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Decreased low‑density lipoprotein and the presence of pulmonary arterial hypertension among newly diagnosed drug‑naïve patients with systemic lupus erythematosus: D‑dimer as a mediator

  • Authors:
    • Jing Huang
    • Qi An
    • Cai-Lian Zhang
    • Lan He
    • Lei Wang
  • View Affiliations / Copyright

    Affiliations: Department of Rheumatism and Immunology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Pulmonary and Critical Care Medicine, Yan'an University Affiliated Hospital, Yan'an, Shaanxi 716000, P.R. China, Department of Pulmonary and Critical Care Medicine, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 595
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    Published online on: July 27, 2022
       https://doi.org/10.3892/etm.2022.11531
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Abstract

Pulmonary arterial hypertension (PAH) is commonly associated with systemic lupus erythematosus (SLE). The present study investigated the relationship between coagulation and changes in lipid parameters in newly‑diagnosed patients with SLE in the presence of PAH and whether the coagulation parameters were mediators between lipids and PAH presence. A total of 301 subjects scheduled for new‑onset drug‑naïve SLE were consecutively enrolled. Baseline data for patients without PAH and with PAH were gathered and compared. Coagulation and lipid parameters were compared across patients without lipid regulating and anticoagulation medications. Multivariable logistic regression model was applied to examine potential predictors of PAH in SLE. The relationships between them were examined using Spearman's correlation analysis. The relationship between coagulation index and lipids with SLE‑PAH was evaluated using mediation analysis. Female patients accounted for 88.0% of the 301 subjects, and the average age was 32 years (range, 25‑45 years). A total of 40 patients (13.3%) had PAH, and the average pulmonary artery systolic pressure (sPAP) was 55.825±26.67 mmHg. Patients with PAH were older and had higher levels of fibrin/fibrinogen degradation products (FDP), D‑dimer, C‑reactive protein, lower levels of complement 3, complement 4 and 25‑hydroxy vitamin D3 compared with the non‑PAH group. Multivariable logistic regression analysis showed that age and D‑dimer were independent predictor factors for PAH. Among patients without lipid regulating and anticoagulation medications, patients in the PAH group had higher levels of D‑dimer and FDP, and lower low‑density lipoprotein (LDL) levels compared with patients without PAH. There was also a positive relationship between sPAP and D‑dimer and FDP, and a negative relationship between sPAP and total cholesterol and LDL. Mediation analysis indicated that 25.61% of the effect of low LDL on PAH presence in systemic lupus erythematosus was mediated by D‑dimer. Overall, the effect of low LDL on SLE‑PAH appeared to be mediated by D‑dimer, which mediated 25.61% of this effect.
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1 

Hoeper MM, Humbert M, Souza R, Idrees M, Kawut SM, Sliwa-Hahnle K, Jing ZC and Gibbs JS: A global view of pulmonary hypertension. Lancet Respir Med. 4:306–322. 2016.PubMed/NCBI View Article : Google Scholar

2 

Raza T and Dilawar M: Pulmonary hypertension: A comprehensive review. Heart Views. 8:90–99. 2007.

3 

McGoon MD and Miller DP: REVEAL: A contemporary US pulmonary arterial hypertension registry. Eur Respir Rev. 21:8–18. 2012.PubMed/NCBI View Article : Google Scholar

4 

Athanasiou KA, Sahni S, Rana A and Talwar A: Diagnosing and managing scleroderma-related pulmonary arterial hypertension. JAAPA. 30:11–18. 2017.PubMed/NCBI View Article : Google Scholar

5 

Shirai Y, Yasuoka H, Okano Y, Takeuchi T, Satoh T and Kuwana M: Clinical characteristics and survival of Japanese patients with connective tissue disease and pulmonary arterial hypertension: A single-centre cohort. Rheumatology (Oxford). 51:1846–1854. 2012.PubMed/NCBI View Article : Google Scholar

