Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-2023 Volume 25 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2023 Volume 25 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Protective effect of cerium oxide on testicular function and oxidative stress after torsion/detorsion in adult male rats

  • Authors:
    • Suleyman Yesil
    • Cagri Ozdemir
    • Mustafa Arslan
    • Ayse Cakir Gundogdu
    • Mustafa Kavutcu
    • Ali Atan
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Medical Faculty, Gazi University, 06510 Ankara, Turkey, Department of Anesthesiology and Reanimation, Medical Faculty, Gazi University, 06510 Ankara, Turkey, Department of Histology and Embryology, Medical Faculty, Kutahya Health Sciences University, 43050 Kutahya, Turkey, Department of Medical Biochemistry, Medical Faculty, Gazi University, 06510 Ankara, Turkey
    Copyright: © Yesil et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1
    |
    Published online on: November 15, 2022
       https://doi.org/10.3892/etm.2022.11700
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Testicular torsion (T)/detorsion (D) can cause testicular injury due to the rotation of the spermatic cord and its vessels, therefore it represents an urological emergency that is surgically treated. Oxidative damage occurs in the testis and distant organs because of the overproduction of free radicals and overexpression of proinflammatory cytokines by reperfusion after surgery. Cerium oxide (CeO2) nanoparticles, a material also known as nanoceria, have regenerative antioxidant properties on oxidative stress. The present study aimed to investigate the effects of nanoceria on testis tissues in testicular T/D in rats. A total of 24 rats were equally and randomly divided into four groups: Control, CeO2, T/D and CeO2‑T/D groups. Left inguinoscrotal incision was performed in the control group. In the CeO2 group, 0.5 mg/kg CeO2 was given intraperitoneally 30 min before inguinoscrotal incision. In the T/D group, unilateral testicular T/D was performed through an inguinoscrotal incision and rotating the left testis 720˚ clockwise, which was then left ischemic for 120 min, followed by 120 min of reperfusion. In the CeO2‑T/D group, 0.5 mg/kg CeO2 was given intraperitoneally 30 min before testicular T/D. At the end of the experiment, testis tissues were removed for histopathological and biochemical examinations. The samples were histologically examined, Glutathione‑s transferase (GST), catalase (CAT), paraoxonase (PON) activities and malondialdehyde (MDA) levels were measured via biochemical analysis methods, while the expression levels of p53, Bax and Bcl‑2 were detected using immunohistochemistry. The present results revealed statistically significant inter‑group differences in PON, CAT and GST activities and MDA levels. GST, CAT and PON activities were significantly higher, whereas MDA levels in the CeO2‑T/D group were significantly lower compared with those in the T/D group. The T/D group had increased Bax and decreased Bcl‑2 expression levels in their seminiferous tubules compared with the control and CeO2 groups. CeO2 treatment led to downregulation of Bax and upregulation of Bcl‑2. The expression of p53 was high in the T/D group compared with that in the control and CeO2 groups, and was upregulated in all germinal cells. However, compared with that in the T/D group, p53 expression was significantly decreased in the CeO2‑T/D group. The testicular injury score significantly increased in the CeO2‑T/D group compared with the control and CeO2 groups. Rats in the CeO2‑T/D group demonstrated significantly milder tissue lesions compared with those in T/D group. The present findings indicated that nanoceria may protect testis in rats against the harmful effects of T/D. Further studies are required to evaluate how CeO2 reduces oxidative stress and cell death in testis tissue that underwent T/D‑related injury.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Sharp VJ, Kieran K and Arlen AM: Testicular torsion: Diagnosis, evaluation, and management. American Family Physician. 88:835–840. 2013.PubMed/NCBI

2 

Selbst SM, Friedman MJ and Singh SB: Epidemiology and etiology of malpractice lawsuits involving children in US emergency departments and urgent care centers. Pediatr Emerg Care. 21:165–169. 2005.PubMed/NCBI

