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Curcumin activates autophagy and attenuates high glucose‑induced apoptosis in HUVECs through the ROS/NF‑κB signaling pathway

  • Authors:
    • Qi-Hui Jin
    • Xu-Jun Hu
    • Hai-Yan Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Geriatric Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, College of Medical Technology, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China, Department of Internal Medicine, Shangcheng District Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang 310000, P.R. China
    Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 596
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    Published online on: July 28, 2022
       https://doi.org/10.3892/etm.2022.11533
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Abstract

Curcumin (CUR) is well known for its anti‑inflammatory and antioxidant effects. However, the endothelial protective effect of CUR in diabetes and the underlying signaling pathway remains unclear. The goal of the current study was to provide evidence regarding the protective mechanism of CUR against the high glucose (HG)‑induced damage to human umbilical vein endothelial cells (HUVECs). HG‑induced HUVECs injury model was used to evaluate the protective effect and the underlying mechanism of CUR against endothelial injury. The cell viability was determined by the MTT method. The cell reactive oxygen species (ROS) were determined by using flow cytometry. The protein expression levels of Bcl‑2, Bax, LC3‑II/I, Beclin‑1, p62, cleaved caspase‑3, IκBα and NF‑κB were measured by the western blotting. Results showed that CUR significantly decreased the cell apoptosis, the ROS generation and the inflammatory cytokine NF‑κB activity in the HG‑induced HUVECs versus the control, P<0.05. In addition, CUR significantly increased the expressions of LC3‑II/I, Beclin‑1, IκBα and Bax/Bcl‑2 in the HG‑induced HUVECs versus the control, P<0.05. Furthermore, the addition of autophagy inhibitor 3‑MA impaired the autophagy, exacerbated the apoptotic death and increased the ROS and NF‑κB levels in HUVECs under the high glucose condition, P<0.05. In brief, autophagy served a protective role in the HG‑induced apoptosis in HUVECs and CUR alleviated apoptosis by promoting autophagy and inhibiting the ROS/NF‑κB signaling pathway.
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1 

Zheng Y, Ley SH and Hu FB: Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 14:88–98. 2018.PubMed/NCBI View Article : Google Scholar

2 

Fowler MJ: Microvascular and macrovascular complications of diabetes. Clin Diabetes. 26:77–82. 2008.

3 

Popov D: Endothelial cell dysfunction in hyperglycemia: Phenotypic change, intracellular signaling modification, ultrastructural alteration, and potential clinical outcomes. Int J Diabetes Mellitus. 2:189–195. 2010.

4 

Giacco F and Brownlee M: Oxidative stress and diabetic complications. Circ Res. 107:1058–1070. 2010.PubMed/NCBI View Article : Google Scholar

5 

Zhang X, He N, Xing Y and Lu Y: Knockdown of GCN2 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells. Clin Exp Pharmacol Physiol. 47:591–598. 2020.PubMed/NCBI View Article : Google Scholar

6 

Wang J, Li G, Wang Z, Zhang X, Yao L, Wang F, Liu S, Yin J, Ling EA, Wang L and Hao A: High glucose-induced expression of inflammatory cytokines and reactive oxygen species in cultured astrocytes. Neuroscience. 202:58–68. 2012.PubMed/NCBI View Article : Google Scholar

7 

Liu T, Gong J, Chen Y and Jiang S: Periodic vs constant high glucose in inducing pro-inflammatory cytokine expression in human coronary artery endothelial cells. Inflamm Res. 62:697–701. 2013.PubMed/NCBI View Article : Google Scholar

8 

Sweet IR, Gilbert M, Maloney E, Hockenbery DM, Schwartz MW and Kim F: Endothelial inflammation induced by excess glucose is associated with cytosolic glucose 6-phosphate but not increased mitochondrial respiration. Diabetologia. 52:921–931. 2009.PubMed/NCBI View Article : Google Scholar

9 

Verma N and Manna SK: Advanced glycation end products (AGE) potently induce autophagy through activation of RAF protein kinase and nuclear factor κB (NF-κB). J Biol Chem. 291:1481–1491. 2016.PubMed/NCBI View Article : Google Scholar

10 

Xie Y, You SJ, Zhang YL, Han Q, Cao YJ, Xu XS, Yang YP, Li J and Liu CF: Protective role of autophagy in AGE-induced early injury of human vascular endothelial cells. Mol Med Rep. 4:459–464. 2011.PubMed/NCBI View Article : Google Scholar

11 

Ge D, Jing Q, Meng N, Su L, Zhang Y, Zhang S, Miao J and Zhao J: Regulation of apoptosis and autophagy by sphingosylphosphorylcholine in vascular endothelial cells. J Cell Physiol. 226:2827–2833. 2011.PubMed/NCBI View Article : Google Scholar

