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Association between long non‑coding RNA HOTAIR polymorphism and lung cancer risk: A systematic review and meta‑analysis

  • Authors:
    • Chunlin Ke
    • Xuegang Feng
    • Jie Li
    • Siyu Chen
    • Xinyu Hu
  • View Affiliations / Copyright

    Affiliations: Department of Radiotherapy, Cancer Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China, Department of Cardio‑Thoracic Surgery, 900 Hospital of The Joint Logistics Team, Fuzhou, Fujian 350025, P.R. China, Department of Oncology, 900 Hospital of The Joint Logistics Team, Fuzhou, Fujian 350025, P.R. China
    Copyright: © Ke et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 540
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    Published online on: June 29, 2022
       https://doi.org/10.3892/etm.2022.11477
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Abstract

Single nucleotide polymorphism (SNP) of long noncoding RNA (lnc)RNA has been reported to be an important factor in cancer development. Recently, lncRNA homeobox transcript antisense intergenic RNA (HOTAIR) was indicated to induce tumorigenesis of several cancer types, but the association between the SNP of lncRNA HOTAIR and lung cancer susceptibility has remained undetermined. The present meta‑analysis aimed to investigate the effect of HOTAIR polymorphism on susceptibility to lung cancer. The PubMed, Ovid Medline, Embase and Cochrane Library databases were thoroughly searched. Studies containing data on the incidence of lung cancer in patients with different HOTAIR SNPs were included. The Hardy‑Weinberg equilibrium was analyzed to determine genotype distribution and allele frequencies. The odds ratio (OR) was pooled to evaluate the association of different SNPs with the susceptibility to lung cancer. A total of six studies comprising 1,715 patients with lung cancer and 2,745 healthy controls were finally included. A total of 4 SNPs (rs12826786, rs1899663, rs920778 and rs4759314) were reported. Analyses for all of these SNPs individually indicated that the lncRNA HOTAIR rs1899663 C>A polymorphism was a risk factor for lung cancer (dominant mode, AA+CA vs. CC: OR=0.816, 95% CI=0.707‑0.942, P=0.005). The present study was the first meta‑analysis investigating the association between lncRNA HOTAIR and lung cancer susceptibility. The results indicated that the lncRNA HOTAIR rs1899663 C>A polymorphism is a risk factor for lung cancer. LncRNA HOTAIR may be of value in lung cancer screening, particularly for populations with high‑risk factors, as well as prognosis prediction. Future investigations are required to further clarify the intrinsic mechanism of the role of HOTAIR in the oncogenesis of lung cancer.
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1 

Barta JA, Powell CA and Wisnivesky JP: Global epidemiology of lung cancer. Ann Glob Health. 85(8)2019.PubMed/NCBI View Article : Google Scholar

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018.PubMed/NCBI View Article : Google Scholar

3 

Cao M and Chen W: Epidemiology of lung cancer in China. Thorac Cancer. 10:3–7. 2019.PubMed/NCBI View Article : Google Scholar

4 

Taghvaee S, Sowlat MH, Hassanvand MS, Yunesian M, Naddafi K and Sioutas C: Source-specific lung cancer risk assessment of ambient PM2.5-bound polycyclic aromatic hydrocarbons (PAHs) in central Tehran. Environ Int. 120:321–332. 2018.PubMed/NCBI View Article : Google Scholar

5 

Brasky TM, White E and Chen CL: Long-term, supplemental, one-carbon metabolism-related vitamin B use in relation to lung cancer risk in the vitamins and lifestyle (VITAL) cohort. J Clin Oncol. 35:3440–3448. 2017.PubMed/NCBI View Article : Google Scholar

6 

Hicks BM, Filion KB, Yin H, Sakr L, Udell JA and Azoulay L: Angiotensin converting enzyme inhibitors and risk of lung cancer: Population based cohort study. BMJ. 363(k4209)2018.PubMed/NCBI View Article : Google Scholar