3 

Bo X, Wang P, Nie Y, Li R, Lu J and Wang H: Protective effect of hypothermia and vitamin E on spermatogenic function after reduction of testicular torsion in rats. Exp Ther Med. 20:796–801. 2020.PubMed/NCBI View Article : Google Scholar

4 

Ringdahl E and Teague L: Testicular torsion. Am Fam Physician. 74:1739–1743. 2006.PubMed/NCBI

5 

Pogorelić Z, Mustapić K, Jukić M, Todorić J, Mrklić I, Mešštrović J, Jurić I and Furlan D: Management of acute scrotum in children: A 25-year single center experience on 558 pediatric patients. Can J Urol. 23:8594–8601. 2016.PubMed/NCBI

6 

Celik E, Oguzturk H, Sahin N, Turtay MG, Oguz F and Ciftci O: Protective effects of hesperidin in experimental testicular ischemia/reperfusion injury in rats. Arch Med Sci. 12:928–934. 2016.PubMed/NCBI View Article : Google Scholar

7 

Minutoli L, Antonuccio P, Polito F, Bitto A, Fiumara T, Squadrito F, Nicotina PA, Arena S, Marini H, Romeo C and Altavilla D: Involvement of mitogen-activated protein kinases (MAPKs) during testicular ischemia-reperfusion injury in nuclear factor-kappaB knock-out mice. Life Sci. 81:413–242. 2007.PubMed/NCBI View Article : Google Scholar

8 

Akbas H, Ozden M, Kanko M, Maral H, Bulbul S, Yavuz S, Ozker E and Berki T: Protective antioxidant effects of carvedilol in a rat model of ischaemia-reperfusion injury. J Int Med Res. 33:528–536. 2005.PubMed/NCBI View Article : Google Scholar

9 

Unsal A, Eroglu M, Avci A, Cimentepe E, Guven C, Derya Balbay M and Durak I: Protective role of natural antioxidant supplementation on testicular tissue after testicular torsion and detorsion. Scand J Urol Nephrol. 40:17–22. 2006.PubMed/NCBI View Article : Google Scholar

10 

Chi KK, Zhang WH, Wang GC, Chen Z, He W, Wang SG, Cui Y, Lu P, Wang XJ and Chen H: Comparison of intraperitoneal and intraepididymal quercetin for the prevention of testicular torsion/detorsion-induced injury. Urology. 99:106–111. 2017.PubMed/NCBI View Article : Google Scholar

11 

Filho DW, Torres MA, Bordin AL, Crezcynski-Pasa TB and Boveris A: Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury. Mol Aspects Med. 25:199–210. 2004.PubMed/NCBI View Article : Google Scholar

12 

Nicoud IB, Knox CD, Jones CM, Anderson CD, Pierce JM, Belous AE, Earl TM and Chari RS: 2-APB protects against liver ischemia-reperfusion injury by reducing cellular and mitochondrial calcium uptake. Am J Physiol Gastrointest Liver Physiol. 293:G623–G30. 2007.PubMed/NCBI View Article : Google Scholar

13 

Vercesi AE, Castilho RF, Kowaltowski AJ, de Oliveira HCF, de Souza-Pinto NC, Figueira TR and Busanello ENB: Mitochondrial calcium transport and the redox nature of the calcium-induced membrane permeability transition. Free Radic Biol Med. 29:1–24. 2018.PubMed/NCBI View Article : Google Scholar

14 

Gaschler MM and Stockwell B: Lipid peroxidation in cell death. Biochem Biophys Res Commun. 482:419–425. 2017.PubMed/NCBI View Article : Google Scholar

15 

Turner TT and Lysiak JJ: Oxidative stress: A common factor in testicular dysfunction. J Androl. 29:488–498. 2008.PubMed/NCBI View Article : Google Scholar

16 

Chan WC and Nie S: Quantum dot bioconjugates for ultra sensitive nonisotopic detection. Science. 281:2016–2018. 1998.PubMed/NCBI View Article : Google Scholar

17 

Vaseashta A and Dimova-Malinovska D: Nanostructured and nanoscale devices, sensors and detectors. Sci Technol Adv Mater. 6(312)2005.

