|
1
|
Li J, Wang Y, Xue J, Wang P and Shi S:
Dietary exposure risk assessment of flonicamid and its effect on
constituents after application in lonicerae japonicae flos. Chem
Pharm Bull (Tokyo). 66:608–611. 2018.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Shingu T, Tai T and Akahori A: A lanostane
triterpenoid from Poria cocos. Phytochemistry. 31:2548–2549.
1992.
|
|
3
|
Zheng Y and Yang XW: Two new lanostane
triterpenoids from Poria cocos. J Asian Nat Prod Res.
10:323–328. 2008.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Dong HJ, Xue ZZ, Geng YL, Wang X and Yang
B: Lanostane triterpenes isolated from epidermis of Poria
cocos. Phytochem Lett. 22:102–106. 2017.
|
|
5
|
Ríos JL: Chemical constituents and
pharmacological properties of Poria cocos. Planta Med.
77:681–691. 2011.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Zhao YY, Feng YL, Du X, Xi ZH, Cheng XL
and Wei F: Diuretic activity of the ethanol and aqueous extracts of
the surface layer of Poria cocos in rat. J Ethnopharmacol.
144:775–778. 2012.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Nie A, Chao Y, Zhang X, Jia W, Zhou Z and
Zhu C: Phytochemistry and pharmacological activities of
WolfiPoria cocos (FA Wolf) Ryvarden & Gilb. Front
Pharmacol. 11(505249)2020.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Liu J, Tian J, Zhou L, Meng L, Chen S, Ma
C, Wang J, Liu Z, Li C and Kang W: Phytochemistry and Biological
Activities of Poria. J Chem. 2021(6659775)2021.
|
|
9
|
Lai KH, Lu MC, Du YC, El-Shazly M, Wu TY,
Hsu YM, Henz A, Yang JC, Backlund A, Chang FR and Wu YC: Cytotoxic
Lanostanoids from Poria cocos. J Nat Prod. 79:2805–2813.
2016.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Taofiq O, Martins A, Barreiro MF and
Ferreira ICFR: Anti-inflammatory potential of mushroom extracts and
isolated metabolites. Trends Food Sci Tech. 50:193–210. 2016.
|
|
11
|
Tang X, Chen J and Shen X: The signaling
pathway for regulation of glucose transporter 4 and its application
in drug devel-opment. Sci Sin Chim. 42:1760–1773. 2012.
|
|
12
|
Wu Z, Chen X, Ni W, Zhou D, Chai S, Ye W,
Zhang Z, Guo Y, Ren L and Zeng Y: The inhibition of Mpro, the
primary protease of COVID-19, by Poria cocos and its active
compounds: A network pharmacology and molecular docking study. RSC
Adv. 11:11821–11843. 2021.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Shah VK, Choi JJ, Han JY, Lee MK, Hong JT
and Oh KW: Pachymic acid enhances pentobarbital-induced sleeping
be-haviors via GABAA-ergic systems in mice. Biomol Ther (Seoul).
22:314–320. 2014.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Pang Y, Zhu S and Pei H: Pachymic acid
protects against cerebral ischemia/reperfusion injury by the
PI3K/Akt signaling pathway. Metab Brain Dis. 35:673–680.
2020.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Tai T, Shingu T, Kikuchi T, Tezuka Y and
Akahori A: Isolation of lanostane-type triterpene acids having an
acetoxyl group from sclerotia of Poria cocos.
