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Verbascoside potentiates the effect of tyrosine kinase inhibitors on the induction of apoptosis and oxidative stress via the Abl-mediated MAPK signalling pathway in chronic myeloid leukaemia

  • Authors:
    • Gulsum Akgun-Cagliyan
    • Aysegul Cort-Donmez
    • Emine Kilic-Toprak
    • Fatih Altintas
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Faculty of Medicine, Pamukkale University, 20160 Denizli, Turkey, Department of Biochemistry, Faculty of Medicine, Pamukkale University, 20160 Denizli, Turkey, Department of Physiology, Faculty of Medicine, Pamukkale University, 20160 Denizli, Turkey
    Copyright: © Akgun-Cagliyan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 514
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    Published online on: June 14, 2022
       https://doi.org/10.3892/etm.2022.11441
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Abstract

Verbascoside (Verb) may exhibit potential antitumour activities in leukaemia. The present study investigated the effect of Verb, in combination with imatinib (IM), dasatinib (Das), lipopolysaccharide (LPS) and TNF, on cell survival, Abl expression, apoptosis, oxidative stress and the MAPK pathway in chronic myeloid leukaemia (CML) cells. Cell viability was determined using the WST‑8 assay in K562 and R‑K562 cells treated with Verb and/or IM, Das, LPS and TNF. Apoptosis and DNA damage in CML cells was detected by caspase‑3 and comet analysis. The protein levels of Abl (Phospho‑Tyr412), and total/phosphorylated p38, JNK and ERK in CML cells were analysed using a Colorimetric Cell‑Based Assay. Oxidative stress was examined using total antioxidant and oxidant status assays. Treatment with Verb and/or tyrosine kinase inhibitors (TKIs), LPS and TNF resulted in a significant decrease in the Tyr‑412 phosphorylation of Abl in K562 and R‑K562 cells. In addition, cotreatment with Verb and IM or Das additively induced apoptosis by activating caspase‑3 levels in both cell lines. Activation of p38 and JNK can result in growth arrest and cell death, whereas ERK stimulation results in cell division and differentiation. The present study demonstrated that cotreatment with Verb and TKIs suppressed phosphorylated‑ERK1/2, whereas the levels of phosphorylated‑p‑38 and phosphorylated‑JNK were significantly elevated by Verb and/or IM, Das, LPS and TNF, thus suggesting that Abl and Src inhibition could be involved in the effects of Verb on MAPK signalling in R‑K562 cells. Furthermore, Verb elevated reactive oxygen species levels additively with TKIs in both cell lines by increasing the oxidant capacity and decreasing the antioxidant capacity. In conclusion, anti‑leukemic mechanisms of Verb may be mediated by Abl protein and regulation of its downstream p38-MAPK/JNK pathway, caspase‑3 and oxidative stress in CML cells.
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1 

Alipieva K, Korkina L, Orhan IE and Georgiev MI: Verbascoside-a review of its occurrence, (bio)synthesis and pharmacological significance. Biotechnol Adv. 32:1065–1076. 2014.PubMed/NCBI View Article : Google Scholar

2 

Song HS and Sim SS: Acteoside inhibits alpha-MSH-induced melanin production in B16 melanoma cells by inactivation of adenyl cyclase. J Pharm Pharmacol. 61:1347–1351. 2009.PubMed/NCBI View Article : Google Scholar

3 

Akdemir Z, Kahraman C, Tatlı II, Küpeli Akkol E, Süntar I and Keles H: Bioassay-guided isolation of anti-inflammatory, antinociceptive and wound healer glycosides from the flowers of Verbascum mucronatum Lam. J Ethnopharmacol. 136:436–443. 2011.PubMed/NCBI View Article : Google Scholar

4 

Georgiev M, Pastore S, Lulli D, Alipieva K, Kostyuk V, Potapovich A, Panetta M and Korkina L: Verbascum xanthophoeniceum-derived phenylethanoid glycosides are potent inhibitors of inflammatory chemokines in dormant and interferon-gamma-stimulated human keratinocytes. J Ethnopharmacol. 144:754–760. 2012.PubMed/NCBI View Article : Google Scholar

5 

Wartenberg M, Budde P, De Mareés M, Grünheck F, Tsang SY, Huang Y, Chen ZY, Hescheler J and Sauer H: Inhibition of tumor-induced angiogenesis and matrix-metalloproteinase expression in confrontation cultures of embryoid bodies and tumor spheroids by plant ingredients used in traditional chinese medicine. Lab Invest. 83:87–98. 2003.PubMed/NCBI View Article : Google Scholar