18 

Langer R: Drugs on target. Science. 293:58–59. 2001.PubMed/NCBI View Article : Google Scholar

19 

Roy K, Mao HQ, Huang SK and Leong KW: Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat Med. 5(387)1999.PubMed/NCBI View Article : Google Scholar

20 

Sachlos E, Gotora D and Czernuszka JT: Collagen scaffolds reinforced with biomimetic composite nano-sized carbonate-substituted hydroxyapatite crystals and shaped by rapid prototyping to contain internal microchannels. Tissue Eng. 12:2479–2487. 2006.PubMed/NCBI View Article : Google Scholar

21 

Farokhzad OC, Cheng J, Teply BA, Sherifi I, Jon S, Kantoff PW, Richie JP and Langer R: Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proc Natl Acad Sci USA. 103(6315)2006.PubMed/NCBI View Article : Google Scholar

22 

Kim J, Kim HY, Song SY, Go SH, Sohn HS, Baik S, Soh M, Kim K, Kim D, Kim HC, et al: Synergistic oxygen generation and reactive oxygen species scavenging by manganese ferrite/ceria co-decorated nanoparticles for rheumatoid arthritis treatment. ACS Nano. 13:3206–3217. 2019.PubMed/NCBI View Article : Google Scholar

23 

Celardo I, De Nicola M, Mandoli C, Pedersen JZ, Traversa E and Ghibelli L: Ce3+ Ions determine redox-dependent anti-apoptotic effect of cerium oxide nanoparticles. ACS Nano. 5:4537–4549. 2011.PubMed/NCBI View Article : Google Scholar

24 

Heckert EG, Karakoti AS, Seal S and Self WT: The role of cerium redox state in the SOD mimetic activity of nanoceria. Biomaterials. 29:2705–2709. 2008.PubMed/NCBI View Article : Google Scholar

25 

Moridi H, Hosseini SA, Shateri H, Kheiripour N, Kaki A, Hatami M and Ranjbar A: Protective effect of cerium oxide nanoparticle on sperm quality and oxidative damage in malathion-induced testicular toxicity in rats: An experimental study. Int J Reprod Biomed. 16:261–266. 2018.PubMed/NCBI

26 

Shcherbakov AB, Reukov VV, Yakimansky AV, Krasnopeeva EL, Ivanova OS, Popov AL and Ivanov VK: CeO2 nanoparticle-containing polymers for biomedical applications: A review. Polymers (Basel). 13(924)2021.PubMed/NCBI View Article : Google Scholar

27 

Singh S, Kumar U, Gittess D, Sakthivel TS, Babu B and Seal S: Cerium oxide nanomaterial with dual antioxidative scavenging potential: Synthesis and characterization. J Biomater Appl. 36:834–842. 2021.PubMed/NCBI View Article : Google Scholar

28 

Cosentino MJ, Nishida M, Rabinowitz R and Cockett AT: Histopathology of prepubertal rat testes subjected to various durations of spermatic cord torsion. J Androl. 7:23–31. 1986.PubMed/NCBI View Article : Google Scholar

29 

Johnsen SG: Testicular biopsy score count-a method for registration of spermatogenesis in human testes: Normal values and results in 335 hypogonadal males. Hormones. 1:2–25. 1970.PubMed/NCBI View Article : Google Scholar

30 

Crowe AR and Yue W: Semi-quantitative determination of protein expression using immunohistochemistry staining and analysis: An integrated protocol. Bio Protoc. 9(e3465)2019.PubMed/NCBI View Article : Google Scholar

31 

Van Ye TM, Roza AM, Pieper GM, Henderson J Jr, Johnson CP and Adams MB: Inhibition of intestinal lipid peroxidation does not minimize morphologic damage. J Surg Res. 55:553–558. 1993.PubMed/NCBI View Article : Google Scholar

32 

Hodges DM, DeLong JM, Forney CF and Prange RK: Improving the thiobarbituric acid reactive substances assay for estimating lipid peroxidation in plant tissues containing anthocyanin and other interfering compounds. Planta. 207:604–611. 1999.PubMed/NCBI View Article : Google Scholar

33 

Aebi H: Catalase. In: H.U.Bergmeyer (Ed): Methods of Enzymatic Analysis, Academic Press, New York and London, pp673-677, 1974.

