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TRIM21‑a potential biomarker for the prognosis of thyroid cancer

  • Authors:
    • Zhen Wu
    • Yongkun Wang
    • Zhengya Yu
    • Zhen Meng
    • Wenchao Duan
    • Wei Zhang
    • Jugao Fang
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology Head and Neck Surgery and Department of Thyroid Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China, Department of Thyroid and Breast Surgery, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China, Department of Stomatology, Medical School of Liaocheng University, Liaocheng, Shandong 252000, P.R. China, Department of Otorhinolaryngology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 761
    |
    Published online on: November 9, 2022
       https://doi.org/10.3892/etm.2022.11697
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Abstract

Thyroid cancer (THCA) is one of the commonest malignancies associated with increased recurrence. Therefore, identifying the putative molecular markers and therapeutic targets to improve the treatment of THCA is essential. The present study analyzed the potential role of tripartite motif‑containing 21 (TRIM21), a member of the TRIM family belonging to the subfamily of E3 ubiquitin ligases, in the progression of THCA. Using bioinformatics analysis and immunohistochemistry of THCA tissues, it was observed that TRIM21 is overexpressed in THCA tissues. The present study also found that TRIM21 is associated with lymph node metastasis and high‑risk recurrence of THCA. Furthermore, it identified a promotional role of TRIM21 in THCA cell migration and invasion. In addition, the present study analyzed TRIM21‑enriched pathways and co‑expressed genes in THCA. The present study suggested that TRIM21 may serve as a potential biomarker for THCA prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Wu Z, Wang Y, Yu Z, Meng Z, Duan W, Zhang W and Fang J: TRIM21‑a potential biomarker for the prognosis of thyroid cancer. Exp Ther Med 24: 761, 2022.
APA
Wu, Z., Wang, Y., Yu, Z., Meng, Z., Duan, W., Zhang, W., & Fang, J. (2022). TRIM21‑a potential biomarker for the prognosis of thyroid cancer. Experimental and Therapeutic Medicine, 24, 761. https://doi.org/10.3892/etm.2022.11697
MLA
Wu, Z., Wang, Y., Yu, Z., Meng, Z., Duan, W., Zhang, W., Fang, J."TRIM21‑a potential biomarker for the prognosis of thyroid cancer". Experimental and Therapeutic Medicine 24.6 (2022): 761.
Chicago
Wu, Z., Wang, Y., Yu, Z., Meng, Z., Duan, W., Zhang, W., Fang, J."TRIM21‑a potential biomarker for the prognosis of thyroid cancer". Experimental and Therapeutic Medicine 24, no. 6 (2022): 761. https://doi.org/10.3892/etm.2022.11697
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Z, Wang Y, Yu Z, Meng Z, Duan W, Zhang W and Fang J: TRIM21‑a potential biomarker for the prognosis of thyroid cancer. Exp Ther Med 24: 761, 2022.
APA
Wu, Z., Wang, Y., Yu, Z., Meng, Z., Duan, W., Zhang, W., & Fang, J. (2022). TRIM21‑a potential biomarker for the prognosis of thyroid cancer. Experimental and Therapeutic Medicine, 24, 761. https://doi.org/10.3892/etm.2022.11697
MLA
Wu, Z., Wang, Y., Yu, Z., Meng, Z., Duan, W., Zhang, W., Fang, J."TRIM21‑a potential biomarker for the prognosis of thyroid cancer". Experimental and Therapeutic Medicine 24.6 (2022): 761.
Chicago
Wu, Z., Wang, Y., Yu, Z., Meng, Z., Duan, W., Zhang, W., Fang, J."TRIM21‑a potential biomarker for the prognosis of thyroid cancer". Experimental and Therapeutic Medicine 24, no. 6 (2022): 761. https://doi.org/10.3892/etm.2022.11697
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