|
1
|
Xue R, Gui D, Zheng L, Zhai R, Wang F and
Wang N: Mechanistic insight and management of diabetic nephropathy:
Recent progress and future perspective. J Diabetes Res.
2017(1839809)2017.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Tuttle KR, Jones CR, Daratha KB, Koyama
AK, Nicholas SB, Alicic RZ, Duru OK, Neumiller JJ, Norris KC, Ríos
Burrows N and Pavkov ME: Incidence of Chronic Kidney Disease among
Adults with Diabetes, 2015-2020. N Engl J Med. 387:1430–1431.
2022.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Alicic RZ, Rooney MT and Tuttle KR:
Diabetic kidney disease: Challenges, progress and possibilities.
Clin J Am Soc Nephrol. 12:2032–2045. 2017.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Qi R and Yang C: Renal tubular epithelial
cells: The neglected mediator of tubulointerstitial fibrosis after
injury. Cell Death Dis. 9(1126)2018.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Huang F, Wang Q, Guo F, Zhao Y, Ji L, An
T, Song Y, Liu Y, He Y and Qin G: FoxO1-mediated inhibition of
STAT1 alleviates tubulointerstitial fibrosis and tubule apoptosis
in diabetic kidney disease. EBioMedicine. 48:491–504.
2019.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Pandey KK, Madhry D, Ravi Kumar YS,
Malvankar S, Sapra L, Srivastava RK, Bhattacharyya S and Verma B:
Regulatory roles of tRNA-derived RNA fragments in human
pathophysiology. Mol Ther Nucleic Acids. 26:161–173.
2021.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Fagan SG, Helm M and Prehn JHM:
tRNA-derived fragments: A new class of non-coding RNA with key
roles in nervous system function and dysfunction. Prog Neurobiol.
205(102118)2021.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Zeng TY, Hua YJ, Sun CX, Zhang Y, Yang F,
Yang M, Yang Y, Li J, Huang X, Wu H, et al: Relationship between
tRNA-derived fragments and human cancers. Int J Cancer.
147:3007–3018. 2020.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Karaca E, Weitzer S, Pehlivan D, Shiraishi
H, Gogakos T, Hanada T, Jhangiani SN, Wiszniewski W, Withers M,
Campbell IM, et al: Human CLP1 mutations alter tRNA biogenesis,
affecting both peripheral and central nervous system function.
Cell. 157:636–650. 2014.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Oberbauer V and Schaefer MR: tRNA-derived
small RNAs: Biogenesis, modification, function and potential impact
on human disease development. Genes (Basel). 9(607)2018.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Khurana R, Ranches G, Schafferer S,
Lukasser M, Rudnicki M, Mayer G and Hüttenhofer A: Identification
of urinary exosomal noncoding RNAs as novel biomarkers in chronic
kidney disease. RNA. 23:142–152. 2017.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Shi H, Yu M, Wu Y, Cao Y, Li S, Qu G, Gong
J, Gan W and Zhang A: tRNA-derived fragments (tRFs) contribute to
podocyte differentiation. Biochem Biophys Res Commun. 521:1–8.
2020.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Li S, Liu Y, He X, Luo X, Shi H, Qu G, Wen
X, Gan W, Wang J and Zhang A: tRNA-Derived fragments in podocytes
with Adriamycin-induced injury reveal the potential mechanism of
idiopathic nephrotic syndrome. Biomed Res Int.
2020(7826763)2020.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Luo C, Zhou S, Zhou Z, Liu Y, Yang L, Liu
J, Zhang Y, Li H, Liu Y, Hou FF and Zhou L: Wnt9a promotes renal
fibrosis by accelerating cellular senescence in tubular epithelial
cells. J Am Soc Nephrol. 29:1238–1256. 2018.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Kilkenny C, Browne W, Cuthill IC, Emerson
M and Altman DG: NC3Rs Reporting Guidelines Working Group. Animal
Research: Reporting of in vivo experiments guidelines. Br J
Pharmacol. 160:1577–1579. 2010.PubMed/NCBI View
Article : Google Scholar
|
|
16
|
National Institutes of Health (NIH): Guide
for the Care and Use of Laboratory Animals. In: National Research
Council (US) Committee for the Update of the Guide for the Care and
Use of Laboratory Animals. 7th Edition. National Academy Press,
Washington, DC, 1996.
|
|
17
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) Method. Methods. 25:402–408.