6 

Kang KY, Jeon CH, Choi SJ, Yoon BY, Choi CB, Lee CH, Suh CH, Lee CW, Cho CS, Nam EJ, et al: Survival and prognostic factors in patients with connective tissue disease-associated pulmonary hypertension diagnosed by echocardiography: Results from a Korean nationwide registry. Int J Rheum Dis. 20:1227–1236. 2017.PubMed/NCBI View Article : Google Scholar

7 

Jing ZC, Xu XQ, Han ZY, Wu Y, Deng KW, Wang H, Wang ZW, Cheng XS, Xu B, Hu SS, et al: Registry and survival study in Chinese patients with idiopathic and familial pulmonary arterial hypertension. Chest. 132:373–379. 2007.PubMed/NCBI View Article : Google Scholar

8 

Li M, Wang Q, Zhao J, Li Z, Ye Z, Li C, Li X, Zhu P, Wang Z, Zheng Y, et al: Chinese SLE treatment and research group (CSTAR) registry: II. Prevalence and risk factors of pulmonary arterial hypertension in Chinese patients with systemic lupus erythematosus. Lupus. 23:1085–1091. 2014.PubMed/NCBI View Article : Google Scholar

9 

Chen HA, Hsu TC, Yang SC, Weng CT, Wu CH, Sun CY and Lin CY: Incidence and survival impact of pulmonary arterial hypertension among patients with systemic lupus erythematosus: A nationwide cohort study. Arthritis Res Ther. 21(82)2019.PubMed/NCBI View Article : Google Scholar

10 

Jankov RP, Luo X, Cabacungan J, Belcastro R, Frndova H, Lye SJ and Tanswell AK: Endothelin-1 and O2-mediated pulmonary hypertension in neonatal rats: A role for products of lipid peroxidation. Pediatr Res. 48:289–298. 2000.PubMed/NCBI View Article : Google Scholar

11 

Kopeć G, Waligóra M, Tyrka A, Jonas K, Pencina MJ, Zdrojewski T, Moertl D, Stokwiszewski J, Zagożdżon P and Podolec P: Low-density lipoprotein cholesterol and survival in pulmonary arterial hypertension. Sci Rep. 7(41650)2017.PubMed/NCBI View Article : Google Scholar

12 

Al-Naamani N, Palevsky HI, Lederer DJ, Horn EM, Mathai SC, Roberts KE, Tracy RP, Hassoun PM, Girgis RE, Shimbo D, et al: Prognostic significance of biomarkers in pulmonary arterial hypertension. Ann Am Thorac Soc. 13:25–30. 2016.PubMed/NCBI View Article : Google Scholar

13 

Wang GF, Guan LH, Zhou DX, Chen DD, Zhang XC and Ge JB: Serum high-density lipoprotein cholesterol is significantly associated with the presence and severity of pulmonary arterial hypertension: A retrospective cross-sectional study. Adv Ther. 37:2199–2209. 2020.PubMed/NCBI View Article : Google Scholar

14 

Jonas K, Magoń W, Waligóra M, Seweryn M, Podolec P and Kopeć G: High-density lipoprotein cholesterol levels and pulmonary artery vasoreactivity in patients with idiopathic pulmonary arterial hypertension. Pol Arch Intern Med. 128:440–446. 2018.PubMed/NCBI View Article : Google Scholar

15 

Pašková U: Lipid profile and risks of cardiovascular diseases in conditions of rheumatoid arthritis. Ceska Slov Farm. 68:219–228. 2019.PubMed/NCBI

16 

Kato F, Tanabe N, Urushibara T, Kasai H, Takeuchi T, Sekine A, Suda R, Nishimura R, Jujo T, Sugiura T, et al: Association of plasma fibrinogen and plasminogen with prognosis of inoperable chronic thromboembolic pulmonary hypertension. Circ J. 78:1754–1761. 2014.PubMed/NCBI View Article : Google Scholar

17 

Shitrit D, Bendayan D, Rudensky B, Izbicki G, Huerta M, Fink G and Kramer MR: Elevation of ELISA D-dimer levels in patients with primary pulmonary hypertension. Respiration. 69:327–329. 2002.PubMed/NCBI View Article : Google Scholar

