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Upregulation of osteoprotegerin inhibits tert‑butyl hydroperoxide‑induced apoptosis of human chondrocytes

  • Authors:
    • Qifeng Ren
    • Wenfei Zhang
    • Ping Li
    • Jianli Zhou
    • Zhonghao Li
    • Yang Zhou
    • Ming Li
  • View Affiliations / Copyright

    Affiliations: Department of Joint Surgery, Dezhou People's Hospital, Dezhou, Shandong 253014, P.R. China, Department of Clinical Psychology, Dezhou People's Hospital, Dezhou, Shandong 253014, P.R. China, Department of Hematology, Dezhou People's Hospital, Dezhou, Shandong 253014, P.R. China, Department of Nuclear Medicine, Dezhou People's Hospital, Dezhou, Shandong 253014, P.R. China, Central Laboratory, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361004, P.R. China, Department of Joint Surgery, Dezhou People's Hospital, Dezhou, Shandong 253014, P.R. China
    Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 470
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    Published online on: May 26, 2022
       https://doi.org/10.3892/etm.2022.11397
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Abstract

Necrosis of the femoral head (NFH) is an orthopedic disease characterized by a severe lack of blood supply to the femoral head and a marked increase in intraosseous pressure. NFH is associated with numerous factors, such as alcohol consumption and hormone levels. The present study focused on the expression levels of osteoprotegerin (OPG) in NFH and the effect of OPG overexpression on chondrocyte apoptosis. The results demonstrated that OPG expression was markedly decreased in the femoral head of patients with NFH compared with normal femoral heads. Lentivirus‑mediated overexpression of OPG in human chondrocytes reversed the decrease in cell viability and the increase in reactive oxygen species production induced by an oxidative stress‑inducing factor, tert‑butyl hydroperoxide. Flow cytometry and TUNEL assays revealed that OPG overexpression inhibited the apoptosis of chondrocytes. In addition, it was revealed that OPG exerted its anti‑apoptotic effect mainly by promoting Bcl‑2 expression and Akt phosphorylation and inhibiting caspase‑3 cleavage and Bax expression. The present study revealed that OPG may be an important regulator of NFH.
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1 

Chen D, Liu Y, Liu Z and Wang P: OPG is required for the postnatal maintenance of condylar cartilage. Calcif Tissue Int. 104:461–474. 2019.PubMed/NCBI View Article : Google Scholar

2 

Liu Y, Ge J, Chen D, Weng Y, Du H, Sun Y and Zhang Q: Osteoprotegerin deficiency leads to deformation of the articular cartilage in femoral head. J Mol Histol. 47:475–483. 2016.PubMed/NCBI View Article : Google Scholar

3 

Bouredji Z, Hamoudi D, Marcadet L, Argaw A and Frenette J: Testing the efficacy of a human full-length OPG-Fc analog in a severe model of cardiotoxin-induced skeletal muscle injury and repair. Mol Ther Methods Clin Dev. 21:559–573. 2021.PubMed/NCBI View Article : Google Scholar

4 

Manolagas SC, O'Brien CA and Almeida M: The role of estrogen and androgen receptors in bone health and disease. Nat Rev Endocrinol. 9:699–712. 2013.PubMed/NCBI View Article : Google Scholar

5 

Al-Omari AA, Aleshawi AJ, Marei OA, Younes HMB, Alawneh KZ, ALQuran E and Mohaidat ZM: Avascular necrosis of the femoral head after single steroid intra-articular injection. Eur J Orthop Surg Traumatol. 30:193–197. 2020.PubMed/NCBI View Article : Google Scholar

6 

Wang T, Azeddine B, Mah W, Harvey EJ, Rosenblatt D and Séguin C: Osteonecrosis of the femoral head: Genetic basis. Int Orthop. 43:519–530. 2019.PubMed/NCBI View Article : Google Scholar

7 

Lee SW, Lim KH, Lee KJ, Heo YR and Lee JH: No association between telomere length and osteonecrosis of the femoral head. BMC Musculoskelet Disord. 22(176)2021.PubMed/NCBI View Article : Google Scholar

