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Case Report Open Access

Diabetes insipidus: A rare endocrine complication of immune check point inhibitors: A case report and literature review

  • Authors:
    • Anna Angelousi
    • Petros Papalexis
    • Athina Karampela
    • Marianna Marra
    • Dimitrios Misthos
    • Dimitriοs Ziogas
    • Helen Gogas
  • View Affiliations / Copyright

    Affiliations: First Department of Internal Medicine, Unit of Endocrinology, Laikon General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece, First Department of Internal Medicine, Unit of Medical Oncology, Laikon General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece
    Copyright: © Angelousi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 10
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    Published online on: November 16, 2022
       https://doi.org/10.3892/etm.2022.11709
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Abstract

Immune checkpoint inhibitors (ICIs), including anti‑programmed cell death protein 1 (PD‑1), anti‑programmed cell death protein ligand 1 (PD‑L1) and anti‑cytotoxic T‑lymphocyte antigen 4 (CTLA‑4) monoclonal antibodies, are novel therapeutic agents widely used in numerous malignancies. They are known to cause multiple immune‑related endocrine adverse events (irAEs); however, anterior pituitary hypophysitis with secondary hypopituitarism is the most frequently reported irAE, especially in patients receiving anti‑CTLA‑4 treatment. By contrast, posterior pituitary involvement, such as central diabetes insipidus (CDI), is relatively rare and only few case reports have been published. The present report describes the case of a 53‑year‑old woman with metastatic melanoma treated with nivolumab an anti‑PD‑L1 monoclonal antibody. At 6 months after the initiation of nivolumab treatment, the patient was diagnosed with deficiency of the corticotrope and thyreotrope axes and in the following 2 months the patient was diagnosed with progressive development of polyuria‑polydipsia syndrome. The diagnosis of partial CDI was retained based on plasma and urinary osmolalities, the water deprivation test and baseline copeptin levels as well as on the absence of the bright spot in the posterior pituitary in magnetic resonance imaging. Systematic research of the literature revealed a total of 13 cases reports (including 14 patients) presenting with CDI treated with monotherapy with CTLA‑4 (n=5) or PD‑1/PD‑L1 Abs (n=6) or combined treatments (n=3). The improved understanding of the mechanisms of ICI action along with their extensive use should contribute to the early recognition of irAE symptoms. We hypothesized that clinicians should be aware of this clinical entity and its symptoms and treat it appropriately.
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1 

Zhao C, Tella SH, Del Rivero J, Kommalapati A, Ebenuwa I, Gulley J, Strauss J and Brownell I: Anti-PD-L1 treatment induced central diabetes insipidus. J Clin Endocrinol Metab. 103:365–369. 2018.PubMed/NCBI View Article : Google Scholar

2 

Husebye ES, Castinetti F, Criseno S, Curigliano G, Decallonne B, Fleseriu M, Higham CE, Lupi I, Paschou SA, Toth M, et al: Endocrine-related adverse conditions in patients receiving immune checkpoint inhibition-an ESE clinical practice guideline. Eur J Endocrinol. (EJE-22-0689)(2022): (Epub ahead of print).

3 

Di Dalmazi G, Ippolito S, Lupi I and Caturegli P: Hypophysitis induced by immune checkpoint inhibitors: A 10-year assessment. Expert Rev Endocrinol Metab. 14:381–398. 2019.PubMed/NCBI View Article : Google Scholar

4 

Fernandes S, Varlamov EV, McCartney S and Fleseriu M: A novel etiology of hypophysitis: Immune checkpoint inhibitors. Endocrinol Metab Clin North Am. 49:387–399. 2020.PubMed/NCBI View Article : Google Scholar

5 

Vaddepally RK, Kharel P, Pandey R, Garje R and Chandra AB: Review of indications of FDA-approved immune checkpoint inhibitors per NCCN guidelines with the level of evidence. Cancers (Basel). 12(738)2020.PubMed/NCBI View Article : Google Scholar

6 

Mutter CM, Smith T, Menze O, Zakharia M and Nguyen H: Diabetes insipidus: Pathogenesis, diagnosis, and clinical management. Cureus. 13(e13523)2021.PubMed/NCBI View Article : Google Scholar

