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Review

Mucormycosis diagnosis revisited: Current and emerging diagnostic methodologies for the invasive fungal infection (Review)

  • Authors:
    • Deepa Ponnaiyan
    • C.M. Anitha
    • P.S.G. Prakash
    • Sangeetha Subramanian
    • Roshan R. Rughwani
    • Gayathri Kumar
    • Sowmya Reddy Nandipati
  • View Affiliations / Copyright

    Affiliations: Department of Periodontics, SRM Dental College, Ramapuram, Chennai, Tamil Nadu 600089, Republic of India, Department of Periodontics, SRM Kattankulathur Dental College, Chengalpettu, Kanchipuram, Tamil Nadu 603203, Republic of India
  • Article Number: 47
    |
    Published online on: December 5, 2022
       https://doi.org/10.3892/etm.2022.11746
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Abstract

Mucormycosis, which is a life threatening condition, is one of the side effects experienced by post‑COVID‑19 patients. Early identification and timely treatment are essential to stop the dissemination of the disease, since invasive mucormycosis has a very high fatality rate and significant disease dispersion. Conventional diagnostic techniques, including clinical diagnosis, serology, histopathology and radiology, have limitations in diagnosing the disease at an early stage. This warrants the need for advanced diagnostic tools such as nucleic acid diagnostics, advanced serological tests (ELISpot), PCR (pan‑Mucorale test) and multiplex PCR. These techniques have been introduced to identify this invasive fungal infection at an incipient stage, thereby helping clinicians to prevent adverse outcomes. The use of biosensors and micro‑needle based diagnostic methodologies will pave the way for devising more point‑of‑care tests that can be employed for the detection of mucormycosis at an incipient stage. The present review discusses the current techniques available and their drawbacks, and the usefulness of advanced diagnostic tools. Furthermore, the possibility of using future diagnostic methods for the diagnosis of mucormycosis is highlighted.
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Copy and paste a formatted citation
Spandidos Publications style
Ponnaiyan D, Anitha C, Prakash P, Subramanian S, Rughwani RR, Kumar G and Nandipati SR: Mucormycosis diagnosis revisited: Current and emerging diagnostic methodologies for the invasive fungal infection (Review). Exp Ther Med 25: 47, 2023.
APA
Ponnaiyan, D., Anitha, C., Prakash, P., Subramanian, S., Rughwani, R.R., Kumar, G., & Nandipati, S.R. (2023). Mucormycosis diagnosis revisited: Current and emerging diagnostic methodologies for the invasive fungal infection (Review). Experimental and Therapeutic Medicine, 25, 47. https://doi.org/10.3892/etm.2022.11746
MLA
Ponnaiyan, D., Anitha, C., Prakash, P., Subramanian, S., Rughwani, R. R., Kumar, G., Nandipati, S. R."Mucormycosis diagnosis revisited: Current and emerging diagnostic methodologies for the invasive fungal infection (Review)". Experimental and Therapeutic Medicine 25.1 (2023): 47.
Chicago
Ponnaiyan, D., Anitha, C., Prakash, P., Subramanian, S., Rughwani, R. R., Kumar, G., Nandipati, S. R."Mucormycosis diagnosis revisited: Current and emerging diagnostic methodologies for the invasive fungal infection (Review)". Experimental and Therapeutic Medicine 25, no. 1 (2023): 47. https://doi.org/10.3892/etm.2022.11746
Copy and paste a formatted citation
x
Spandidos Publications style
Ponnaiyan D, Anitha C, Prakash P, Subramanian S, Rughwani RR, Kumar G and Nandipati SR: Mucormycosis diagnosis revisited: Current and emerging diagnostic methodologies for the invasive fungal infection (Review). Exp Ther Med 25: 47, 2023.
APA
Ponnaiyan, D., Anitha, C., Prakash, P., Subramanian, S., Rughwani, R.R., Kumar, G., & Nandipati, S.R. (2023). Mucormycosis diagnosis revisited: Current and emerging diagnostic methodologies for the invasive fungal infection (Review). Experimental and Therapeutic Medicine, 25, 47. https://doi.org/10.3892/etm.2022.11746
MLA
Ponnaiyan, D., Anitha, C., Prakash, P., Subramanian, S., Rughwani, R. R., Kumar, G., Nandipati, S. R."Mucormycosis diagnosis revisited: Current and emerging diagnostic methodologies for the invasive fungal infection (Review)". Experimental and Therapeutic Medicine 25.1 (2023): 47.
Chicago
Ponnaiyan, D., Anitha, C., Prakash, P., Subramanian, S., Rughwani, R. R., Kumar, G., Nandipati, S. R."Mucormycosis diagnosis revisited: Current and emerging diagnostic methodologies for the invasive fungal infection (Review)". Experimental and Therapeutic Medicine 25, no. 1 (2023): 47. https://doi.org/10.3892/etm.2022.11746
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