Open Access

Knockdown of lncRNA‑NEAT1 expression inhibits hypoxia‑induced scar fibroblast proliferation through regulation of the miR‑488‑3p/COL3A1 axis

  • Authors:
    • Huan Xu
    • Xuesong Guo
    • Yu Tian
    • Junqing Wang
  • View Affiliations

  • Published online on: May 13, 2022     https://doi.org/10.3892/etm.2022.11369
  • Article Number: 442
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long non‑coding (lnc)RNA nuclear‑enriched transcripts 1 (NEAT1) has been demonstrated to be involved in the inhibition of hypoxia‑induced scar fibroblast proliferation, but the specific mechanism remains undetermined. The present study found that with the decrease of oxygen concentration, lncRNA NEAT1 was upregulated in hypoxia‑induced scar fibroblasts, which promoted the mRNA and protein expression levels of collagen (COL)‑I, COL‑III and α‑smooth muscle actin, thereby suppressing hypoxia‑induced scar fibroblasts proliferation. In addition, the microRNA (miR)‑488‑3p/COL3A1 axis was involved in lncRNA NEAT1's regulation of the proliferation of hypoxia‑induced scar fibroblasts. In conclusion, the knockdown of lncRNA‑NEAT1 expression can inhibit hypoxia‑induced scar fibroblasts proliferation through regulation of the miR‑488‑3p/COL3A1 axis, which will provide a novel therapeutic target for the treatment of hypertrophic scars.
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July-2022
Volume 24 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Xu H, Guo X, Tian Y and Wang J: Knockdown of lncRNA‑NEAT1 expression inhibits hypoxia‑induced scar fibroblast proliferation through regulation of the miR‑488‑3p/COL3A1 axis. Exp Ther Med 24: 442, 2022
APA
Xu, H., Guo, X., Tian, Y., & Wang, J. (2022). Knockdown of lncRNA‑NEAT1 expression inhibits hypoxia‑induced scar fibroblast proliferation through regulation of the miR‑488‑3p/COL3A1 axis. Experimental and Therapeutic Medicine, 24, 442. https://doi.org/10.3892/etm.2022.11369
MLA
Xu, H., Guo, X., Tian, Y., Wang, J."Knockdown of lncRNA‑NEAT1 expression inhibits hypoxia‑induced scar fibroblast proliferation through regulation of the miR‑488‑3p/COL3A1 axis". Experimental and Therapeutic Medicine 24.1 (2022): 442.
Chicago
Xu, H., Guo, X., Tian, Y., Wang, J."Knockdown of lncRNA‑NEAT1 expression inhibits hypoxia‑induced scar fibroblast proliferation through regulation of the miR‑488‑3p/COL3A1 axis". Experimental and Therapeutic Medicine 24, no. 1 (2022): 442. https://doi.org/10.3892/etm.2022.11369