8 

Li Y, Guo Y, Wang Q, Ouyang Y, Cao Y, Jin T and Wang J: Osteoprotegerin polymorphisms are associated with alcohol-induced osteonecrosis of femoral head in Chinese Han population from Henan province. J Genet. 95:983–989. 2016.PubMed/NCBI View Article : Google Scholar

9 

Hardy R, Juarez M, Naylor A, Tu J, Rabbitt EH, Filer A, Stewart PM, Buckley CD, Raza K and Cooper MS: Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritis. Arthritis Res Ther. 14(R226)2012.PubMed/NCBI View Article : Google Scholar

10 

Holt V, Caplan AI and Haynesworth SE: Identification of a subpopulation of marrow MSC-derived medullary adipocytes that express osteoclast-regulating molecules: Marrow adipocytes express osteoclast mediators. PLoS One. 9(e108920)2014.PubMed/NCBI View Article : Google Scholar

11 

Walsh MC and Choi Y: Biology of the RANKL-RANK-OPG system in immunity, bone, and beyond. Front Immunol. 5(511)2014.PubMed/NCBI View Article : Google Scholar

12 

Kuhn MC, Willenberg HS, Schott M, Papewalis C, Stumpf U, Flohé S, Scherbaum WA and Schinner S: Adipocyte-secreted factors increase osteoblast proliferation and the OPG/RANKL ratio to influence osteoclast formation. Mol Cell Endocrinol. 349:180–188. 2012.PubMed/NCBI View Article : Google Scholar

13 

Liu Y, Berendsen AD, Jia S, Lotinun S, Baron R, Ferrara N and Olsen B: Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation. J Clin Invest. 122:3101–3113. 2012.PubMed/NCBI View Article : Google Scholar

14 

Milanova V, Ivanovska N and Dimitrova P: TLR2 elicits IL-17-mediated RANKL expression, IL-17, and OPG production in neutrophils from arthritic mice. Mediators Inflamm. 2014(643406)2014.PubMed/NCBI View Article : Google Scholar

15 

Cheng J, Zhuo H, Wang L, Zheng W, Chen X, Hou J, Zhao J and Cai J: Identification of the combinatorial effect of miRNA family regulatory network in different growth patterns of GC. Mol Ther Oncolytics. 17:531–546. 2020.PubMed/NCBI View Article : Google Scholar

16 

Peng W, Zhang J, Zhang F, Zhao Y and Dong W: Expression of osteoprotegerin and receptor activator for the nuclear factor-κB ligand in XACB/LV-bFGF/MSCs transplantation for repair of rabbit femoral head defect necrosis. J Cell Biochem: Oct 18, 2018 (Epub ahead of print).

17 

Kovács B, Vajda E and Nagy EE: Regulatory effects and interactions of the Wnt and OPG-RANKL-RANK signaling at the bone-cartilage interface in osteoarthritis. Int J Mol Sci. 20(4653)2019.PubMed/NCBI View Article : Google Scholar

18 

Zhou Y, Chen X, Qu N, Zhang B and Xia C: Chondroprotection of PPARα activation by WY14643 via autophagy involving Akt and ERK in LPS-treated mouse chondrocytes and osteoarthritis model. J Cell Mol Med. 23:2782–2793. 2019.PubMed/NCBI View Article : Google Scholar

19 

Huang M, Thomas D, Li MX, Feng W, Chan SM, Majeti R and Mitchell BS: Role of cysteine 288 in nucleophosmin cytoplasmic mutations: Sensitization to toxicity induced by arsenic trioxide and bortezomib. Leukemia. 27:1970–1980. 2013.PubMed/NCBI View Article : Google Scholar

20 

Yenerall P, Kollipara RK, Avila K, Peyton M, Eide CA, Bottomly D, McWeeney SK, Liu Y, Westover KD, Druker BJ, et al: Lentiviral-driven discovery of cancer drug resistance mutations. Cancer Res. 81:4685–4695. 2021.PubMed/NCBI View Article : Google Scholar

