Open Access

Ferroptosis and renal fibrosis: A new target for the future (Review)

  • Authors:
    • Han Yin Zhang
    • Meng Cheng
    • Lei Zhang
    • Yi Ping Wang
  • View Affiliations

  • Published online on: November 17, 2022     https://doi.org/10.3892/etm.2022.11712
  • Article Number: 13
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ferroptosis is a type of non‑apoptotic controlled cell death triggered by oxidative stress and iron‑dependent lipid peroxidation. Ferroptosis is regulated by signalling pathways that are associated with metabolism, including glutathione peroxidase 4 dysfunction, the cystine/glutamate antiporter system, lipid peroxidation and inadequate iron metabolism. Ferroptosis is associated with renal fibrosis; however, further research is required to understand the specific molecular mechanisms involved. The present review aimed to discuss the known molecular mechanisms of ferroptosis and outline the biological reactions that occur during renal fibrosis that may be associated with ferroptosis. Further investigation into the association between ferroptosis and renal fibrosis may lead to the development of novel treatment methods.
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January-2023
Volume 25 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang HY, Cheng M, Zhang L and Wang YP: Ferroptosis and renal fibrosis: A new target for the future (Review). Exp Ther Med 25: 13, 2023
APA
Zhang, H.Y., Cheng, M., Zhang, L., & Wang, Y.P. (2023). Ferroptosis and renal fibrosis: A new target for the future (Review). Experimental and Therapeutic Medicine, 25, 13. https://doi.org/10.3892/etm.2022.11712
MLA
Zhang, H. Y., Cheng, M., Zhang, L., Wang, Y. P."Ferroptosis and renal fibrosis: A new target for the future (Review)". Experimental and Therapeutic Medicine 25.1 (2023): 13.
Chicago
Zhang, H. Y., Cheng, M., Zhang, L., Wang, Y. P."Ferroptosis and renal fibrosis: A new target for the future (Review)". Experimental and Therapeutic Medicine 25, no. 1 (2023): 13. https://doi.org/10.3892/etm.2022.11712