7 

Dillard T, Yedinak CG, Alumkal J and Fleseriu M: Anti-CTLA-4 antibody therapy associated autoimmune hypophysitis: Serious immune related adverse events across a spectrum of cancer subtypes. Pituitary. 13:29–38. 2010.PubMed/NCBI View Article : Google Scholar

8 

Nallapaneni NN, Mourya R, Bhatt VR, Malhotra S, Ganti AK and Tendulkar KK: Ipilimumab-induced hypophysitis and uveitis in a patient with metastatic melanoma and a history of ipilimumab-induced skin rash. J Natl Compr Cancer Netw. 12:1077–1081. 2014.PubMed/NCBI View Article : Google Scholar

9 

Gunawan F, George E and Roberts A: Combination immune checkpoint inhibitor therapy nivolumab and ipilimumab associated with multiple endocrinopathies. Endocrinol Diabetes Metab Case Reports. 2018:17–0146. 2018.PubMed/NCBI View Article : Google Scholar

10 

Tshuma N, Glynn N, Evanson J, Powles T and Drake WM: Hypothalamitis and severe hypothalamic dysfunction associated with anti-programmed cell death ligand 1 antibody treatment. Eur J Cancer. 104:247–249. 2018.PubMed/NCBI View Article : Google Scholar

11 

Deligiorgi MV, Siasos G, Vergadis C and Trafalis DT: Central diabetes insipidus related to anti-programmed cell-death 1 protein active immunotherapy. Int Immunopharmacol. 83(106427)2020.PubMed/NCBI View Article : Google Scholar

12 

Barnabei A, Carpano S, Chiefari A, Bianchini M, Lauretta R, Mormando M, Puliani G, Paoletti G, Appetecchia M and Torino F: Case report: Ipilimumab-induced panhypophysitis: An infrequent occurrence and literature review. Front Oncol. 10(582394)2020.PubMed/NCBI View Article : Google Scholar

13 

Grami Z, Manjappachar N and Reddy DR: 323: Diabetes insipidus in checkpoint inhibitor treatment and acute myeloid leukemia. Crit Care Med. 48(144)2020.

14 

Yu M, Liu L, Shi P, Zhou H, Qian S and Chen K: Anti-PD-1 treatment-induced immediate central diabetes insipidus: A case report. Immunotherapy. 13:1255–1260. 2021.PubMed/NCBI View Article : Google Scholar

15 

Fosci M, Pigliaru F, Salcuni AS, Ghiani M, Cherchi MV, Calia MA, Loviselli A and Velluzzi F: Diabetes insipidus secondary to nivolumab-induced neurohypophysitis and pituitary metastasis. Endocrinol Diabetes Metab Case Rep. 2021:20–0123. 2021.PubMed/NCBI View Article : Google Scholar : (Epub ahead of print).

16 

Brilli L, Calabrò L, Campanile M, Pilli T, Agostinis C, Cerase A, Maio M and Castagna MG: Permanent diabetes insipidus in a patient with mesothelioma treated with immunotherapy. Arch Endocrinol Metab. 64:483–486. 2020.PubMed/NCBI View Article : Google Scholar

17 

Bai X, Chen X, Wu X, Huang Y, Zhuang Y, Chen Y, Feng C and Lin X: Immune checkpoint inhibitor-associated pituitary adverse events: An observational, retrospective, disproportionality study. J Endocrinol Invest. 43:1473–1483. 2020.PubMed/NCBI View Article : Google Scholar

18 

Gubbi S, Hannah-Shmouni F, Koch CA, Verbalis JG, Feingold KR, Anawalt B, Boyce A, Chrousos G, de Herder WW, Dhatariya K (eds), et al: Diagnostic testing for diabetes insipidus. In: Endotext [Internet]. MDText.com, Inc., South Dartmouth, MA, 2000.