Phytochemistry. 40:225–231. 1995.
|
|
16
|
Li G, Xu ML, Lee CS, Woo MH, Chang HW and
Son JK: Cytotoxicity and DNA topoisomerases inhibitory activity of
constituents from the sclerotium of Poria cocos. Arch Pharm
Res. 27:829–833. 2004.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Akihisa T, Nakamura Y, Tokuda H, Uchiyama
E, Suzuki T, Kimura Y, Uchikura K and Nishino H: Triterpene acids
from Poria cocos and their anti-tumor-promoting effects. J
Nat Prod. 70:948–953. 2007.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Zhou L, Zhang Y, Gapter LA, Ling H,
Agarwal R and Ng KY: Cytotoxic and anti-oxidant activities of
lanostane-type triterpenes isolated from Poria cocos. Chem
Pharm Bull (Tokyo). 56:1459–1462. 2008.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Cai TG and Cai Y: Triterpenes from the
fungus Poria cocos and their inhibitory activity on nitric
oxide production in mouse macrophages via blockade of activating
protein-1 pathway. Chem Biodivers. 8:2135–2143. 2011.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Yang H, Shen Y, Chen B, Jia X and Cai B:
RP-HPLC-DAD determination of six triterpenes in a herbal tonic
hoelen. J Liq Chromatogr Relat Technol. 34:1772–1782. 2011.
|
|
21
|
Li S, Wang Z, Gu R, Zhao Y, Huang W, Wang
Z and Xiao W: A new epidioxy-tetracyclic triterpenoid from Poria
cocos Wolf. Nat Prod Res. 30:1712–1717. 2016.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Li M, Wang GZ, Nie L and Shen JY: Study on
the content comparison of pachymic acid from different medicinal
parts of Poria cocos (Schw.) Wolf. Lishizhen Med Mater Med
Res. 26:2858–2860. 2015.
|
|
23
|
Fu M, Wang L, Wang X, Deng B, Hu X and Zou
J: Determination of the five main terpenoids in different tissues
of WolfiPoria cocos. Molecules. 23(1839)2018.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Yang PF, Hua T, Wang D, Zhao ZW, Xi GL and
Chen ZF: Phytochemical and chemotaxonomic study of Poria
cocos (Schw.) Wolf. Biochem Syst Ecol. 83:54–56. 2019.
|
|
25
|
Jiang TT, Ding LF, Nie W, Wang LY, Lei T,
Wu XD and Zhao QS: Tetranorlanostane and lanostane triterpenoids
with cytotoxic activity from the epidermis of Poria cocos.
Chem Biodivers. 18(e2100196)2021.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Kim TG, Lee YH, Lee NH, Bhattarai G, Lee
IK, Yun BS and Yi HK: The antioxidant property of pachymic acid
improves bone disturbance against AH Plus-induced inflammation in
MC-3T3 E1 cells. J Endod. 39:461–466. 2013.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Lee YH, Lee NH, Bhattarai G, Kim GE, Lee
IK, Yun BS, Hwang PH and Yi HK: Anti-inflammatory effect of
pachymic acid promotes odontoblastic differentiation via HO-1 in
dental pulp cells. Oral Dis. 19:193–199. 2013.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Keller AC, Maillard MP and Hostettmann K:
Antimicrobial steroids from the fungus Fomitopsis pinicola.
Phytochemistry. 41:1041–1046. 1996.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Kuo PC, Tai SH, Hung CC, Hwang TL, Kuo LM,
Lam SH, Cheng KC, Kuo DH, Hung HY and Wu TS: Anti-inflammatory
triterpenoids from the fruiting bodies of Fomitopsis
pinicola. Bioorg Chem. 108(104562)2021.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Ma J, Liu J, Lu CW and Cai DF: Pachymic
acid modified carbon nanoparticles reduced angiogenesis via
inhibition of MMP-3. Int J Clin Exp Pathol. 8:5464–5470.
2015.PubMed/NCBI
|
|
31
|
Zhu W, Liu Y, Tang J, Liu H, Jing N, Li F,
Xu R and Shu S: Functional analysis of sterol O-Acyltransferase
involved in the biosynthetic pathway of pachymic acid in
WolfiPoria cocos. Molecules. 27(143)2021.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Cai SY, Lv SW, Wang YH, Guo YY and Li YJ:
Solubility and Apparent Oil/Water Partition Coefficient of
Glycyrrhizin and Pachymic Acid. Inf Tradit Chin Med. 29:118–121.
