|
1
|
Kumar B, Garcia M, Weng L, Jung X,
Murakami JL, Hu X, McDonald T, Lin A, Kumar AR, DiGiusto DL, et al:
Acute myeloid leukemia transforms the bone marrow niche into a
leukemia-permissive microenvironment through exosome secretion.
Leukemia. 32:575–587. 2018.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Hanahan D and Coussens LM: Accessories to
the crime: Functions of cells recruited to the tumor
microenvironment. Cancer Cell. 21:309–322. 2012.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Uy GL, Rettig MP, Motabi IH, McFarland K,
Trinkaus KM, Hladnik LM, Kulkarni S, Abboud CN, Cashen AF,
Stockerl-Goldstein KE, et al: A phase 1/2 study of
chemosensitization with the CXCR4 antagonist plerixafor in relapsed
or refractory acute myeloid leukemia. Blood. 119:3917–3924.
2012.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Schmid D, Woehs F, Svoboda M, Thalhammer
T, Chiba P and Moeslinger T: Aqueous extracts of Cimicifuga
racemosa and phenolcarboxylic constituents inhibit production of
proinflammatory cytokines in LPS-stimulated human whole blood. Can
J Physiol Pharmacol. 87:963–972. 2009.PubMed/NCBI View
Article : Google Scholar
|
|
5
|
Sakurai N, Kozuka M, Tokuda H, Mukainaka
T, Enjo F, Nishino H, Nagai M, Sakurai Y and Lee KH: Cancer
preventive agents. Part 1: Chemopreventive potential of cimigenol,
cimigenol-3,15-dione, and related compounds. Bioorg Med Chem.
13:1403–1408. 2005.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Jöhrer K, Stuppner H, Greil R and Çiçek
SS: Structure-guided identification of black cohosh (actaea
racemosa) triterpenoids with in vitro activity against multiple
myeloma. Molecules. 25(766)2020.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Li X, Wang W, Fan Y, Wei Y, Yu LQ, Wei JF
and Wang YF: Anticancer efficiency of cycloartane triterpenoid
derivatives isolated from Cimicifuga yunnanensis Hsiao on
triple-negative breast cancer cells. Cancer Manag Res.
10:6715–6729. 2018.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408.
2001.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Zaitseva L, Murray MY, Shafat MS, Lawes
MJ, MacEwan DJ, Bowles KM and Rushworth SA: Ibrutinib inhibits
SDF1/CXCR4 mediated migration in AML. Oncotarget. 5:9930–9938.
2014.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Peled A and Tavor S: Role of CXCR4 in the
pathogenesis of acute myeloid leukemia. Theranostics. 3:34–39.
2013.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Sugiyama T, Kohara H, Noda M and Nagasawa
T: Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4
chemokine signaling in bone marrow stromal cell niches. Immunity.
25:977–988. 2006.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Konoplev S, Rassidakis GZ, Estey E,
Kantarjian H, Liakou CI, Huang X, Xiao L, Andreeff M, Konopleva M
and Medeiros LJ: Overexpression of CXCR4 predicts adverse overall
and event-free survival in patients with unmutated FLT3 acute
myeloid leukemia with normal karyotype. Cancer. 109:1152–1156.
2007.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Jiang Z, Zhou W, Guan S, Wang J and Liang
Y: Contribution of SDF-1α/CXCR4 signaling to brain development and
glioma progression. Neurosignals. 21:240–258. 2013.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Greenbaum A, Hsu YM, Day RB, Schuettpelz
LG, Christopher MJ, Borgerding JN, Nagasawa T and Link DC: CXCL12
in early mesenchymal progenitors is required for haematopoietic
stem-cell maintenance. Nature. 495:227–230. 2013.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Sipkins DA, Wei X, Wu JW, Runnels JM, Côté
D, Means TK, Luster AD, Scadden DT and Lin CP: In vivo imaging of
specialized bone marrow endothelial microdomains for tumour
engraftment. Nature. 435:969–973. 2005.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Tavor S, Eisenbach M, Jacob-Hirsch J,
Golan T, Petit I, Benzion K, Kay S, Baron S, Amariglio N, Deutsch
V, et al: The CXCR4 antagonist AMD3100 impairs survival of human
AML cells and induces their differentiation. Leukemia.
22:2151–5158. 2008.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Avigdor A, Goichberg P, Shivtiel S, Dar A,
Peled A, Samira S, Kollet O, Hershkoviz R, Alon R, Hardan I, et al:
CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of
human CD34+ stem/progenitor cells to bone marrow. Blood.