2001.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Ji JL, Zhao YJ, Na C, Yang M, Zhu X, Shi
H, Gan W and Zhang A: Connexin 43-autophagy loop in the podocyte
injury of diabetic nephropathy. Int J Mol Med. 44:1781–1788.
2019.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Peng F, Gong W, Li S, Yin B, Zhao C, Liu
W, Chen X, Luo C, Huang Q, Chen T, et al: circRNA_010383 Acts as a
Sponge for miR-135a and its downregulated expression contributes to
renal fibrosis in diabetic nephropathy. Diabetes. 70:603–615.
2021.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Liu XQ, Jiang L, Lei L, Nie ZY, Zhu W,
Wang S, Zeng HX, Zhang SQ, Zhang Q, Yard B and Wu YG: Carnosine
alleviates diabetic nephropathy by targeting GNMT, a key enzyme
mediating renal inflammation and fibrosis. Clin Sci (Lond).
134:3175–3193. 2020.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Wang XX, Wang D, Luo Y, Myakala K,
Dobrinskikh E, Rosenberg AZ, Levi J, Kopp JB, Field A, Hill A, et
al: FXR/TGR5 dual agonist prevents progression of nephropathy in
diabetes and obesity. J Am Soc Nephrol. 29:118–137. 2018.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Liu Y: Cellular and molecular mechanisms
of renal fibrosis. Nat Rev Nephrol. 7:684–696. 2011.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Yu X, Xie Y, Zhang S, Song X, Xiao B and
Yan Z: tRNA-derived fragments: Mechanisms underlying their
regulation of gene expression and potential applications as
therapeutic targets in cancers and virus infections. Theranostics.
11:461–469. 2021.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Tuttle KR, Agarwal R, Alpers CE, Bakris
GL, Brosius FC, Kolkhof P and Uribarri J: Molecular mechanisms and
therapeutic targets for diabetic kidney disease. Kidney Int.
102:248–260. 2022.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Nellaiappan K, Preeti K, Khatri DK and
Singh SB: Diabetic complications: An update on pathobiology and
therapeutic strategies. Curr Diabetes Rev.
18(e030821192146)2022.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Xu Z, Zhang M, Wang Y, Chen R, Xu S, Sun
X, Yang Y, Lin Z, Wang S and Huang H: Gentiopicroside ameliorates
diabetic renal tubulointerstitial fibrosis via inhibiting the
AT1R/CK2/NF-κB pathway. Front Pharmacol. 13(848915)2022.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Martens-Uzunova ES, Olvedy M and Jenster
G: Beyond microRNA-novel RNAs derived from small non-coding RNA and
their implication in cancer. Cancer Lett. 340:201–211.
2013.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Wang Y, Weng Q, Ge J, Zhang X, Guo J and
Ye G: tRNA-derived small RNAs: Mechanisms and potential roles in
cancers. Genes Dis. 9:1431–1442. 2022.PubMed/NCBI View Article : Google Scholar
|
|
29
|
George S, Rafi M, Aldarmaki M, ElSiddig M,
Al Nuaimi M and Amiri KMA: tRNA derived small RNAs-Small players
with big roles. Front Genet. 13(997780)2022.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Lu Z, Su K, Wang X, Zhang M, Ma S, Li H
and Qiu Y: Expression profiles of tRNA-derived small rnas and their
potential roles in primary nasopharyngeal carcinoma. Front Mol
Biosci. 8(780621)2021.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Li S, Xu Z and Sheng J: tRNA-derived small
RNA: A novel regulatory small non-coding RNA. Genes (Basel).
