Expression and clinical significance of lncRNA BC041954 in ovarian cancer

  • Authors:
    • Yan-Ming Lu
    • Ya-Ru Guo
    • Meng-Ya Zhou
    • Yue Wang
  • View Affiliations

  • Published online on: April 26, 2022     https://doi.org/10.3892/etm.2022.11335
  • Article Number: 408
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Ovarian cancer (OC) is a highly lethal disease among all gynecologic malignant tumor types. Accumulating studies have indicated that certain long non‑coding RNAs (lncRNAs) serve important roles in the development and progression of OC. In a previous study by our group, lncRNA BC041954 was identified as one of the most upregulated lncRNAs in OC. In the present study, the clinical significance of lncRNA BC041954 in OC was evaluated. The expression of BC041954 was detected in OC and non‑tumor tissue (NT) samples using reverse transcription‑quantitative PCR. Furthermore, the association between BC041954 and clinicopathological variables was analyzed using the Chi‑square test. Survival was determined using Kaplan‑Meier analysis. The prognostic significance of BC041954 was evaluated using univariate and multivariate logistic regression analyses. MicroRNA (miRNA)‑lncRNA and miRNA‑mRNA pairs were used to construct the lncRNA‑miRNA‑mRNA competing endogenous RNA network with an in‑house Perl script. BC041954 expression was increased in 103 OC tissues as compared with that in NT tissues. Upregulated BC041954 expression was significantly associated with the International Federation of Gynecology and Obstetrics stage and distant metastasis. Kaplan‑Meier analysis demonstrated that patients with high BC041954 expression had lower overall survival (OS). In the multivariate logistic regression analysis, BC041954 was also identified as an independent poor prognostic factor for OS in patients with OC. The results suggested that overexpression of the lncRNA BC041954 is a poor prognostic indicator in patients with OC.

Related Articles

Journal Cover

June-2022
Volume 23 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Lu Y, Guo Y, Zhou M and Wang Y: Expression and clinical significance of lncRNA BC041954 in ovarian cancer. Exp Ther Med 23: 408, 2022
APA
Lu, Y., Guo, Y., Zhou, M., & Wang, Y. (2022). Expression and clinical significance of lncRNA BC041954 in ovarian cancer. Experimental and Therapeutic Medicine, 23, 408. https://doi.org/10.3892/etm.2022.11335
MLA
Lu, Y., Guo, Y., Zhou, M., Wang, Y."Expression and clinical significance of lncRNA BC041954 in ovarian cancer". Experimental and Therapeutic Medicine 23.6 (2022): 408.
Chicago
Lu, Y., Guo, Y., Zhou, M., Wang, Y."Expression and clinical significance of lncRNA BC041954 in ovarian cancer". Experimental and Therapeutic Medicine 23, no. 6 (2022): 408. https://doi.org/10.3892/etm.2022.11335