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Resveratrol protects against atherosclerosis by downregulating the PI3K/AKT/mTOR signaling pathway in atherosclerosis model mice

  • Authors:
    • Wuguang Ji
    • Jing Sun
    • Zonghua Hu
    • Bo Sun
  • View Affiliations / Copyright

    Affiliations: Department of Vascular Surgery, The People's Hospital of Weifang, Weifang, Shandong 310009, P.R. China, Department of Radiology, Traditional Chinese Medicine Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China, Department of Interventional Radiology, The People's Hospital of Weifang, Weifang, Shandong 310009, P.R. China
    Copyright: © Ji et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 414
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    Published online on: April 27, 2022
       https://doi.org/10.3892/etm.2022.11341
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Abstract

Atherosclerosis is a cardiovascular disease, which is characterized by the interaction between carbohydrates, lipids, cells and various other molecules and genetic factors. Previous studies have demonstrated that resveratrol (RV) served protective roles in numerous types of human disease by regulating different signaling pathways. The aim of the present study was to investigate the therapeutic effects of RV and analyze the potential RV‑mediated mechanism in umbilical vein endothelial cells (UVECS) in atherosclerosis model mice. Reverse transcription‑quantitative PCR, western blotting and immunohistochemistry were used to analyze the therapeutic effects of RV both in vitro and in vivo. The results demonstrated that total cholesterol, triglycerides, low‑density lipoprotein cholesterin and high‑density lipoprotein cholesterin levels were significantly decreased in the RV group compared with the control group. RV demonstrated significant anti‑atherosclerotic activity, which was determined through the atherogenic index, 3‑hydroxy‑3‑methyl‑glutaryl‑Coa (HMG‑CoA) reductase activity and marker enzymes, such as lactate dehydrogenase, creatine phosphokinase, aspartate transaminase, alanine transaminase and alkaline phosphatase. It was also observed that RV treatment significantly decreased the area of the arteriosclerotic lesion in the RV group compared with the control, as well as significantly decreasing the expression levels of matrix metalloproteinase‑9 and CD40 ligand (CD40L) in arterial lesion tissue compared with the control group. Serum expression levels of tumor necrosis factor‑α and C‑reactive protein were also significantly decreased by RV treatment compared with the control group. Furthermore, RV treatment significantly decreased the expression levels of PI3K, AKT and mTOR in UVECS in vitro. In conclusion, these results suggested that the anti‑atherosclerotic activity of RV may be due to its modulatory activity over the PI3K/AKT/mTOR signaling pathway. These findings suggested a potential novel treatment option for patients with atherosclerosis.
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1 

Gandhi S, Chen S, Hong L, Sun K, Gong E, Li C, Yan LL and Schwalm JD: Effect of mobile health interventions on the secondary prevention of cardiovascular disease: Systematic review and meta-analysis. Can J Cardiol. 33:219–231. 2017.PubMed/NCBI View Article : Google Scholar

2 

Huang Y, Cai X, Mai W, Li M and Hu Y: Association between prediabetes and risk of cardiovascular disease and all cause mortality: Systematic review and meta-analysis. BMJ. 355(i5953)2016.PubMed/NCBI View Article : Google Scholar

3 

Aziz M, Ali SS, Das S, Younus A, Malik R, Latif MA, Humayun C, Anugula D, Abbas G, Salami J, et al: Association of subjective and objective sleep duration as well as sleep quality with non-invasive markers of sub-clinical cardiovascular disease (CVD): A systematic review. J Atheroscler Thromb. 24:208–226. 2017.PubMed/NCBI View Article : Google Scholar

4 

Sedighi M, Bahmani M, Asgary S, Beyranvand F and Rafieian-Kopaei M: A review of plant-based compounds and medicinal plants effective on atherosclerosis. J Res Med Sci. 22(30)2017.PubMed/NCBI View Article : Google Scholar

5 

Milic NM, Milin-Lazovic J, Weissgerber TL, Trajkovic G, White WM and Garovic VD: Preclinical atherosclerosis at the time of pre-eclamptic pregnancy and up to 10 years postpartum: Systematic review and meta-analysis. Ultrasound Obstet Gynecol. 49:110–115. 2017.PubMed/NCBI View Article : Google Scholar : (In En, Spanish).