7 

Lin KF, Wu HF, Huang WC, Tang PL, Wu MT and Wu FZ: Propensity score analysis of lung cancer risk in a population with high prevalence of non-smoking related lung cancer. BMC Pulm Med. 17(120)2017.PubMed/NCBI View Article : Google Scholar

8 

Fortunato O, Borzi C, Milione M, Centonze G, Conte D, Boeri M, Verri C, Moro M, Facchinetti F, Andriani F, et al: Circulating mir-320a promotes immunosuppressive macrophages M2 phenotype associated with lung cancer risk. Int J Cancer. 144:2746–2761. 2019.PubMed/NCBI View Article : Google Scholar

9 

ENCODE Project Consortium. The ENCODE (ENCyclopedia of DNA elements) project. Science. 306:636–340. 2004.PubMed/NCBI View Article : Google Scholar

10 

Huarte M: The emerging role of lncRNAs in cancer. Nat Med. 21:1253–1261. 2015.PubMed/NCBI View Article : Google Scholar

11 

Wu Y, Shao A, Wang L, Hu K, Yu C, Pan C and Zhang S: The role of lncRNAs in the distant metastasis of breast cancer. Front Oncol. 9(407)2019.PubMed/NCBI View Article : Google Scholar

12 

Zhang Y and Tang L: The application of lncRNAs in cancer treatment and diagnosis. Recent Pat Anticancer Drug Discov. 13:292–301. 2018.PubMed/NCBI View Article : Google Scholar

13 

Lu T, Wang Y, Di Chen JL and Jiao W: Potential clinical application of lncRNAs in non-small cell lung cancer. Onco Targets Ther. 11:8045–8052. 2018.PubMed/NCBI View Article : Google Scholar

14 

Engle L, Simpson C and Landers J: Using high-throughput SNP technologies to study cancer. Oncogene. 25:1594–1601. 2006.PubMed/NCBI View Article : Google Scholar

15 

Syvänen AC: Toward genome-wide SNP genotyping. Nat Genet. 37 (Suppl):S5–S10. 2005.PubMed/NCBI View Article : Google Scholar

16 

Andrew AS, Gui J, Sanderson AC, Mason RA, Morlock EV, Schned AR, Kelsey KT, Marsit CJ, Moore JH and Karagas MR: Bladder cancer SNP panel predicts susceptibility and survival. Hum Genet. 125:527–539. 2009.PubMed/NCBI View Article : Google Scholar

17 

Duboule D: The rise and fall of Hox gene clusters. Development. 134:2549–2560. 2007.PubMed/NCBI View Article : Google Scholar

18 

Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E and Chang HY: Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell. 129:1311–1323. 2007.PubMed/NCBI View Article : Google Scholar

19 

Hajjari M and Salavaty A: HOTAIR: an oncogenic long non-coding RNA in different cancers. Cancer Biol Med. 12:1–9. 2015.PubMed/NCBI View Article : Google Scholar

20 

Loewen G, Jayawickramarajah J, Zhuo Y and Shan B: Functions of lncRNA HOTAIR in lung cancer. J Hematol Oncol. 7(90)2014.PubMed/NCBI View Article : Google Scholar

21 

Fatica A and Bozzoni I: Long non-coding RNAs: New players in cell differentiation and development. Nat Rev Genet. 15:7–21. 2014.PubMed/NCBI View Article : Google Scholar

22 

Somarowthu S, Legiewicz M, Chillón I, Marcia M, Liu F and Pyle AM: HOTAIR forms an intricate and modular secondary structure. Mol Cell. 58:353–361. 2015.PubMed/NCBI View Article : Google Scholar

23 

Bhan A and Mandal SS: LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer. Biochim Biophys Acta. 1856:151–164. 2015.PubMed/NCBI View Article : Google Scholar

24 

Zhuang Y, Wang X, Nguyen HT, Zhuo Y, Cui X, Fewell C, Flemington EK and Shan B: Induction of long intergenic non-coding RNA HOTAIR in lung cancer cells by type I collagen. J Hematol Oncol. 6(35)2013.PubMed/NCBI View Article : Google Scholar