2012.(In Chinese).
|
|
33
|
Sung H, Ferlay J, Siegel RL, Laversanne M,
Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020:
GLOBOCAN estimates of incidence and mortality worldwide for 36
cancers in 185 countries. CA Cancer J Clin. 71:209–249.
2021.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Xu H, Wang Y, Zhao J, Jurutka PW, Huang D,
Liu L, Zhang L, Wang S, Chen Y and Cheng S: Triterpenes from
Poria cocos are revealed as potential retinoid X receptor
selective agonists based on cell and in silico evidence. Chem Biol
Drug Des. 95:493–502. 2020.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Jeong JW, Baek JY, Kim KD, Choi YH and Lee
JD: Induction of apoptosis by pachymic acid in T24 human bladder
cancer cells. J Life Sci. 25:93–100. 2015.
|
|
36
|
Jeong JW, Lee WS, Go SI, Nagappan A, Baek
JY, Lee JD, Park C, Kim GY, Kim HJ, Kim GS, et al: Pachymic acid
induces apoptosis of EJ bladder cancer cells by DR5 up-regulation,
ROS generation, modulation of Bcl-2 and IAP family members.
Phytother Res. 29:1516–1524. 2015.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Zhang YH, Zhang Y, Li XY, Feng XD, Jian W
and Li RQ: Antitumor activity of the pachymic acid in
nasopharyngeal carcinoma cells. Ultrastruct Pathol. 41:245–251.
2017.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Gapter L, Wang Z, Glinski J and Ng KY:
Induction of apoptosis in prostate cancer cells by pachymic acid
from Poria cocos. Biochem Biophys Res Commun. 332:1153–1161.
2005.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Wen H, Wu Z, Hu H, Wu Y, Yang G, Lu J,
Yang G, Guo G and Dong Q: The anti-tumor effect of pachymic acid on
osteosarcoma cells by inducing PTEN and Caspase 3/7-dependent
apoptosis. J Nat Med. 72:57–63. 2018.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Miao G, Han J, Zhang J, Wu Y and Tong G:
Targeting pyruvate kinase M2 and Hexokinase II, pachymic acid
impairs glucose metabolism and induces mitochondrial apoptosis.
Biol Pharm Bull. 42:123–129. 2019.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Jiang Y and Fan L: Evaluation of
anticancer activities of Poria cocos ethanol extract in
breast cancer: In vivo and in vitro, identification and mechanism.
J Ethnopharmacol. 257(112851)2020.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Ling H, Jia X, Zhang Y, Gapter LA, Lim YS,
Agarwal R and Ng KY: Pachymic acid inhibits cell growth and
modulates arachidonic acid metabolism in nonsmall cell lung cancer
A549 cells. Mol Carcinog. 49:271–282. 2010.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Ma J, Liu J, Lu C and Cai D: Pachymic acid
induces apoptosis via activating ROS-dependent JNK and ER stress
pathways in lung cancer cells. Cancer Cell Int.
15(78)2015.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Sun KX and Xia HW: Pachymic acid inhibits
growth and induces cell cycle arrest and apoptosis in gastric
cancer SGC-7901 cells. Oncol Lett. 16:2517–2524. 2018.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Lu C, Ma J and Cai D: Pachymic acid
inhibits the tumorigenicity of gastric cancer cells by the
mitochondrial pathway. Anticancer Drugs. 28:170–179.
