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Adenosine vs. regadenoson for stress induction in dynamic CT perfusion scan of the myocardium: A single‑center retrospective comparison

  • Authors:
    • Claudia Gibarti
    • Pavol Murín
    • Mikuláš Huňavý
    • Roman Koribský
    • Lukáš Urban
    • Martin Studenčan
    • Peter Gál
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, East‑Slovak Institute of Cardiovascular Diseases, Inc., 040 11 Košice, Slovakia, Department of First Department of Cardiology, East‑Slovak Institute of Cardiovascular Diseases, Inc., 040 11 Košice, Slovakia, Department of Biomedical Research, East‑Slovak Institute of Cardiovascular Diseases, Inc., 040 11 Košice, Slovakia
    Copyright: © Gibarti et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 192
    |
    Published online on: March 16, 2023
       https://doi.org/10.3892/etm.2023.11891
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Abstract

Cardiac computed tomography (CT) angiography offers several approaches to determine the hemodynamic severity of coronary artery obstruction. Dynamic myocardial perfusion is based on serial CT imaging of contrast flow into the myocardium and calculation of absolute myocardial perfusion rates. East‑Slovak Institute of Cardiovascular Diseases has been the first center in Slovakia intensively using this modern technique to increase the quality level of non‑invasive diagnosis of symptomatic patients with a low to moderate pre‑test probability of ischemic heart disease. The present study included 46 patients with a mean age of 64 years (33 men and 13 women). Prior to the CT study, myocardial stress was pharmacologically (adenosine, n=15 and regadenoson, n=31) induced by vasodilatation of the coronary arteries. Hemodynamic parameters (myocardial blood flow) were evaluated in all patients following successful CT perfusion without complications, allergic reaction or other severe side effects. The present study revealed that regadenoson increased the heart rate following infusion with a higher magnitude compared with adenosine. Moreover, the effect of regadenoson was independent of patient's body mass index and was associated with a lower incidence of mild adverse effects. The present study provided further clinical evidence for a more wider use of regadenoson over adenosine.
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Copy and paste a formatted citation
Spandidos Publications style
Gibarti C, Murín P, Huňavý M, Koribský R, Urban L, Studenčan M and Gál P: Adenosine vs. regadenoson for stress induction in dynamic CT perfusion scan of the myocardium: A single‑center retrospective comparison. Exp Ther Med 25: 192, 2023.
APA
Gibarti, C., Murín, P., Huňavý, M., Koribský, R., Urban, L., Studenčan, M., & Gál, P. (2023). Adenosine vs. regadenoson for stress induction in dynamic CT perfusion scan of the myocardium: A single‑center retrospective comparison. Experimental and Therapeutic Medicine, 25, 192. https://doi.org/10.3892/etm.2023.11891
MLA
Gibarti, C., Murín, P., Huňavý, M., Koribský, R., Urban, L., Studenčan, M., Gál, P."Adenosine vs. regadenoson for stress induction in dynamic CT perfusion scan of the myocardium: A single‑center retrospective comparison". Experimental and Therapeutic Medicine 25.5 (2023): 192.
Chicago
Gibarti, C., Murín, P., Huňavý, M., Koribský, R., Urban, L., Studenčan, M., Gál, P."Adenosine vs. regadenoson for stress induction in dynamic CT perfusion scan of the myocardium: A single‑center retrospective comparison". Experimental and Therapeutic Medicine 25, no. 5 (2023): 192. https://doi.org/10.3892/etm.2023.11891
Copy and paste a formatted citation
x
Spandidos Publications style
Gibarti C, Murín P, Huňavý M, Koribský R, Urban L, Studenčan M and Gál P: Adenosine vs. regadenoson for stress induction in dynamic CT perfusion scan of the myocardium: A single‑center retrospective comparison. Exp Ther Med 25: 192, 2023.
APA
Gibarti, C., Murín, P., Huňavý, M., Koribský, R., Urban, L., Studenčan, M., & Gál, P. (2023). Adenosine vs. regadenoson for stress induction in dynamic CT perfusion scan of the myocardium: A single‑center retrospective comparison. Experimental and Therapeutic Medicine, 25, 192. https://doi.org/10.3892/etm.2023.11891
MLA
Gibarti, C., Murín, P., Huňavý, M., Koribský, R., Urban, L., Studenčan, M., Gál, P."Adenosine vs. regadenoson for stress induction in dynamic CT perfusion scan of the myocardium: A single‑center retrospective comparison". Experimental and Therapeutic Medicine 25.5 (2023): 192.
Chicago
Gibarti, C., Murín, P., Huňavý, M., Koribský, R., Urban, L., Studenčan, M., Gál, P."Adenosine vs. regadenoson for stress induction in dynamic CT perfusion scan of the myocardium: A single‑center retrospective comparison". Experimental and Therapeutic Medicine 25, no. 5 (2023): 192. https://doi.org/10.3892/etm.2023.11891
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