Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July-2022 Volume 24 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2022 Volume 24 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Probable progressive supranuclear palsy in a patient with chronic schizophrenia: A case report

  • Authors:
    • Akira Kita
    • Tomikimi Tsuji
    • Jinsoo Koh
    • Shun Takahashi
    • Masahiro Yamamoto
    • Yuka Sakamoto
    • Hideaki Itogawa
    • Sohei Kimoto
  • View Affiliations / Copyright

    Affiliations: Department of Neuropsychiatry, Kinan Psychiatric Center, Tanabe, Wakayama 646‑0015, Japan, Department of Neuropsychiatry, Wakayama Medical University, Wakayama, Wakayama 641‑8510, Japan, Department of Neurology, Kinan Hospital, Tanabe, Wakayama 646‑8588, Japan
    Copyright: © Kita et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 484
    |
    Published online on: June 1, 2022
       https://doi.org/10.3892/etm.2022.11411
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Rare neurodegenerative disorders may be considered in the differential diagnosis of Parkinsonism in patients with schizophrenia who show worsening signs of Parkinsonism under treatment with antipsychotics. To the best of our knowledge, the present study is the first report describing probable progressive supranuclear palsy (PSP) in a patient with chronic schizophrenia. A 64‑year‑old man presented with hallucinations, delusions and asociality. He had received treatment with both typical and atypical antipsychotics for ~13 years. He began experiencing short‑term memory impairment and bradykinesia two years before presentation, and then showed increased dysphagia, upper‑limb muscle rigidity, extrapyramidal symptoms, vision loss and photophobia. Psychological manifestations included chronic depression, irritability and, occasionally, euphoria. His gait worsened, leading to repeated falls. Antipsychotics were discontinued, and the patient was almost completely dependent on a wheelchair in daily life. In a neurology consultation, he was diagnosed with probable progressive supranuclear palsy‑Richardson's syndrome presenting as vertical supranuclear gaze palsy and prominent postural instability with falls. Brain magnetic resonance imaging (MRI) revealed atrophy of the mesencephalic tegmentum, and 123I‑ioflupane single‑photon emission computed tomography (SPECT) revealed reduced bilateral striatal reuptake. Overall, PSP should be considered in patients with schizophrenia with worsening Parkinsonism, especially when it is accompanied by supranuclear ophthalmoplegia, pseudobulbar palsy, dysarthria and dystonic stiffness of the neck and upper body. In the present case, the combination of brain MRI and 123I‑ioflupane SPECT helped to discriminate PSP from other Parkinsonian syndromes, including drug‑induced Parkinsonism, in the differential diagnosis.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Savica R, Grossardt BR, Bower JH, Ahlskog JE, Mielke MM and Rocca WA: Incidence and time trends of drug-induced parkinsonism: A 30-year population-based study. Mov Disord. 32:227–234. 2017.PubMed/NCBI View Article : Google Scholar

2 

Komatsu H, Kato M, Kinpara T, Ono T and Kakuto Y: Possible multiple system atrophy with predominant parkinsonism in a patient with chronic schizophrenia: A case report. BMC Psychiatry. 18(141)2018.PubMed/NCBI View Article : Google Scholar

3 

Steele JC, Richardson JC and Olszewski J: Progressive supranuclear palsy. A heterogeneous degeneration involving the brain stem, basal ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia. Arch Neurol. 10:333–359. 1964.PubMed/NCBI View Article : Google Scholar

4 

Höglinger GU, Respondek G, Stamelou M, Kurz C, Josephs KA, Lang AE, Mollenhauer B, Müller U, Nilsson C, Whitwell JL, et al: Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria. Mov Disord. 32:853–864. 2017.PubMed/NCBI View Article : Google Scholar

5 

Coyle-Gilchrist IT, Dick KM, Patterson K, Vázquez Rodríquez P, Wehmann E, Wilcox A, Lansdall CJ, Dawson KE, Wiggins J, Mead S, et al: Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes. Neurology. 86:1736–1743. 2016.PubMed/NCBI View Article : Google Scholar

6 

Nath U, Ben-Shlomo Y, Thomson RG, Morris HR, Wood NW, Lees AJ and Burn DJ: The prevalence of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) in the UK. Brain. 124:1438–1449. 2001.PubMed/NCBI View Article : Google Scholar

7 

Respondek G, Kurz C, Arzberger T, Compta Y, Englund E, Ferguson LW, Gelpi E, Giese A, Irwin DJ, Meissner WG, et al: Which ante mortem clinical features predict progressive supranuclear palsy pathology. Mov Disord. 32:995–1005. 2017.PubMed/NCBI View Article : Google Scholar

8 

Boxer AL, Yu JT, Golbe LI, Litvan I, Lang AE and Höglinger GU: Advances in progressive supranuclear palsy: New diagnostic criteria, biomarkers, and therapeutic approaches. Lancet Neurol. 16:552–563. 2017.PubMed/NCBI View Article : Google Scholar

9 

Williams DR and Lees AJ: Progressive supranuclear palsy: Clinicopathological concepts and diagnostic challenges. Lancet Neurol. 8:270–279. 2009.PubMed/NCBI View Article : Google Scholar

10 

Gerstenecker A, Duff K, Mast B and Litvan I: ENGENE-PSP Study Group. Behavioral abnormalities in progressive supranuclear palsy. Psychiatry Res. 210:1205–1210. 2013.PubMed/NCBI View Article : Google Scholar