34 

Brites FD, Verona J, Schreier LE, Fruchart JC, Castro GR and Wikinski RL: Paraoxonase 1 and platelet-activating factor acetylhydrolase activities in patients with low hdl-cholesterol levels with or without primary hypertriglyceridemia. Arch Med Res. 35:235–240. 2004.PubMed/NCBI View Article : Google Scholar

35 

Habig WH, Pabst MJ and Jakoby WB: Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem. 249:7130–7139. 1974.PubMed/NCBI

36 

Bodur A, Alver A, Kahraman C, Altay DU and İnce İ: Investigation of N-acetylcysteine on contralateral testis tissue injury by experimental testicular torsion: Long-term effect. Am J Emerg Med. 34:1069–1074. 2016.PubMed/NCBI View Article : Google Scholar

37 

Mallick IH, Yang W, Winslet MC and Seifalian AM: Ischemia-reperfusion injury of the intestine and protective strategies against injury. Dig Dis Sci. 49:1359–1377. 2004.PubMed/NCBI View Article : Google Scholar

38 

Ustün H, Akgül KT, Ayyildiz A, Yağmurdur H, Nuhoğlu B, Karagüzel E, Oğüş E and Germiyanoğlu C: Effect of phospodiesterase 5 inhibitors on apoptosis and nitric oxide synthases in testis torsion: An experimental study. Pediatr Surg Int. 24:205–211. 2008.PubMed/NCBI View Article : Google Scholar

39 

Kazez A, Demirbağ M, Ustündağ B, Ozercan IH and Sağlam M: The role of melatonin in prevention of intestinal ischemia-reperfusion injury in rats. J Pediatr Surg. 35:1444–1448. 2000.PubMed/NCBI View Article : Google Scholar

40 

Ates B, Yilmaz I, Geckil H, Iraz M, Birincioglu M and Fiskin K: Protective role of melatonin given either before ischemia or prior to reperfusion on intestinal ischemia-reperfusion damage. J Pineal Res. 37:149–152. 2004.PubMed/NCBI View Article : Google Scholar

41 

Elahi MM, Kong YX and Matata BM: Oxidative stress as a mediator of cardiovascular disease. Oxid Med Cell Longev. 2:259–269. 2009.PubMed/NCBI View Article : Google Scholar

42 

McCord JM: Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med. 312:159–163. 1985.PubMed/NCBI View Article : Google Scholar

43 

Su LJ, Zhang JH, Gomez H, Murugan R, Hong X, Xu D, Jiang F and Peng ZY: Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis. Oxid Med Cell Longev. 2019(5080843)2019.PubMed/NCBI View Article : Google Scholar

44 

Kasahara E, Sato EF, Miyoshi M, Konaka R, Hiramoto K, Sasaki J, Tokuda M, Nakano Y and Inoue M: Role of oxidative stress in germ cell apoptosis induced by di(2-ethylhexyl)phthalate. Biochem J. 365:849–56. 2002.PubMed/NCBI View Article : Google Scholar

45 

Lin WW, Lamb DJ, Wheeler TM, Abrams J, Lipshultz LI and Kim ED: Apoptotic frequency is increased in spermatogenic maturation arrest and hypospermatogenic states. J Urol. 158:1791–1793. 1997.PubMed/NCBI View Article : Google Scholar

