Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
April-2023 Volume 25 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2023 Volume 25 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Role of arterial hypertension and angiotensin II in chronic kidney disease (Review)

  • Authors:
    • Minela Aida Maranduca
    • Andreea Clim
    • Alin Constantin Pinzariu
    • Cristian Statescu
    • Radu Andy Sascau
    • Daniela Maria Tanase
    • Dragomir Nicolae Serban
    • Daniel Constantin Branisteanu
    • Daciana Elena Branisteanu
    • Bogdan Huzum
    • Ionela Lacramioara Serban
  • View Affiliations / Copyright

    Affiliations: Department of Physiology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Internal Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Internal Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Ophthalmology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Dermatology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania
  • Article Number: 153
    |
    Published online on: February 16, 2023
       https://doi.org/10.3892/etm.2023.11852
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Chronic kidney disease (CKD) is a major public health issue, due to its effect on the quality of life of patients and by the huge costs incurred in treating this disease. It is an irreversible process, characterized by the progressive loss of functional nephrons. CKD ultimately requires the support of renal function by dialysis or even renal transplantation. It has a multiple etiology, but the most common causes remain arterial hypertension and diabetes. High arterial blood pressure affects the target organs (kidneys) and this leads to a vicious circle involved in maintaining high blood pressure. Arterial hypertension is closely related to the renal pathology of CKD. The result of excessive activation of the renin angiotensin system (RAS) is increased angiotensin II (Ang II), which acts upon the systemic circulation and especially upon the kidneys. The outcome is high blood pressure and also the stimulation of proinflammatory and profibrotic effects in the kidneys. Collectively these ultimately lead to CKD. The aim of this review was to provide a brief overview of the pathophysiological associations between CKD, arterial hypertension, and Ang II.
View Figures

Figure 1

Figure 2

View References

1 

Burke M, Pabbidi MR, Farley J and Roman RJ: Molecular mechanisms of renal blood flow autoregulation. Curr Vasc Pharmacol. 12:845–858. 2014.PubMed/NCBI View Article : Google Scholar

2 

Touyz RM: Molecular and cellular mechanisms in vascular injury in hypertension: Role of angiotensin II. Curr Opin Nephrol Hypertens. 14:125–131. 2005.PubMed/NCBI View Article : Google Scholar

3 

Nogueira A, Piresi MJ and Oliveira PA: Pathophysiological mechanisms of renal fibrosis: A review of animal models and therapeutic strategies. In vivo. 31:1–22. 2017.PubMed/NCBI View Article : Google Scholar

4 

Hewitson TD: Renal tubulointerstitial fibrosis: Common but never simple. Am J Physiol Renal Physiol. 296:F1239–F1244. 2009.PubMed/NCBI View Article : Google Scholar

5 

López-Novoa JM, Martínez-Salgado C, Rodríguez-Peña AB and López-Hernández FJ: Common pathophysiological mechanisms of chronic kidney disease: Therapeutic perspectives. Pharmacol Ther. 128:61–81. 2010.PubMed/NCBI View Article : Google Scholar

6 

Tanase DM, Gosav EM, Costea CF, Ciocoiu M, Lacatusu CM, Maranduca MA, Ouatu A and Floria M: The intricate relationship between type 2 diabetes mellitus (T2DM), insulin resistance (IR), and nonalcoholic fatty liver disease (NAFLD). J Diabetes Res. 2020(3920196)2020.PubMed/NCBI View Article : Google Scholar

7 

Remuzzi G, Benigni A and Remuzzi A: Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes. J Clin Invest. 116:288–296. 2006.PubMed/NCBI View Article : Google Scholar

8 

Owens EP, Vesey DA, Kassianos AJ, Healy H, Hoy WE and Gobe GC: Biomarkers and the role of mast cells as facilitators of inflammation and fibrosis in chronic kidney disease. Transl Androl Urol. 8 (Suppl 2):S175–S183. 2019.PubMed/NCBI View Article : Google Scholar

9 

Fan J, Xie K, Wang L, Zheng N and Yu X: Roles of inflammasomes in inflammatory kidney diseases. Mediators Inflamm. 2019(2923072)2019.PubMed/NCBI View Article : Google Scholar

10 

Meng XM, Nikolic-Paterson DJ and Lan HY: Inflammatory processes in renal fibrosis. Nat Rev Nephrol. 10:493–503. 2014.PubMed/NCBI View Article : Google Scholar