11 

Massey LA, Micallef C, Paviour DC, O'Sullivan SS, Ling H, Williams DR, Kallis C, Holton JL, Revesz T, Burn DJ, et al: Conventional magnetic resonance imaging in confirmed progressive supranuclear palsy and multiple system atrophy. Mov Disord. 27:1754–1762. 2012.PubMed/NCBI View Article : Google Scholar

12 

Whitwell JL, Höglinger GU, Antonini A, Bordelon Y, Boxer AL, Colosimo C, van Eimeren T, Golbe LI, Kassubek J, Kurz C, et al: Radiological biomarkers for diagnosis in PSP: Where are we and where do we need to be. Mov Disord. 32:955–971. 2017.PubMed/NCBI View Article : Google Scholar

13 

DeMaagd G and Philip A: Parkinson's disease and its management: Part 1: Disease entity, risk factors, pathophysiology, clinical presentation, and diagnosis. P T. 40:504–532. 2015.PubMed/NCBI

14 

Lee PE, Sykora K, Gill SS, Mamdani M, Marras C, Anderson G, Shulman KI, Stukel T, Normand SL and Rochon PA: Antipsychotic medications and drug-induced movement disorders other than parkinsonism: A population-based cohort study in older adults. J Am Geriatr Soc. 53:1374–1379. 2005.PubMed/NCBI View Article : Google Scholar

15 

Hayes MT: Parkinson's disease and parkinsonism. Am J Med. 132:802–807. 2019.PubMed/NCBI View Article : Google Scholar

16 

Tolosa E, Coelho M and Gallardo M: DAT imaging in drug-induced and psychogenic parkinsonism. Mov Disord. 18 (Suppl 7):S28–S33. 2003.PubMed/NCBI View Article : Google Scholar

17 

Oh J, Shen G and Nan G: Comorbid schizophrenia and Parkinson's disease: A case series and brief review. Neurol Asia. 22:139–142. 2017.

18 

Grover S, Sahoo S and Goyal MK: Schizophrenia with comorbid idiopathic Parkinson's disease: A difficult clinical management scenario. Indian J Psychol Med. 39:823–827. 2017.PubMed/NCBI View Article : Google Scholar

19 

Winter C, Juckel G, Plotkin M, Niehaus L and Kupsch A: Paranoid schizophrenia and idiopathic Parkinson's disease do coexist: A challenge for clinicians. Psychiatry Clin Neurosci. 60(639)2006.PubMed/NCBI View Article : Google Scholar

20 

Waddington JL: Psychosis in Parkinson's disease and parkinsonism in antipsychotic-naive schizophrenia spectrum psychosis: Clinical, nosological and pathobiological challenges. Acta Pharmacol Sin. 41:464–470. 2020.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kita A, Tsuji T, Koh J, Takahashi S, Yamamoto M, Sakamoto Y, Itogawa H and Kimoto S: Probable progressive supranuclear palsy in a patient with chronic schizophrenia: A case report. Exp Ther Med 24: 484, 2022.
APA
Kita, A., Tsuji, T., Koh, J., Takahashi, S., Yamamoto, M., Sakamoto, Y. ... Kimoto, S. (2022). Probable progressive supranuclear palsy in a patient with chronic schizophrenia: A case report. Experimental and Therapeutic Medicine, 24, 484. https://doi.org/10.3892/etm.2022.11411
MLA
Kita, A., Tsuji, T., Koh, J., Takahashi, S., Yamamoto, M., Sakamoto, Y., Itogawa, H., Kimoto, S."Probable progressive supranuclear palsy in a patient with chronic schizophrenia: A case report". Experimental and Therapeutic Medicine 24.1 (2022): 484.
Chicago
Kita, A., Tsuji, T., Koh, J., Takahashi, S., Yamamoto, M., Sakamoto, Y., Itogawa, H., Kimoto, S."Probable progressive supranuclear palsy in a patient with chronic schizophrenia: A case report". Experimental and Therapeutic Medicine 24, no. 1 (2022): 484. https://doi.org/10.3892/etm.2022.11411
Copy and paste a formatted citation
x
Spandidos Publications style
Kita A, Tsuji T, Koh J, Takahashi S, Yamamoto M, Sakamoto Y, Itogawa H and Kimoto S: Probable progressive supranuclear palsy in a patient with chronic schizophrenia: A case report. Exp Ther Med 24: 484, 2022.
APA
Kita, A., Tsuji, T., Koh, J., Takahashi, S., Yamamoto, M., Sakamoto, Y. ... Kimoto, S. (2022). Probable progressive supranuclear palsy in a patient with chronic schizophrenia: A case report. Experimental and Therapeutic Medicine, 24, 484. https://doi.org/10.3892/etm.2022.11411
MLA
Kita, A., Tsuji, T., Koh, J., Takahashi, S., Yamamoto, M., Sakamoto, Y., Itogawa, H., Kimoto, S."Probable progressive supranuclear palsy in a patient with chronic schizophrenia: A case report". Experimental and Therapeutic Medicine 24.1 (2022): 484.
Chicago
Kita, A., Tsuji, T., Koh, J., Takahashi, S., Yamamoto, M., Sakamoto, Y., Itogawa, H., Kimoto, S."Probable progressive supranuclear palsy in a patient with chronic schizophrenia: A case report". Experimental and Therapeutic Medicine 24, no. 1 (2022): 484. https://doi.org/10.3892/etm.2022.11411
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team