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Bisdemethoxycurcumin attenuates OVA‑induced food allergy by inhibiting the MAPK and NF‑κB signaling pathways

  • Authors:
    • Yanjie Wang
    • Ping Zhang
    • Jingyu Zhang
    • Tie Hong
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, School of Pharmaceutical Sciences, Jilin University, Jilin, Changchun 130021, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 401
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    Published online on: April 20, 2022
       https://doi.org/10.3892/etm.2022.11328
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Abstract

Bisdemethoxycurcumin (BDMC) is an important ingredient derived from turmeric in addition to curcumin. It has been reported that BDMC can be used to treat mast cell‑mediated allergic diseases. In the present study, a food allergy (FA) murine model sensitized by intraperitoneal injection followed by oral challenge with ovalbumin (OVA) was established. BDMC was orally administered at 100 and 200 mg/kg for 11 days in the challenge phase to treat OVA‑induced FA mice. FA symptoms such as diarrhea score, anaphylactic symptom score and rectal temperature were recorded. Intestinal tissue was also observed by hematoxylin and eosin staining. In addition, other allergic indicators were also analyzed by ELISA and western blot analysis. The present study demonstrated that BDMC could suppress the decreases in rectal temperature, diarrhea and anaphylactic symptoms in FA mice. BDMC could also ameliorate the inflammation of intestinal tissues in FA mice. BDMC not only decreased the production of OVA‑specific immunoglobulin (OVA‑sIg)E, IgG1, histamine, mouse mast cell protease‑1, diamine oxidase, cytokines (IL‑4, IL‑5 and IL‑13) but increased cytokines interferon‑γ production. The protein expression results showed that the levels of Gata‑3 were decreased but T‑bet levels were increased. Furthermore, compared with the OVA group, phosphorylated (p)‑p38, p‑JNK, p‑ERK and p‑NF‑κBp65 levels were decreased and p‑IκBα level was increased. In conclusion, the results showed that BDMC possessed a protective effect on FA. Furthermore, BDMC was able to regulate the T‑helper cells (Th)1/Th2 immune balance and inhibit the activation of MAPK and NF‑κB pathways in FA mice.
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1 

Prescott S and Allen KJ: Food allergy: Riding the second wave of the allergy epidemic. Pediatr Allergy Immunol. 22:155–160. 2011.PubMed/NCBI View Article : Google Scholar

2 

Johnston LK, Chien KB and Bryce PJ: The immunology of food allergy. J Immunol. 192:2529–2534. 2014.PubMed/NCBI View Article : Google Scholar

3 

Sicherer SH: Epidemiology of food allergy. J Allergy Clin Immunol. 127:594–602. 2011.PubMed/NCBI View Article : Google Scholar

4 

Sicherer SH and Sampson HA: Food allergy: Recent advances in pathophysiology and treatment. Annu Rev Med. 60:261–277. 2009.PubMed/NCBI View Article : Google Scholar

5 

Venter C and Arshad SH: Epidemiology of food allergy. Pediatr Clin North Am. 58:327–349. 2011.PubMed/NCBI View Article : Google Scholar

6 

Krogulska A, Polakowska E, Wąsowska-Królikowska K, Małachowska B, Młynarski W and Borowiec M: Decreased FOXP3 mRNA expression in children with atopic asthma and IgE-mediated food allergy. Ann Allergy Asthma Immunol. 115:415–421. 2015.PubMed/NCBI View Article : Google Scholar

7 

Kucuk ZY, Strait R, Khodoun MV, Mahler A, Hogan S and Finkelman FD: Induction and suppression of allergic diarrhea and systemic anaphylaxis in a murine model of food allergy. J Allergy Clin Immunol. 129:1343–1348. 2012.PubMed/NCBI View Article : Google Scholar

8 

Gendel SM: Bioinformatics and Food Allergens. J AOAC Int. 87:1417–1422. 2004.PubMed/NCBI

9 

Bernhisel-Broadbent J, Dintzis HM, Dintzis RZ and Sampson HA: Allergenicity and antigenicity of chicken egg ovomucoid (Gal d III) compared with ovalbumin (Gal d I) in children with egg allergy and in mice. J Allergy Clin Immunol. 93:1047–1059. 1994.PubMed/NCBI View Article : Google Scholar

10 

Van Asperen P, Kemp AS and Mellis CM: Skin test reactivity and clinical allergen sensitivity in infancy. J Allergy Clin Immunol. 73:381–386. 1984.PubMed/NCBI View Article : Google Scholar