21 

Cheng L, Zeng G, Liu Z, Zhang B, Cui X, Zhao H, Zheng X, Song G, Kang J and Xia C: Protein kinase B and extracellular signal-regulated kinase contribute to the chondroprotective effect of morroniside on osteoarthritis chondrocytes. J Cell Mol Med. 19:1877–1886. 2015.PubMed/NCBI View Article : Google Scholar

22 

Yang P, Qiu Z, Jiang Y, Dong L, Yang W, Gu C, Li G and Zhu Y: Silencing of cZNF292 circular RNA suppresses human glioma tube formation via the Wnt/β-catenin signaling pathway. Oncotarget. 7(63449)2016.PubMed/NCBI View Article : Google Scholar

23 

Zhong Z, Lv M and Chen J: Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma. Sci Rep. 6(30919)2016.PubMed/NCBI View Article : Google Scholar

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

25 

Gao S, Cheng J, Li G, Sun T, Xu Y, Wang Y, Du X, Xu G and Duan S: Catechol-O-methyltransferase gene promoter methylation as a peripheral biomarker in male schizophrenia. Eur Psychiatry. 44:39–46. 2017.PubMed/NCBI View Article : Google Scholar

26 

Tian H, Li G, Xu G, Liu J, Wan X, Zhang J, Xie S, Cheng J and Gao S: Inflammatory cytokines derived from peripheral blood contribute to the modified electroconvulsive therapy-induced cognitive deficits in major depressive disorder. Eur Arch Psychiatry Clin Neurosci. 271:475–485. 2021.PubMed/NCBI View Article : Google Scholar

27 

Cheng J, Zhuo H, Xu M, Wang L, Xu H, Peng J, Hou J, Lin L and Cai J: Regulatory network of circRNA-miRNA-mRNA contributes to the histological classification and disease progression in gastric cancer. J Transl Med. 16:1–14. 2018.PubMed/NCBI View Article : Google Scholar

28 

Shafiey SI, Mohamed WR and Abo-Saif AA: Paroxetine and rivastigmine mitigates adjuvant-induced rheumatoid arthritis in rats: Impact on oxidative stress, apoptosis and RANKL/OPG signals. Life Sci. 212:109–118. 2018.PubMed/NCBI View Article : Google Scholar

29 

Carneiro BA and El-Deiry WS: Targeting apoptosis in cancer therapy. Nat Rev Clin Oncol. 17:395–417. 2020.PubMed/NCBI View Article : Google Scholar

30 

Voss AK and Strasser A: The essentials of developmental apoptosis. F1000Res 9: F1000 Faculty Rev-148, 2020.

31 

Tanaka H, Mine T, Ogasa H, Taguchi T and Liang CT: Expression of RANKL/OPG during bone remodeling in vivo. Biochem Biophys Res Commun. 411:690–694. 2011.PubMed/NCBI View Article : Google Scholar

32 

Upton AR, Holding CA, Dharmapatni AA and Haynes DR: The expression of RANKL and OPG in the various grades of osteoarthritic cartilage. Rheumatol Int. 32:535–540. 2012.PubMed/NCBI View Article : Google Scholar

33 

Nishida D, Arai A, Zhao L, Yang M, Nakamichi Y, Horibe K, Hosoya A, Kobayashi Y, Udagawa N and Mizoguchi T: RANKL/OPG ratio regulates odontoclastogenesis in damaged dental pulp. Sci Rep. 11(4575)2021.PubMed/NCBI View Article : Google Scholar

34 

Guo Y, Xu C, Wu X, Zhang W, Sun Y and Shrestha A: Leptin regulates OPG and RANKL expression in gingival fibroblasts and tissues of chronic periodontitis patients. Int J Med Sci. 18:2431–2437. 2021.PubMed/NCBI View Article : Google Scholar

35 

Song HM, Wei YC, Li N, Wu B, Xie N, Zhang KM, Wang SZ and Wang HM: Effects of Wenyangbushen formula on the expression of VEGF, OPG, RANK and RANKL in rabbits with steroid-induced femoral head avascular necrosis. Mol Med Rep. 12:8155–8161. 2015.PubMed/NCBI View Article : Google Scholar