46 

Shin JH, Mori C and Shiota K: Involvement of germ cell apoptosis in the induction of testicular toxicity following hydroxyurea treatment. Toxicol Appl Pharmacol. 155:139–149. 1999.PubMed/NCBI View Article : Google Scholar

47 

Tesarik J, Greco E, Cohen-Bacrie P and Mendoza C: Germ cell apoptosis in men with complete and incomplete spermiogenesis failure. Mol Hum Reprod. 4:757–762. 1998.PubMed/NCBI View Article : Google Scholar

48 

Payabvash S, Salmasi AH, Kiumehr S, Tavangar SM, Nourbakhsh B, Faghihi SH and Dehpour AR: Salutary effects of N-acetylcysteine on apoptotic damage in a rat model of testicular torsion. Urol Int. 79:248–254. 2007.PubMed/NCBI View Article : Google Scholar

49 

Suwalsky M, Villena F and Gallardo MJ: In vitro protective effects of resveratrol against oxidative damage in human erythrocytes. Biochim Biophys Acta. 1848:76–82. 2015.PubMed/NCBI View Article : Google Scholar

50 

Espino J, Bejarano I, Ortiz A, Lozano GM, García JF, Pariente JA and Rodríguez AB: Melatonin as a potential tool against oxidative damage and apoptosis in ejaculated human spermatozoa. Fertil Steril. 94:1915–1957. 2010.PubMed/NCBI View Article : Google Scholar

51 

Ranjbar A, Firozian F, Soleimani Asl S, Ghasemi H, Taheri Azandariani M, Larki A, Hosseini A and Naserabadi A: Nitrosative DNA damage after sub-chronic exposure to silver nanoparticle induces stress nephrotoxicity in rat kidney. Toxin Rev. 37:327–333. 2017.

52 

Saleh H, Nassar AMK, Noreldin AE, Samak D, Elshony N, Wasef L, Elewa YHA, Hassan SMA, Saati AA, Hetta HF, et al: Chemo-protective potential of cerium oxide nanoparticles against fipronil-induced oxidative stress, apoptosis, inflammation and reproductive dysfunction in male white albino rats. Molecules. 25(3479)2020.PubMed/NCBI View Article : Google Scholar

53 

Tuncay A, Sivgin V, Ozdemirkan A, Sezen SC, Boyunaga H, Kucuk A, Gunes I and Arslan M: The effect of cerium oxide on lung tissue in lower extremity ischemia reperfusion injury in sevoflurane administered rats. Int J Nanomedicine. 15:7481–7489. 2020.PubMed/NCBI View Article : Google Scholar

54 

Ni D, Wei H, Chen W, Bao Q, Rosenkrans ZT, Barnhart TE, Ferreira CA, Wang Y, Yao H, Sun T, et al: Ceria nanoparticles meet hepatic Ischemia-reperfusion injury: The perfect imperfection. Adv Mater. 31(e1902956)2019.PubMed/NCBI View Article : Google Scholar

55 

Artimani T, Amiri I, Soleimani Asl S, Saidijam M, Hasanvand D and Afshar S: Amelioration of diabetes-induced testicular and sperm damage in rats by cerium oxide nanoparticle treatment. Andrologia. 50(e13089)2018.PubMed/NCBI View Article : Google Scholar

56 

Charbgoo F, Ahmad MB and Darroudi M: Cerium oxide nanoparticles: Green synthesis and biological applications. Int J Nanomedicine. 12:1401–1413. 2017.PubMed/NCBI View Article : Google Scholar

57 

Adebayo OA, Akinloye O and Adaramoye OA: Cerium oxide nanoparticle elicits oxidative stress, endocrine imbalance and lowers sperm characteristics in testes of balb/c mice. Andrologia. 50:2018.PubMed/NCBI View Article : Google Scholar : doi: 10.1111/and.12920.