19 

Christ-Crain M, Winzeler B and Refardt J: Diagnosis and management of diabetes insipidus for the internist: An update. J Intern Med. 290:73–87. 2021.PubMed/NCBI View Article : Google Scholar

20 

Terán Brage E, Heras Benito M, Navalón Jiménez MB, Vidal Tocino R, del Barco Morillo E and Fonseca Sánchez E: Severe hyponatremia masking central diabetes insipidus in a patient with a lung adenocarcinoma. Case Rep Oncol. 15:91–98. 2022.PubMed/NCBI View Article : Google Scholar

21 

Amereller F, Deutschbein T, Joshi M, Schopohl J, Schilbach K, Detomas M, Duffy L, Carroll P, Papa S and Störmann S: Differences between immunotherapy-induced and primary hypophysitis-a multicenter retrospective study. Pituitary. 25:152–158. 2022.PubMed/NCBI View Article : Google Scholar

22 

Di Iorgi N, Napoli F, Allegri AE, Olivieri I, Bertelli E, Gallizia A, Rossi A and Maghnie M: Diabetes insipidus-diagnosis and management. Horm Res Paediatr. 77:69–84. 2012.PubMed/NCBI View Article : Google Scholar

23 

Di Nunno V, Mollica V, Corcioni B, Fiorentino M, Nobili E, Schiavina R, Golfieri R, Brunocilla E, Ardizzoni A and Massari F: Clinical management of a pituitary gland metastasis from clear cell renal cell carcinoma. Anticancer Drugs. 29:710–715. 2018.PubMed/NCBI View Article : Google Scholar

24 

Javanbakht A, D'Apuzzo M, Badie B and Salehian B: Pituitary metastasis: A rare condition. Endocr Connect. 7:1049–1057. 2018.PubMed/NCBI View Article : Google Scholar : (Epub ahead of print).

25 

Faje A: Immunotherapy and hypophysitis: Clinical presentation, treatment, and biologic insights. Pituitary. 19:82–92. 2016.PubMed/NCBI View Article : Google Scholar

26 

Ryder M, Callahan M, Postow MA, Wolchok J and Fagin JA: Endocrine-related adverse events following ipilimumab in patients with advanced melanoma: A comprehensive retrospective review from a single institution. Endocr Relat Cancer. 21:371–381. 2014.PubMed/NCBI View Article : Google Scholar

27 

Byun DJ, Wolchok JD, Rosenberg LM and Girotra M: Cancer immunotherapy-immune checkpoint blockade and associated endocrinopathies. Nat Rev Endocrinol. 13:195–207. 2017.PubMed/NCBI View Article : Google Scholar

28 

Bellastella G, Maiorino MI, Bizzarro A, Giugliano D, Esposito K, Bellastella A and De Bellis A: Revisitation of autoimmune hypophysitis: Knowledge and uncertainties on pathophysiological and clinical aspects. Pituitary. 19:625–642. 2016.PubMed/NCBI View Article : Google Scholar

29 

Iwama S, De Remigis A, Callahan MK, Slovin SF, Wolchok JD and Caturegli P: Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody. Sci Transl Med. 6(230ra45)2014.PubMed/NCBI View Article : Google Scholar

30 

Caturegli P, Di Dalmazi G, Lombardi M, Grosso F, Larman HB, Larman T, Taverna G, Cosottini M and Lupi I: Hypophysitis secondary to cytotoxic T-lymphocyte-associated protein 4 blockade: Insights into pathogenesis from an autopsy series. Am J Pathol. 186:3225–3235. 2016.PubMed/NCBI View Article : Google Scholar

31 

Mei Y, Bi WL, Greenwald NF, Du Z, Agar NY, Kaiser UB, Woodmansee WW, Reardon DA, Freeman GJ, Fecci PE, et al: Increased expression of programmed death ligand 1 (PD-L1) in human pituitary tumors. Oncotarget. 7(76565)2016.PubMed/NCBI View Article : Google Scholar

32 

Priya G, Kalra S, Dasgupta A and Grewal E: Diabetes insipidus: A pragmatic approach to management. Cureus. 13(e12498)2021.PubMed/NCBI View Article : Google Scholar

33 

Christ-Crain M and Fenske W: Copeptin in the diagnosis of vasopressin-dependent disorders of fluid homeostasis. Nat Rev Endocrinol. 12:168–176. 2016.PubMed/NCBI View Article : Google Scholar

34 

Christ-Crain M, Hoorn EJ, Sherlock M, Thompson CJ and Wass J: Endocrinology in the time of COVID-19-2021 updates: The management of diabetes insipidus and hyponatraemia. Eur J Endocrinol. 185:G35–G42. 2021.PubMed/NCBI View Article : Google Scholar

35 

Garrahy A, Moran C and Thompson CJ: Diagnosis and management of central diabetes insipidus in adults. Clin Endocrinol (Oxf). 90:23–30. 2019.PubMed/NCBI View Article : Google Scholar