25 

Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, Tsai MC, Hung T, Argani P, Rinn JL, et al: Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 464:1071–1076. 2010.PubMed/NCBI View Article : Google Scholar

26 

Wu Y, Zhang L, Wang Y, Li H, Ren X, Wei F, Yu W, Wang X, Zhang L, Yu J and Hao X: Long noncoding RNA HOTAIR involvement in cancer. Tumour Biol. 35:9531–9538. 2014.PubMed/NCBI View Article : Google Scholar

27 

Xu ZY, Yu QM, Du YA, Yang LT, Dong RZ, Huang L, Yu PF and Cheng XD: Knockdown of long non-coding RNA HOTAIR suppresses tumor invasion and reverses epithelial-mesenchymal transition in gastric cancer. Int J Biol Sci. 9:587–597. 2013.PubMed/NCBI View Article : Google Scholar

28 

Liu XH, Liu ZL, Sun M, Liu J, Wang ZX and De W: The long non-coding RNA HOTAIR indicates a poor prognosis and promotes metastasis in non-small cell lung cancer. BMC Cancer. 13(464)2013.PubMed/NCBI View Article : Google Scholar

29 

Zhao W, An Y, Liang Y and Xie XW: Role of HOTAIR long noncoding RNA in metastatic progression of lung cancer. Eur Rev Med Pharmacol Sci. 18:1930–1936. 2014.PubMed/NCBI

30 

Nakagawa T, Endo H, Yokoyama M, Abe J, Tamai K, Tanaka N, Sato I, Takahashi S, Kondo T and Satoh K: Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer. Biochem Biophys Res Commun. 436:319–324. 2013.PubMed/NCBI View Article : Google Scholar

31 

Moher D, Liberati A, Tetzlaff J and Altman DG: PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med. 6(e1000097)2009.PubMed/NCBI View Article : Google Scholar

32 

Stang A: Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 25:603–605. 2010.PubMed/NCBI View Article : Google Scholar

33 

Ren MM, Xu S, Wei YB, Yang JJ, Yang YN, Sun SS, Li YJ, Wang PY and Xie SY: Roles of HOTAIR in lung cancer susceptibility and prognosis. Mol Genet Genomic Med. 8(e1299)2020.PubMed/NCBI View Article : Google Scholar

34 

Minn AKK, Sato N, Mieno MN, Arai T and Muramatsu M: Association study of long non-coding RNA HOTAIR rs920778 polymorphism with the risk of cancer in an elderly Japanese population. Gene. 729(144263)2020.PubMed/NCBI View Article : Google Scholar

35 

Wang C, Li Y, Li YW, Zhang HB, Gong H, Yuan Y, Li WT, Liu HY and Chen J: HOTAIR lncRNA SNPs rs920778 and rs1899663 are associated with smoking, male gender, and squamous cell carcinoma in a Chinese lung cancer population. Acta Pharmacol Sin. 39:1797–1803. 2018.PubMed/NCBI View Article : Google Scholar

36 

Li H, Yang Z, Li J, Lv X, Gao M, Bi Y, Zhang Z, Wang S, Li S, Li N, et al: Genetic variants in lncRNA HOTAIR are associated with lung cancer susceptibility in a Chinese Han population in China: A case-control study. Cancer Manag Res. 10:5209–5218. 2018.PubMed/NCBI View Article : Google Scholar

37 

Dadaş E and Aydin M: Effect of HOTAIR rs12826786 and rs1899663 polymorphisms on lung cancer susceptibility and clinicopathological characteristics in a Turkish population: A hospital-based case-control study. Cell Mol Biol (Noisy-le-grand). 64:97–102. 2018.