2017.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Cheng S, Swanson K, Eliaz I, McClintick
JN, Sandusky GE and Sliva D: Pachymic acid inhibits growth and
induces apoptosis of pancreatic cancer in vitro and in vivo by
targeting ER stress. PLoS One. 10(e0122270)2015.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Kaminaga T, Yasukawa K, Kanno H, Tai T,
Nunoura Y and Takido M: Inhibitory effects of lanostane-type
triterpene acids, the components of Poria cocos, on tumor
promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage
carcinogenesis in mouse skin. Oncology. 53:382–385. 1996.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Shan H, Qinglin Z, Fengjun X, Yuxin L,
Xiaochen C and Yuan H: Reversal of multidrug resistance of KBV200
cells by triterpenoids isolated from Poria cocos. Planta
Med. 78:428–433. 2012.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Lu C, Cai D and Ma J: Pachymic acid
sensitizes gastric cancer cells to radiation therapy by
upregulating bax through hypoxia. Am J Chin Med. 46:875–890.
2018.PubMed/NCBI View Article : Google Scholar
|
|
50
|
Chen Y, Lian P, Liu Y and Xu K: Pachymic
acid inhibits tumorigenesis in gallbladder carcinoma cells. Int J
Clin Exp Med. 8:17781–17788. 2015.PubMed/NCBI
|
|
51
|
Gao AH, Zhang L, Chen X, Chen Y, Xu ZZ,
Liu YN and Zhang H: Inhibition of ovarian cancer proliferation and
invasion by pachymic acid. Int J Clin Exp Pathol. 8:2235–2241.
2015.PubMed/NCBI
|
|
52
|
Ling H, Zhang Y, Ng KY and Chew EH:
Pachymic acid impairs breast cancer cell invasion by suppressing
nuclear factor-κB-dependent matrix metalloproteinase-9 expression.
Breast Cancer Res Treat. 126:609–620. 2011.PubMed/NCBI View Article : Google Scholar
|
|
53
|
Hong R, Shen MH, Xie XH and Ruan SM:
Inhibition of breast cancer metastasis via PITPNM3 by pachymic
acid. Asian Pac J Cancer Prev. 13:1877–1880. 2012.PubMed/NCBI View Article : Google Scholar
|
|
54
|
Cheng S, Eliaz I, Lin J, Thyagarajan-Sahu
A and Sliva D: Triterpenes from Poria cocos suppress growth
and invasiveness of pancreatic cancer cells through the
downregulation of MMP-7. Int J Oncol. 42:1869–1874. 2013.PubMed/NCBI View Article : Google Scholar
|
|
55
|
Medzhitov R: Origin and physiological
roles of inflammation. Nature. 454:428–435. 2008.PubMed/NCBI View Article : Google Scholar
|
|
56
|
Cuéllar MJ, Giner RM, Recio MC, Just MJ,
Máñez S and Ríos JL: Two fungal lanostane derivatives as
phospholipase A2 inhibitors. J Nat Prod. 59:977–979.
1996.PubMed/NCBI View Article : Google Scholar
|
|
57
|
Prieto JM, Recio MC, Giner RM, Máñez S,
Giner-Larza EM and Ríos JL: Influence of traditional Chinese
anti-inflammatory medicinal plants on leukocyte and platelet
functions. J Pharm Pharmacol. 55:1275–1282. 2003.PubMed/NCBI View Article : Google Scholar
|
|
58
|
Li FF, Yuan Y, Liu Y, Wu QQ, Jiao R, Yang
Z, Zhou MQ and Tang QZ: Pachymic acid protects H9c2 cardiomyocytes
from lipopolysaccharide-induced inflammation and apoptosis by
inhibiting the extracellular signal-regulated kinase 1/2 and p38
pathways. Mol Med Rep. 12:2807–2813. 2015.PubMed/NCBI View Article : Google Scholar
|
|
59
|
Cuélla MJ, Giner RM, Recio MC, Just MJ,
Mañez S and Rios JL: Effect of the basidiomycete Poria cocos
on experimental dermatitis and other inflammatory conditions. Chem
Pharm Bull (Tokyo). 45:492–494. 1997.PubMed/NCBI View Article : Google Scholar
|
|
60
|
Yasukawa K, Kaminaga T, Kitanaka S, Tai T,
Nunoura Y, Natori S and Takido M:
3beta-p-Hydroxybenzoyldehydrotumulosic acid from Poria
cocos, and its anti-inflammatory effect. Phytochemistry.