11 

Sampson HA: Food allergy. Part 1: Immunopathogenesis and clinical disorders. J Allergy Clin Immunol. 103 (5 Pt 1):717–728. 1999.PubMed/NCBI View Article : Google Scholar

12 

Yu W, Freeland DMH and Nadeau KC: Food allergy: Immune mechanisms, diagnosis and immunotherapy. Nat Rev Immunol. 16:751–765. 2016.PubMed/NCBI View Article : Google Scholar

13 

Kumar S, Verma AK, Das M and Dwivedi PD: Molecular mechanisms of IgE mediated food allergy. Int Immunopharmacol. 13:432–439. 2012.PubMed/NCBI View Article : Google Scholar

14 

Duan W and Wong WS: Targeting mitogen-activated protein kinases for asthma. Curr Drug Targets. 7:691–698. 2006.PubMed/NCBI View Article : Google Scholar

15 

Li L, Zhang XH, Liu GR, Liu C and Dong YM: Isoquercitrin suppresses the expression of histamine and pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-κB in human KU812 cells. Chin J Nat Med. 14:407–412. 2016.PubMed/NCBI View Article : Google Scholar

16 

Zhou Y, Yang Q, Xu H, Zhang J, Deng H, Gao H, Yang J, Zhao D and Liu F: MiRNA-221-3p Enhances the secretion of interleukin-4 in mast cells through the phosphatase and tensin Homolog/p38/Nuclear Factor-kappaB pathway. PLoS One. 11(e0148821)2016.PubMed/NCBI View Article : Google Scholar

17 

Shin HS, See HJ, Jung SY, Choi DW, Kwon DA, Bae MJ, Sung KS and Shon DH: Turmeric (Curcuma longa) attenuates food allergy symptoms by regulating type 1/2 helper T cells (Th1/Th2) balance in a mouse model of food allergy. J Ethnopharmacol. 175:21–29. 2015.PubMed/NCBI View Article : Google Scholar

18 

Kinney SR, Carlson L, Ser-Dolansky J, Thompson C, Shah S, Gambrah A, Xing W, Schneider SS and Mathias CB: Curcumin ingestion inhibits mastocytosis and suppresses intestinal anaphylaxis in a murine model of food allergy. PLoS One. 10(e0132467)2015.PubMed/NCBI View Article : Google Scholar

19 

Zhang N, Li H, Jia J and He M: Anti-inflammatory effect of curcumin on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouse. Cell Immunol. 298:88–95. 2015.PubMed/NCBI View Article : Google Scholar

20 

Gordon ON, Luis PB, Ashley RE, Osheroff N and Schneider C: Oxidative transformation of demethoxy-and bisdemethoxycurcumin: Products, mechanism of formation, and poisoning of human topoisomerase IIα. Chem Res Toxicol. 28:989–996. 2015.PubMed/NCBI View Article : Google Scholar

21 

Ramezani M, Hatamipour M and Sahebkar A: Promising Anti-tumor properties of Bisdemethoxycurcumin: A naturally occurring curcumin analogue. J Cell Physiol. 233:880–887. 2018.PubMed/NCBI View Article : Google Scholar

22 

Xu JH, Yang HP, Zhou XD, Wang HJ, Gong L and Tang CL: Role of Wnt inhibitory factor-1 in inhibition of bisdemethoxycurcumin mediated epithelial-to-mesenchymal transition in highly metastatic lung cancer 95D cells. Chin Med J (Engl). 128:1376–1383. 2015.PubMed/NCBI View Article : Google Scholar

23 

Li YB, Gao JL, Zhong ZF, Hoi PM, Lee SM and Wang YT: Bisdemethoxycurcumin suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways. Pharmacol Rep. 65:700–709. 2013.PubMed/NCBI View Article : Google Scholar

24 

Haukvik T, Bruzell E, Kristensen S and Tønnesen HH: A screening of curcumin derivatives for antibacterial phototoxic effects Studies on curcumin and curcuminoids. XLIII. Pharmazie. 66:69–74. 2011.PubMed/NCBI

25 

Fu M, Fu S, Ni S, Wang D and Hong T: Inhibitory effects of bisdemethoxycurcumin on mast cell-mediated allergic diseases. Int Immunopharmacol. 65:182–189. 2018.PubMed/NCBI View Article : Google Scholar