6 

Zanoli L, Signorelli SS, Inserra G and Castellino P: Subclinical atherosclerosis in patients with inflammatory bowel diseases: A systematic review and meta-analysis. Angiology. 68(463)2017.PubMed/NCBI View Article : Google Scholar

7 

Wu GC, Leng RX, Lu Q, Fan YG, Wang DG and Ye DQ: Subclinical atherosclerosis in patients with inflammatory bowel diseases: A systematic review and meta-analysis. Angiology. 68:447–461. 2017.PubMed/NCBI View Article : Google Scholar

8 

Usai MV, Bosiers MJ, Bisdas T, Torsello G, Beropoulis E, Kasprzak B, Stachmann A and Stavroulakis K: Surgical versus endovascular revascularization of subclavian artery arteriosclerotic disease. J Cardiovasc Surg (Torino). 61:53–59. 2020.PubMed/NCBI View Article : Google Scholar

9 

Petrovski G, Gurusamy N and Das DK: Resveratrol in cardiovascular health and disease. Ann N Y Acad Sci. 1215:22–33. 2011.PubMed/NCBI View Article : Google Scholar

10 

Li H, Yan Z, Zhu J, Yang J and He J: Neuroprotective effects of resveratrol on ischemic injury mediated by improving brain energy metabolism and alleviating oxidative stress in rats. Neuropharmacology. 60:252–258. 2011.PubMed/NCBI View Article : Google Scholar

11 

Csiszar A: Anti-inflammatory effects of resveratrol: Possible role in prevention of age-related cardiovascular disease. Ann N Y Acad Sci. 1215:117–122. 2011.PubMed/NCBI View Article : Google Scholar

12 

Wang H, Yang YJ, Qian HY, Zhang Q, Xu H and Li JJ: Resveratrol in cardiovascular disease: What is known from current research? Heart Fail Rev. 17:437–448. 2012.PubMed/NCBI View Article : Google Scholar

13 

Tomé-Carneiro J, Gonzálvez M, Larrosa M, Yáñez-Gascón MJ, García-Almagro FJ, Ruiz-Ros JA, Tomás-Barberán FA, García-Conesa MT and Espín JC: Resveratrol in primary and secondary prevention of cardiovascular disease: A dietary and clinical perspective. Ann NY Acad Sci. 1290:37–51. 2013.PubMed/NCBI View Article : Google Scholar

14 

Ruan BF, Lu XQ, Song J and Zhu HL: Derivatives of resveratrol: Potential agents in prevention and treatment of cardiovascular disease. Curr Med Chem. 19:4175–4183. 2012.PubMed/NCBI View Article : Google Scholar

15 

Kattoor AJ, Pothineni NVK, Palagiri D and Mehta JL: Oxidative stress in atherosclerosis. Curr Atheroscler Rep. 19(42)2017.PubMed/NCBI View Article : Google Scholar

16 

Niroumand S, Khajedaluee M, Khadem-Rezaiyan M, Abrishami M, Juya M, Khodaee G and Dadgarmoghaddam M: Atherogenic index of plasma (AIP): A marker of cardiovascular disease. Med J Islam Repub Iran. 29(240)2015.PubMed/NCBI

17 

Henrot P, Foret J, Barnetche T, Lazaro E, Duffau P, Seneschal J, Schaeverbeke T, Truchetet ME and Richez C: Assessment of subclinical atherosclerosis in systemic lupus erythematosus: A systematic review and meta-analysis. Joint Bone Spine. 85:155–163. 2018.PubMed/NCBI View Article : Google Scholar