48:1357–1360. 1998.PubMed/NCBI View Article : Google Scholar
|
|
61
|
Giner EM, Máñez S, Recio MC, Giner RM,
Cerdá-Nicolás M and Ríos JL: In vivo studies on the
anti-inflammatory activity of pachymic and dehydrotumulosic acids.
Planta Med. 66:221–227. 2000.PubMed/NCBI View Article : Google Scholar
|
|
62
|
Feng Z, Shi H, Liang B, Ge T, Cai M, Liu
F, Huang K, Wen J, Chen Q and Ge B: Bioinformatics and experimental
findings reveal the therapeutic actions and targets of pachymic
acid against cystitis glandularis. Biofactors. 47:665–673.
2021.PubMed/NCBI View Article : Google Scholar
|
|
63
|
Li JY, Wu HX and Yang G: Pachymic acid
improves survival and attenuates acute lung injury in septic rats
induced by cecal ligation and puncture. Eur Rev Med Pharmacol Sci.
21:1904–1910. 2017.PubMed/NCBI
|
|
64
|
Gui Y, Sun L, Liu R and Luo J: Pachymic
acid inhibits inflammation and cell apoptosis in lipopolysaccharide
(LPS)-induced rat model with pneumonia by regulating NF-κB and MAPK
pathways. Allergol Immunopathol (Madr). 49:87–93. 2021.PubMed/NCBI View Article : Google Scholar
|
|
65
|
Cai ZY, Sheng ZX and Yao H: Pachymic acid
ameliorates sepsis-induced acute kidney injury by suppressing
inflammation and activating the Nrf2/HO-1 pathway in rats. Eur Rev
Med Pharmacol Sci. 21:1924–1931. 2017.PubMed/NCBI
|
|
66
|
Younis NN, Mohamed HE, Shaheen MA,
Abdelghafour AM and Hammad SK: Potential therapeutic efficacy of
pachymic acid in chronic kidney disease induced in rats: Role of
Wnt/β-catenin/renin-angiotensin axis. J Pharm Pharmacol.
74:112–123. 2022.PubMed/NCBI View Article : Google Scholar
|
|
67
|
Huang YC, Chang WL, Huang SF, Lin CY, Lin
HC and Chang TC: Pachymic acid stimulates glucose uptake through
enhanced GLUT4 expression and translocation. Eur J Pharmacol.
648:39–49. 2010.PubMed/NCBI View Article : Google Scholar
|
|
68
|
Chen B, Zhang J, Han J, Zhao R, Bao L,
Huang Y and Liu H: Lanostane triterpenoids with
glucose-uptake-stimulatory activity from peels of the cultivated
edible mushroom Wolfi Poria cocos. J Agric Food Chem.
67:7348–7364. 2019.PubMed/NCBI View Article : Google Scholar
|
|
69
|
Li TH, Hou CC, Chang CL and Yang WC:
Anti-Hyperglycemic properties of crude extract and triterpenes from
Poria cocos. Evid. Based Complement. Alternat Med.
2011(128402)2011.PubMed/NCBI View Article : Google Scholar
|
|
70
|
Yang Z, Du R, Chang A, Zhang J and Li Q:
The in vitro anti-biofilm activity of the etoac extract of Poria
cocos against Escherichia coli. Asian J Pharma Res Deve.
1:152–156. 2013.
|
|
71
|
Singh A and Zhao K: Treatment of insomnia
with traditional Chinese herbal medicine. Int Rev Neurobiol.
135:97–115. 2017.PubMed/NCBI View Article : Google Scholar
|
|
72
|
Shah VK, Na SS, Chong MS, Woo JH, Kwon YO,
Lee MK and Oh KW: Poria cocos ethanol extract and its active
constituent, pachymic acid, modulate sleep architectures via
activation of GABAA-ergic transmission in rats. J Biomed Res.