26 

Lee D, Kim HS, Shin E, Do SG, Lee CK, Kim YM, Lee MB, Min KY, Koo J, Kim SJ, et al: Polysaccharide isolated from Aloe vera gel suppresses ovalbumin-induced food allergy through inhibition of Th2 immunity in mice. Biomed Pharmacother. 101:201–210. 2018.PubMed/NCBI View Article : Google Scholar

27 

Sicherer SH and Sampson HA: Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment. J Allergy Clin Immunol. 133:291–307. 2013.PubMed/NCBI View Article : Google Scholar

28 

Berin MC: Pathogenesis of IgE-mediated food allergy. Clin Exp Allergy. 45:1483–1496. 2015.PubMed/NCBI View Article : Google Scholar

29 

Sicherer SH and Sampson HA: Food allergy. J Allergy Clin Immunol. 125 (Suppl 2):S116–S125. 2010.PubMed/NCBI View Article : Google Scholar

30 

Kweon MN, Yamamoto M, Kajiki M, Takahashi I and Kiyono H: Systemically derived large intestinal CD4(+) Th2 cells play a central role in STAT6-mediated allergic diarrhea. J Clin Invest. 106:199–206. 2000.PubMed/NCBI View Article : Google Scholar

31 

Yamaki K and Yoshino S: Remission of food allergy by the Janus kinase inhibitor ruxolitinib in mice. Int Immunopharmacol. 18:217–224. 2014.PubMed/NCBI View Article : Google Scholar

32 

Bischoff S and Crowe SE: Gastrointestinal food allergy: New insights into pathophysiology and clinical perspectives. Gastroenterology. 128:1089–1113. 2005.PubMed/NCBI View Article : Google Scholar

33 

Wollin A, Wang X and Tso P: Nutrients regulate diamine oxidase release from intestinal mucosa. Am J Physiol. 275:R969–R975. 1998.PubMed/NCBI View Article : Google Scholar

34 

Jiang S, Han S, Chen J, Li X and Che H: Inhibition effect of blunting Notch signaling on food allergy through improving TH1/TH2 balance in mice. Ann Allergy Asthma Immunol. 118:94–102. 2017.PubMed/NCBI View Article : Google Scholar

35 

Galli SJ, Tsai M and Piliponsky AM: The development of allergic inflammation. Nature. 454:445–454. 2008.PubMed/NCBI View Article : Google Scholar

36 

Ciprandi G, Marseglia GL, Castagnoli R, Valsecchi C, Tagliacarne C, Caimmi S and Licari A: From IgE to clinical trials of allergic rhinitis. Expert Rev Clin Immunol. 11:1321–1333. 2015.PubMed/NCBI View Article : Google Scholar

37 

Wang M, Takeda K, Shiraishi Y, Okamoto M, Dakhama A, Joetham A and Gelfand EW: Peanut-induced intestinal allergy is mediated through a mast cell-IgE-FcepsilonRI-IL-13 pathway. J Allergy Clin Immunol. 126:306–316, 316.e1-12. 2010.PubMed/NCBI View Article : Google Scholar

38 

Hua X and He SH: Roles of histamine and its receptors in allergic and inflammatory bowel diseases. World J Gastroenterol. 11:2851–2857. 2005.PubMed/NCBI View Article : Google Scholar

39 

Maintz L and Novak N: Histamine and histamine intolerance. Am J Clin Nutr. 85:1185–1196. 2007.PubMed/NCBI View Article : Google Scholar

40 

Yamamoto T, Fujiwara K, Yoshida M, Kageyama-Yahara N, Kuramoto H, Shibahara N and Kadowaki M: Therapeutic effect of kakkonto in a mouse model of food allergy with gastrointestinal symptoms. Int Arch Allergy Immunol. 148:175–185. 2009.PubMed/NCBI View Article : Google Scholar

41 

Brandt EB, Strait RT, Hershko D, Wang Q, Muntel EE, Scribner TA, Zimmermann N, Finkelman FD and Rothenberg ME: Mast cells are required for experimental oral allergen-induced diarrhea. J Clin Invest. 112:1666–1677. 2003.PubMed/NCBI View Article : Google Scholar

42 

Matsui T, Yamashita H, Mori M, Tanaka H and Inagaki N: Eppikajutsuto protects against food allergy induced by ovalbumin in a murine model. Int Arch Allergy Immunol. 173:71–83. 2017.PubMed/NCBI View Article : Google Scholar

