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Tobacco nicotine promotes TRAIL resistance in lung cancer through SNHG5

  • Authors:
    • Xin Xiao
    • Juan Xu
    • Xiaoan Sheng
    • Chao Wang
    • Juanjuan Dong
    • Xianfeng Shi
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Chaohu Hospital Affiliated to Anhui Medical University, Chaohu, Anhui 231500, P.R. China, Department of Oncology, Chaohu Hospital Affiliated to Anhui Medical University, Chaohu, Anhui 231500, P.R. China
    Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 131
    |
    Published online on: February 10, 2023
       https://doi.org/10.3892/etm.2023.11830
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Abstract

Tobacco nicotine use is carcinogenic and a well‑known risk factor for lung cancer. However, whether tobacco nicotine can induce drug resistance in lung cancer is not clear. The objective of the present study was to identify the TNF‑related apoptosis‑inducing ligand (TRAIL) resistance of long noncoding RNAs (lncRNAs) that are differentially expressed in smokers and nonsmokers with lung cancer. The results suggested that the nicotine upregulated small nucleolar RNA host gene 5 (SNHG5) and markedly decreased the levels of cleaved caspase‑3. The present study found that cytoplasm lncRNA SNHG5 overexpression was associated with TRAIL resistance in lung cancer and that SNHG5 can interact with X‑linked inhibitor of apoptosis protein to promote TRAIL resistance. Therefore, nicotine promoted TRAIL resistance in lung cancer through SNHG5/X‑linked inhibitor of apoptosis protein.
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Copy and paste a formatted citation
Spandidos Publications style
Xiao X, Xu J, Sheng X, Wang C, Dong J and Shi X: Tobacco nicotine promotes TRAIL resistance in lung cancer through SNHG5. Exp Ther Med 25: 131, 2023.
APA
Xiao, X., Xu, J., Sheng, X., Wang, C., Dong, J., & Shi, X. (2023). Tobacco nicotine promotes TRAIL resistance in lung cancer through SNHG5. Experimental and Therapeutic Medicine, 25, 131. https://doi.org/10.3892/etm.2023.11830
MLA
Xiao, X., Xu, J., Sheng, X., Wang, C., Dong, J., Shi, X."Tobacco nicotine promotes TRAIL resistance in lung cancer through SNHG5". Experimental and Therapeutic Medicine 25.3 (2023): 131.
Chicago
Xiao, X., Xu, J., Sheng, X., Wang, C., Dong, J., Shi, X."Tobacco nicotine promotes TRAIL resistance in lung cancer through SNHG5". Experimental and Therapeutic Medicine 25, no. 3 (2023): 131. https://doi.org/10.3892/etm.2023.11830
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao X, Xu J, Sheng X, Wang C, Dong J and Shi X: Tobacco nicotine promotes TRAIL resistance in lung cancer through SNHG5. Exp Ther Med 25: 131, 2023.
APA
Xiao, X., Xu, J., Sheng, X., Wang, C., Dong, J., & Shi, X. (2023). Tobacco nicotine promotes TRAIL resistance in lung cancer through SNHG5. Experimental and Therapeutic Medicine, 25, 131. https://doi.org/10.3892/etm.2023.11830
MLA
Xiao, X., Xu, J., Sheng, X., Wang, C., Dong, J., Shi, X."Tobacco nicotine promotes TRAIL resistance in lung cancer through SNHG5". Experimental and Therapeutic Medicine 25.3 (2023): 131.
Chicago
Xiao, X., Xu, J., Sheng, X., Wang, C., Dong, J., Shi, X."Tobacco nicotine promotes TRAIL resistance in lung cancer through SNHG5". Experimental and Therapeutic Medicine 25, no. 3 (2023): 131. https://doi.org/10.3892/etm.2023.11830
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