search button
Open Access

Decreased low‑density lipoprotein and the presence of pulmonary arterial hypertension among newly diagnosed drug‑naïve patients with systemic lupus erythematosus: D‑dimer as a mediator

  • Authors:
    • Jing Huang
    • Qi An
    • Cai-Lian Zhang
    • Lan He
    • Lei Wang

  • View Affiliations

  • Published online on: July 27, 2022     https://doi.org/10.3892/etm.2022.11531
  • Article Number: 595

  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Pulmonary arterial hypertension (PAH) is commonly associated with systemic lupus erythematosus (SLE). The present study investigated the relationship between coagulation and changes in lipid parameters in newly‑diagnosed patients with SLE in the presence of PAH and whether the coagulation parameters were mediators between lipids and PAH presence. A total of 301 subjects scheduled for new‑onset drug‑naïve SLE were consecutively enrolled. Baseline data for patients without PAH and with PAH were gathered and compared. Coagulation and lipid parameters were compared across patients without lipid regulating and anticoagulation medications. Multivariable logistic regression model was applied to examine potential predictors of PAH in SLE. The relationships between them were examined using Spearman's correlation analysis. The relationship between coagulation index and lipids with SLE‑PAH was evaluated using mediation analysis. Female patients accounted for 88.0% of the 301 subjects, and the average age was 32 years (range, 25‑45 years). A total of 40 patients (13.3%) had PAH, and the average pulmonary artery systolic pressure (sPAP) was 55.825±26.67 mmHg. Patients with PAH were older and had higher levels of fibrin/fibrinogen degradation products (FDP), D‑dimer, C‑reactive protein, lower levels of complement 3, complement 4 and 25‑hydroxy vitamin D3 compared with the non‑PAH group. Multivariable logistic regression analysis showed that age and D‑dimer were independent predictor factors for PAH. Among patients without lipid regulating and anticoagulation medications, patients in the PAH group had higher levels of D‑dimer and FDP, and lower low‑density lipoprotein (LDL) levels compared with patients without PAH. There was also a positive relationship between sPAP and D‑dimer and FDP, and a negative relationship between sPAP and total cholesterol and LDL. Mediation analysis indicated that 25.61% of the effect of low LDL on PAH presence in systemic lupus erythematosus was mediated by D‑dimer. Overall, the effect of low LDL on SLE‑PAH appeared to be mediated by D‑dimer, which mediated 25.61% of this effect.
View Figures
View References

Related Articles

Journal Cover

September-2022
Volume 24 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 2.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Huang J, An Q, Zhang C, He L and Wang L: Decreased low‑density lipoprotein and the presence of pulmonary arterial hypertension among newly diagnosed drug‑naïve patients with systemic lupus erythematosus: D‑dimer as a mediator. Exp Ther Med 24: 595, 2022
APA
Huang, J., An, Q., Zhang, C., He, L., & Wang, L. (2022). Decreased low‑density lipoprotein and the presence of pulmonary arterial hypertension among newly diagnosed drug‑naïve patients with systemic lupus erythematosus: D‑dimer as a mediator. Experimental and Therapeutic Medicine, 24, 595. https://doi.org/10.3892/etm.2022.11531
MLA
Huang, J., An, Q., Zhang, C., He, L., Wang, L."Decreased low‑density lipoprotein and the presence of pulmonary arterial hypertension among newly diagnosed drug‑naïve patients with systemic lupus erythematosus: D‑dimer as a mediator". Experimental and Therapeutic Medicine 24.3 (2022): 595.
Chicago
Huang, J., An, Q., Zhang, C., He, L., Wang, L."Decreased low‑density lipoprotein and the presence of pulmonary arterial hypertension among newly diagnosed drug‑naïve patients with systemic lupus erythematosus: D‑dimer as a mediator". Experimental and Therapeutic Medicine 24, no. 3 (2022): 595. https://doi.org/10.3892/etm.2022.11531