18 

Kiatchoosakun S, Ungkasekvinai W, Wonvipaporn C, Tatsanavivat P, Foocharoen C, Suwannaroj S and Nanagara R: D-dimer and pulmonary arterial hypertension in systemic sclerosis. J Med Assoc Thai. 90:2024–2029. 2007.PubMed/NCBI

19 

Tracy RP: Diet and hemostatic factors. Curr Atheroscler Rep. 1:243–248. 1999.PubMed/NCBI View Article : Google Scholar

20 

Hochberg MC: Updating the American college of rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 40(1725)1997.PubMed/NCBI View Article : Google Scholar

21 

Pyxaras SA, Pinamonti B, Barbati G, Santangelo S, Valentincic M, Cettolo F, Secoli G, Magnani S, Merlo M, Lo Giudice F, et al: Echocardiographic evaluation of systolic and mean pulmonary artery pressure in the follow-up of patients with pulmonary hypertension. Eur J Echocardiogr. 12:696–701. 2011.PubMed/NCBI View Article : Google Scholar

22 

Crouse WL, Keele GR, Gastonguay MS, Churchill GA and Valdar W: A bayesian model selection approach to mediation analysis. PLoS Genet. 18(e1010184)2022.PubMed/NCBI View Article : Google Scholar

23 

Baron RM and Kenny DA: The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 51:1173–1182. 1986.PubMed/NCBI View Article : Google Scholar

24 

Shrout PE and Bolger N: Mediation in experimental and nonexperimental studies: New procedures and recommendations. Psychol Methods. 7:422–445. 2002.PubMed/NCBI

25 

Guo X, Lai J, Wang H, Tian Z, Wang Q, Zhao J, Li M, Fang Q, Fang L, Liu Y and Zeng X: Predictive value of non-invasive right ventricle to pulmonary circulation coupling in systemic lupus erythematosus patients with pulmonary arterial hypertension. Eur Heart J Cardiovasc Imaging. 22:111–118. 2021.PubMed/NCBI View Article : Google Scholar

26 

Qu J, Li M, Wang Y, Duan X, Luo H, Zhao C, Zhan F, Wu Z, Li H, Yang M, et al: Predicting the risk of pulmonary arterial hypertension in systemic lupus erythematosus: A chinese systemic lupus erythematosus treatment and research group cohort study. Arthritis Rheumatol. 73:1847–1855. 2021.PubMed/NCBI View Article : Google Scholar

27 

Johnson SR, Gladman DD, Urowitz MB, Ibanez D and Granton JT: Pulmonary hypertension in systemic lupus. Lupus. 13:506–509. 2004.PubMed/NCBI View Article : Google Scholar

28 

Kiani R, Siddiqui MD and Tantoush H: Severe pulmonary hypertension as initial presentation of SLE: A case report and literature review. Case Rep Rheumatol. 2020(6014572)2020.PubMed/NCBI View Article : Google Scholar

29 

Lian F, Chen D, Wang Y, Ye Y, Wang X, Zhan Z, Xu H, Liang L and Yang X: Clinical features and independent predictors of pulmonary arterial hypertension in systemic lupus erythematosus. Rheumatol Int. 32:1727–1731. 2012.PubMed/NCBI View Article : Google Scholar

30 

Chung L, Liu J, Parsons L, Hassoun PM, McGoon M, Badesch DB, Miller DP, Nicolls MR and Zamanian RT: Characterization of connective tissue disease-associated pulmonary arterial hypertension from REVEAL: Identifying systemic sclerosis as a unique phenotype. Chest. 138:1383–1394. 2010.PubMed/NCBI View Article : Google Scholar

31 

Liu X, Zhou F, Yang Y, Wang W, Niu L, Zuo D, Li X, Hua H, Zhang B, Kou Y, et al: MiR-409-3p and MiR-1896 co-operatively participate in IL-17-induced inflammatory cytokine production in astrocytes and pathogenesis of EAE mice via targeting SOCS3/STAT3 signaling. Glia. 67:101–112. 2019.PubMed/NCBI View Article : Google Scholar

32 

Ferreira KS, Cicarini WB, Alves LCV, Loures CMG, Campos FMF, Santos LID, da Silva MVF, Guimarães TMD, Toledo VPCP, Reis EA, et al: Correlation between active disease and hypercoagulability state in patients with systemic lupus erythematosus. Clin Chim Acta. 490:107–112. 2019.PubMed/NCBI View Article : Google Scholar : (In French).

