827)2020.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Liang T, Zhao P, Zhang X, Han X, Hong B, Kong L, Chang H and Liu L: FOXA1 transcription activates TFF1 to reduce 6‑OHDA‑induced dopaminergic neuron damage. Exp Ther Med 23: 372, 2022.
APA
Liang, T., Zhao, P., Zhang, X., Han, X., Hong, B., Kong, L. ... Liu, L. (2022). FOXA1 transcription activates TFF1 to reduce 6‑OHDA‑induced dopaminergic neuron damage. Experimental and Therapeutic Medicine, 23, 372. https://doi.org/10.3892/etm.2022.11299
MLA
Liang, T., Zhao, P., Zhang, X., Han, X., Hong, B., Kong, L., Chang, H., Liu, L."FOXA1 transcription activates TFF1 to reduce 6‑OHDA‑induced dopaminergic neuron damage". Experimental and Therapeutic Medicine 23.6 (2022): 372.
Chicago
Liang, T., Zhao, P., Zhang, X., Han, X., Hong, B., Kong, L., Chang, H., Liu, L."FOXA1 transcription activates TFF1 to reduce 6‑OHDA‑induced dopaminergic neuron damage". Experimental and Therapeutic Medicine 23, no. 6 (2022): 372. https://doi.org/10.3892/etm.2022.11299
Copy and paste a formatted citation
x
Spandidos Publications style
Liang T, Zhao P, Zhang X, Han X, Hong B, Kong L, Chang H and Liu L: FOXA1 transcription activates TFF1 to reduce 6‑OHDA‑induced dopaminergic neuron damage. Exp Ther Med 23: 372, 2022.
APA
Liang, T., Zhao, P., Zhang, X., Han, X., Hong, B., Kong, L. ... Liu, L. (2022). FOXA1 transcription activates TFF1 to reduce 6‑OHDA‑induced dopaminergic neuron damage. Experimental and Therapeutic Medicine, 23, 372. https://doi.org/10.3892/etm.2022.11299
MLA
Liang, T., Zhao, P., Zhang, X., Han, X., Hong, B., Kong, L., Chang, H., Liu, L."FOXA1 transcription activates TFF1 to reduce 6‑OHDA‑induced dopaminergic neuron damage". Experimental and Therapeutic Medicine 23.6 (2022): 372.
Chicago
Liang, T., Zhao, P., Zhang, X., Han, X., Hong, B., Kong, L., Chang, H., Liu, L."FOXA1 transcription activates TFF1 to reduce 6‑OHDA‑induced dopaminergic neuron damage". Experimental and Therapeutic Medicine 23, no. 6 (2022): 372. https://doi.org/10.3892/etm.2022.11299
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