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Use of granulocyte and monocyte adsorption apheresis in dermatology (Review)

  • Authors:
    • Laura Gnesotto
    • Guido Mioso
    • Mauro Alaibac
  • View Affiliations / Copyright

    Affiliations: Dermatology Unit, Department of Medicine, University of Padova, I‑35128 Padova, Italy
    Copyright: © Gnesotto et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 536
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    Published online on: June 24, 2022
       https://doi.org/10.3892/etm.2022.11463
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Abstract

Adsorptive granulocyte and monocyte apheresis (GMA) is an extracorporeal treatment that selectively removes activated myeloid lineage leukocytes from peripheral blood. This technique consists of a column with cellulose acetate beads as absorptive leukocytapheresis carriers, and was initially used to treat ulcerative colitis. A literature search was conducted to extract recently published studies about the clinical efficacy of GMA in patients with different skin disorders, reporting information on demographics, clinical symptoms, treatment and clinical course. Dermatological diseases, in which GMA has been performed, include generalized pustular psoriasis, pyoderma gangrenosum, palmoplantar pustular psoriasis, Behcet's disease, Sweet's syndrome, adult‑onset Still's disease, impetigo herpetiformis, reactive arthritis, acne and hidradenitis suppurativa syndrome, cutaneous allergic vasculitis and systemic lupus erythematosus. In most patients, GMA was started after the failure of conventional therapeutic options and it was helpful in the majority of cases. Based on the information summarized, GMA could be considered a valid non‑pharmacological treatment option for patients with several dermatological conditions, which are difficult to treat with other pharmacological preparations.
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Copy and paste a formatted citation
Spandidos Publications style
Gnesotto L, Mioso G and Alaibac M: Use of granulocyte and monocyte adsorption apheresis in dermatology (Review). Exp Ther Med 24: 536, 2022.
APA
Gnesotto, L., Mioso, G., & Alaibac, M. (2022). Use of granulocyte and monocyte adsorption apheresis in dermatology (Review). Experimental and Therapeutic Medicine, 24, 536. https://doi.org/10.3892/etm.2022.11463
MLA
Gnesotto, L., Mioso, G., Alaibac, M."Use of granulocyte and monocyte adsorption apheresis in dermatology (Review)". Experimental and Therapeutic Medicine 24.2 (2022): 536.
Chicago
Gnesotto, L., Mioso, G., Alaibac, M."Use of granulocyte and monocyte adsorption apheresis in dermatology (Review)". Experimental and Therapeutic Medicine 24, no. 2 (2022): 536. https://doi.org/10.3892/etm.2022.11463
Copy and paste a formatted citation
x
Spandidos Publications style
Gnesotto L, Mioso G and Alaibac M: Use of granulocyte and monocyte adsorption apheresis in dermatology (Review). Exp Ther Med 24: 536, 2022.
APA
Gnesotto, L., Mioso, G., & Alaibac, M. (2022). Use of granulocyte and monocyte adsorption apheresis in dermatology (Review). Experimental and Therapeutic Medicine, 24, 536. https://doi.org/10.3892/etm.2022.11463
MLA
Gnesotto, L., Mioso, G., Alaibac, M."Use of granulocyte and monocyte adsorption apheresis in dermatology (Review)". Experimental and Therapeutic Medicine 24.2 (2022): 536.
Chicago
Gnesotto, L., Mioso, G., Alaibac, M."Use of granulocyte and monocyte adsorption apheresis in dermatology (Review)". Experimental and Therapeutic Medicine 24, no. 2 (2022): 536. https://doi.org/10.3892/etm.2022.11463
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