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Knockdown of lncRNA‑NEAT1 expression inhibits hypoxia‑induced scar fibroblast proliferation through regulation of the miR‑488‑3p/COL3A1 axis

  • Authors:
    • Huan Xu
    • Xuesong Guo
    • Yu Tian
    • Junqing Wang
  • View Affiliations / Copyright

    Affiliations: Department of Burns and Plastic Surgery, Children's Hospital of Shanxi, Taiyuan, Shanxi 030013, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 442
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    Published online on: May 13, 2022
       https://doi.org/10.3892/etm.2022.11369
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Abstract

Long non‑coding (lnc)RNA nuclear‑enriched transcripts 1 (NEAT1) has been demonstrated to be involved in the inhibition of hypoxia‑induced scar fibroblast proliferation, but the specific mechanism remains undetermined. The present study found that with the decrease of oxygen concentration, lncRNA NEAT1 was upregulated in hypoxia‑induced scar fibroblasts, which promoted the mRNA and protein expression levels of collagen (COL)‑I, COL‑III and α‑smooth muscle actin, thereby suppressing hypoxia‑induced scar fibroblasts proliferation. In addition, the microRNA (miR)‑488‑3p/COL3A1 axis was involved in lncRNA NEAT1's regulation of the proliferation of hypoxia‑induced scar fibroblasts. In conclusion, the knockdown of lncRNA‑NEAT1 expression can inhibit hypoxia‑induced scar fibroblasts proliferation through regulation of the miR‑488‑3p/COL3A1 axis, which will provide a novel therapeutic target for the treatment of hypertrophic scars.
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Copy and paste a formatted citation
Spandidos Publications style
Xu H, Guo X, Tian Y and Wang J: Knockdown of lncRNA‑NEAT1 expression inhibits hypoxia‑induced scar fibroblast proliferation through regulation of the miR‑488‑3p/COL3A1 axis. Exp Ther Med 24: 442, 2022.
APA
Xu, H., Guo, X., Tian, Y., & Wang, J. (2022). Knockdown of lncRNA‑NEAT1 expression inhibits hypoxia‑induced scar fibroblast proliferation through regulation of the miR‑488‑3p/COL3A1 axis. Experimental and Therapeutic Medicine, 24, 442. https://doi.org/10.3892/etm.2022.11369
MLA
Xu, H., Guo, X., Tian, Y., Wang, J."Knockdown of lncRNA‑NEAT1 expression inhibits hypoxia‑induced scar fibroblast proliferation through regulation of the miR‑488‑3p/COL3A1 axis". Experimental and Therapeutic Medicine 24.1 (2022): 442.
Chicago
Xu, H., Guo, X., Tian, Y., Wang, J."Knockdown of lncRNA‑NEAT1 expression inhibits hypoxia‑induced scar fibroblast proliferation through regulation of the miR‑488‑3p/COL3A1 axis". Experimental and Therapeutic Medicine 24, no. 1 (2022): 442. https://doi.org/10.3892/etm.2022.11369
Copy and paste a formatted citation
x
Spandidos Publications style
Xu H, Guo X, Tian Y and Wang J: Knockdown of lncRNA‑NEAT1 expression inhibits hypoxia‑induced scar fibroblast proliferation through regulation of the miR‑488‑3p/COL3A1 axis. Exp Ther Med 24: 442, 2022.
APA
Xu, H., Guo, X., Tian, Y., & Wang, J. (2022). Knockdown of lncRNA‑NEAT1 expression inhibits hypoxia‑induced scar fibroblast proliferation through regulation of the miR‑488‑3p/COL3A1 axis. Experimental and Therapeutic Medicine, 24, 442. https://doi.org/10.3892/etm.2022.11369
MLA
Xu, H., Guo, X., Tian, Y., Wang, J."Knockdown of lncRNA‑NEAT1 expression inhibits hypoxia‑induced scar fibroblast proliferation through regulation of the miR‑488‑3p/COL3A1 axis". Experimental and Therapeutic Medicine 24.1 (2022): 442.
Chicago
Xu, H., Guo, X., Tian, Y., Wang, J."Knockdown of lncRNA‑NEAT1 expression inhibits hypoxia‑induced scar fibroblast proliferation through regulation of the miR‑488‑3p/COL3A1 axis". Experimental and Therapeutic Medicine 24, no. 1 (2022): 442. https://doi.org/10.3892/etm.2022.11369
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