9(246)2018.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Yu M, Lu B, Zhang J, Ding J, Liu P and Lu
Y: tRNA-derived RNA fragments in cancer: Current status and future
perspectives. J Hematol Oncol. 13(121)2020.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Guzzi N and Bellodi C: Novel insights into
the emerging roles of tRNA-derived fragments in mammalian
development. RNA Biol. 17:1214–1222. 2020.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Zhang Y, Bi Z, Dong X, Yu M, Wang K and
Song X, Xie L and Song X: tRNA-derived fragments: tRF-Gly-CCC-046,
tRF-Tyr-GTA-010 and tRF-Pro-TGG-001 as novel diagnostic biomarkers
for breast cancer. Thorac Cancer. 12:2314–2323. 2021.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Li D, Zhang H, Wu X, Dai Q, Tang S, Liu Y,
Yang S and Zhang W: Role of tRNA derived fragments in renal
ischemia-reperfusion injury. Ren Fail. 44:815–825. 2022.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Lee YS, Shibata Y, Malhotra A and Dutta A:
A novel class of small RNAs: tRNA-derived RNA fragments (tRFs).
Genes Dev. 23:2639–2649. 2009.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Pan Q, Han T and Li G: Novel insights into
the roles of tRNA-derived small RNAs. RNA Biol. 18:2157–2167.
2021.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Soares AR and Santos M: Discovery and
function of transfer RNA-derived fragments and their role in
disease. Wiley Interdiscip Rev RNA. 8(e1423)2017.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Zhu P, Lu J, Zhi X, Zhou Y, Wang X, Wang
C, Gao Y, Zhang X, Yu J, Sun Y and Zhou P: tRNA-derived fragment
tRFLys-CTT-010 promotes triple-negative breast cancer progression
by regulating glucose metabolism via G6PC. Carcinogenesis.
42:1196–1207. 2021.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Zhong F, Hu Z, Jiang K, Lei B, Wu Z, Yuan
G, Luo H, Dong C, Tang B, Zheng C, et al: Complement C3 activation
regulates the production of tRNA-derived fragments Gly-tRFs and
promotes alcohol-induced liver injury and steatosis. Cell Res.
29:548–561. 2019.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Haussecker D, Huang Y, Lau A, Parameswaran
P, Fire AZ and Kay MA: Human tRNA-derived small RNAs in the global
regulation of RNA silencing. RNA. 16:673–695. 2010.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Shen Y, Yu X, Zhu L, Li T, Yan Z and Guo
J: Transfer RNA-derived fragments and tRNA halves: Biogenesis,
biological functions and their roles in diseases. J Mol Med (Berl).
96:1167–1176. 2018.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Han Y, Peng Y, Liu S, Wang X, Cai C, Guo
C, Chen Y, Gao L, Huang Q, He M, et al: tRF3008A suppresses the
progression and metastasis of colorectal cancer by destabilizing
FOXK1 in an AGO-dependent manner. J Exp Clin Cancer Res.
41(32)2022.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Goodarzi H, Liu X, Nguyen HC, Zhang S,
Fish L and Tavazoie SF: Endogenous tRNA-derived fragments suppress
breast cancer progression via YBX1 displacement. Cell. 161:790–802.
2015.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Fabregat I, Moreno-Caceres J, Sanchez A,
Dooley S, Dewidar B, Giannelli G and Ten Dijke P: IT-LIVER
Consortium. TGF-β signaling and liver disease. FEBS J.
283:2219–2232. 2016.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Lear TB, Lockwood KC, Larsen M, Tuncer F,
Kennerdell JR, Morse C, Valenzi E, Tabib T, Jurczak MJ, Kass DJ, et
al: Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase
involved in systemic sclerosis. J Biol Chem. 295:4171–4180.
2020.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Li L, Kang H, Zhang Q, D'Agati VD,
Al-Awqati Q and Lin F: FoxO3 activation in hypoxic tubules prevents
chronic kidney disease. J Clin Invest. 129:2374–2389.
2019.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Herman-Edelstein M, Scherzer P, Tobar A,
Levi M and Gafter U: Altered renal lipid metabolism and renal lipid
accumulation in human diabetic nephropathy. J Lipid Res.
55:561–572. 2014.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Wang W, Luo Y, Yang S, Zeng M, Zhang S,
Liu J, Han Y, Liu Y, Zhu X, Wu H, et al: Ectopic lipid
accumulation: Potential role in tubular injury and inflammation in
diabetic kidney disease. Clin Sci (Lond). 132:2407–2422.