6 

Attia YM, El-Kersh DM, Wagdy HA and Elmazar MM: Verbascoside: Identification, quantification, and potential sensitization of colorectal cancer cells to 5-FU by targeting PI3K/AKT pathway. Sci Rep. 8(16939)2018.PubMed/NCBI View Article : Google Scholar

7 

Qin YZ and Huang XJ: Molecular detection of BCR-ABL in chronic myeloid leukemia. Methods Mol Biol. 1465:1–15. 2016.PubMed/NCBI View Article : Google Scholar

8 

Zhang F, Jia Z, Deng Z, Wei Y, Zheng R and Yu L: In vitro modulation of telomerase activity, telomere length and cell cycle in MKN45 cells by verbascoside. Planta Med. 68:115–118. 2002.PubMed/NCBI View Article : Google Scholar

9 

Lee KW, Kim HJ, Lee YS, Park HJ, Choi JW, Ha J and Lee KT: Acteoside inhibits human promyelocytic HL-60 leukemia cell proliferation via inducing cell cycle arrest at G0/G1 phase and differentiation into monocyte. Carcinogenesis. 28:1928–1936. 2007.PubMed/NCBI View Article : Google Scholar

10 

Bardellini E, Amadori F, Schumacher RF, D'Ippolito C, Porta F and Majorana A: Efficacy of a solution composed by verbascoside, polyvinylpyrrolidone (PVP) and sodium hyaluronate in the treatment of chemotherapy-induced oral mucositis in children with acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 38:559–562. 2016.PubMed/NCBI View Article : Google Scholar

11 

Yilmaz M and Jabbour E: Tyrosine kinase inhibitors early in the disease course: Lessons from chronic myelogenous leukemia. Semin Oncol. 42:876–886. 2015.PubMed/NCBI View Article : Google Scholar

12 

Assouline S and Lipton JH: Monitoring response and resistance to treatment in chronic myeloid leukemia. Curr Oncol. 18:e71–e83. 2011.PubMed/NCBI View Article : Google Scholar

13 

Jabbour EJ, Cortes JE and Kantarjian HM: Resistance to tyrosine kinase inhibition therapy for chronic myelogenous leukemia: A clinical perspective and emerging treatment options. Clin Lymphoma Myeloma Leuk. 13:515–529. 2013.PubMed/NCBI View Article : Google Scholar

14 

Bixby D and Talpaz M: Mechanisms of resistance to tyrosine kinase inhibitors in chronic myeloid leukemia and recent therapeutic strategies to overcome resistance. Hematology Am Soc Hematol Educ Program. 461–476. 2009.PubMed/NCBI View Article : Google Scholar

15 

Mitchell R, Hopcroft LEM, Baquero P, Allan EK, Hewit K, James D, Hamilton G, Mukhopadhyay A, O'Prey J, Hair A, et al: Targeting BCR-ABL-independent TKI resistance in chronic myeloid leukemia by mTOR and autophagy inhibition. J Natl Cancer Inst. 110:467–478. 2018.PubMed/NCBI View Article : Google Scholar

16 

Olivieri A and Manzione L: Dasatinib: A new step in molecular target therapy. Ann Oncol. 18 (Suppl 6):vi42–vi46. 2007.PubMed/NCBI View Article : Google Scholar

17 

Damiano S, Montagnaro S, Puzio MV, Severino L, Pagnini U, Barbarino M, Cesari D, Giordano A, Florio S and Ciarcia R: Effects of antioxidants on apoptosis induced by dasatinib and nilotinib in K562 cells. J Cell Biochem. 119:4845–4854. 2018.PubMed/NCBI View Article : Google Scholar

18 

Welner RS, Amabile G, Bararia D, Czibere A, Yang H, Zhang H, Pontes LL, Ye M, Levantini E, Di Ruscio A, et al: Treatment of chronic myelogenous leukemia by blocking cytokine alterations found in normal stem and progenitor cells. Cancer Cell. 27:671–681. 2015.PubMed/NCBI View Article : Google Scholar

19 

González-Flores D, Rodriguez AB and Pariente JA: TNFα-induced apoptosis in human myeloid cell lines HL-60 and K562 is dependent of intracellular ROS generation. Mol Cell Biochem. 390:281–287. 2014.PubMed/NCBI View Article : Google Scholar