58 

Alpaslan E, Geilich BM, Yazici H and Webster TJ: pH-Controlled cerium oxide nanoparticle inhibition of both gram-positive and gram-negative bacteria growth. Sci Rep. 7(45859)2017.PubMed/NCBI View Article : Google Scholar

59 

Kalyanaraman V, Naveen SV, Mohana N, Balaje RM, Navaneethakrishnan KR, Brabu B, Murugan SS and Kumaravel TS: Biocompatibility studies on cerium oxide nanoparticles-combined study for local effects, systemic toxicity and genotoxicity via implantation route. Toxicol Res (Camb). 8:25–37. 2019.PubMed/NCBI View Article : Google Scholar

60 

Karakoti AS, Singh S, Kumar A, Malinska M, Kuchibhatla SV, Wozniak K, Self WT and Seal S: PEGylated nanoceria as radical scavenger with tunable redox chemistry. J Am Chem Soc. 131:14144–14145. 2009.PubMed/NCBI View Article : Google Scholar

61 

Yang X, Pan H, Wang P and Zhao FJ: Particle-specific toxicity and bioavailability of cerium oxide (CeO2) nanoparticles to Arabidopsis thaliana. J Hazard Mater. 322:292–300. 2017.PubMed/NCBI View Article : Google Scholar

62 

Ganji M, Osman H, Karimi J, Hosseini SA, Moridi H, Hosseini A, Ahmadimoghaddam D and Ranjbar A: Experimental study of cerium oxide nanoparticles (CeNP) against malathion induced lung oxidative toxic stress in rats. Iranian J Pharmacol Ther. 15:1–7. 2017.

63 

Tatar T, Polat Y, Comu FM, Kartal H, Arslan M and Kucuk A: Effect of cerium oxide on erythrocyte deformability in rat lower extremity ischemia reperfusion injury. Bratisl Lek Listy. 119:441–443. 2018.PubMed/NCBI View Article : Google Scholar

64 

Hegazy MA, Maklad HM, Samy DM, Abdelmonsif DA, El Sabaa BM and Elnozahy FY: Cerium oxide nanoparticles could ameliorate behavioral and neurochemical impairments in 6-hydroxydopamine induced Parkinson's disease in rats. Neurochem Int. 108:361–371. 2017.PubMed/NCBI View Article : Google Scholar

65 

Manne NDPK, Arvapalli R, Graffeo VA, Bandarupalli VVK, Shokuhfar T, Patel S, Rice KM, Ginjupalli GK and Blough ER: Prophylactic treatment with cerium oxide nanoparticles attenuate hepatic ischemia reperfusion injury in sprague dawley rats. Cell Physiol Biochem. 42:1837–1846. 2017.PubMed/NCBI View Article : Google Scholar

66 

Ozbal S, Ergur BU, Erbil G, Tekmen I, Bagrıyanık A and Cavdar Z: The effects of α-lipoic acid against testicular ischemia-reperfusion injury in Rats. ScientificWorldJournal. 2012(489248)2012.PubMed/NCBI View Article : Google Scholar

67 

Işlekel S, Işlekel H, Güner G and Ozdamar N: Alterations in superoxide dismutase, glutathione peroxidase and catalase activities in experimental cerebral ischemia-reperfusion. Res Exp Med (Berl). 199:167–176. 1999.PubMed/NCBI View Article : Google Scholar

68 

Stanimirovic DB, Micic DV, Markovic M, Spatz M and Mrsulja BB: ‘Therapeutic window’ for multiple drug treatment of experimental cerebral ischemia in gerbils. Neurochem Res. 19:189–194. 1994.PubMed/NCBI View Article : Google Scholar

69 

Koltuksuz U, Ozen S, Uz E, Aydinç M, Karaman A, Gültek A, Akyol O, Gürsoy MH and Aydin E: Caffeic acid phenethyl ester prevents intestinal reperfusion injury in rats. J Pediatr Surg. 34:1458–1462. 1999.PubMed/NCBI View Article : Google Scholar

70 

Yildiz Y, Serter M, Ek RO, Ergin K, Cecen S, Demir EM and Yenisey C: Protective effects of caffeic acid phenethyl ester on intestinal ischemia-reperfusion injury. Dig Dis Sci. 54:738–744. 2009.PubMed/NCBI View Article : Google Scholar

71 

Erdemir F, Parlaktas BS, Ozyurt H, Boztepe O, Atis O and Sahin S: Antioxidant effect of melatonin in systemic circulation of rats after unilateral testicular torsion. Turk J Med Sci. 38:1–6. 2008.

