Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2022 Volume 24 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2022 Volume 24 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Resveratrol ameliorates oxaliplatin‑induced neuropathic pain via anti‑inflammatory effects in rats

  • Authors:
    • Zhi-Bin Dong
    • Yu-Jia Wang
    • Wen-Jun Wan
    • Ji Wu
    • Bo-Jun Wang
    • Hai-Li Zhu
    • Min Xie
    • Ling Liu
  • View Affiliations / Copyright

    Affiliations: School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China, Xishui Hospital Affiliated to Hubei Institute of Science and Technology, Huanggang, Hubei 438299, P.R. China, Department of Neurosurgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Zhuang Autonomous Region 531412, P.R. China, School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China
    Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 586
    |
    Published online on: July 21, 2022
       https://doi.org/10.3892/etm.2022.11523
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Oxaliplatin (OXA) is a common chemotherapy drug and exhibits clinical activity in several cancer types. Its anticancer clinical effect is frequently accompanied by neurotoxicity. The symptoms include paresthesia and pain, which adversely affect the quality of life of patients. In the present study, five consecutive intraperitoneal injections of 4 mg/kg OXA were used to mimic chemotherapy in rats. OXA administration induced mechanical allodynia, activated spinal astrocytes and triggered the inflammatory response. To explore potential therapeutic options for OXA‑induced neuropathic pain, resveratrol (Res) was intrathecally injected into the spinal cord of OXA‑treated rats. Paw withdrawal threshold values of OXA‑treated rats were increased, indicating an antinociception effect of Res on OXA‑induced pain. Additionally, Res treatment reduced the levels of glial fibrillary acidic protein, TNF‑α, IL‑1β and NF‑κB, which were upregulated in OXA‑treated rats (compared with control). Furthermore, Auto Dock data showed that Res binds to cyclooxygenase‑2 (COX‑2) through six hydrogen bonds. Western blot analysis and reactive oxygen species (ROS) assays indicated that Res treatment decreased COX‑2 expression and suppressed ROS production. In summary, intrathecal injection of Res reduced the spinal COX‑2‑mediated ROS generation and inflammatory reaction, suppressed astrocytic activation, and alleviated OXA‑induced neuropathic pain.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Yi Y, Li L, Song F, Li P, Chen M, Ni S, Zhang H, Zhou H, Zeng S and Jiang H: L-tetrahydropalmatine reduces oxaliplatin accumulation in the dorsal root ganglion and mitochondria through selectively inhibiting the transporter-mediated uptake thereby attenuates peripheral neurotoxicity. Toxicology. 459(152853)2021.PubMed/NCBI View Article : Google Scholar

2 

Kang L, Tian Y, Xu S and Chen H: Oxaliplatin-induced peripheral neuropathy: Clinical features, mechanisms, prevention and treatment. J Neurol. 268:3269–3282. 2021.PubMed/NCBI View Article : Google Scholar

3 

Takeshita E, Ishibashi K, Koda K, Oda N, Yoshimatsu K, Sato Y, Oya M, Yamaguchi S, Nakajima H, Momma T, et al: The updated five-year overall survival and long-term oxaliplatin-related neurotoxicity assessment of the FACOS study. Surg Today. 51:1309–1319. 2021.PubMed/NCBI View Article : Google Scholar

4 

Furgała-Wojas A, Kowalska M, Nowaczyk A, Fijałkowski Ł and Sałat K: Comparison of bromhexine and its active metabolite-ambroxol as potential analgesics reducing oxaliplatin-induced neuropathic pain-pharmacodynamic and molecular docking studies. Curr Drug Metab. 21:548–561. 2020.PubMed/NCBI View Article : Google Scholar

5 

Kong VKF and Irwin MG: Adjuvant analgesics in neuropathic pain. Eur J Anaesthesiol. 26:96–100. 2009.PubMed/NCBI View Article : Google Scholar

6 

Tuttle AH, Tohyama S, Ramsay T, Kimmelman J, Schweinhardt P, Bennett GJ and Mogil JS: Increasing placebo responses over time in U.S. clinical trials of neuropathic pain. Pain. 156:2616–2626. 2015.PubMed/NCBI View Article : Google Scholar

7 

Wang J, Zhang XS, Tao R, Zhang J, Liu L, Jiang YH, Ma SH, Song LX and Xia LJ: Upregulation of CX3CL1 mediated by NF-κB activation in dorsal root ganglion contributes to peripheral sensitization and chronic pain induced by oxaliplatin administration. Mol Pain. 13(1744806917726256)2017.PubMed/NCBI View Article : Google Scholar