12 

Allen DA, Yaqoob MM and Harwood SM: Mechanisms of high glucose-induced apoptosis and its relationship to diabetic complications. J Nutr Biochem. 16:705–713. 2005.PubMed/NCBI View Article : Google Scholar

13 

Ao H, Li H, Zhao X, Liu B and Lu L: TXNIP positively regulates the autophagy and apoptosis in the rat müller cell of diabetic retinopathy. Life Sci. 267(118988)2021.PubMed/NCBI View Article : Google Scholar

14 

Li Q, Yin Y, Zheng Y, Chen F and Jin P: Inhibition of autophagy promoted high glucose/ROS-mediated apoptosis in ADSCs. Stem Cell Res Ther. 9(289)2018.PubMed/NCBI View Article : Google Scholar

15 

Liu H, Yu S, Zhang H and Xu J: Angiogenesis impairment in diabetes: Role of methylglyoxal-induced receptor for advanced glycation endproducts, autophagy and vascular endothelial growth factor receptor 2. PLoS One. 7(e46720)2012.PubMed/NCBI View Article : Google Scholar

16 

Tu Q, Li Y, Jin J, Jiang X, Ren Y and He Q: Curcumin alleviates diabetic nephropathy via inhibiting podocyte mesenchymal transdifferentiation and inducing autophagy in rats and MPC5 cells. Pharm Biol. 57:778–786. 2019.PubMed/NCBI View Article : Google Scholar

17 

Wang L, Xiong X, Zhang X, Ye Y, Jian Z, Gao W and Gu L: Sodium Tanshinone IIA sulfonate protects against cerebral ischemia-reperfusion injury by inhibiting autophagy and inflammation. Neuroscience. 441:46–57. 2020.PubMed/NCBI View Article : Google Scholar

18 

Kelany ME, Hakami TM and Omar AH: Curcumin improves the metabolic syndrome in high-fructose-diet-fed rats: Role of TNF-α, NF-κB, and oxidative stress. Can J Physiol Pharmacol. 95:140–150. 2017.PubMed/NCBI View Article : Google Scholar

19 

Zhang Z and Li K: Curcumin attenuates high glucose-induced inflammatory injury through the reactive oxygen species-phosphoinositide 3-kinase/protein kinase B-nuclear factor-κB signaling pathway in rat thoracic aorta endothelial cells. J Diabetes Investig. 9:731–740. 2018.PubMed/NCBI View Article : Google Scholar

20 

Huang J, Fu J, Liu B, Wang R and You T: A synthetic curcuminoid analog, (2E,6E)-2,6-bis(2-(trifluoromethyl)benzylidene)cyclohexanone, ameliorates impaired wound healing in streptozotocin-induced diabetic mice by increasing miR-146a. Molecules. 25(920)2020.PubMed/NCBI View Article : Google Scholar

21 

Shimizu K, Sunagawa Y, Funamoto M, Wakabayashi H, Genpei M, Miyazaki Y, Katanasaka Y, Sari N, Shimizu S, Katayama A, et al: The synthetic curcumin analogue GO-Y030 effectively suppresses the development of pressure overload-induced heart failure in mice. Sci Rep. 10(7172)2020.PubMed/NCBI View Article : Google Scholar

22 

Jin QH, Shen HX, Wang H, Shou QY and Liu Q: Curcumin improves expression of SCF/c-kit through attenuating oxidative stress and NF-κB activation in gastric tissues of diabetic gastroparesis rats. Diabetol Metab Syndr. 5(12)2013.PubMed/NCBI View Article : Google Scholar

23 

Han J, Pan XY, Xu Y, Xiao Y, An Y, Tie L, Pan Y and Li XJ: Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage. Autophagy. 8:812–825. 2012.PubMed/NCBI View Article : Google Scholar

24 

Yu W, Zha W, Ke Z, Min Q, Li C, Sun H and Liu C: Curcumin protects neonatal rat cardiomyocytes against high glucose-induced apoptosis via PI3K/Akt signaling pathway. J Diabetes Res. 2016(4158591)2016.PubMed/NCBI View Article : Google Scholar

25 

Tu Y, Guo C, Song F, Huo Y, Geng Y, Guo M, Bao H, Wu X and Fan W: Mild hypothermia alleviates diabetes aggravated cerebral ischemic injury via activating autophagy and inhibiting pyroptosis. Brain Res Bull. 150:1–12. 2019.PubMed/NCBI View Article : Google Scholar

26 

Wei Y, Gao J, Qin L, Xu Y, Shi H, Qu L, Liu Y, Xu T and Liu T: Curcumin suppresses AGEs induced apoptosis in tubular epithelial cells via protective autophagy. Exp Ther Med. 14:6052–6058. 2017.PubMed/NCBI View Article : Google Scholar