72 

Wei SM, Yan ZZ and Zhou J: Protective effect of rutin on testicular ischemia-reperfusion injury. J Pediatr Surg. 46:1419–1424. 2011.PubMed/NCBI View Article : Google Scholar

73 

Akgür FM, Kilinç K and Aktuğ T: Reperfusion injury after detorsion of unilateral testicular torsion. Urol Res. 21:395–399. 1993.PubMed/NCBI View Article : Google Scholar

74 

Gökçe A, Oktar S, Koc A, Gonenci R, Yalcinkaya F, Yonden Z and Duru M: Protective effect of thymoquinone in experimental testicular torsion. Urol Int. 85:461–465. 2010.PubMed/NCBI View Article : Google Scholar

75 

Blank ML, O'Neill PJ, Steigman CK, Cobb LM, Wilde RA, Havenstein PJ and Chaudry IH: Reperfusion injury following testicular torsion and detorsion in prepubertal rats. Urol Res. 21:389–393. 1993.PubMed/NCBI View Article : Google Scholar

76 

Prillaman HM and Turner TT: Rescue of testicular function after acute experimental torsion. J Urol. 157:340–345. 1997.PubMed/NCBI

77 

Ward TH, Cummings J, Dean E, Greystoke A, Hou JM, Backen A, Ranson M and Dive C: Biomarkers of apoptosis. Br J Cancer. 99:841–846. 2008.PubMed/NCBI View Article : Google Scholar

78 

Porter AG and Jänicke RU: Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 6:99–104. 1999.PubMed/NCBI View Article : Google Scholar

79 

Ishizuya-Oka A, Hasebe T and Shi YB: Apoptosis in amphibian organs during metamorphosis. Apoptosis. 15:350–364. 2010.PubMed/NCBI View Article : Google Scholar

80 

Elmore S: Apoptosis: A review of programmed cell death. Toxicol Pathol. 35:495–516. 2007.PubMed/NCBI View Article : Google Scholar

81 

Goldar S, Khaniani MS, Derakhshan SM and Baradaran B: Molecular mechanisms of apoptosis and roles in cancer development and treatment. Asian Pac J Cancer Prev. 16:2129–2144. 2015.PubMed/NCBI View Article : Google Scholar

82 

Bejarano I, Rodríguez AB and Pariente JA: Apoptosis is a demanding selective tool during the development of fetal male germ cells. Front Cell Dev Biol. 6(65)2018.PubMed/NCBI View Article : Google Scholar

83 

Jairajpuri ZS, Ghai R, Saluja S, Kapur S and Bhowmik KT: Expression of apoptosis related and proliferative proteins in malignant lympho-proliferative disorders. Iran J Pathol. 12:231–240. 2007.PubMed/NCBI

84 

Shi Y, Norberg E and Vakifahmetoglu-Norberg H: Mutant p53 as a regulator and target of autophagy. Front Oncol. 10(607149)2021.PubMed/NCBI View Article : Google Scholar

85 

Scorrano L and Korsmeyer SJ: Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochem Biophys Res Commun. 304:437–444. 2003.PubMed/NCBI View Article : Google Scholar

86 

Chen X, Ko LJ, Jayaraman L and Prives C: p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev. 10:2438–2451. 1996.PubMed/NCBI View Article : Google Scholar