11 

Fogo AB: Progression and potential regression of glomerulosclerosis. Kidney Int. 59:804–819. 2001.PubMed/NCBI View Article : Google Scholar

12 

Gupta J, Mitra N, Kanetsky PA, Devaney J, Wing MR, Reilly M, Shah VO, Balakrishnan VS, Guzman NJ, Girndt M, et al: Association between albuminuria, kidney function, and inflammatory biomarker profile in CKD in CRIC. Clin J Am Soc Nephrol. 7:1938–1946. 2012.PubMed/NCBI View Article : Google Scholar

13 

Wynn TA and Ramalingam TR: Mechanisms of fibrosis: Therapeutic translation for fibrotic disease. Nat Med. 18:1028–1040. 2012.PubMed/NCBI View Article : Google Scholar

14 

Sievers LK and Eckardt K: Molecular mechanisms of kidney injury and repair in arterial hypertension. Int J Mol Sci. 20(2138)2019.PubMed/NCBI View Article : Google Scholar

15 

Gabriele MM and Nogueira PCK: Management of hypertension in CAKUT: Protective factor for CKD. Front Pediatr. 7(222)2019.PubMed/NCBI View Article : Google Scholar

16 

Liang S, Le W, Liang D, Chen H, Xu F, Chen H, Liu Z and Zeng C: Clinico-pathological characteristics and outcomes of patients with biopsy-proven hypertensive nephrosclerosis: A retrospective cohort study. BMC Nephrol. 17(42)2016.PubMed/NCBI View Article : Google Scholar

17 

Maranduca MA, Tarniceriu CC, Carasevici E and Cojocaru E: Interaction between angiotensin II, hypertension and inflammation in rat kidney. Rev Med Soc Nat. 119:791–797. 2015.

18 

Mărănducă MA, Cojocaru E and Carasevici E: Correlations between arterial hypertension induced by angiotensin II and systemic inflammation in rat. Rev Med Chir Soc Med Nat Iasi. 120:77–82. 2016.PubMed/NCBI

19 

Hill GS: Hypertensive nephrosclerosis. Curr Opin Nephrol Hypertens. 17:266–270. 2008.PubMed/NCBI View Article : Google Scholar

20 

Jordan J: Device-based approaches for the treatment of arterial hypertension. Curr Hypertens Rep. 19(59)2017.PubMed/NCBI View Article : Google Scholar

21 

VanDeVoorde RG and Mitsnefes MM: Hypertension and CKD. Adv Chronic Kidney Dis. 18:355–361. 2011.PubMed/NCBI View Article : Google Scholar

22 

Schaefer B and Wühl E: Educational paper: Progression in chronic kidney disease and prevention strategies. Eur J Pediatr. 171:1579–1588. 2012.PubMed/NCBI View Article : Google Scholar

23 

Klahr S and Morrissey JJ: The role of vasoactive compounds, growth factors and cytokines in the progression of renal disease. Kidney Int Suppl. 57:S7–S14. 2000.PubMed/NCBI

24 

Liang XB, Ma LJ, Naito T, Wang Y, Madaio M, Zent R, Pozzi A and Fogo AB: Angiotensin type 1 receptor blocker restores podocyte potential to promote glomerular endothelial cell growth. J Am Soc Nephrol. 17:1886–1895. 2006.PubMed/NCBI View Article : Google Scholar

25 

Liebau MC, Lang D, Böhm J, Endlich N, Bek MJ, Witherden I, Mathieson PW, Saleem MA, Pavenstädt H and Fischer KG: Functional expression of the renin-angiotensin system in human podocytes. Am J Physiol Renal Physiol. 290:F710–F719. 2006.PubMed/NCBI View Article : Google Scholar

26 

Kobori H, Ozawa Y, Suzaki Y, Prieto-Carrasquero MC, Nishiyama A, Shoji T, Cohen EP and Navar LG: Young Scholars Award Lecture: Intratubular angiotensinogen in hypertension and kidney diseases. Am J Hypertens. 19:541–550. 2006.PubMed/NCBI View Article : Google Scholar

27 

el Nahas AM, Muchaneta-Kubara EC, Essawy M and Soylemezoglu O: Renal fibrosis: Insights into pathogenesis and treatment. Int J Biochem Cell Biol. 29:55–62. 1997.PubMed/NCBI View Article : Google Scholar

