A retrospective study on the relationship between fibrosis‑4 index and all‑cause mortality in patients with acute myocardial infarction

The fibrosis‑4 (FIB‑4) index is a non‑invasive score used to determine liver fibrosis. The present study aimed to assess the predictive ability of FIB‑4 for all‑cause mortality in patients with acute myocardial infarction (AMI). It retrospectively analyzed a total of 797 patients who were diagnosed with AMI. The patients were equally divided into three tertiles based on the values of the FIB‑4 index scores: Group A (FIB‑4 index <3.19; n=265), group B (3.19 ≤FIB‑4 <8.14; n=267) and group C (FIB‑4 index ≥8.14 group; n=265). Kaplan‑Meier curves were used to analyze the incidence of all‑cause mortality among the three groups. Multivariate Cox regression analysis was used to assess the association of risk of all‑cause mortality in the patients. The Kaplan‑Meier curves showed that the incidence of all‑cause mortality was statistically significantly higher in group C than in groups A and B (P<0.001). After adjusting for confounding factors, multivariate Cox analysis demonstrated the risk of all‑cause mortality in group C was significantly higher than in group A (hazard ratio: 2.898, 95% confidence interval: 1.069‑7.857, P=0.037). In receiver‑operating characteristics (ROC) analysis, an FIB‑4 index of 6.647 and a Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) score of 26.75 had sensitivities of 67.3 and 55.8% and specificities of 63 and 71.9%, respectively. Comparing the area under the ROC curve revealed no statistical differences between the FIB‑4 index and SYNTAX score (0.654 vs. 0.661; P=0.864). Higher FIB‑4 index were associated with increased risks of all‑cause mortality among AMI patients. The FIB‑4 index, a noninvasive and convenient tool, plays a potential role in the prognosis of AMI.