18 

Yong WC, Sanguankeo A and Upala S: Association between sarcoidosis, pulse wave velocity, and other measures of subclinical atherosclerosis: A systematic review and meta-analysis. Clin Rheumatol. 37:2825–2832. 2018.PubMed/NCBI View Article : Google Scholar

19 

Cho IJ, Ahn JY, Kim S, Choi MS and Ha TY: Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters. Biochem Biophys Res Commun. 367:190–194. 2008.PubMed/NCBI View Article : Google Scholar

20 

Liu G, Wang B, Zhang J, Jiang H and Liu F: Total panax notoginsenosides prevent atherosclerosis in apolipoprotein E-knockout mice: Role of downregulation of CD40 and MMP-9 expression. J Ethnopharmacol. 126:350–354. 2009.PubMed/NCBI View Article : Google Scholar

21 

Zhang Y, Yang X, Bian F, Wu P, Xing S, Xu G, Li W, Chi J, Ouyang C, Zheng T, et al: TNF-α promotes early atherosclerosis by increasing transcytosis of LDL across endothelial cells: Crosstalk between NF-κB and PPAR-γ. J Mol Cell Cardiol. 72:85–94. 2014.PubMed/NCBI View Article : Google Scholar

22 

Piechota W: Correlation of high-sensitivity CRP concentration with the extent of coronary atherosclerosis in men with symptoms of ischemic heart disease. Pol Merkur Lekarski. 18:511–515. 2005.PubMed/NCBI(In Polish).

23 

Egorova MO: Increased serum level of the acute inflammation phase parameter CRP and the high level of low density lipoprotein cholesterol-factors of increased risk of development of atherosclerosis and its complications (a literature review). Klin Lab Diagn. 3-6:2002.PubMed/NCBI(In Russian).

24 

Xing SS, Yang XY, Zheng T, Li WJ, Wu D, Chi JY, Bian F, Bai XL, Wu GJ, Zhang YZ, et al: Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway. Vascul Pharmacol. 72:141–152. 2015.PubMed/NCBI View Article : Google Scholar

25 

Kurdi A, Martinet W and De Meyer GRY: mTOR inhibition and cardiovascular diseases: Dyslipidemia and atherosclerosis. Transplantation. 102 (Suppl 1):S44–S46. 2018.PubMed/NCBI View Article : Google Scholar

26 

Hu Q, Chai J, Liu L, Hou Y, Wang Y, Li B and Yang H: Isolation, culture, and identification of canine umbilical vein vascular endothelial cells. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 27:460–463. 2013.PubMed/NCBI(In Chinese).

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

28 

Song R, Li WQ, Dou JL, Li L, Hu Y, Guo J, Lu D, Zhang G and Sun L: Resveratrol reduces inflammatory cytokines via inhibiting nuclear factor-κB and mitogen-activated protein kinase signal pathway in a rabbit atherosclerosis model. Zhonghua Xin Xue Guan Bing Za Zhi. 41:866–869. 2013.PubMed/NCBI(In Chinese).

29 

Pan W, Yu H, Huang S and Zhu P: Resveratrol protects against TNF-α-induced injury in human umbilical endothelial cells through promoting sirtuin-1-induced repression of NF-KB and p38 MAPK. PLoS One. 11(e0147034)2016.PubMed/NCBI View Article : Google Scholar

30 

Verschuren L, Wielinga PY, van Duyvenvoorde W, Tijani S, Toet K, van Ommen B, Kooistra T and Kleemann R: A dietary mixture containing fish oil, resveratrol, lycopene, catechins, and vitamins E and C reduces atherosclerosis in transgenic mice. J Nutr. 141:863–869. 2011.PubMed/NCBI View Article : Google Scholar

31 

Kleemann R and Kooistra T: HMG-CoA reductase inhibitors: Effects on chronic subacute inflammation and onset of atherosclerosis induced by dietary cholesterol. Curr Drug Targets Cardiovasc Haematol Disord. 5:441–453. 2005.PubMed/NCBI View Article : Google Scholar

