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Biology of interleukin‑37 and its role in autoimmune diseases (Review)

  • Authors:
    • Huiqiong Zeng
    • Kaixia Zhou
    • Zhizhong Ye
  • View Affiliations / Copyright

    Affiliations: Department of Rheumatology, Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, Guangdong 518040, P.R. China, School of Biomedical Sciences, CUHK‑GIBH CAS Joint Laboratory on Stem Cell and Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, P.R. China
    Copyright: © Zeng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 495
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    Published online on: June 7, 2022
       https://doi.org/10.3892/etm.2022.11422
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Abstract

Autoimmune diseases (AIDs) are characterized by dysfunction and tissue destruction, and recent studies have shown that interleukin (IL)‑37 expression is dysregulated in AIDs. Among cytokines of the IL‑1 family, most are pro‑inflammatory agents, and as an anti‑inflammatory cytokine, IL‑37 may have the potential to alleviate excessive inflammation and can be used as a ligand or transcription factor that is involved in regulating innate and adaptive immunity. IL‑37 plays important roles in the development of AIDs. This review summarizes the biological characteristics and functions of IL‑37 and discusses the potential of IL‑37 as a therapeutic target for effective cytokine therapy and as a biomarker in AIDs.
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Copy and paste a formatted citation
Spandidos Publications style
Zeng H, Zhou K and Ye Z: Biology of interleukin‑37 and its role in autoimmune diseases (Review). Exp Ther Med 24: 495, 2022.
APA
Zeng, H., Zhou, K., & Ye, Z. (2022). Biology of interleukin‑37 and its role in autoimmune diseases (Review). Experimental and Therapeutic Medicine, 24, 495. https://doi.org/10.3892/etm.2022.11422
MLA
Zeng, H., Zhou, K., Ye, Z."Biology of interleukin‑37 and its role in autoimmune diseases (Review)". Experimental and Therapeutic Medicine 24.2 (2022): 495.
Chicago
Zeng, H., Zhou, K., Ye, Z."Biology of interleukin‑37 and its role in autoimmune diseases (Review)". Experimental and Therapeutic Medicine 24, no. 2 (2022): 495. https://doi.org/10.3892/etm.2022.11422
Copy and paste a formatted citation
x
Spandidos Publications style
Zeng H, Zhou K and Ye Z: Biology of interleukin‑37 and its role in autoimmune diseases (Review). Exp Ther Med 24: 495, 2022.
APA
Zeng, H., Zhou, K., & Ye, Z. (2022). Biology of interleukin‑37 and its role in autoimmune diseases (Review). Experimental and Therapeutic Medicine, 24, 495. https://doi.org/10.3892/etm.2022.11422
MLA
Zeng, H., Zhou, K., Ye, Z."Biology of interleukin‑37 and its role in autoimmune diseases (Review)". Experimental and Therapeutic Medicine 24.2 (2022): 495.
Chicago
Zeng, H., Zhou, K., Ye, Z."Biology of interleukin‑37 and its role in autoimmune diseases (Review)". Experimental and Therapeutic Medicine 24, no. 2 (2022): 495. https://doi.org/10.3892/etm.2022.11422
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