28 

Rodríguez-Peña A, Prieto M, Duwel A, Rivas JV, Eleno N, Pérez-Barriocanal F, Arévalo M, Smith JD, Vary CP, Bernabeu C and López-Novoa JM: Up-regulation of endoglin, a TGF-beta-binding protein, in rats with experimental renal fibrosis induced by renal mass reduction. Nephrol Dial Transplant. 16 (Suppl 1):S34–S39. 2001.PubMed/NCBI View Article : Google Scholar

29 

Cattran DC and Rao P: Long-term outcome in children and adults with classic focal segmental glomerulosclerosis. Am J Kidney Dis. 32:72–79. 1998.PubMed/NCBI View Article : Google Scholar

30 

Pei Y, Cattran D, Delmore T, Katz A, Lang A and Rance P: Evidence suggesting under-treatment in adults with idiopathic focal segmental glomerulosclerosis. Regional glomerulonephritis registry study. Am J Med. 82:938–944. 1987.PubMed/NCBI View Article : Google Scholar

31 

Maranduca MA, Tanase DM, Branisteanu DC, Serban DN, Branisteanu DE and Serban IL: Involvement of proinflammatory cytokines in angiotensin II-induced hypertension in rat. Exp Ther Med. 20:3541–3545. 2020.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Maranduca MA, Clim A, Pinzariu AC, Statescu C, Sascau RA, Tanase DM, Serban DN, Branisteanu DC, Branisteanu DE, Huzum B, Huzum B, et al: Role of arterial hypertension and angiotensin II in chronic kidney disease (Review). Exp Ther Med 25: 153, 2023.
APA
Maranduca, M.A., Clim, A., Pinzariu, A.C., Statescu, C., Sascau, R.A., Tanase, D.M. ... Serban, I.L. (2023). Role of arterial hypertension and angiotensin II in chronic kidney disease (Review). Experimental and Therapeutic Medicine, 25, 153. https://doi.org/10.3892/etm.2023.11852
MLA
Maranduca, M. A., Clim, A., Pinzariu, A. C., Statescu, C., Sascau, R. A., Tanase, D. M., Serban, D. N., Branisteanu, D. C., Branisteanu, D. E., Huzum, B., Serban, I. L."Role of arterial hypertension and angiotensin II in chronic kidney disease (Review)". Experimental and Therapeutic Medicine 25.4 (2023): 153.
Chicago
Maranduca, M. A., Clim, A., Pinzariu, A. C., Statescu, C., Sascau, R. A., Tanase, D. M., Serban, D. N., Branisteanu, D. C., Branisteanu, D. E., Huzum, B., Serban, I. L."Role of arterial hypertension and angiotensin II in chronic kidney disease (Review)". Experimental and Therapeutic Medicine 25, no. 4 (2023): 153. https://doi.org/10.3892/etm.2023.11852
Copy and paste a formatted citation
x
Spandidos Publications style
Maranduca MA, Clim A, Pinzariu AC, Statescu C, Sascau RA, Tanase DM, Serban DN, Branisteanu DC, Branisteanu DE, Huzum B, Huzum B, et al: Role of arterial hypertension and angiotensin II in chronic kidney disease (Review). Exp Ther Med 25: 153, 2023.
APA
Maranduca, M.A., Clim, A., Pinzariu, A.C., Statescu, C., Sascau, R.A., Tanase, D.M. ... Serban, I.L. (2023). Role of arterial hypertension and angiotensin II in chronic kidney disease (Review). Experimental and Therapeutic Medicine, 25, 153. https://doi.org/10.3892/etm.2023.11852
MLA
Maranduca, M. A., Clim, A., Pinzariu, A. C., Statescu, C., Sascau, R. A., Tanase, D. M., Serban, D. N., Branisteanu, D. C., Branisteanu, D. E., Huzum, B., Serban, I. L."Role of arterial hypertension and angiotensin II in chronic kidney disease (Review)". Experimental and Therapeutic Medicine 25.4 (2023): 153.
Chicago
Maranduca, M. A., Clim, A., Pinzariu, A. C., Statescu, C., Sascau, R. A., Tanase, D. M., Serban, D. N., Branisteanu, D. C., Branisteanu, D. E., Huzum, B., Serban, I. L."Role of arterial hypertension and angiotensin II in chronic kidney disease (Review)". Experimental and Therapeutic Medicine 25, no. 4 (2023): 153. https://doi.org/10.3892/etm.2023.11852
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team