16:84–92. 2015.
|
|
73
|
Wu MY, Yiang GT, Liao WT, Tsai AP, Cheng
YL, Cheng PW, Li CY and Li CJ: Current mechanistic concepts in
ischemia and reperfusion injury. Cell Physiol Biochem.
46:1650–1667. 2018.PubMed/NCBI View Article : Google Scholar
|
|
74
|
Jiang GP, Liao YJ, Huang LL, Zeng XJ and
Liao XH: Effects and molecular mechanism of pachymic acid on
ferroptosis in renal ischemia reperfusion injury. Mol Med Rep.
23(63)2021.PubMed/NCBI View Article : Google Scholar
|
|
75
|
Lee JH, Lee YJ, Shin JK, Nam JW, Nah SY,
Kim SH, Jeong JH, Kim Y, Shin M, Hong M, et al: Effects of
triterpenoids from Poria cocos Wolf on the serotonin type 3A
receptor-mediated ion current in Xenopus oocytes. Eur J
Pharmacol. 615:27–32. 2009.PubMed/NCBI View Article : Google Scholar
|
|
76
|
Eom S, Kim YS, Lee SB, Noh S, Yeom HD, Bae
H and Lee JH: Molecular determinants of α3β4 nicotinic
acetylcholine receptors inhibition by triterpenoids. Biol Pharm
Bull. 41:65–72. 2018.PubMed/NCBI View Article : Google Scholar
|
|
77
|
Zhang F, Zhang XF, Wang BC, Liu HY, Li CY,
Liu ZH, Zhang GW, Lü H, Chi C and Wang F: Pachymic acid, a novel
compound for anti-rejection: Effect in rats following cardiac
allograft transplantation. Chin Med J (Engl). 122:2898–2902.
2009.PubMed/NCBI
|
|
78
|
Lee SG and Kim MM: Pachymic acid promotes
induction of autophagy related to IGF-1 signaling pathway in WI-38
cells. Phytomedicine. 36:82–87. 2017.PubMed/NCBI View Article : Google Scholar
|
|
79
|
Arun S, Sampath V, Mahalaxmi S and
Rajkumar K: A comparative evaluation of the effect of the addition
of pachymic acid on the cytotoxicity of 4 different root canal
sealers-an in vitro study. J Endod. 43:96–99. 2017.PubMed/NCBI View Article : Google Scholar
|
|
80
|
Kamalakannan Preethi O, Sampath V,
Ravikumar N and Mahalaxmi S: Comparative evaluation of
physicochemical properties and apical sealing ability of a resin
sealer modified with Pachymic Acid. Eur Endod J. 5:23–27.
2020.PubMed/NCBI View Article : Google Scholar
|
|
81
|
Matsubara Y, Matsumoto T, Koseki J, Kaneko
A, Aiba S and Yamasaki K: Inhibition of human kallikrein 5 protease
by triterpenoids from natural sources. Molecules.
22(1829)2017.PubMed/NCBI View Article : Google Scholar
|
|
82
|
Kim JH, Sim HA, Jung DY, Lim EY, Kim YT,
Kim BJ and Jung MH: Poria cocus Wolf extract ameliorates
hepatic steatosis through regulation of lipid metabolism,
inhibition of ER stress, and activation of autophagy via AMPK
activation. Int J Mol Sci. 20(4801)2019.PubMed/NCBI View Article : Google Scholar
|
|
83
|
Fu XP, Xu L, Fu BB, Wei KN, Liu Y, Liao
BQ, He SW, Wang YL, Chen MH, Lin YH, et al: Pachymic acid protects
oocyte by improving the ovarian microenvironment in polycystic
ovary syndrome mice. Biol Reprod. 103:1085–1098. 2020.PubMed/NCBI View Article : Google Scholar
|
|
84
|
He Y, Zhong JH, Wei XD, Huang CY, Peng PL,
Yao J, Song XS, Fan WL and Li GC: Pachymic acid ameliorates
pulmonary hypertension by regulating Nrf2-Keap1-ARE pathway. Curr
Med Sci. 42:56–67. 2022.PubMed/NCBI View Article : Google Scholar
|
|
85
|
Li W, Wang C, Zhang M, Yuan Y, Zhang Z,
Liu X, Zhang F and Wu Y: Pachymic acid protects against kidney
injury in mice with diabetic nephropathy by inhibiting the PI3K/AKT
pathway. Trop J Pharm Res. 20:2539–2544. 2021.