36 

Chen K, Liu Y, He J, Pavlos N, Wang C, Kenny J, Yuan J, Zhang Q, Xu J and He W: Steroid-induced osteonecrosis of the femoral head reveals enhanced reactive oxygen species and hyperactive osteoclasts. Int J Biol Sci. 16:1888–1900. 2020.PubMed/NCBI View Article : Google Scholar

37 

Hardaway AL, Herroon MK, Rajagurubandara E and Podgorski I: Bone marrow fat: Linking adipocyte-induced inflammation with skeletal metastases. Cancer Metastasis Rev. 33:527–543. 2014.PubMed/NCBI View Article : Google Scholar

38 

Boyce BF and Xing L: Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys. 473:139–146. 2008.PubMed/NCBI View Article : Google Scholar

39 

Sakamoto K, Osaki M, Hozumi A, Goto H, Fukushima T, Baba H and Shindo H: Simvastatin suppresses dexamethasone-induced secretion of plasminogen activator inhibitor-1 in human bone marrow adipocytes. BMC Musculoskelet Disord. 12(82)2011.PubMed/NCBI View Article : Google Scholar

40 

Shimizu S, Asou Y, Itoh S, Chung UI, Kawaguchi H, Shinomiya K and Muneta T: Prevention of cartilage destruction with intraarticular osteoclastogenesis inhibitory factor/osteoprotegerin in a murine model of osteoarthritis. Arthritis Rheum. 56:3358–3365. 2007.PubMed/NCBI View Article : Google Scholar

41 

Busillo JM and Cidlowski JA: The five Rs of glucocorticoid action during inflammation: Ready, reinforce, repress, resolve, and restore. Trends Endocrinol Metab. 24:109–119. 2013.PubMed/NCBI View Article : Google Scholar

42 

Soliman S and Ahmed M: The effect of orthognathic surgery on osteoprotegerin as immunological caliper of bone healing. Open Access Maced J Med Sci. 4:705–708. 2016.PubMed/NCBI View Article : Google Scholar

43 

Reid PE, Brown NJ and Holen I: Breast cancer cells stimulate osteoprotegerin (OPG) production by endothelial cells through direct cell contact. Mol Cancer. 8(49)2009.PubMed/NCBI View Article : Google Scholar

44 

Baud'huin M, Duplomb L, Teletchea S, Lamoureux F, Ruiz-Velasco C, Maillasson M, Redini F, Heymann MF and Heymann D: Osteoprotegerin: Multiple partners for multiple functions. Cytokine Growth Factor Rev. 24:401–409. 2013.PubMed/NCBI View Article : Google Scholar

45 

Bayer CM, Beckmann MW and Fasching PA: Updates on the role of receptor activator of nuclear factor κB/receptor activator of nuclear factor kappaB ligand/osteoprotegerin pathway in breast cancer risk and treatment. Curr Opin Obstet Gynecol. 29:4–11. 2017.PubMed/NCBI View Article : Google Scholar

46 

Zhang L, Liu M, Zhou X, Liu Y, Jing B, Wang X, Zhang Q and Sun Y: Role of osteoprotegerin (OPG) in bone marrow adipogenesis. Cell Physiol Biochem. 40:681–692. 2016.PubMed/NCBI View Article : Google Scholar

47 

Liu W, Xu C, Zhao H, Xia P, Song R, Gu J, Liu X, Bian J, Yuan Y and Liu Z: Osteoprotegerin induces apoptosis of osteoclasts and osteoclast precursor cells via the Fas/Fas ligand pathway. PLoS One. 10(e0142519)2015.PubMed/NCBI View Article : Google Scholar

48 

Kim CS, Bae EH, Ma SK, Han SH, Choi KH, Lee J, Chae DW, Oh KH, Ahn C and Kim SW: Representatives of the KNOW-CKD Investigator Group. Association of serum osteoprotegerin levels with bone loss in chronic kidney disease: Insights from the KNOW-CKD study. PLoS One. 11(e0166792)2016.PubMed/NCBI View Article : Google Scholar