8 

Shigematsu N, Kawashiri T, Kobayashi D, Shimizu S, Mine K, Hiromoto S, Uchida M, Egashira N and Shimazoe T: Neuroprotective effect of alogliptin on oxaliplatin-induced peripheral neuropathy in vivo and in vitro. Sci Rep. 10(6734)2020.PubMed/NCBI View Article : Google Scholar

9 

Zhang P, Li X, Hu D, Lai Q, Wang Y, Ma X, Xu Q, Li W, Huang J and He J: Peripheral neural interface. Adv Exp Med Biol. 1101:91–122. 2019.PubMed/NCBI View Article : Google Scholar

10 

Zhang X, Guan Z, Wang X, Sun D, Wang D, Li Y, Pei B, Ye M, Xu J and Yue X: Curcumin alleviates oxaliplatin-induced peripheral neuropathic pain through inhibiting oxidative stress-mediated activation of NF-κB and mitigating inflammation. Biol Pharm Bull. 43:348–355. 2020.PubMed/NCBI View Article : Google Scholar

11 

Menyhárt Á, Frank R, Farkas AE, Süle Z, Varga VÉ, Nyúl-Tóth Á, Meiller A, Ivánkovits-Kiss O, Lemale CL, Szabó Í, et al: Malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci. J Cereb Blood Flow Metab. 24(271678X211040056)2021.PubMed/NCBI View Article : Google Scholar

12 

Li D, Liu N, Zhao HH, Zhang X, Kawano H, Liu L, Zhao L and Li HP: Interactions between Sirt1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo. J Neuroinflammation. 14(67)2017.PubMed/NCBI View Article : Google Scholar

13 

Eto K, Kim SK, Takeda I and Nabekura J: The roles of cortical astrocytes in chronic pain and other brain pathologies. Neurosci Res. 126:3–8. 2018.PubMed/NCBI View Article : Google Scholar

14 

Shaito A, Posadino AM, Younes N, Hasan H, Halabi S, Alhababi D, Al-Mohannadi A, Abdel-Rahman WM, Eid AH, Nasrallah GK and Pintus G: Potential adverse effects of resveratrol: A literature review. Int J Mol Sci. 21(2084)2020.PubMed/NCBI View Article : Google Scholar

15 

Salehi B, Mishra AP, Nigam M, Sener B, Kilic M, Sharifi-Rad M, Fokou PVT, Martins N and Sharifi-Rad J: Resveratrol: A double-edged sword in health benefits. Biomedicines. 6(91)2018.PubMed/NCBI View Article : Google Scholar

16 

Wilson T, Knight TJ, Beitz DC, Lewis DS and Engen RL: Resveratrol promotes atherosclerosis in hypercholesterolemic rabbits. Life Sci. 59:PL15–PL21. 1996.PubMed/NCBI View Article : Google Scholar

17 

Xu D, Li Y, Zhang B, Wang Y, Liu Y, Luo Y, Niu W, Dong M, Liu M, Dong H, et al: Resveratrol alleviate hypoxic pulmonary hypertension via anti-inflammation and anti-oxidant pathways in rats. Int J Med Sci. 13:942–954. 2016.PubMed/NCBI View Article : Google Scholar

18 

Ma Y, Liu S, Shu H, Crawford J, Xing Y and Tao F: Resveratrol alleviates temporomandibular joint inflammatory pain by recovering disturbed gut microbiota. Brain Behav Immun. 87:455–464. 2020.PubMed/NCBI View Article : Google Scholar

19 

Tao L, Ding Q, Gao C and Sun X: Resveratrol attenuates neuropathic pain through balancing pro-inflammatory and anti-inflammatory cytokines release in mice. Int Immunopharmacol. 34:165–172. 2016.PubMed/NCBI View Article : Google Scholar

20 

Wang Y, Shi Y, Huang Y, Liu W, Cai G, Huang S, Zeng Y, Ren S, Zhan H and Wu W: Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model. J Neuroinflammation. 17(311)2020.PubMed/NCBI View Article : Google Scholar

21 

Hao M, Tang Q, Wang B, Li Y, Ding J, Li M, Xie M and Zhu H: Resveratrol suppresses bone cancer pain in rats by attenuating inflammatory responses through the AMPK/Drp1 signaling. Acta Biochim Biophys Sin (Shanghai). 52:231–240. 2020.PubMed/NCBI View Article : Google Scholar