32 

Doganer YC, Rohrer JE, Aydogan U, Agerter DC, Cayci T and Barcin C: Atherosclerosis and liver function tests in coronary angiography patients. West Indian Med J. 64:333–337. 2015.PubMed/NCBI View Article : Google Scholar

33 

Lin JH, Lin YF, Wang WJ, Lin YF, Chueh SJ, Wu VC, Chu TS and Wu KD: Taiwan Primary Aldosteronism Investigation (TAIPAI) Study Group. Plasma aldosterone concentration as a determinant for statin use among middle-aged hypertensive patients for atherosclerotic cardiovascular disease. J Clin Med. 7(382)2018.PubMed/NCBI View Article : Google Scholar

34 

Agarwal R and Agarwal P: Targeting extracellular matrix remodeling in disease: Could resveratrol be a potential candidate? Exp Biol Med (Maywood). 242:374–383. 2017.PubMed/NCBI View Article : Google Scholar

35 

Vilar-Pereira G, Carneiro VC, Mata-Santos H, Vicentino ARR, Ramos IP, Giarola NLL, Feijó DF, Meyer-Fernandes JR, Paula-Neto HA, Medei E, et al: Resveratrol reverses functional chagas heart disease in mice. PLoS Pathog. 12(e1005947)2016.PubMed/NCBI View Article : Google Scholar

36 

Naia L, Rosenstock TR, Oliveira AM, Oliveira-Sousa SI, Caldeira GL, Carmo C, Laço MN, Hayden MR, Oliveira CR and Rego AC: Comparative mitochondrial-based protective effects of resveratrol and nicotinamide in Huntington's disease models. Mol Neurobiol. 54:5385–5399. 2017.PubMed/NCBI View Article : Google Scholar

37 

Silvello D, Narvaes LB, Albuquerque LC, Forgiarini LF, Meurer L, Martinelli NC, Andrades ME, Clausell N, dos Santos KG and Rohde LE: Serum levels and polymorphisms of matrix metalloproteinases (MMPs) in carotid artery atherosclerosis: Higher MMP-9 levels are associated with plaque vulnerability. Biomarkers. 19:49–55. 2014.PubMed/NCBI View Article : Google Scholar

38 

Ishigaki Y, Kono S, Katagiri H, Oka Y and Oikawa S: NTTP investigators. Elevation of HDL-C in response to statin treatment is involved in the regression of carotid atherosclerosis. J Atheroscler Thromb. 21:1055–1065. 2014.PubMed/NCBI View Article : Google Scholar

39 

Zhang Y, Wu NQ, Li S, Zhu CG, Guo YL, Qing P, Gao Y, Li XL, Liu G, Dong Q and Li JJ: Non-HDL-C is a better predictor for the severity of coronary atherosclerosis compared with LDL-C. Heart Lung Circ. 25:975–981. 2016.PubMed/NCBI View Article : Google Scholar

40 

Mueller MA, Beutner F, Teupser D, Ceglarek U and Thiery J: Prevention of atherosclerosis by the mTOR inhibitor everolimus in LDLR-/-mice despite severe hypercholesterolemia. Atherosclerosis. 198:39–48. 2008.PubMed/NCBI View Article : Google Scholar

41 

Lu XL, Zhao CH, Yao XL and Zhang H: Quercetin attenuates high fructose feeding-induced atherosclerosis by suppressing inflammation and apoptosis via ROS-regulated PI3K/AKT signaling pathway. Biomed Pharmacother. 85:658–671. 2017.PubMed/NCBI View Article : Google Scholar

42 

Lv J, Yang L, Guo R, Shi Y, Zhang Z and Ye J: Ox-LDL-induced microRNA-155 promotes autophagy in human endothelial cells via repressing the Rheb/mTOR pathway. Cell Physiol Biochem. 43:1436–1448. 2017.PubMed/NCBI View Article : Google Scholar