38 

Gong WJ, Yin JY, Li XP, Fang C, Xiao D, Zhang W, Zhou HH, Li X and Liu ZQ: Association of well-characterized lung cancer lncRNA polymorphisms with lung cancer susceptibility and platinum-based chemotherapy response. Tumour Biol. 37:8349–8358. 2016.PubMed/NCBI View Article : Google Scholar

39 

Dor Y and Cedar H: Principles of DNA methylation and their implications for biology and medicine. Lancet. 392:777–786. 2018.PubMed/NCBI View Article : Google Scholar

40 

Shimizu Y, Sato S, Noguchi Y, Koyamatsu J, Yamanashi H, Higashi M, Nagayoshi M, Kadota K, Kawashiri SY, Nagata Y, et al: Impact of single nucleotide polymorphism on short stature and reduced tongue pressure among community-dwelling elderly Japanese participants: A cross-sectional study. Environ Health Prev Med. 22(62)2017.PubMed/NCBI View Article : Google Scholar

41 

Leaché AD and Oaks JR: The utility of single nucleotide polymorphism (SNP) data in phylogenetics. Annu Rev Ecol Evol Syst. 48:69–84. 2017.

42 

Zhang X, Zhou L, Fu G, Sun F, Shi J, Wei J, Lu C, Zhou C, Yuan Q and Yang M: The identification of an ESCC susceptibility SNP rs920778 that regulates the expression of lncRNA HOTAIR via a novel intronic enhancer. Carcinogenesis. 35:2062–2067. 2014.PubMed/NCBI View Article : Google Scholar

43 

Zhu H, Lv Z, An C, Shi M, Pan W, Zhou L, Yang W and Yang M: Onco-lncRNA HOTAIR and its functional genetic variants in papillary thyroid carcinoma. Sci Rep. 6(31969)2016.PubMed/NCBI View Article : Google Scholar

44 

Pan W, Liu L, Wei J, Ge Y, Zhang J, Chen H, Zhou L, Yuan Q, Zhou C and Yang M: A functional lncRNA HOTAIR genetic variant contributes to gastric cancer susceptibility. Mol Carcinog. 55:90–96. 2016.PubMed/NCBI View Article : Google Scholar

45 

Liu Z, Sun M, Lu K, Liu J, Zhang M, Wu W, De W, Wang Z and Wang R: The long noncoding RNA HOTAIR contributes to cisplatin resistance of human lung adenocarcinoma cells via downregualtion of p21(WAF1/CIP1) expression. PLoS One. 8(e77293)2013.PubMed/NCBI View Article : Google Scholar

46 

Fan L, Lei H, Lin Y, Zhou Z, Li J, Wu A, Shu G, Ruger S and Yin G: Hotair promotes the migration and proliferation in ovarian cancer by miR-222-3p/CDK19 axis. Cell Mol Life Sci. 79(254)2022.PubMed/NCBI View Article : Google Scholar

47 

Chen J, Hou SF, Tang FJ, Liu DS, Chen ZZ, Zhang HL and Wang SH: HOTAIR/Sp1/miR-199a critically regulates cancer stemness and malignant progression of cutaneous squamous cell carcinoma. Oncogene. 41:99–111. 2022.PubMed/NCBI View Article : Google Scholar

48 

Zhang W, Wu Q, Liu Y, Wang X, Ma C and Zhu W: LncRNA HOTAIR promotes chemoresistance by facilitating epithelial to mesenchymal transition through miR-29b/PTEN/PI3K signaling in cervical cancer. Cells Tissues Organs. 211:16–29. 2022.PubMed/NCBI View Article : Google Scholar

49 

Zhang W, Liu J, Wu Q, Liu Y and Ma C: HOTAIR contributes to stemness acquisition of cervical cancer through regulating miR-203 interaction with ZEB1 on epithelial-mesenchymal transition. J Oncol. 2021(4190764)2021.PubMed/NCBI View Article : Google Scholar

50 

Zhang M, Wu K, Zhang P, Qiu Y, Bai F and Chen H: HOTAIR facilitates endocrine resistance in breast cancer through ESR1/miR-130b-3p axis: Comprehensive analysis of mRNA-miRNA-lncRNA network. Int J Gen Med. 14:4653–4663. 2021.PubMed/NCBI View Article : Google Scholar