103:2981–2989. 2004.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Zhan T, Cao C, Li L, Gu N, Civin CI and
Zhan X: MIM regulates the trafficking of bone marrow cells via
modulating surface expression of CXCR4. Leukemia. 30:1327–1334.
2016.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Zeng Z, Shi YX, Samudio IJ, Wang RY, Ling
X, Frolova O, Levis M, Rubin JB, Negrin RR, Estey EH, et al:
Targeting the leukemia microenvironment by CXCR4 inhibition
overcomes resistance to kinase inhibitors and chemotherapy in AML.
Blood. 113:6215–6224. 2009.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Galsky MD, Vogelzang NJ, Conkling P,
Raddad E, Polzer J, Roberson S, Stille JR, Saleh M and Thornton D:
A phase I trial of LY2510924, a CXCR4 peptide antagonist, in
patients with advanced cancer. Clin Cancer Res. 20:3581–3588.
2014.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Karpova D, Bräuninger S, Wiercinska E,
Krämer A, Stock B, Graff J, Martin H, Wach A, Escot C, Douglas G,
et al: Mobilization of hematopoietic stem cells with the novel
CXCR4 antagonist POL6326 (balixafortide) in healthy
volunteers-results of a dose escalation trial. J Transl Med.
15(2)2017.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Hoellenriegel J, Zboralski D, Maasch C,
Rosin NY, Wierda WG, Keating MJ, Kruschinski A and Burger JA: The
spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with
chronic lymphocytic leukemia cell motility and causes
chemosensitization. Blood. 123:1032–1039. 2014.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Gros SJ, Graeff H, Drenckhan A, Kurschat
N, Blessmann M, Rawnaq T and Izbicki JR: CXCR4/SDF-1α-mediated
chemotaxis in an in vivo model of metastatic esophageal carcinoma.
In Vivo. 26:711–718. 2012.PubMed/NCBI
|
|
24
|
Zhu H, Sun Q, Tan C, Xu M, Dai Z, Wang Z,
Fan J and Zhou J: Tacrolimus promotes hepatocellular carcinoma and
enhances CXCR4/SDF-1α expression in vivo. Mol Med Rep.
10:585–592. 2014.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Holt RU, Fagerli UM, Baykov V, Rø TB, Hov
H, Waage A, Sundan A and Børset M: Hepatocyte growth factor
promotes migration of human myeloma cells. Haematologica.
93:619–622. 2008.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Fan X, Chen X, Feng Q, Peng K, Wu Q,
Passerini AG, Simon SI and Sun C: Downregulation of GATA6 in
mTOR-inhibited human aortic endothelial cells: Effects on
TNF-α-induced VCAM-1 expression and monocytic cell adhesion. Am J
Physiol Heart Circ Physiol. 316:H408–H420. 2019.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Wagner JA, Rosario M, Romee R,
Berrien-Elliott MM, Schneider SE, Leong JW, Sullivan RP, Jewell BA,
Becker-Hapak M, Schappe T, et al: CD56bright NK cells exhibit
potent antitumor responses following IL-15 priming. J Clin Invest.
127:4042–4058. 2017.PubMed/NCBI View
Article : Google Scholar
|
|
28
|
Chen W, Drakos E, Grammatikakis I,
Schlette EJ, Li J, Leventaki V, Staikou-Drakopoulou E, Patsouris E,
Panayiotidis P, Medeiros LJ and Rassidakis GZ: mTOR signaling is
activated by FLT3 kinase and promotes survival of FLT3-mutated
acute myeloid leukemia cells. Mol Cancer. 9(292)2010.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Marzec M, Kasprzycka M, Liu X, El-Salem M,
Halasa K, Raghunath PN, Bucki R, Wlodarski P and Wasik MA:
Oncogenic tyrosine kinase NPM/ALK induces activation of the
rapamycin-sensitive mTOR signaling pathway. Oncogene. 26:5606–5614.
2007.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Watanabe M, Hisatake M and Fujimori K:
Fisetin suppresses lipid accumulation in mouse adipocytic 3T3-L1
cells by repressing GLUT4-mediated glucose uptake through
inhibition of mTOR-C/EBPα signaling. J Agric Food Chem.
63:4979–4987. 2015.PubMed/NCBI View Article : Google Scholar
|
