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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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May-2023 Volume 25 Issue 5

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Case Report Open Access

A false positive serology test of SARS‑CoV‑2 in a patient with Waldenström's macroglobulinemia: A case report

  • Authors:
    • Ni-Na Lu
    • Ling-Zhi Liang
    • Xiao-Yuan Yan
    • Bi-Ying Song
    • Ya-Qiong Zhang
    • Hai-Rong Shu
    • Ling-Long Xu
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang 318000, P.R. China, Department of Laboratory Medicine, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang 318000, P.R. China, Department of Medical Affairs, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang 318000, P.R. China
    Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 200
    |
    Published online on: March 21, 2023
       https://doi.org/10.3892/etm.2023.11899
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Abstract

The serology test of SARS‑CoV‑2 is one of the critical assays to make a diagnosis of SARS‑CoV‑2 infection. The gold immunochromatography assay (GICA) is a common measure to test SARS‑CoV‑2 specific IgG and IgM. The sensitivity and specificity of the assay are ~>80%. It has been reported that the result of GICA could be compromised in various situations, such as auto‑immune diseases, Kawasaki disease, pregnancy or other conditions. However, following the European Hematology Association's consensus statement on the management of Waldenström's Macroglobulinemia (WM) patients, serological tests for SARS‑CoV‑2 specific IgM should not be affected by the total IgM or paraprotein levels. The present study reports a patient with duplicate positive serology tests of SARS‑CoV‑2 which is hypothesized to be due to monoclonal IgM caused by WM.
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Copy and paste a formatted citation
Spandidos Publications style
Lu N, Liang L, Yan X, Song B, Zhang Y, Shu H and Xu L: A false positive serology test of SARS‑CoV‑2 in a patient with Waldenström's macroglobulinemia: A case report. Exp Ther Med 25: 200, 2023.
APA
Lu, N., Liang, L., Yan, X., Song, B., Zhang, Y., Shu, H., & Xu, L. (2023). A false positive serology test of SARS‑CoV‑2 in a patient with Waldenström's macroglobulinemia: A case report. Experimental and Therapeutic Medicine, 25, 200. https://doi.org/10.3892/etm.2023.11899
MLA
Lu, N., Liang, L., Yan, X., Song, B., Zhang, Y., Shu, H., Xu, L."A false positive serology test of SARS‑CoV‑2 in a patient with Waldenström's macroglobulinemia: A case report". Experimental and Therapeutic Medicine 25.5 (2023): 200.
Chicago
Lu, N., Liang, L., Yan, X., Song, B., Zhang, Y., Shu, H., Xu, L."A false positive serology test of SARS‑CoV‑2 in a patient with Waldenström's macroglobulinemia: A case report". Experimental and Therapeutic Medicine 25, no. 5 (2023): 200. https://doi.org/10.3892/etm.2023.11899
Copy and paste a formatted citation
x
Spandidos Publications style
Lu N, Liang L, Yan X, Song B, Zhang Y, Shu H and Xu L: A false positive serology test of SARS‑CoV‑2 in a patient with Waldenström's macroglobulinemia: A case report. Exp Ther Med 25: 200, 2023.
APA
Lu, N., Liang, L., Yan, X., Song, B., Zhang, Y., Shu, H., & Xu, L. (2023). A false positive serology test of SARS‑CoV‑2 in a patient with Waldenström's macroglobulinemia: A case report. Experimental and Therapeutic Medicine, 25, 200. https://doi.org/10.3892/etm.2023.11899
MLA
Lu, N., Liang, L., Yan, X., Song, B., Zhang, Y., Shu, H., Xu, L."A false positive serology test of SARS‑CoV‑2 in a patient with Waldenström's macroglobulinemia: A case report". Experimental and Therapeutic Medicine 25.5 (2023): 200.
Chicago
Lu, N., Liang, L., Yan, X., Song, B., Zhang, Y., Shu, H., Xu, L."A false positive serology test of SARS‑CoV‑2 in a patient with Waldenström's macroglobulinemia: A case report". Experimental and Therapeutic Medicine 25, no. 5 (2023): 200. https://doi.org/10.3892/etm.2023.11899
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