Open Access

Evaluating the concept of gas‑based intraperitoneal hyperthermia beyond 43˚C in the treatment of peritoneal metastasis: A pilot study

  • Authors:
    • Simon Thelen
    • Agata Mikolajczyk‑Martinez
    • Agata Diakun
    • Tanja Khosrawipour
    • Kacper Zielinski
    • Jakub Nicpoń
    • Zdzisław Kiełbowicz
    • Przemysław Prządka
    • Bartłomiej Liszka
    • Piotr Kuropka
    • Shiri Li
    • Hien Lau
    • Wojciech Kielan
    • Veria Khosrawipour
  • View Affiliations

  • Published online on: November 8, 2022     https://doi.org/10.3892/etm.2022.11687
  • Article Number: 752
  • Copyright: © Thelen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

While hyperthermic intraperitoneal applications have demonstrated high efficacy in treating peritoneal metastases (PM), these applications are limited to temperatures of 41‑43˚C to prevent a harmful increase in core temperature. However, since gaseous substances display low specific heat capacities, gas‑based hyperthermia could potentially increase surface temperatures without affecting the body's core temperature. To the best of our knowledge, the present study is the first to explore the in vivo feasibility of gas‑based hyperthermia via spatial and time‑based distribution. In the present study, a temperature‑isolated, abdominal box model was created with fresh peritoneal tissue exposed to continuous high‑volume airflow temperatures ranging between 47 and 69˚C. Heat conduction within the peritoneal tissues was measured using temperature microsensors. Temperature build‑up at different time points during the procedure was calculated and the safest option to perform gas‑based intraperitoneal hyperthermia beyond 43˚C was identified using an in vivo swine model. In subsequent experiments, viability and cytotoxicity of HT‑29 colon cancer cells were measured following short‑term hyperthermia. The present study demonstrated that the application of gas‑based intraperitoneal hyperthermia with temperatures up to 50˚C is possible without increasing the core temperature to harmful levels. Gas‑based intraperitoneal hyperthermia can induce a histological reaction on the peritoneal surface, and it can also result in decreased viability and increased cytotoxicity of HT‑29 cells. The concept of extreme hyperthermia may be of great clinical importance as it could significantly increase local cytotoxicity in PM without increasing the body's core temperature. Further studies are required to investigate the benefits, as well as the restrictions, of this novel concept.

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December-2022
Volume 24 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Thelen S, Mikolajczyk‑Martinez A, Diakun A, Khosrawipour T, Zielinski K, Nicpoń J, Kiełbowicz Z, Prządka P, Liszka B, Kuropka P, Kuropka P, et al: Evaluating the concept of gas‑based intraperitoneal hyperthermia beyond 43˚C in the treatment of peritoneal metastasis: A pilot study. Exp Ther Med 24: 752, 2022
APA
Thelen, S., Mikolajczyk‑Martinez, A., Diakun, A., Khosrawipour, T., Zielinski, K., Nicpoń, J. ... Khosrawipour, V. (2022). Evaluating the concept of gas‑based intraperitoneal hyperthermia beyond 43˚C in the treatment of peritoneal metastasis: A pilot study. Experimental and Therapeutic Medicine, 24, 752. https://doi.org/10.3892/etm.2022.11687
MLA
Thelen, S., Mikolajczyk‑Martinez, A., Diakun, A., Khosrawipour, T., Zielinski, K., Nicpoń, J., Kiełbowicz, Z., Prządka, P., Liszka, B., Kuropka, P., Li, S., Lau, H., Kielan, W., Khosrawipour, V."Evaluating the concept of gas‑based intraperitoneal hyperthermia beyond 43˚C in the treatment of peritoneal metastasis: A pilot study". Experimental and Therapeutic Medicine 24.6 (2022): 752.
Chicago
Thelen, S., Mikolajczyk‑Martinez, A., Diakun, A., Khosrawipour, T., Zielinski, K., Nicpoń, J., Kiełbowicz, Z., Prządka, P., Liszka, B., Kuropka, P., Li, S., Lau, H., Kielan, W., Khosrawipour, V."Evaluating the concept of gas‑based intraperitoneal hyperthermia beyond 43˚C in the treatment of peritoneal metastasis: A pilot study". Experimental and Therapeutic Medicine 24, no. 6 (2022): 752. https://doi.org/10.3892/etm.2022.11687