2018.PubMed/NCBI View Article : Google Scholar
|
|
50
|
Chen X, Han Y, Gao P, Yang M, Xiao L,
Xiong X, Zhao H, Tang C, Chen G, Zhu X, et al: Disulfide-bond A
oxidoreductase-like protein protects against ectopic fat deposition
and lipid-related kidney damage in diabetic nephropathy. Kidney
Int. 95:880–895. 2019.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Falconi M, Giangrossi M, Zabaleta ME, Wang
J, Gambini V, Tilio M, Bencardino D, Occhipinti S, Belletti B,
Laudadio E, et al: A novel 3'-tRNAGlu-derived fragment
acts as a tumor suppressor in breast cancer by targeting nucleolin.
FASEB J. 33:13228–13240. 2019.PubMed/NCBI View Article : Google Scholar
|
|
52
|
Livingston MJ, Shu S, Fan Y, Li Z, Jiao Q,
Yin XM, Venkatachalam MA and Dong Z: Tubular cells produce FGF2 via
autophagy after acute kidney injury leading to fibroblast
activation and renal fibrosis. Autophagy. 1-22:2022.PubMed/NCBI View Article : Google Scholar : (Epub ahead of
print).
|
|
53
|
Majumder S, Ren L, Pushpakumar S and Sen
U: Hydrogen sulphide mitigates homocysteine-induced apoptosis and
matrix remodelling in mesangial cells through Akt/FOXO1 signalling
cascade. Cell Signal. 61:66–77. 2019.PubMed/NCBI View Article : Google Scholar
|
|
54
|
Tang C, Han H, Yan M, Zhu S, Liu J, Liu Z,
He L, Tan J, Liu Y, Liu H, et al: PINK1-PRKN/PARK2 pathway of
mitophagy is activated to protect against renal
ischemia-reperfusion injury. Autophagy. 14:880–897. 2018.PubMed/NCBI View Article : Google Scholar
|
|
55
|
Kong D, Zhang Z, Chen L, Huang W, Zhang F,
Wang L, Wang Y, Cao P and Zheng S: Curcumin blunts
epithelial-mesenchymal transition of hepatocytes to alleviate
hepatic fibrosis through regulating oxidative stress and autophagy.
Redox Biol. 36(101600)2020.PubMed/NCBI View Article : Google Scholar
|
|
56
|
Rao P, Qiao X, Hua W, Hu M, Tahan M, Chen
T, Yu H, Ren X, Cao Q, Wang Y, et al: Promotion of
β-catenin/forkhead box protein O signaling mediates epithelial
repair in kidney injury. Am J Pathol. 191:993–1009. 2021.PubMed/NCBI View Article : Google Scholar
|
|
57
|
Qiao X, Rao P, Zhang Y, Liu L, Pang M,
Wang H, Hu M, Tian X, Zhang J, Zhao Y, et al: Redirecting TGF-β
Signaling through the β-Catenin/Foxo complex prevents kidney
fibrosis. J Am Soc Nephrol. 29:557–570. 2018.PubMed/NCBI View Article : Google Scholar
|
|
58
|
Ma MKM, Yung S and Chan TM: mTOR
inhibition and kidney diseases. Transplantation. 102 (2S Suppl
1):S32–S40. 2018.PubMed/NCBI View Article : Google Scholar
|
|
59
|
Jimenez-Uribe AP, Gomez-Sierra T,
Aparicio-Trejo OE, Orozco-Ibarra M and Pedraza-Chaverri J:
Backstage players of fibrosis: NOX4, mTOR, HDAC and S1P; companions
of TGF-β. Cell Signal. 87(110123)2021.PubMed/NCBI View Article : Google Scholar
|
|
60
|
Malik S, Suchal K, Khan SI, Bhatia J,
Kishore K, Dinda AK and Arya DS: Apigenin ameliorates
streptozotocin-induced diabetic nephropathy in rats via
MAPK-NF-κB-TNF-α and TGF-β1-MAPK-fibronectin pathways. Am J Physiol
Renal Physiol. 313:F414–F422. 2017.PubMed/NCBI View Article : Google Scholar
|
|
61
|
Su J, Morgani SM, David CJ, Wang Q, Er EE,
Huang YH, Basnet H, Zou Y, Shu W, Soni RK, et al: TGF-β
orchestrates fibrogenic and developmental EMTs via the RAS effector
RREB1. Nature. 577:566–571. 2020.PubMed/NCBI View Article : Google Scholar
|
