Open Access

Resveratrol ameliorates oxaliplatin‑induced neuropathic pain via anti‑inflammatory effects in rats

  • Authors:
    • Zhi-Bin Dong
    • Yu-Jia Wang
    • Wen-Jun Wan
    • Ji Wu
    • Bo-Jun Wang
    • Hai-Li Zhu
    • Min Xie
    • Ling Liu
  • View Affiliations

  • Published online on: July 21, 2022     https://doi.org/10.3892/etm.2022.11523
  • Article Number: 586
  • Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Oxaliplatin (OXA) is a common chemotherapy drug and exhibits clinical activity in several cancer types. Its anticancer clinical effect is frequently accompanied by neurotoxicity. The symptoms include paresthesia and pain, which adversely affect the quality of life of patients. In the present study, five consecutive intraperitoneal injections of 4 mg/kg OXA were used to mimic chemotherapy in rats. OXA administration induced mechanical allodynia, activated spinal astrocytes and triggered the inflammatory response. To explore potential therapeutic options for OXA‑induced neuropathic pain, resveratrol (Res) was intrathecally injected into the spinal cord of OXA‑treated rats. Paw withdrawal threshold values of OXA‑treated rats were increased, indicating an antinociception effect of Res on OXA‑induced pain. Additionally, Res treatment reduced the levels of glial fibrillary acidic protein, TNF‑α, IL‑1β and NF‑κB, which were upregulated in OXA‑treated rats (compared with control). Furthermore, Auto Dock data showed that Res binds to cyclooxygenase‑2 (COX‑2) through six hydrogen bonds. Western blot analysis and reactive oxygen species (ROS) assays indicated that Res treatment decreased COX‑2 expression and suppressed ROS production. In summary, intrathecal injection of Res reduced the spinal COX‑2‑mediated ROS generation and inflammatory reaction, suppressed astrocytic activation, and alleviated OXA‑induced neuropathic pain.

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September-2022
Volume 24 Issue 3

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Spandidos Publications style
Dong Z, Wang Y, Wan W, Wu J, Wang B, Zhu H, Xie M and Liu L: Resveratrol ameliorates oxaliplatin‑induced neuropathic pain via anti‑inflammatory effects in rats. Exp Ther Med 24: 586, 2022
APA
Dong, Z., Wang, Y., Wan, W., Wu, J., Wang, B., Zhu, H. ... Liu, L. (2022). Resveratrol ameliorates oxaliplatin‑induced neuropathic pain via anti‑inflammatory effects in rats. Experimental and Therapeutic Medicine, 24, 586. https://doi.org/10.3892/etm.2022.11523
MLA
Dong, Z., Wang, Y., Wan, W., Wu, J., Wang, B., Zhu, H., Xie, M., Liu, L."Resveratrol ameliorates oxaliplatin‑induced neuropathic pain via anti‑inflammatory effects in rats". Experimental and Therapeutic Medicine 24.3 (2022): 586.
Chicago
Dong, Z., Wang, Y., Wan, W., Wu, J., Wang, B., Zhu, H., Xie, M., Liu, L."Resveratrol ameliorates oxaliplatin‑induced neuropathic pain via anti‑inflammatory effects in rats". Experimental and Therapeutic Medicine 24, no. 3 (2022): 586. https://doi.org/10.3892/etm.2022.11523