20 

Yu C, Krystal G, Varticovksi L, McKinstry R, Rahmani M, Dent P and Grant S: Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells. Cancer Res. 62:188–199. 2002.PubMed/NCBI

21 

Wu GS: Role of mitogen-activated protein kinase phosphatases (MKPs) in cancer. Cancer Metastasis Rev. 26:579–585. 2007.PubMed/NCBI View Article : Google Scholar

22 

Deininger MW and Druker BJ: Specific targeted therapy of chronic myelogenous leukemia with imatinib. Pharmacol Rev. 55:401–423. 2003.PubMed/NCBI View Article : Google Scholar

23 

Shah NP, Kasap C, Weier C, Balbas M, Nicoll JM, Bleickardt E, Nicaise C and Sawyers CL: Transient potent BCR-ABL inhibition is sufficient to commit chronic myeloid leukemia cells irreversibly to apoptosis. Cancer Cell. 14:485–493. 2008.PubMed/NCBI View Article : Google Scholar

24 

García LT, Leal AF, Morenoa ÉM, Stashenko EE and Arteaga J: Differential anti-proliferative effect on K562 leukemia cells of Lippia alba (Verbenaceae) essential oils produced under diverse growing, collection and extraction conditions. sInd Crops Prod. 96:140–148. 2017.

25 

Oukerrou MA, Tilaoui M, Mouse HA, Bouchmaa N and Zyad A: Differential cytotoxic activity of essential oil of Lippia citriodora from different regions in morocco. Chem Biodivers. 14:2017.PubMed/NCBI View Article : Google Scholar

26 

Yang X, Feng W, Wang R, Yang F, Wang L, Chen S, Ru Y, Cheng T and Zheng G: Repolarizing heterogeneous leukemia-associated macrophages with more M1 characteristics eliminates their pro-leukemic effects. Oncoimmunology. 7(e1412910)2017.PubMed/NCBI View Article : Google Scholar

27 

Dorey K, Engen JR, Kretzschmar J, Wilm M, Neubauer G, Schindler T and Superti-Furga G: Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase. Oncogene. 20:8075–8084. 2001.PubMed/NCBI View Article : Google Scholar

28 

Baykal-Köse S, Acikgoz E, Yavuz AS, Gönül Geyik Ö, Ateş H, Sezerman OU, Özsan GH and Yüce Z: Adaptive phenotypic modulations lead to therapy resistance in chronic myeloid leukemia cells. PLoS One. 15(e0229104)2020.PubMed/NCBI View Article : Google Scholar

29 

Erel O: A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem. 37:112–119. 2004.PubMed/NCBI View Article : Google Scholar

30 

Olive PL and Banáth JP: The comet assay: A method to measure DNA damage in individual cells. Nat Protoc. 1:23–29. 2006.PubMed/NCBI View Article : Google Scholar

31 

Modi H, Li L, Chu S, Rossi J, Yee JK and Bhatia R: Inhibition of Grb2 expression demonstrates an important role in BCR-ABL-mediated MAPK activation and transformation of primary human hematopoietic cells. Leukemia. 25:305–312. 2011.PubMed/NCBI View Article : Google Scholar

32 

Flis S and Chojnacki T: Chronic myelogenous leukemia, a still unsolved problem: Pitfalls and new therapeutic possibilities. Drug Des Devel Ther. 13:825–843. 2019.PubMed/NCBI View Article : Google Scholar

33 

Alfarouk KO, Stock CM, Taylor S, Walsh M, Muddathir AK, Verduzco D, Bashir AH, Mohammed OY, Elhassan GO, Harguindey S, et al: Resistance to cancer chemotherapy: Failure in drug response from ADME to P-gp. Cancer Cell Int. 15(71)2015.PubMed/NCBI View Article : Google Scholar

34 

Ma Z, Zhao X, Jiang C, Yu J, Wu J and Zeng X: Gold nanoshells with verbascoside induce the apoptosis of drug-resistant leukemia cells through caspases pathway and inhibit tumor growth. J Nanosci Nanotechnol. 16:7118–7124. 2016.