36 

Fenske W, Refardt J, Chifu I, Schnyder I, Winzeler B, Drummond J, Ribeiro-Oliveira A Jr, Drescher T, Bilz S, Vogt DR, et al: A copeptin-based approach in the diagnosis of diabetes insipidus. N Engl J Med. 379:428–439. 2018.PubMed/NCBI View Article : Google Scholar

37 

Winzeler B, Cesana-Nigro N, Refardt J, Vogt DR, Imber C, Morin B, Popovic M, Steinmetz M, Sailer CO, Szinnai G, et al: Arginine-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus: A prospective diagnostic study. Lancet. 394:587–595. 2019.PubMed/NCBI View Article : Google Scholar

38 

Timper K, Fenske W, Kühn F, Frech N, Arici B, Rutishauser J, Kopp P, Allolio B, Stettler C, Müller B, et al: Diagnostic accuracy of copeptin in the differential diagnosis of the polyuria-polydipsia syndrome: A prospective multicenter study. J Clin Endocrinol Metab. 100:2268–2274. 2015.PubMed/NCBI View Article : Google Scholar

39 

Brooks BS, el Gammal T, Allison JD and Hoffman WH: Frequency and variation of the posterior pituitary bright signal on MR images. Am J Roentgenol. 153:1033–1038. 1989.PubMed/NCBI

40 

Corsello SM, Barnabei A, Marchetti P, De Vecchis L, Salvatori R and Torino F: Endocrine side effects induced by immune checkpoint inhibitors. J Clin Endocrinol Metab. 98:1361–1375. 2013.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Angelousi A, Papalexis P, Karampela A, Marra M, Misthos D, Ziogas D and Gogas H: Diabetes insipidus: A rare endocrine complication of immune check point inhibitors: A case report and literature review. Exp Ther Med 25: 10, 2023.
APA
Angelousi, A., Papalexis, P., Karampela, A., Marra, M., Misthos, D., Ziogas, D., & Gogas, H. (2023). Diabetes insipidus: A rare endocrine complication of immune check point inhibitors: A case report and literature review. Experimental and Therapeutic Medicine, 25, 10. https://doi.org/10.3892/etm.2022.11709
MLA
Angelousi, A., Papalexis, P., Karampela, A., Marra, M., Misthos, D., Ziogas, D., Gogas, H."Diabetes insipidus: A rare endocrine complication of immune check point inhibitors: A case report and literature review". Experimental and Therapeutic Medicine 25.1 (2023): 10.
Chicago
Angelousi, A., Papalexis, P., Karampela, A., Marra, M., Misthos, D., Ziogas, D., Gogas, H."Diabetes insipidus: A rare endocrine complication of immune check point inhibitors: A case report and literature review". Experimental and Therapeutic Medicine 25, no. 1 (2023): 10. https://doi.org/10.3892/etm.2022.11709
Copy and paste a formatted citation
x
Spandidos Publications style
Angelousi A, Papalexis P, Karampela A, Marra M, Misthos D, Ziogas D and Gogas H: Diabetes insipidus: A rare endocrine complication of immune check point inhibitors: A case report and literature review. Exp Ther Med 25: 10, 2023.
APA
Angelousi, A., Papalexis, P., Karampela, A., Marra, M., Misthos, D., Ziogas, D., & Gogas, H. (2023). Diabetes insipidus: A rare endocrine complication of immune check point inhibitors: A case report and literature review. Experimental and Therapeutic Medicine, 25, 10. https://doi.org/10.3892/etm.2022.11709
MLA
Angelousi, A., Papalexis, P., Karampela, A., Marra, M., Misthos, D., Ziogas, D., Gogas, H."Diabetes insipidus: A rare endocrine complication of immune check point inhibitors: A case report and literature review". Experimental and Therapeutic Medicine 25.1 (2023): 10.
Chicago
Angelousi, A., Papalexis, P., Karampela, A., Marra, M., Misthos, D., Ziogas, D., Gogas, H."Diabetes insipidus: A rare endocrine complication of immune check point inhibitors: A case report and literature review". Experimental and Therapeutic Medicine 25, no. 1 (2023): 10. https://doi.org/10.3892/etm.2022.11709
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