51 

Deng S, Wang J, Zhang L, Li J and Jin Y: LncRNA HOTAIR promotes cancer stem-like cells properties by sponging miR-34a to activate the JAK2/STAT3 pathway in pancreatic ductal adenocarcinoma. Onco Targets Ther. 14:1883–1893. 2021.PubMed/NCBI View Article : Google Scholar

52 

Sun N, Zhang W, Liu J, Yang X and Chu Q: Propofol inhibits the progression of cervical cancer by regulating HOTAIR/miR-129-5p/RPL14 axis. Onco Targets Ther. 14:551–564. 2021.PubMed/NCBI View Article : Google Scholar

53 

Wu D, Zhu J, Fu Y, Li C and Wu B: LncRNA HOTAIR promotes breast cancer progression through regulating the miR-129-5p/FZD7 axis. Cancer Biomark. 30:203–212. 2021.PubMed/NCBI View Article : Google Scholar

54 

Zhan Y, Abuduwaili K, Wang X, Shen Y, Nuerlan S and Liu C: Knockdown of long non-coding RNA HOTAIR suppresses cisplatin resistance, cell proliferation, migration and invasion of DDP-resistant NSCLC cells by targeting miR-149-5p/doublecortin-like kinase 1 axis. Cancer Manag Res. 12:7725–7737. 2020.PubMed/NCBI View Article : Google Scholar

55 

Liang H and Peng J: LncRNA HOTAIR promotes proliferation, invasion and migration in NSCLC cells via the CCL22 signaling pathway. PLoS One. 17(e0263997)2022.PubMed/NCBI View Article : Google Scholar

56 

Tang Y, Song G, Liu H, Yang S, Yu X and Shi L: Silencing of long non-coding RNA HOTAIR alleviates epithelial-mesenchymal transition in pancreatic cancer via the Wnt/β-catenin signaling pathway. Cancer Manag Res. 13:3247–3257. 2021.PubMed/NCBI View Article : Google Scholar

57 

Dai ZY, Jin SM, Luo HQ, Leng HL and Fang JD: LncRNA HOTAIR regulates anoikis-resistance capacity and spheroid formation of ovarian cancer cells by recruiting EZH2 and influencing H3K27 methylation. Neoplasma. 68:509–518. 2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Ke C, Feng X, Li J, Chen S and Hu X: Association between long non‑coding RNA HOTAIR polymorphism and lung cancer risk: A systematic review and meta‑analysis. Exp Ther Med 24: 540, 2022.
APA
Ke, C., Feng, X., Li, J., Chen, S., & Hu, X. (2022). Association between long non‑coding RNA HOTAIR polymorphism and lung cancer risk: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 24, 540. https://doi.org/10.3892/etm.2022.11477
MLA
Ke, C., Feng, X., Li, J., Chen, S., Hu, X."Association between long non‑coding RNA HOTAIR polymorphism and lung cancer risk: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 24.2 (2022): 540.
Chicago
Ke, C., Feng, X., Li, J., Chen, S., Hu, X."Association between long non‑coding RNA HOTAIR polymorphism and lung cancer risk: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 24, no. 2 (2022): 540. https://doi.org/10.3892/etm.2022.11477
Copy and paste a formatted citation
x
Spandidos Publications style
Ke C, Feng X, Li J, Chen S and Hu X: Association between long non‑coding RNA HOTAIR polymorphism and lung cancer risk: A systematic review and meta‑analysis. Exp Ther Med 24: 540, 2022.
APA
Ke, C., Feng, X., Li, J., Chen, S., & Hu, X. (2022). Association between long non‑coding RNA HOTAIR polymorphism and lung cancer risk: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 24, 540. https://doi.org/10.3892/etm.2022.11477
MLA
Ke, C., Feng, X., Li, J., Chen, S., Hu, X."Association between long non‑coding RNA HOTAIR polymorphism and lung cancer risk: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 24.2 (2022): 540.
Chicago
Ke, C., Feng, X., Li, J., Chen, S., Hu, X."Association between long non‑coding RNA HOTAIR polymorphism and lung cancer risk: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 24, no. 2 (2022): 540. https://doi.org/10.3892/etm.2022.11477
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