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Cyclooxygenase‑2 contributes to the hypoxia‑induced aggravation of the neuroinflammation response stimulated by lipopolysaccharide in microglia

  • Authors:
    • Yifan Yang
    • Yanan Geng
    • Xiang Cheng
    • Jiayue Gao
    • Zibi Shi
    • Ming Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Pain Medicine, Peking University People's Hospital, Beijing 100044, P.R. China, Department of Brain Plasticity, Beijing Institute of Basic Medical Sciences, Beijing 100850, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 123
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    Published online on: February 3, 2023
       https://doi.org/10.3892/etm.2023.11822
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Abstract

Hypoxia and neuroinflammation are key risk factors involved in various pathophysiological neural disorders. Hypoxia can aggravate neuroinflammation in vitro and in vivo; however, the underlying mechanisms remain unknown. In the present study, hypoxia [either 3 or 1% oxygen (O2)] increased lipopolysaccharide (LPS)‑induced expression of the IL‑6, IL‑1β and TNF‑α proinflammatory cytokines in BV2 cells. At the molecular level, both hypoxia and FG‑4592, an hypoxia inducible factor 1 pathway activator, effectively induced cyclooxygenase‑2 (COX‑2) expression. The COX‑2 inhibitor celecoxib significantly reduced the expression of cytokines induced by LPS under hypoxic conditions. Additionally, the administration of celecoxib inhibited the activation of microglia as well as cytokine expression in mice administered with hypoxia exposure and LPS injection. The present data demonstrated that COX‑2 is involved in the hypoxia‑induced aggravation of neuroinflammation stimulated by LPS.
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Copy and paste a formatted citation
Spandidos Publications style
Yang Y, Geng Y, Cheng X, Gao J, Shi Z and Zhao M: Cyclooxygenase‑2 contributes to the hypoxia‑induced aggravation of the neuroinflammation response stimulated by lipopolysaccharide in microglia. Exp Ther Med 25: 123, 2023.
APA
Yang, Y., Geng, Y., Cheng, X., Gao, J., Shi, Z., & Zhao, M. (2023). Cyclooxygenase‑2 contributes to the hypoxia‑induced aggravation of the neuroinflammation response stimulated by lipopolysaccharide in microglia. Experimental and Therapeutic Medicine, 25, 123. https://doi.org/10.3892/etm.2023.11822
MLA
Yang, Y., Geng, Y., Cheng, X., Gao, J., Shi, Z., Zhao, M."Cyclooxygenase‑2 contributes to the hypoxia‑induced aggravation of the neuroinflammation response stimulated by lipopolysaccharide in microglia". Experimental and Therapeutic Medicine 25.3 (2023): 123.
Chicago
Yang, Y., Geng, Y., Cheng, X., Gao, J., Shi, Z., Zhao, M."Cyclooxygenase‑2 contributes to the hypoxia‑induced aggravation of the neuroinflammation response stimulated by lipopolysaccharide in microglia". Experimental and Therapeutic Medicine 25, no. 3 (2023): 123. https://doi.org/10.3892/etm.2023.11822
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Y, Geng Y, Cheng X, Gao J, Shi Z and Zhao M: Cyclooxygenase‑2 contributes to the hypoxia‑induced aggravation of the neuroinflammation response stimulated by lipopolysaccharide in microglia. Exp Ther Med 25: 123, 2023.
APA
Yang, Y., Geng, Y., Cheng, X., Gao, J., Shi, Z., & Zhao, M. (2023). Cyclooxygenase‑2 contributes to the hypoxia‑induced aggravation of the neuroinflammation response stimulated by lipopolysaccharide in microglia. Experimental and Therapeutic Medicine, 25, 123. https://doi.org/10.3892/etm.2023.11822
MLA
Yang, Y., Geng, Y., Cheng, X., Gao, J., Shi, Z., Zhao, M."Cyclooxygenase‑2 contributes to the hypoxia‑induced aggravation of the neuroinflammation response stimulated by lipopolysaccharide in microglia". Experimental and Therapeutic Medicine 25.3 (2023): 123.
Chicago
Yang, Y., Geng, Y., Cheng, X., Gao, J., Shi, Z., Zhao, M."Cyclooxygenase‑2 contributes to the hypoxia‑induced aggravation of the neuroinflammation response stimulated by lipopolysaccharide in microglia". Experimental and Therapeutic Medicine 25, no. 3 (2023): 123. https://doi.org/10.3892/etm.2023.11822
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