Open Access

Clinical significance of early IgA anti‑SARS‑CoV‑2 antibody detection in patients from a Romanian referral COVID‑19 hospital

  • Authors:
    • Andrei Vâţă
    • Adriana Anita
    • Carmen Doina Manciuc
    • Gheorghe Savuta
    • Catalina Mihaela Luca
    • Florin Manuel Roșu
    • Ioana Florina Mihai
    • Dragos Anita
  • View Affiliations

  • Published online on: April 12, 2022     https://doi.org/10.3892/etm.2022.11318
  • Article Number: 391
  • Copyright: © Vâţă et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Controlling the spread of coronavirus disease 2019 (COVID‑19) includes institute isolation, quarantine measures and appropriate clinical management, which all require effective screening, diagnostic and prognostic tools. The present study aimed to analyze severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2)‑specific immunoglobulin (Ig)A detection and determine the potential association with the clinical course of COVID‑19 and the levels of inflammation. In the present study, the presence of IgA and IgG SARS‑CoV‑2 antibodies in 75 consecutive patients with confirmed COVID‑19 infection was investigated. No significant differences were found between the IgA positive and negative groups, regarding the presence of symptoms, haematological and inflammatory variables, or the presence of pneumonia. In the majority of cases, antibody detection was comparable, for example, 79.7% of patients in the IgA positive group exhibited both types of antibodies, while 80.9% of patients in the IgA negative group were also IgG negative. A total of four patients in the IgA negative group presented with anti‑SARS‑CoV‑2 IgG antibodies. Early detection of IgA was more frequent in patients who later developed severe forms of the disease. In addition, the IgG SARS‑CoV‑2 antibody response was higher in patients with the severe form of the disease.
View Figures
View References

Related Articles

Journal Cover

June-2022
Volume 23 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Vâţă A, Anita A, Manciuc CD, Savuta G, Luca CM, Roșu FM, Mihai IF and Anita D: Clinical significance of early IgA anti‑SARS‑CoV‑2 antibody detection in patients from a Romanian referral COVID‑19 hospital. Exp Ther Med 23: 391, 2022
APA
Vâţă, A., Anita, A., Manciuc, C.D., Savuta, G., Luca, C.M., Roșu, F.M. ... Anita, D. (2022). Clinical significance of early IgA anti‑SARS‑CoV‑2 antibody detection in patients from a Romanian referral COVID‑19 hospital. Experimental and Therapeutic Medicine, 23, 391. https://doi.org/10.3892/etm.2022.11318
MLA
Vâţă, A., Anita, A., Manciuc, C. D., Savuta, G., Luca, C. M., Roșu, F. M., Mihai, I. F., Anita, D."Clinical significance of early IgA anti‑SARS‑CoV‑2 antibody detection in patients from a Romanian referral COVID‑19 hospital". Experimental and Therapeutic Medicine 23.6 (2022): 391.
Chicago
Vâţă, A., Anita, A., Manciuc, C. D., Savuta, G., Luca, C. M., Roșu, F. M., Mihai, I. F., Anita, D."Clinical significance of early IgA anti‑SARS‑CoV‑2 antibody detection in patients from a Romanian referral COVID‑19 hospital". Experimental and Therapeutic Medicine 23, no. 6 (2022): 391. https://doi.org/10.3892/etm.2022.11318