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Production and immunogenicity of different prophylactic vaccines for hepatitis C virus (Review)

  • Authors:
    • Qianqian Zhao
    • Kun He
    • Xiuhua Zhang
    • Mingjie Xu
    • Xiuping Zhang
    • Huanjie Li
  • View Affiliations / Copyright

    Affiliations: Microbiology Department, Jinan Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250013, P.R. China, Key Laboratory of Biological Drugs, Shandong Academy of Pharmaceutical Science, Jinan, Shandong 250101, P.R. China, Medical Research and Laboratory Diagnostic Center, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250013, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 474
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    Published online on: May 30, 2022
       https://doi.org/10.3892/etm.2022.11401
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Abstract

Hepatitis C virus (HCV) infection is a global health challenge, and prophylactic vaccines are the most effective way to eliminate the infection. To date, numerous forms of preventive vaccines have entered the clinical trial stage, including the virus‑like particle (VLP) vaccine, recombinant subunit vaccine, peptide vaccine and nucleic acid vaccine. The rational design makes it easier to obtain specific vaccine structures with a broad spectrum and strong immunogenicity. Different vaccine antigens can evoke different immune responses, including humoral and T‑cell immune responses, and can be produced using different expression systems, such as bacteria, yeast, mammals, plants, insects or parasites. Intracellular and insoluble production and a narrow immune spectrum are two difficulties that limit the application of vaccines. The present study summarizes the immunogenicity of different preventive vaccines, evaluates the characteristics of different expression systems used for vaccine production, and analyzes the strategies to enhance the secretion and immune spectrum of vaccine proteins.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao Q, He K, Zhang X, Xu M, Zhang X and Li H: Production and immunogenicity of different prophylactic vaccines for hepatitis C virus (Review). Exp Ther Med 24: 474, 2022.
APA
Zhao, Q., He, K., Zhang, X., Xu, M., Zhang, X., & Li, H. (2022). Production and immunogenicity of different prophylactic vaccines for hepatitis C virus (Review). Experimental and Therapeutic Medicine, 24, 474. https://doi.org/10.3892/etm.2022.11401
MLA
Zhao, Q., He, K., Zhang, X., Xu, M., Zhang, X., Li, H."Production and immunogenicity of different prophylactic vaccines for hepatitis C virus (Review)". Experimental and Therapeutic Medicine 24.1 (2022): 474.
Chicago
Zhao, Q., He, K., Zhang, X., Xu, M., Zhang, X., Li, H."Production and immunogenicity of different prophylactic vaccines for hepatitis C virus (Review)". Experimental and Therapeutic Medicine 24, no. 1 (2022): 474. https://doi.org/10.3892/etm.2022.11401
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Q, He K, Zhang X, Xu M, Zhang X and Li H: Production and immunogenicity of different prophylactic vaccines for hepatitis C virus (Review). Exp Ther Med 24: 474, 2022.
APA
Zhao, Q., He, K., Zhang, X., Xu, M., Zhang, X., & Li, H. (2022). Production and immunogenicity of different prophylactic vaccines for hepatitis C virus (Review). Experimental and Therapeutic Medicine, 24, 474. https://doi.org/10.3892/etm.2022.11401
MLA
Zhao, Q., He, K., Zhang, X., Xu, M., Zhang, X., Li, H."Production and immunogenicity of different prophylactic vaccines for hepatitis C virus (Review)". Experimental and Therapeutic Medicine 24.1 (2022): 474.
Chicago
Zhao, Q., He, K., Zhang, X., Xu, M., Zhang, X., Li, H."Production and immunogenicity of different prophylactic vaccines for hepatitis C virus (Review)". Experimental and Therapeutic Medicine 24, no. 1 (2022): 474. https://doi.org/10.3892/etm.2022.11401
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