22 

Ding H, Chen J, Su M, Lin Z, Zhan H, Yang F, Li W, Xie J, Huang Y, Liu X, et al: BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis. J Neuroinflammation. 17(19)2020.PubMed/NCBI View Article : Google Scholar

23 

Hylden JL and Wilcox GL: Intrathecal morphine in mice: A new technique. Eur J Pharmacol. 67:313–316. 1980.PubMed/NCBI View Article : Google Scholar

24 

Luo H, Liu L, Zhao JJ, Mi XF, Wang QJ and Yu M: Effects of oxaliplatin on inflammation and intestinal floras in rats with colorectal cancer. Eur Rev Med Pharmacol Sci. 24:10542–10549. 2020.PubMed/NCBI View Article : Google Scholar

25 

Song S, Guo R, Mehmood A, Zhang L, Yin B, Yuan C, Zhang H, Guo L and Li B: Liraglutide attenuate central nervous inflammation and demyelination through AMPK and pyroptosis-related NLRP3 pathway. CNS Neurosci Ther. 28:422–434. 2022.PubMed/NCBI View Article : Google Scholar

26 

Matsuda M, Huh Y and Ji RR: Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain. J Anesth. 33:131–139. 2019.PubMed/NCBI View Article : Google Scholar

27 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021.PubMed/NCBI View Article : Google Scholar

28 

Austin PJ, Wu A and Moalem-Taylor G: Chronic constriction of the sciatic nerve and pain hypersensitivity testing in rats. J Vis Exp. 13(3393)2012.PubMed/NCBI View Article : Google Scholar

29 

Forstenpointner J, Oberlojer VC, Naleschinski D, Höper J, Helfert SM, Binder A, Gierthmühlen J and Baron R: A-fibers mediate cold hyperalgesia in patients with oxaliplatin-induced neuropathy. Pain Pract. 18:758–767. 2018.PubMed/NCBI View Article : Google Scholar

30 

Lee JH and Kim W: The role of satellite glial cells, astrocytes and microglia in oxaliplatin-induced neuropathic pain. Biomedicines. 8(324)2020.PubMed/NCBI View Article : Google Scholar

31 

DiAntonio A: Axon degeneration: Mechanistic insights lead to therapeutic opportunities for the prevention and treatment of peripheral neuropathy. Pain. 160 (Suppl 1):S17–S22. 2019.PubMed/NCBI View Article : Google Scholar

32 

Lu Y, Lin Y, Huang X, Wu S, Wei J and Yang C: Oxaliplatin aggravates hepatic oxidative stress, inflammation and fibrosis in a non-alcoholic fatty liver disease mouse model. Int J Mol Med. 43:2398–2408. 2019.PubMed/NCBI View Article : Google Scholar

33 

Agnes JP, Santos VW, das Neves RN, Gonçalves RM, Delgobo M, Girardi CS, Lückemeyer DD, Ferreira MA, Macedo-Júnior SJ, Lopes SC, et al: Antioxidants improve oxaliplatin-induced peripheral neuropathy in tumor-bearing mice model: Role of spinal cord oxidative stress and inflammation. J Pain Aug. 22:996–1013. 2021.PubMed/NCBI View Article : Google Scholar

34 

Amić A, Marković Z, Marković JM, Jeremić S, Lučić B and Amić D: Free radical scavenging and COX-2 inhibition by simple colon metabolites of polyphenols: A theoretical approach. Comput Biol Chem. 65:45–53. 2016.PubMed/NCBI View Article : Google Scholar

35 

Hellenbrand DJ, Quinn CM, Piper ZJ, Morehouse CN, Fixel JA and Hanna AS: Inflammation after spinal cord injury: A review of the critical timeline of signaling cues and cellular infiltration. J Neuroinflammation. 18(284)2021.PubMed/NCBI View Article : Google Scholar

36 

Teixeira-Santos L, Albino-Teixeira A and Pinho D: Neuroinflammation, oxidative stress and their interplay in neuropathic pain: Focus on specialized pro-resolving mediators and NADPH oxidase inhibitors as potential therapeutic strategies. Pharmacol Res. 162(105280)2020.PubMed/NCBI View Article : Google Scholar

37 

Gebremedhn EG, Shortland PJ and Mahns DA: The incidence of acute oxaliplatin-induced neuropathy and its impact on treatment in the first cycle: A systematic review. BMC Cancer. 18(410)2018.PubMed/NCBI View Article : Google Scholar