35 

Dalgıç CT, Kaymaz BT, Özkan MC, Dalmızrak A, Şahin F and Saydam G: Investigating the role of JAK/STAT pathway on dasatinib-induced apoptosis for CML cell model K562. Clin Lymphoma Myeloma Leuk. 15 (Suppl):S161–S166. 2015.PubMed/NCBI View Article : Google Scholar

36 

De Martino L, D'Arena G, Minervini MM, Deaglio S, Fusco BM, Cascavilla N and De*Feo V: Verbena officinalis essential oil and its component citral as apoptotic-inducing agent in chronic lymphocytic leukemia. Int J Immunopathol Pharmacol. 22:1097–1104. 2009.PubMed/NCBI View Article : Google Scholar

37 

Ma L, Xu Z, Wang J, Zhu Z, Lin G, Jiang L, Lu X and Zou C: Matrine inhibits BCR/ABL mediated ERK/MAPK pathway in human leukemia cells. Oncotarget. 8:108880–108889. 2017.PubMed/NCBI View Article : Google Scholar

38 

Baykal-Kose S and Yalcin P: Altered apoptotic protein expressions characterize the survival of Bcr-Abl-independent drug-resistant chronic myeloid leukemia cell line. 1 J Basic Clin Health Sci. 1:1–5. 2021.

39 

Dumka D, Puri P, Carayol N, Lumby C, Balachandran H, Schuster K, Verma AK, Terada LS, Platanias LC and Parmar S: Activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib. Leuk Lymphoma. 50:2017–2029. 2009.PubMed/NCBI View Article : Google Scholar

40 

Aceves-Luquero CI, Agarwal A, Callejas-Valera JL, Arias-González L, Esparís-Ogando A, del Peso Ovalle L, Bellón-Echeverria I, de la Cruz-Morcillo MA, Galán Moya EM, Moreno Gimeno I, et al: ERK2, but not ERK1, mediates acquired and ‘de novo’ resistance to imatinib mesylate: implication for CML therapy. PLoS One. 4(e6124)2009.PubMed/NCBI View Article : Google Scholar

41 

Pesce M, Franceschelli S, Ferrone A, De Lutiis MA, Patruno A, Grilli A, Felaco M and Speranza L: Verbascoside down-regulates some pro-inflammatory signal transduction pathways by increasing the activity of tyrosine phosphatase SHP-1 in the U937 cell line. J Cell Mol Med. 19:1548–1556. 2015.PubMed/NCBI View Article : Google Scholar

42 

Puissant A, Dufies M, Fenouille N, Ben Sahra I, Jacquel A, Robert G, Cluzeau T, Deckert M, Tichet M, Chéli Y, et al: Imatinib triggers mesenchymal-like conversion of CML cells associated with increased aggressiveness. J Mol Cell Biol. 4:207–220. 2012.PubMed/NCBI View Article : Google Scholar

43 

Cort A, Ozben T, Saso L, De Luca C and Korkina L: Redox control of multidrug resistance and its possible modulation by antioxidants. Oxid Med Cell Longev. 2016(4251912)2016.PubMed/NCBI View Article : Google Scholar

44 

Vasincu A, Neophytou CM, Luca SV, Skalicka-Woźniak K, Miron A and Constantinou AI: 6-O-(3',4'-di-O-trans-cinnamoyl)-α-l-rhamnopyranosylcatalpol and verbascoside: Cytotoxicity, cell cycle kinetics, apoptosis, and ROS production evaluation in tumor cells. J Biochem Mol Toxicol. 34(e22443)2020.PubMed/NCBI View Article : Google Scholar

45 

Wang L, Wang M, Dou H, Lin W and Zou L: Sirtuin 1 inhibits lipopolysaccharide-induced inflammation in chronic myelogenous leukemia k562 cells through interacting with the Toll-like receptor 4-nuclear factor kappa B-reactive oxygen species signaling axis. Cancer Cell Int. 20(73)2020.PubMed/NCBI View Article : Google Scholar

46 

Speranza L, Franceschelli S, Pesce M, Reale M, Menghini L, Vinciguerra I, De Lutiis MA, Felaco M and Grilli A: Antiinflammatory effects in THP-1 cells treated with verbascoside. Phytother Res. 24:1398–1404. 2010.PubMed/NCBI View Article : Google Scholar

47 

Huang YH, Henriques ST, Wang CK, Thorstholm L, Daly NL, Kaas Q and Craik DJ: Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold. Sci Rep. 5(12974)2015.PubMed/NCBI View Article : Google Scholar