33 

Xu SZ, Liang Y, Li XP, Li XM, Shuai ZW, Leng RX, Pan HF and Ye DQ: Features associated with pulmonary arterial hypertension in Chinese hospitalized systemic lupus erythematosus patients. Clin Rheumatol. 37:1547–1553. 2018.PubMed/NCBI View Article : Google Scholar

34 

Wang Y, Yu H and He J: Role of dyslipidemia in accelerating inflammation, autoimmunity, and atherosclerosis in systemic lupus erythematosus and other autoimmune diseases. Discov Med. 30:49–56. 2020.PubMed/NCBI

35 

Robinson G, Pineda-Torra I, Ciurtin C and Jury EC: Lipid metabolism in autoimmune rheumatic disease: Implications for modern and conventional therapies. J Clin Invest. 132(e148552)2022.PubMed/NCBI View Article : Google Scholar

36 

Zhou B, Xia Y and She J: Dysregulated serum lipid profile and its correlation to disease activity in young female adults diagnosed with systemic lupus erythematosus: A cross-sectional study. Lipids Health Dis. 19(40)2020.PubMed/NCBI View Article : Google Scholar

37 

Heresi GA, Aytekin M, Newman J, DiDonato J and Dweik RA: Plasma levels of high-density lipoprotein cholesterol and outcomes in pulmonary arterial hypertension. Am J Respir Crit Care Med. 182:661–668. 2010.PubMed/NCBI View Article : Google Scholar

38 

Zhao QH, Peng FH, Wei H, He J, Chen FD, Di RM, Jiang X, Jiang R, Chen YJ, Heresi GA and Jing ZC: Serum high-density lipoprotein cholesterol levels as a prognostic indicator in patients with idiopathic pulmonary arterial hypertension. Am J Cardiol. 110:433–439. 2012.PubMed/NCBI View Article : Google Scholar

39 

Chen J, Rathinasabapathy A, Luo J, Yang X, Luo P, Chen Y, Li Z and Li J: Differential serum lipid distribution in IPAH and CHD-PAH patients. Respir Med. 191(106711)2021.PubMed/NCBI View Article : Google Scholar

40 

Choy E and Sattar N: Interpreting lipid levels in the context of high-grade inflammatory states with a focus on rheumatoid arthritis: A challenge to conventional cardiovascular risk actions. Ann Rheum Dis. 68:460–469. 2009.PubMed/NCBI View Article : Google Scholar

41 

Alexopoulos CG, Pournaras S, Vaslamatzis M, Avgerinos A and Raptis S: Changes in serum lipids and lipoproteins in cancer patients during chemotherapy. Cancer Chemother Pharmacol. 30:412–416. 1992.PubMed/NCBI View Article : Google Scholar

42 

Peev V, Nayer A and Contreras G: Dyslipidemia, malnutrition, inflammation, cardiovascular disease and mortality in chronic kidney disease. Curr Opin Lipidol. 25:54–60. 2014.PubMed/NCBI View Article : Google Scholar

43 

Gombos T, Förhécz Z, Pozsonyi Z, Jánoskuti L, Prohászka Z and Karádi I: Long-term survival and apolipoprotein A1 level in chronic heart failure: Interaction with tumor necrosis factor α-308 G/A polymorphism. J Card Fail. 23:113–120. 2017.PubMed/NCBI View Article : Google Scholar

44 

Liu Y, Coresh J, Eustace JA, Longenecker JC, Jaar B, Fink NE, Tracy RP, Powe NR and Klag MJ: Association between cholesterol level and mortality in dialysis patients: Role of inflammation and malnutrition. JAMA. 291:451–459. 2004.PubMed/NCBI View Article : Google Scholar

