Open Access

Pharmacological profiles and therapeutic applications of pachymic acid (Review)

  • Authors:
    • Chunyong Wei
    • Hezhen Wang
    • Xun Sun
    • Zhixun Bai
    • Jing Wang
    • Guohui Bai
    • Qizheng Yao
    • Yingshu Xu
    • Lei Zhang
  • View Affiliations

  • Published online on: July 1, 2022     https://doi.org/10.3892/etm.2022.11484
  • Article Number: 547
  • Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Poria cocos is a saprophytic fungus that grows in diverse species of Pinus. Its sclerotium, called fu‑ling or hoelen, has been used in various traditional Chinese medicines and health foods for thousands of years, and in several modern proprietary traditional Chinese medicinal products. It has extensive clinical indications, including sedative, diuretic, and tonic effects. Pachymic acid (PA) is the main lanostane‑type triterpenoid in Poria cocos. Evidence suggests that PA has various biological properties such as cytotoxic, anti‑inflammatory, antihyperglycemic, antiviral, antibacterial, sedative‑hypnotic, and anti‑ischemia/reperfusion activities. Although considerable advancements have been made, some fundamental and intricate issues remain unclear, such as the underlying mechanisms of PA. The present study aimed to summarize the biological properties and therapeutic potential of PA. The biosynthetic, pharmacokinetic, and metabolic pathways of PA, and its underlying mechanisms were also comprehensively summarized.

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September-2022
Volume 24 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Wei C, Wang H, Sun X, Bai Z, Wang J, Bai G, Yao Q, Xu Y and Zhang L: Pharmacological profiles and therapeutic applications of pachymic acid (Review). Exp Ther Med 24: 547, 2022
APA
Wei, C., Wang, H., Sun, X., Bai, Z., Wang, J., Bai, G. ... Zhang, L. (2022). Pharmacological profiles and therapeutic applications of pachymic acid (Review). Experimental and Therapeutic Medicine, 24, 547. https://doi.org/10.3892/etm.2022.11484
MLA
Wei, C., Wang, H., Sun, X., Bai, Z., Wang, J., Bai, G., Yao, Q., Xu, Y., Zhang, L."Pharmacological profiles and therapeutic applications of pachymic acid (Review)". Experimental and Therapeutic Medicine 24.3 (2022): 547.
Chicago
Wei, C., Wang, H., Sun, X., Bai, Z., Wang, J., Bai, G., Yao, Q., Xu, Y., Zhang, L."Pharmacological profiles and therapeutic applications of pachymic acid (Review)". Experimental and Therapeutic Medicine 24, no. 3 (2022): 547. https://doi.org/10.3892/etm.2022.11484