43 

Yao X, Yan C, Zhang L, Li Y and Wan Q: LncRNA ENST00113 promotes proliferation, survival, and migration by activating PI3K/Akt/mTOR signaling pathway in atherosclerosis. Medicine (Baltimore). 97(e0473)2018.PubMed/NCBI View Article : Google Scholar

44 

Che J, Liang B, Zhang Y, Wang Y, Tang J and Shi G: Kaempferol alleviates ox-LDL-induced apoptosis by up-regulation of autophagy via inhibiting PI3K/Akt/mTOR pathway in human endothelial cells. Cardiovasc Pathol. 31:57–62. 2017.PubMed/NCBI View Article : Google Scholar

45 

Zhai C, Cheng J, Mujahid H, Wang H, Kong J, Yin Y, Li J, Zhang Y, Ji X and Chen W: Selective inhibition of PI3K/Akt/mTOR signaling pathway regulates autophagy of macrophage and vulnerability of atherosclerotic plaque. PLoS One. 9(e90563)2014.PubMed/NCBI View Article : Google Scholar

46 

Tang F and Yang TL: MicroRNA-126 alleviates endothelial cells injury in atherosclerosis by restoring autophagic flux via inhibiting of PI3K/Akt/mTOR pathway. Biochem Biophys Res Commun. 495:1482–1489. 2018.PubMed/NCBI View Article : Google Scholar

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Spandidos Publications style
Ji W, Sun J, Hu Z and Sun B: Resveratrol protects against atherosclerosis by downregulating the PI3K/AKT/mTOR signaling pathway in atherosclerosis model mice. Exp Ther Med 23: 414, 2022.
APA
Ji, W., Sun, J., Hu, Z., & Sun, B. (2022). Resveratrol protects against atherosclerosis by downregulating the PI3K/AKT/mTOR signaling pathway in atherosclerosis model mice. Experimental and Therapeutic Medicine, 23, 414. https://doi.org/10.3892/etm.2022.11341
MLA
Ji, W., Sun, J., Hu, Z., Sun, B."Resveratrol protects against atherosclerosis by downregulating the PI3K/AKT/mTOR signaling pathway in atherosclerosis model mice". Experimental and Therapeutic Medicine 23.6 (2022): 414.
Chicago
Ji, W., Sun, J., Hu, Z., Sun, B."Resveratrol protects against atherosclerosis by downregulating the PI3K/AKT/mTOR signaling pathway in atherosclerosis model mice". Experimental and Therapeutic Medicine 23, no. 6 (2022): 414. https://doi.org/10.3892/etm.2022.11341
Copy and paste a formatted citation
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Spandidos Publications style
Ji W, Sun J, Hu Z and Sun B: Resveratrol protects against atherosclerosis by downregulating the PI3K/AKT/mTOR signaling pathway in atherosclerosis model mice. Exp Ther Med 23: 414, 2022.
APA
Ji, W., Sun, J., Hu, Z., & Sun, B. (2022). Resveratrol protects against atherosclerosis by downregulating the PI3K/AKT/mTOR signaling pathway in atherosclerosis model mice. Experimental and Therapeutic Medicine, 23, 414. https://doi.org/10.3892/etm.2022.11341
MLA
Ji, W., Sun, J., Hu, Z., Sun, B."Resveratrol protects against atherosclerosis by downregulating the PI3K/AKT/mTOR signaling pathway in atherosclerosis model mice". Experimental and Therapeutic Medicine 23.6 (2022): 414.
Chicago
Ji, W., Sun, J., Hu, Z., Sun, B."Resveratrol protects against atherosclerosis by downregulating the PI3K/AKT/mTOR signaling pathway in atherosclerosis model mice". Experimental and Therapeutic Medicine 23, no. 6 (2022): 414. https://doi.org/10.3892/etm.2022.11341
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