87 

Misao J, Hayakawa Y, Ohno M, Kato S, Fujiwara T and Fujiwara H: Expression of bcl-2 protein, an inhibitor of apoptosis, and Bax, an accelerator of apoptosis, in ventricular myocytes of human hearts with myocardial infarction. Circulation. 94:1506–1512. 1996.PubMed/NCBI View Article : Google Scholar

88 

Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M and Green DR: Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science. 303:1010–1014. 2004.PubMed/NCBI View Article : Google Scholar

89 

Kumi-Diaka J and Butler A: Caspase-3 protease activation during the process of genistein-induced apoptosis in TM4 testicular cells. Biol Cell. 92:115–124. 2000.PubMed/NCBI View Article : Google Scholar

90 

Kolli MB, Manne NDPK, Para R, Nalabotu SK, Nandyala G, Shokuhfar T, He K, Hamlekhan A, Ma JY, Wehner PS, et al: Cerium oxide nanoparticles attenuate monocrotaline induced right ventricular hypertrophy following pulmonary arterial hypertension. Biomaterials. 35:9951–9962. 2014.PubMed/NCBI View Article : Google Scholar

91 

Mousavi A, Gharzi A, Gholami M, Beyranvand F and Takesh M: The therapeutic effect of cerium oxide nanoparticle on ischaemia/reperfusion injury in rat testis. Andrologia. 53(e14231)2021.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yesil S, Ozdemir C, Arslan M, Gundogdu AC, Kavutcu M and Atan A: Protective effect of cerium oxide on testicular function and oxidative stress after torsion/detorsion in adult male rats. Exp Ther Med 25: 1, 2023.
APA
Yesil, S., Ozdemir, C., Arslan, M., Gundogdu, A.C., Kavutcu, M., & Atan, A. (2023). Protective effect of cerium oxide on testicular function and oxidative stress after torsion/detorsion in adult male rats. Experimental and Therapeutic Medicine, 25, 1. https://doi.org/10.3892/etm.2022.11700
MLA
Yesil, S., Ozdemir, C., Arslan, M., Gundogdu, A. C., Kavutcu, M., Atan, A."Protective effect of cerium oxide on testicular function and oxidative stress after torsion/detorsion in adult male rats". Experimental and Therapeutic Medicine 25.1 (2023): 1.
Chicago
Yesil, S., Ozdemir, C., Arslan, M., Gundogdu, A. C., Kavutcu, M., Atan, A."Protective effect of cerium oxide on testicular function and oxidative stress after torsion/detorsion in adult male rats". Experimental and Therapeutic Medicine 25, no. 1 (2023): 1. https://doi.org/10.3892/etm.2022.11700
Copy and paste a formatted citation
x
Spandidos Publications style
Yesil S, Ozdemir C, Arslan M, Gundogdu AC, Kavutcu M and Atan A: Protective effect of cerium oxide on testicular function and oxidative stress after torsion/detorsion in adult male rats. Exp Ther Med 25: 1, 2023.
APA
Yesil, S., Ozdemir, C., Arslan, M., Gundogdu, A.C., Kavutcu, M., & Atan, A. (2023). Protective effect of cerium oxide on testicular function and oxidative stress after torsion/detorsion in adult male rats. Experimental and Therapeutic Medicine, 25, 1. https://doi.org/10.3892/etm.2022.11700
MLA
Yesil, S., Ozdemir, C., Arslan, M., Gundogdu, A. C., Kavutcu, M., Atan, A."Protective effect of cerium oxide on testicular function and oxidative stress after torsion/detorsion in adult male rats". Experimental and Therapeutic Medicine 25.1 (2023): 1.
Chicago
Yesil, S., Ozdemir, C., Arslan, M., Gundogdu, A. C., Kavutcu, M., Atan, A."Protective effect of cerium oxide on testicular function and oxidative stress after torsion/detorsion in adult male rats". Experimental and Therapeutic Medicine 25, no. 1 (2023): 1. https://doi.org/10.3892/etm.2022.11700
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team