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Article Open Access

Lipoblastoma in one adult and 35 pediatric patients: Retrospective analysis of 36 cases

  • Authors:
    • Wenchuan Zhang
    • Shuwan Zhang
    • Zixin Yang
    • Ying Zhang
    • Zhe Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 11
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    Published online on: November 16, 2022
       https://doi.org/10.3892/etm.2022.11710
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Abstract

Lipoblastoma is a rare benign mesenchymal neoplasm that typically occurs at various sites in infants and children but may also occur in adults. Thus, differential diagnoses are often performed. To understand this tumor type, the present study described clinicopathological features, diagnosis and differential diagnosis of different morphological lipoblastomas. A single‑institution retrospective review of 36 lipoblastoma cases diagnosed between 2015 and 2021 was performed. Formalin‑fixed paraffin‑embedded tissue was used for S‑100, CD34, P16 and desmin immunohistochemistry analysis, along with rapid fluorescence in situ hybridization (FISH) detection with pleiomorphic adenoma gene 1 (PLAG1). The 36 cases included 14 females and 22 males [age range, 7 days to 33 years (median, 16.5 years); 28 patients were aged ≤3 years] and the tumors were located in the trunk (n=16), limbs (n=12), head and neck (n=6), and perineum (n=2). Histologically, lipoblastomas were divided into classic (n=15), lipoma‑like (n=13) and myxoid (n=8) subtypes. They comprised lobules of mature adipose tissue of varying size and a fine capillary network surrounded by mucinous stroma. Single‑ or multivesicular lipoblasts positive for S‑100 (29/36, 81%) were observed, with occasional mature adipocytes. Peripheral vessels and cytoplasm of primitive mesenchymal cells were diffusely positive for CD34 (36/36, 100%), whereas primitive mesenchymal cells and striated muscle tissue were positive for desmin (26/36, 72%). Most tumor cells were negative while only few were positive for P16 (8/36, 22%). FISH revealed PLAG1 breakage and rearrangement in 24/32 (75%) patients. In total, 28 patients were followed up post‑operatively (range, 2‑84 months; median, 41 months; 3 patients relapsed and 8 were lost to follow‑up). In conclusion, diagnosis of a typical lipoblastoma is not difficult and PLAG1 breakage detection is key for the diagnosis.
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Zhang W, Zhang S, Yang Z, Zhang Y and Wang Z: Lipoblastoma in one adult and 35 pediatric patients: Retrospective analysis of 36 cases. Exp Ther Med 25: 11, 2023.
APA
Zhang, W., Zhang, S., Yang, Z., Zhang, Y., & Wang, Z. (2023). Lipoblastoma in one adult and 35 pediatric patients: Retrospective analysis of 36 cases. Experimental and Therapeutic Medicine, 25, 11. https://doi.org/10.3892/etm.2022.11710
MLA
Zhang, W., Zhang, S., Yang, Z., Zhang, Y., Wang, Z."Lipoblastoma in one adult and 35 pediatric patients: Retrospective analysis of 36 cases". Experimental and Therapeutic Medicine 25.1 (2023): 11.
Chicago
Zhang, W., Zhang, S., Yang, Z., Zhang, Y., Wang, Z."Lipoblastoma in one adult and 35 pediatric patients: Retrospective analysis of 36 cases". Experimental and Therapeutic Medicine 25, no. 1 (2023): 11. https://doi.org/10.3892/etm.2022.11710
Copy and paste a formatted citation
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Spandidos Publications style
Zhang W, Zhang S, Yang Z, Zhang Y and Wang Z: Lipoblastoma in one adult and 35 pediatric patients: Retrospective analysis of 36 cases. Exp Ther Med 25: 11, 2023.
APA
Zhang, W., Zhang, S., Yang, Z., Zhang, Y., & Wang, Z. (2023). Lipoblastoma in one adult and 35 pediatric patients: Retrospective analysis of 36 cases. Experimental and Therapeutic Medicine, 25, 11. https://doi.org/10.3892/etm.2022.11710
MLA
Zhang, W., Zhang, S., Yang, Z., Zhang, Y., Wang, Z."Lipoblastoma in one adult and 35 pediatric patients: Retrospective analysis of 36 cases". Experimental and Therapeutic Medicine 25.1 (2023): 11.
Chicago
Zhang, W., Zhang, S., Yang, Z., Zhang, Y., Wang, Z."Lipoblastoma in one adult and 35 pediatric patients: Retrospective analysis of 36 cases". Experimental and Therapeutic Medicine 25, no. 1 (2023): 11. https://doi.org/10.3892/etm.2022.11710
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