27 

Guo S, Long M, Li X, Zhu S, Zhang M and Yang Z: Curcumin activates autophagy and attenuates oxidative damage in EA.hy926 cells via the Akt/mTOR pathway. Mol Med Rep. 13:2187–2193. 2016.PubMed/NCBI View Article : Google Scholar

28 

Wang Y, Gao A, Xu X, Dang B, You W, Li H, Yu Z and Chen G: The neuroprotection of lysosomotropic agents in experimental subarachnoid hemorrhage probably involving the apoptosis pathway triggering by cathepsins via chelating intralysosomal iron. Mol Neurobiol. 52:64–77. 2015.PubMed/NCBI View Article : Google Scholar

29 

Yan H, Ma Y, Li Y, Zheng X, Lv P, Zhang Y, Li J, Ma M, Zhang L, Li C, et al: Insulin inhibits inflammation and promotes atherosclerotic plaque stability via PI3K-Akt pathway activation. Immunol Lett. 170:7–14. 2016.PubMed/NCBI View Article : Google Scholar

30 

Arshad L, Haque MA, Abbas Bukhari SN and Jantan I: An overview of structure-activity relationship studies of curcumin analogs as antioxidant and anti-inflammatory agents. Future Med Chem. 9:605–626. 2017.PubMed/NCBI View Article : Google Scholar

31 

Parsamanesh N, Moossavi M, Bahrami A, Butler AF and Sahebkar A: Therapeutic potential of Curcumin in diabetic complications. Pharmacol Res. 136:181–193. 2018.PubMed/NCBI View Article : Google Scholar

32 

Yao Q, Ke ZQ, Guo S, Yang XS, Zhang FX, Liu XF, Chen X, Chen HG, Ke HY and Liu C: Curcumin protects against diabetic cardiomyopathy by promoting autophagy and alleviating apoptosis. J Mol Cell Cardiol. 124:26–34. 2018.PubMed/NCBI View Article : Google Scholar

33 

Zhang X, Li ZL, Crane JA, Jordan KL, Pawar AS, Textor SC, Lerman A and Lerman LO: Valsartan regulates myocardial autophagy and mitochondrial turnover in experimental hypertension. Hypertension. 64:87–93. 2014.PubMed/NCBI View Article : Google Scholar

34 

Wu S, Lu Q, Ding Y, Wu Y, Qiu Y, Wang P, Mao X, Huang K, Xie Z and Zou MH: Hyperglycemia-driven inhibition of AMP-activated protein kinase α2 induces diabetic cardiomyopathy by promoting mitochondria-associated endoplasmic reticulum membranes in vivo. Circulation. 139:1913–1936. 2019.PubMed/NCBI View Article : Google Scholar

35 

Yu W, Gao B, Li N, Wang J, Qiu C, Zhang G, Liu M, Zhang R, Li C, Ji G and Zhang Y: Sirt3 deficiency exacerbates diabetic cardiac dysfunction: Role of Foxo3A-Parkin-mediated mitophagy. Biochim Biophys Acta Mol Basis Dis. 1863:1973–1983. 2017.PubMed/NCBI View Article : Google Scholar

36 

Ihnat MA, Thorpe JE, Kamat CD, Szabó C, Green DE, Warnke LA, Lacza Z, Cselenyák A, Ross K, Shakir S, et al: Reactive oxygen species mediate a cellular ‘memory’ of high glucose stress signalling. Diabetologia. 50:1523–1531. 2007.PubMed/NCBI View Article : Google Scholar

37 

Quagliaro L, Piconi L, Assaloni R, Martinelli L, Motz E and Ceriello A: Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: The role of protein kinase C and NAD(P)H-oxidase activation. Diabetes. 52:2795–2804. 2003.PubMed/NCBI View Article : Google Scholar

38 

Ortiz-Cordero C, Bincoletto C, Dhoke NR, Selvaraj S, Magli A, Zhou H, Kim DH, Bang AG and Perlingeiro RC: Defective autophagy and increased apoptosis contribute toward the pathogenesis of FKRP-associated muscular dystrophies. Stem Cell Reports. 16:2752–2767. 2021.PubMed/NCBI View Article : Google Scholar

39 

Xu J, Kitada M, Ogura Y, Liu H and Koya D: Dapagliflozin restores impaired autophagy and suppresses inflammation in high glucose-treated HK-2 cells. Cells. 10(1457)2021.PubMed/NCBI View Article : Google Scholar