49 

Van Poznak C, Cross SS, Saggese M, Hudis C, Panageas KS, Norton L, Coleman RE and Holen I: Expression of osteoprotegerin (OPG), TNF related apoptosis inducing ligand (TRAIL), and receptor activator of nuclear factor kappaB ligand (RANKL) in human breast tumours. J Clin Pathol. 59:56–63. 2006.PubMed/NCBI View Article : Google Scholar

50 

Ren H, Ren H, Li X, Yu D, Mu S, Chen Z and Fu Q: Effects of intermedin on proliferation, apoptosis and the expression of OPG/RANKL/M-CSF in the MC3T3-E1 osteoblast cell line. Mol Med Rep. 12:6711–6717. 2015.PubMed/NCBI View Article : Google Scholar

51 

Cheng Z, Landish B, Chi Z, Nannan C, Jingyu D, Sen L and Xiangjin L: 3D printing hydrogel with graphene oxide is functional in cartilage protection by influencing the signal pathway of Rank/Rankl/OPG. Mater Sci Eng C Mater Biol Appl. 82:244–252. 2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Ren Q, Zhang W, Li P, Zhou J, Li Z, Zhou Y and Li M: Upregulation of osteoprotegerin inhibits <em>tert</em>‑butyl hydroperoxide‑induced apoptosis of human chondrocytes. Exp Ther Med 24: 470, 2022.
APA
Ren, Q., Zhang, W., Li, P., Zhou, J., Li, Z., Zhou, Y., & Li, M. (2022). Upregulation of osteoprotegerin inhibits <em>tert</em>‑butyl hydroperoxide‑induced apoptosis of human chondrocytes. Experimental and Therapeutic Medicine, 24, 470. https://doi.org/10.3892/etm.2022.11397
MLA
Ren, Q., Zhang, W., Li, P., Zhou, J., Li, Z., Zhou, Y., Li, M."Upregulation of osteoprotegerin inhibits <em>tert</em>‑butyl hydroperoxide‑induced apoptosis of human chondrocytes". Experimental and Therapeutic Medicine 24.1 (2022): 470.
Chicago
Ren, Q., Zhang, W., Li, P., Zhou, J., Li, Z., Zhou, Y., Li, M."Upregulation of osteoprotegerin inhibits <em>tert</em>‑butyl hydroperoxide‑induced apoptosis of human chondrocytes". Experimental and Therapeutic Medicine 24, no. 1 (2022): 470. https://doi.org/10.3892/etm.2022.11397
Copy and paste a formatted citation
x
Spandidos Publications style
Ren Q, Zhang W, Li P, Zhou J, Li Z, Zhou Y and Li M: Upregulation of osteoprotegerin inhibits <em>tert</em>‑butyl hydroperoxide‑induced apoptosis of human chondrocytes. Exp Ther Med 24: 470, 2022.
APA
Ren, Q., Zhang, W., Li, P., Zhou, J., Li, Z., Zhou, Y., & Li, M. (2022). Upregulation of osteoprotegerin inhibits <em>tert</em>‑butyl hydroperoxide‑induced apoptosis of human chondrocytes. Experimental and Therapeutic Medicine, 24, 470. https://doi.org/10.3892/etm.2022.11397
MLA
Ren, Q., Zhang, W., Li, P., Zhou, J., Li, Z., Zhou, Y., Li, M."Upregulation of osteoprotegerin inhibits <em>tert</em>‑butyl hydroperoxide‑induced apoptosis of human chondrocytes". Experimental and Therapeutic Medicine 24.1 (2022): 470.
Chicago
Ren, Q., Zhang, W., Li, P., Zhou, J., Li, Z., Zhou, Y., Li, M."Upregulation of osteoprotegerin inhibits <em>tert</em>‑butyl hydroperoxide‑induced apoptosis of human chondrocytes". Experimental and Therapeutic Medicine 24, no. 1 (2022): 470. https://doi.org/10.3892/etm.2022.11397
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