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Article Open Access

Platelet‑related parameters as potential biomarkers for the prognosis of sepsis

  • Authors:
    • Chao Zhang
    • Xueyi Shang
    • Yuan Yuan
    • Yan Li
  • View Affiliations / Copyright

    Affiliations: Hebei Key Laboratory of Nerve Injury and Repair, Institute of Basic Medicine, Chengde Medical University, Chengde, Hebei 067000, P.R. China, Department of Critical Care Medicine, The Fifth Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100071, P.R. China, State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 133
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    Published online on: February 10, 2023
       https://doi.org/10.3892/etm.2023.11832
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Abstract

Early diagnosis and accurate prognosis are key for reducing the fatality rate and medical expenses associated with sepsis. Platelets are involved in the delayed tissue injury that occurs during sepsis. Therefore, the aim of the present study was to investigate the usefulness of platelets and associated parameters as prognostic markers of sepsis. The present study collected patient samples based on The Third International Consensus Definitions for Sepsis and Septic Shock criteria. Platelet‑associated parameters were detected by flow cytometry and their correlation with clinical scores and prognoses was analyzed. Considering the association between endothelial cells and platelet activation, levels of plasma tumor necrosis factor‑like weak inducer of apoptosis (TWEAK) and angiopoietin‑2 (Ang‑2) were analyzed by ELISA. The results showed significant differences in platelet P‑selectin expression and phosphatidylserine exposure, mitochondrial membrane potential (Mmp)‑Index values and plasma levels of TWEAK and Ang‑2 between patients and healthy controls (P<0.05). Except for P‑selectin and TWEAK levels, all parameters were correlated with clinical scores (acute physiology and chronic health evaluation II and sequential/sepsis‑related organ failure assessment). Additionally, platelet Mmp‑Index between admission and the end of therapy was only different in non‑survivors (P<0.001) and platelet phosphatidylserine exposure was significantly lower in survivors (P=0.006). Therefore, of the parameters tested, the dynamic monitoring of phosphatidylserine exposure, platelet Mmp‑Index values and plasma Ang‑2 levels had the most potential for the assessment of disease severity and clinical outcomes.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang C, Shang X, Yuan Y and Li Y: Platelet‑related parameters as potential biomarkers for the prognosis of sepsis. Exp Ther Med 25: 133, 2023.
APA
Zhang, C., Shang, X., Yuan, Y., & Li, Y. (2023). Platelet‑related parameters as potential biomarkers for the prognosis of sepsis. Experimental and Therapeutic Medicine, 25, 133. https://doi.org/10.3892/etm.2023.11832
MLA
Zhang, C., Shang, X., Yuan, Y., Li, Y."Platelet‑related parameters as potential biomarkers for the prognosis of sepsis". Experimental and Therapeutic Medicine 25.3 (2023): 133.
Chicago
Zhang, C., Shang, X., Yuan, Y., Li, Y."Platelet‑related parameters as potential biomarkers for the prognosis of sepsis". Experimental and Therapeutic Medicine 25, no. 3 (2023): 133. https://doi.org/10.3892/etm.2023.11832
Copy and paste a formatted citation
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Spandidos Publications style
Zhang C, Shang X, Yuan Y and Li Y: Platelet‑related parameters as potential biomarkers for the prognosis of sepsis. Exp Ther Med 25: 133, 2023.
APA
Zhang, C., Shang, X., Yuan, Y., & Li, Y. (2023). Platelet‑related parameters as potential biomarkers for the prognosis of sepsis. Experimental and Therapeutic Medicine, 25, 133. https://doi.org/10.3892/etm.2023.11832
MLA
Zhang, C., Shang, X., Yuan, Y., Li, Y."Platelet‑related parameters as potential biomarkers for the prognosis of sepsis". Experimental and Therapeutic Medicine 25.3 (2023): 133.
Chicago
Zhang, C., Shang, X., Yuan, Y., Li, Y."Platelet‑related parameters as potential biomarkers for the prognosis of sepsis". Experimental and Therapeutic Medicine 25, no. 3 (2023): 133. https://doi.org/10.3892/etm.2023.11832
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