40 

Zhang Z, Zhang S, Wang Y, Yang M, Zhang N, Jin Z, Ding L, Jiang W, Yang J, Sun Z, et al: Autophagy inhibits high glucose induced cardiac microvascular endothelial cells apoptosis by mTOR signal pathway. Apoptosis. 22:1510–1523. 2017.PubMed/NCBI View Article : Google Scholar

41 

Rezabakhsh A, Ahmadi M, Khaksar M, Montaseri A, Malekinejad H, Rahbarghazi R and Garjani A: Rapamycin inhibits oxidative/nitrosative stress and enhances angiogenesis in high glucose-treated human umbilical vein endothelial cells: Role of autophagy. Biomed Pharmacother. 93:885–894. 2017.PubMed/NCBI View Article : Google Scholar

42 

Hou G, Zhao H, Teng H, Li P, Xu W, Zhang J, Lv L, Guo Z, Wei L, Yao H and Xu Y: N-Cadherin attenuates high glucose-induced nucleus pulposus cell senescence through regulation of the ROS/NF-κB pathway. Cell Physio Biochem. 47:257–265. 2018.PubMed/NCBI View Article : Google Scholar

43 

Cao G, Fan J, Yu H and Chen Z: Resveratrol attenuates high glucose-induced cardiomyocytes injury via interfering ROS-MAPK-NF-κB signaling pathway. Int J Clin Exp Pathol. 11:48–57. 2018.PubMed/NCBI

44 

Teng JF, Mei QB, Zhou XG, Tang Y, Xiong R, Qiu WQ, Pan R, Law BY, Wong VK, Yu CL, et al: Polyphyllin VI induces Caspase-1-mediated pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer. Cancers (Basel). 12(193)2020.PubMed/NCBI View Article : Google Scholar

45 

Ma B, Wang X, Zhang R, Niu S, Rong Z, Ni L, Di X, Han Q and Liu C: Cigarette smoke extract stimulates PCSK9 production in HepG2 cells via ROS/NF-κB signaling. Mol Med Rep. 23(331)2021.PubMed/NCBI View Article : Google Scholar

46 

Morgan MJ and Liu Z: Crosstalk of reactive oxygen species and NF-κB signaling. Cell Res. 21:103–115. 2010.PubMed/NCBI View Article : Google Scholar

47 

Xu X, Huang X, Zhang L, Huang X, Qin Z and Hua F: Adiponectin protects obesity-related glomerulopathy by inhibiting ROS/NF-κB/NLRP3 inflammation pathway. BMC Nephrol. 22(218)2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Jin Q, Hu X and Zhao H: Curcumin activates autophagy and attenuates high glucose‑induced apoptosis in HUVECs through the ROS/NF‑κB signaling pathway. Exp Ther Med 24: 596, 2022.
APA
Jin, Q., Hu, X., & Zhao, H. (2022). Curcumin activates autophagy and attenuates high glucose‑induced apoptosis in HUVECs through the ROS/NF‑κB signaling pathway. Experimental and Therapeutic Medicine, 24, 596. https://doi.org/10.3892/etm.2022.11533
MLA
Jin, Q., Hu, X., Zhao, H."Curcumin activates autophagy and attenuates high glucose‑induced apoptosis in HUVECs through the ROS/NF‑κB signaling pathway". Experimental and Therapeutic Medicine 24.3 (2022): 596.
Chicago
Jin, Q., Hu, X., Zhao, H."Curcumin activates autophagy and attenuates high glucose‑induced apoptosis in HUVECs through the ROS/NF‑κB signaling pathway". Experimental and Therapeutic Medicine 24, no. 3 (2022): 596. https://doi.org/10.3892/etm.2022.11533
Copy and paste a formatted citation
x
Spandidos Publications style
Jin Q, Hu X and Zhao H: Curcumin activates autophagy and attenuates high glucose‑induced apoptosis in HUVECs through the ROS/NF‑κB signaling pathway. Exp Ther Med 24: 596, 2022.
APA
Jin, Q., Hu, X., & Zhao, H. (2022). Curcumin activates autophagy and attenuates high glucose‑induced apoptosis in HUVECs through the ROS/NF‑κB signaling pathway. Experimental and Therapeutic Medicine, 24, 596. https://doi.org/10.3892/etm.2022.11533
MLA
Jin, Q., Hu, X., Zhao, H."Curcumin activates autophagy and attenuates high glucose‑induced apoptosis in HUVECs through the ROS/NF‑κB signaling pathway". Experimental and Therapeutic Medicine 24.3 (2022): 596.
Chicago
Jin, Q., Hu, X., Zhao, H."Curcumin activates autophagy and attenuates high glucose‑induced apoptosis in HUVECs through the ROS/NF‑κB signaling pathway". Experimental and Therapeutic Medicine 24, no. 3 (2022): 596. https://doi.org/10.3892/etm.2022.11533
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