43 

Wang C, Collins M and Kuchroo VK: Effector T cell differentiation: Are master regulators of effector T cells still the masters? Curr Opin Immunol. 37:6–10. 2015.PubMed/NCBI View Article : Google Scholar

44 

Cook PC, Jones LH, Jenkins SJ, Wynn TA, Allen JE and MacDonald AS: Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo. Proc Natl Acad Sci USA. 109:9977–9982. 2012.PubMed/NCBI View Article : Google Scholar

45 

Yamane H and Paul WE: Cytokines of the γ(c) family control CD4+ T cell differentiation and function. Nat Immunol. 13:1037–1044. 2012.PubMed/NCBI View Article : Google Scholar

46 

Manise M, Holtappels G, Van Crombruggen K, Schleich F, Bachert C and Louis R: Sputum IgE and cytokines in asthma: Relationship with sputum cellular profile. PLoS One. 8(e58388)2013.PubMed/NCBI View Article : Google Scholar

47 

Gilfillan AM and Tkaczyk C: Integrated signalling pathways for mast-cell activation. Nat Rev Immunol. 6:218–230. 2006.PubMed/NCBI View Article : Google Scholar

48 

Qi M and Elion EA: MAP kinase pathways. J Cell Sci. 118(Pt 16):3569–3572. 2005.PubMed/NCBI View Article : Google Scholar

49 

Azzolina A, Bongiovanni A and Lampiasi N: Substance P. induces TNF alpha and IL-6 production through NF kappa B in peritoneal mast cells. Biochim Biophys Acta. 1643:75–83. 2003.PubMed/NCBI View Article : Google Scholar

50 

Schuliga M: NF-kappaB signaling in chronic inflammatory airway disease. Biomolecules. 5:1266–1283. 2015.PubMed/NCBI View Article : Google Scholar

51 

Kong R, Kang OH, Seo YS, Zhou T, Kim SA, Shin DW and Kwon DY: MAPKs and NF-κB pathway inhibitory effect of bisdemethoxycurcumin on phorbol-12-myristate-13-acetate and A23187-induced inflammation in human mast cells. Mol Med Rep. 17:630–635. 2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Zhang P, Zhang J and Hong T: Bisdemethoxycurcumin attenuates OVA‑induced food allergy by inhibiting the MAPK and NF‑κB signaling pathways. Exp Ther Med 23: 401, 2022.
APA
Wang, Y., Zhang, P., Zhang, J., & Hong, T. (2022). Bisdemethoxycurcumin attenuates OVA‑induced food allergy by inhibiting the MAPK and NF‑κB signaling pathways. Experimental and Therapeutic Medicine, 23, 401. https://doi.org/10.3892/etm.2022.11328
MLA
Wang, Y., Zhang, P., Zhang, J., Hong, T."Bisdemethoxycurcumin attenuates OVA‑induced food allergy by inhibiting the MAPK and NF‑κB signaling pathways". Experimental and Therapeutic Medicine 23.6 (2022): 401.
Chicago
Wang, Y., Zhang, P., Zhang, J., Hong, T."Bisdemethoxycurcumin attenuates OVA‑induced food allergy by inhibiting the MAPK and NF‑κB signaling pathways". Experimental and Therapeutic Medicine 23, no. 6 (2022): 401. https://doi.org/10.3892/etm.2022.11328
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Zhang P, Zhang J and Hong T: Bisdemethoxycurcumin attenuates OVA‑induced food allergy by inhibiting the MAPK and NF‑κB signaling pathways. Exp Ther Med 23: 401, 2022.
APA
Wang, Y., Zhang, P., Zhang, J., & Hong, T. (2022). Bisdemethoxycurcumin attenuates OVA‑induced food allergy by inhibiting the MAPK and NF‑κB signaling pathways. Experimental and Therapeutic Medicine, 23, 401. https://doi.org/10.3892/etm.2022.11328
MLA
Wang, Y., Zhang, P., Zhang, J., Hong, T."Bisdemethoxycurcumin attenuates OVA‑induced food allergy by inhibiting the MAPK and NF‑κB signaling pathways". Experimental and Therapeutic Medicine 23.6 (2022): 401.
Chicago
Wang, Y., Zhang, P., Zhang, J., Hong, T."Bisdemethoxycurcumin attenuates OVA‑induced food allergy by inhibiting the MAPK and NF‑κB signaling pathways". Experimental and Therapeutic Medicine 23, no. 6 (2022): 401. https://doi.org/10.3892/etm.2022.11328
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