|
|
86
|
Younis NN, Salama A, Shaheen MA and Eissa
RG: Pachymic acid attenuated doxorubicin-induced heart failure by
suppressing miR-24 and preserving cardiac junctophilin-2 in rats.
Int J Mol Sci. 22(10710)2021.PubMed/NCBI View Article : Google Scholar
|
|
87
|
Ling Y, Chen M, Wang K, Sun Z, Li Z, Wu B
and Huang C: Systematic screening and characterization of the major
bioactive components of Poria cocos and their metabolites in
rats by LC-ESI-MS(n). Biomed Chromatogr. 26:1109–1117.
2012.PubMed/NCBI View Article : Google Scholar
|
|
88
|
Zheng Y and Yang XW: Absorption and
transport of pachymic acid in the human intestinal cell line Caco-2
monolayers. Zhong Xi Yi Jie He Xue Bao. 6:704–710. 2008.PubMed/NCBI View Article : Google Scholar
|
|
89
|
Alatengqimuge Y, Yang XW, Zheng Y, Ma L
and Lu W: LC analysis and pharmacokinetic study of pachymic acid
after intravenous administration to rats. Chroma. 67:807–811.
2008.
|
|
90
|
Wang FY, Lv WS and Han L: Determination
and pharmacokinetic study of pachymic acid by LC-MS/MS. Biol Pharm
Bull. 38:1337–1344. 2015.PubMed/NCBI View Article : Google Scholar
|
|
91
|
Zhang J, Guo H, Yan F, Yuan S, Li S, Zhu
P, Chen W, Peng C and Peng D: An UPLC-Q-Orbitrap method for
pharmacokinetics and tissue distribution of four triterpenoids in
rats after oral administration of Poria cocos ethanol
extracts. J Pharm Biomed Anal. 203(114237)2021.PubMed/NCBI View Article : Google Scholar
|
|
92
|
Ding B, Ji X, Sun X, Zhang T and Mu S: In
vitro effect of pachymic acid on the activity of Cytochrome P450
enzymes. Xenobiotica. 50:913–918. 2020.PubMed/NCBI View Article : Google Scholar
|
|
93
|
Zhang J, Liu L, Li H and Zhang B:
Pharmacokinetic study on the interaction between pachymic acid and
bavachin and its potential mechanism. Pharm Biol. 59:1256–1259.
2021.PubMed/NCBI View Article : Google Scholar
|
|
94
|
Staton CA, Reed MW and Brown NJ: A
critical analysis of current in vitro and in vivo angiogenesis
assays. Int J Exp Path. 90:195–221. 2009.PubMed/NCBI View Article : Google Scholar
|
|
95
|
Saeidnia S, Manayi A and Abdollahi M: From
in vitro experiments to in vivo and clinical studies; pros and
cons. Curr Drug Discov Technol. 12:218–224. 2015.PubMed/NCBI View Article : Google Scholar
|
|
96
|
Wang P, She G, Yang Y, Li Q, Zhang H, Liu
J, Cao Y, Xu X and Lei H: Synthesis and biological evaluation of
new ligustrazine derivatives as anti-tumor agents. Molecules.
17:4972–4985. 2012.PubMed/NCBI View Article : Google Scholar
|
