Open Access

Properties of flavonoids in the treatment of bladder cancer (Review)

  • Authors:
    • Yue Lv
    • Zhonghao Liu
    • Haixing Jia
    • Youcheng Xiu
    • Zan Liu
    • Leihong Deng
  • View Affiliations

  • Published online on: September 19, 2022     https://doi.org/10.3892/etm.2022.11612
  • Article Number: 676
  • Copyright: © Lv et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Given its high recurrence and rapid progress, bladder cancer (BLCA) treatment has become a major problem for clinicians. BLCA is difficult to control even with surgical resection and extensive use of chemotherapeutic drugs. The non‑toxicity and ease of accessibility of natural compounds have attracted much attention in recent years. Flavonoids serve an essential role given their antioxidant, antibacterial, anticancer and cardiovascular properties. They are mainly divided into several subclasses; flavones, flavanones, flavonols, flavanols, anthocyanins isoflavones and chalcones. Over the years, the role of flavonoids in BLCA has been extensively studied. The present review provided a comprehensive overview of the classification of flavonoids and substantiate the role of epithelial‑mesenchymal transition, cancer stem cells, angiogenesis, epigenetic regulation and programmed cell death in BLCA. The present review emphasized that flavonoids for BLCA treatment are worthy of further study and anti‑BLCA drugs have huge prospects for clinical use.
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November-2022
Volume 24 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Lv Y, Liu Z, Jia H, Xiu Y, Liu Z and Deng L: Properties of flavonoids in the treatment of bladder cancer (Review). Exp Ther Med 24: 676, 2022
APA
Lv, Y., Liu, Z., Jia, H., Xiu, Y., Liu, Z., & Deng, L. (2022). Properties of flavonoids in the treatment of bladder cancer (Review). Experimental and Therapeutic Medicine, 24, 676. https://doi.org/10.3892/etm.2022.11612
MLA
Lv, Y., Liu, Z., Jia, H., Xiu, Y., Liu, Z., Deng, L."Properties of flavonoids in the treatment of bladder cancer (Review)". Experimental and Therapeutic Medicine 24.5 (2022): 676.
Chicago
Lv, Y., Liu, Z., Jia, H., Xiu, Y., Liu, Z., Deng, L."Properties of flavonoids in the treatment of bladder cancer (Review)". Experimental and Therapeutic Medicine 24, no. 5 (2022): 676. https://doi.org/10.3892/etm.2022.11612