48 

Trela E, Glowacki S and Błasiak J: Therapy of chronic myeloid leukemia: Twilight of the imatinib era? ISRN Oncol. 2014(596483)2014.PubMed/NCBI View Article : Google Scholar

49 

Rossari F, Minutolo F and Orciuolo E: Past, present, and future of Bcr-Abl inhibitors: From chemical development to clinical efficacy. J Hematol Oncol. 11(84)2018.PubMed/NCBI View Article : Google Scholar

50 

Aggul AG, Taslimi P, Kuzu M, Uzun N, Bilginer S and Gulcin I: Oleuropein and verbascoside-their inhibition effects on carbonic anhydrase and molecular docking studies. J Oleo Sci. 70:1275–1283. 2021.PubMed/NCBI View Article : Google Scholar

51 

Cheimonidi C, Samara P, Polychronopoulos P, Tsakiri EN, Nikou T, Myrianthopoulos V, Sakellaropoulos T, Zoumpourlis V, Mikros E, Papassideri I, et al: Selective cytotoxicity of the herbal substance acteoside against tumor cells and its mechanistic insights. Redox Biol. 16:169–178. 2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Akgun-Cagliyan G, Cort-Donmez A, Kilic-Toprak E and Altintas F: Verbascoside potentiates the effect of tyrosine kinase inhibitors on the induction of apoptosis and oxidative stress via the Abl-mediated MAPK signalling pathway in chronic myeloid leukaemia. Exp Ther Med 24: 514, 2022.
APA
Akgun-Cagliyan, G., Cort-Donmez, A., Kilic-Toprak, E., & Altintas, F. (2022). Verbascoside potentiates the effect of tyrosine kinase inhibitors on the induction of apoptosis and oxidative stress via the Abl-mediated MAPK signalling pathway in chronic myeloid leukaemia. Experimental and Therapeutic Medicine, 24, 514. https://doi.org/10.3892/etm.2022.11441
MLA
Akgun-Cagliyan, G., Cort-Donmez, A., Kilic-Toprak, E., Altintas, F."Verbascoside potentiates the effect of tyrosine kinase inhibitors on the induction of apoptosis and oxidative stress via the Abl-mediated MAPK signalling pathway in chronic myeloid leukaemia". Experimental and Therapeutic Medicine 24.2 (2022): 514.
Chicago
Akgun-Cagliyan, G., Cort-Donmez, A., Kilic-Toprak, E., Altintas, F."Verbascoside potentiates the effect of tyrosine kinase inhibitors on the induction of apoptosis and oxidative stress via the Abl-mediated MAPK signalling pathway in chronic myeloid leukaemia". Experimental and Therapeutic Medicine 24, no. 2 (2022): 514. https://doi.org/10.3892/etm.2022.11441
Copy and paste a formatted citation
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Spandidos Publications style
Akgun-Cagliyan G, Cort-Donmez A, Kilic-Toprak E and Altintas F: Verbascoside potentiates the effect of tyrosine kinase inhibitors on the induction of apoptosis and oxidative stress via the Abl-mediated MAPK signalling pathway in chronic myeloid leukaemia. Exp Ther Med 24: 514, 2022.
APA
Akgun-Cagliyan, G., Cort-Donmez, A., Kilic-Toprak, E., & Altintas, F. (2022). Verbascoside potentiates the effect of tyrosine kinase inhibitors on the induction of apoptosis and oxidative stress via the Abl-mediated MAPK signalling pathway in chronic myeloid leukaemia. Experimental and Therapeutic Medicine, 24, 514. https://doi.org/10.3892/etm.2022.11441
MLA
Akgun-Cagliyan, G., Cort-Donmez, A., Kilic-Toprak, E., Altintas, F."Verbascoside potentiates the effect of tyrosine kinase inhibitors on the induction of apoptosis and oxidative stress via the Abl-mediated MAPK signalling pathway in chronic myeloid leukaemia". Experimental and Therapeutic Medicine 24.2 (2022): 514.
Chicago
Akgun-Cagliyan, G., Cort-Donmez, A., Kilic-Toprak, E., Altintas, F."Verbascoside potentiates the effect of tyrosine kinase inhibitors on the induction of apoptosis and oxidative stress via the Abl-mediated MAPK signalling pathway in chronic myeloid leukaemia". Experimental and Therapeutic Medicine 24, no. 2 (2022): 514. https://doi.org/10.3892/etm.2022.11441
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