38 

Carothers AM, Davids JS, Damas BC and Bertagnolli MM: Persistent cyclooxygenase-2 inhibition downregulates NF-{kappa}B, resulting in chronic intestinal inflammation in the min/+ mouse model of colon tumorigenesis. Cancer Res. 70:4433–4442. 2010.PubMed/NCBI View Article : Google Scholar

39 

Chen Z, Liu M, Liu X, Huang S, Li L, Song B, Li H, Ren Q, Hu Z, Zhou Y and Qiao L: COX-2 regulates E-cadherin expression through the NF-κB/Snail signaling pathway in gastric cancer. Int J Mol Med. 32:93–100. 2013.PubMed/NCBI View Article : Google Scholar

40 

Song Q, Feng YB, Wang L, Shen J, Li Y, Fan C, Wang P and Yu SY: COX-2 inhibition rescues depression-like behaviors via suppressing glial activation, oxidative stress and neuronal apoptosis in rats. Neuropharmacology. 160(107779)2019.PubMed/NCBI View Article : Google Scholar

41 

Meng T, Xiao D, Muhammed A, Deng J, Chen L and He J: Anti-inflammatory action and mechanisms of resveratrol. Molecules. 26(229)2021.PubMed/NCBI View Article : Google Scholar

42 

Shamsara J and Shahir-Sadr A: Developing a CoMSIA Model for Inhibition of COX-2 by resveratrol derivatives. Iran J Pharm Res. 15:459–469. 2016.PubMed/NCBI

43 

Ito J, Shirasuna K, Kuwayama T and Iwata H: Resveratrol treatment increases mitochondrial biogenesis and improves viability of porcine germinal-vesicle stage vitrified-warmed oocytes. Cryobiology. 93:37–43. 2020.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Dong Z, Wang Y, Wan W, Wu J, Wang B, Zhu H, Xie M and Liu L: Resveratrol ameliorates oxaliplatin‑induced neuropathic pain via anti‑inflammatory effects in rats. Exp Ther Med 24: 586, 2022.
APA
Dong, Z., Wang, Y., Wan, W., Wu, J., Wang, B., Zhu, H. ... Liu, L. (2022). Resveratrol ameliorates oxaliplatin‑induced neuropathic pain via anti‑inflammatory effects in rats. Experimental and Therapeutic Medicine, 24, 586. https://doi.org/10.3892/etm.2022.11523
MLA
Dong, Z., Wang, Y., Wan, W., Wu, J., Wang, B., Zhu, H., Xie, M., Liu, L."Resveratrol ameliorates oxaliplatin‑induced neuropathic pain via anti‑inflammatory effects in rats". Experimental and Therapeutic Medicine 24.3 (2022): 586.
Chicago
Dong, Z., Wang, Y., Wan, W., Wu, J., Wang, B., Zhu, H., Xie, M., Liu, L."Resveratrol ameliorates oxaliplatin‑induced neuropathic pain via anti‑inflammatory effects in rats". Experimental and Therapeutic Medicine 24, no. 3 (2022): 586. https://doi.org/10.3892/etm.2022.11523
Copy and paste a formatted citation
x
Spandidos Publications style
Dong Z, Wang Y, Wan W, Wu J, Wang B, Zhu H, Xie M and Liu L: Resveratrol ameliorates oxaliplatin‑induced neuropathic pain via anti‑inflammatory effects in rats. Exp Ther Med 24: 586, 2022.
APA
Dong, Z., Wang, Y., Wan, W., Wu, J., Wang, B., Zhu, H. ... Liu, L. (2022). Resveratrol ameliorates oxaliplatin‑induced neuropathic pain via anti‑inflammatory effects in rats. Experimental and Therapeutic Medicine, 24, 586. https://doi.org/10.3892/etm.2022.11523
MLA
Dong, Z., Wang, Y., Wan, W., Wu, J., Wang, B., Zhu, H., Xie, M., Liu, L."Resveratrol ameliorates oxaliplatin‑induced neuropathic pain via anti‑inflammatory effects in rats". Experimental and Therapeutic Medicine 24.3 (2022): 586.
Chicago
Dong, Z., Wang, Y., Wan, W., Wu, J., Wang, B., Zhu, H., Xie, M., Liu, L."Resveratrol ameliorates oxaliplatin‑induced neuropathic pain via anti‑inflammatory effects in rats". Experimental and Therapeutic Medicine 24, no. 3 (2022): 586. https://doi.org/10.3892/etm.2022.11523
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team