45 

Araújo JP, Friões F, Azevedo A, Lourenço P, Rocha-Gonçalves F, Ferreira A and Bettencourt P: Cholesterol-a marker of nutritional status in mild to moderate heart failure. Int J Cardiol. 129:65–68. 2008.PubMed/NCBI View Article : Google Scholar

46 

Møller S and Bernardi M: Interactions of the heart and the liver. Eur Heart J. 34:2804–2811. 2013.PubMed/NCBI View Article : Google Scholar

47 

Umar S, Ruffenach G, Moazeni S, Vaillancourt M, Hong J, Cunningham C, Cao N, Navab S, Sarji S, Li M, et al: Involvement of low-density lipoprotein receptor in the pathogenesis of pulmonary hypertension. J Am Heart Assoc. 9(e012063)2020.PubMed/NCBI View Article : Google Scholar

48 

Tehrani DM, Grinstein J, Kalantari S, Kim G, Sarswat N, Adatya S, Sayer G and Uriel N: Cardiac output assessment in patients supported with left ventricular assist device: Discordance between thermodilution and indirect fick cardiac output measurements. ASAIO J. 63:433–437. 2017.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Huang J, An Q, Zhang C, He L and Wang L: Decreased low‑density lipoprotein and the presence of pulmonary arterial hypertension among newly diagnosed drug‑naïve patients with systemic lupus erythematosus: D‑dimer as a mediator. Exp Ther Med 24: 595, 2022.
APA
Huang, J., An, Q., Zhang, C., He, L., & Wang, L. (2022). Decreased low‑density lipoprotein and the presence of pulmonary arterial hypertension among newly diagnosed drug‑naïve patients with systemic lupus erythematosus: D‑dimer as a mediator. Experimental and Therapeutic Medicine, 24, 595. https://doi.org/10.3892/etm.2022.11531
MLA
Huang, J., An, Q., Zhang, C., He, L., Wang, L."Decreased low‑density lipoprotein and the presence of pulmonary arterial hypertension among newly diagnosed drug‑naïve patients with systemic lupus erythematosus: D‑dimer as a mediator". Experimental and Therapeutic Medicine 24.3 (2022): 595.
Chicago
Huang, J., An, Q., Zhang, C., He, L., Wang, L."Decreased low‑density lipoprotein and the presence of pulmonary arterial hypertension among newly diagnosed drug‑naïve patients with systemic lupus erythematosus: D‑dimer as a mediator". Experimental and Therapeutic Medicine 24, no. 3 (2022): 595. https://doi.org/10.3892/etm.2022.11531
Copy and paste a formatted citation
x
Spandidos Publications style
Huang J, An Q, Zhang C, He L and Wang L: Decreased low‑density lipoprotein and the presence of pulmonary arterial hypertension among newly diagnosed drug‑naïve patients with systemic lupus erythematosus: D‑dimer as a mediator. Exp Ther Med 24: 595, 2022.
APA
Huang, J., An, Q., Zhang, C., He, L., & Wang, L. (2022). Decreased low‑density lipoprotein and the presence of pulmonary arterial hypertension among newly diagnosed drug‑naïve patients with systemic lupus erythematosus: D‑dimer as a mediator. Experimental and Therapeutic Medicine, 24, 595. https://doi.org/10.3892/etm.2022.11531
MLA
Huang, J., An, Q., Zhang, C., He, L., Wang, L."Decreased low‑density lipoprotein and the presence of pulmonary arterial hypertension among newly diagnosed drug‑naïve patients with systemic lupus erythematosus: D‑dimer as a mediator". Experimental and Therapeutic Medicine 24.3 (2022): 595.
Chicago
Huang, J., An, Q., Zhang, C., He, L., Wang, L."Decreased low‑density lipoprotein and the presence of pulmonary arterial hypertension among newly diagnosed drug‑naïve patients with systemic lupus erythematosus: D‑dimer as a mediator". Experimental and Therapeutic Medicine 24, no. 3 (2022): 595. https://doi.org/10.3892/etm.2022.11531
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