Open Access

Tobacco nicotine promotes TRAIL resistance in lung cancer through SNHG5

  • Authors:
    • Xin Xiao
    • Juan Xu
    • Xiaoan Sheng
    • Chao Wang
    • Juanjuan Dong
    • Xianfeng Shi
  • View Affiliations

  • Published online on: February 10, 2023     https://doi.org/10.3892/etm.2023.11830
  • Article Number: 131
  • Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Tobacco nicotine use is carcinogenic and a well‑known risk factor for lung cancer. However, whether tobacco nicotine can induce drug resistance in lung cancer is not clear. The objective of the present study was to identify the TNF‑related apoptosis‑inducing ligand (TRAIL) resistance of long noncoding RNAs (lncRNAs) that are differentially expressed in smokers and nonsmokers with lung cancer. The results suggested that the nicotine upregulated small nucleolar RNA host gene 5 (SNHG5) and markedly decreased the levels of cleaved caspase‑3. The present study found that cytoplasm lncRNA SNHG5 overexpression was associated with TRAIL resistance in lung cancer and that SNHG5 can interact with X‑linked inhibitor of apoptosis protein to promote TRAIL resistance. Therefore, nicotine promoted TRAIL resistance in lung cancer through SNHG5/X‑linked inhibitor of apoptosis protein.
View Figures
View References

Related Articles

Journal Cover

March-2023
Volume 25 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Xiao X, Xu J, Sheng X, Wang C, Dong J and Shi X: Tobacco nicotine promotes TRAIL resistance in lung cancer through SNHG5. Exp Ther Med 25: 131, 2023.
APA
Xiao, X., Xu, J., Sheng, X., Wang, C., Dong, J., & Shi, X. (2023). Tobacco nicotine promotes TRAIL resistance in lung cancer through SNHG5. Experimental and Therapeutic Medicine, 25, 131. https://doi.org/10.3892/etm.2023.11830
MLA
Xiao, X., Xu, J., Sheng, X., Wang, C., Dong, J., Shi, X."Tobacco nicotine promotes TRAIL resistance in lung cancer through SNHG5". Experimental and Therapeutic Medicine 25.3 (2023): 131.
Chicago
Xiao, X., Xu, J., Sheng, X., Wang, C., Dong, J., Shi, X."Tobacco nicotine promotes TRAIL resistance in lung cancer through SNHG5". Experimental and Therapeutic Medicine 25, no. 3 (2023): 131. https://doi.org/10.3892/etm.2023.11830