Pregnant woman with acute promyelocytic leukemia delivers healthy twins and is cured successfully: A case report

  • Authors:
    • Wenpeng Ni
    • Kunyi Deng
    • Yanhui Chen
    • Lilian Li
    • Ji Liu
    • Wendong Ju
    • Li Wang
  • View Affiliations

  • Published online on: March 22, 2023     https://doi.org/10.3892/etm.2023.11905
  • Article Number: 206
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Abstract

Acute promyelocytic leukemia (APL) during pregnancy is rare and difficult to treat. To the best of our knowledge, there is little precedent for successful treatment with combined chemotherapeutic agents without affecting delivery. The present study reported the case of a 31‑year‑old woman pregnant with twins who presented to the antenatal service at 13‑week gestational age with complaints of vaginal bleeding, lower abdominal pain, bleeding gums and skin ecchymosis, and was eventually diagnosed with APL. After treatment with all‑trans‑retinoic acid (ATRA) and arsenic trioxide (ATO)‑based induction regimen, the patient achieved a complete remission (CR) and delivered two healthy male infants at 34 weeks of gestation. The use of ATRA and ATO for the treatment of APL is controversial due to teratogenic effects and lethal retinoic acid syndrome. However, the patient demonstrated that the chemotherapy regimen with ATRA and ATO during the second and third trimesters can result in a sustainable remission and successful pregnancy outcome.5
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May-2023
Volume 25 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ni W, Deng K, Chen Y, Li L, Liu J, Ju W and Wang L: Pregnant woman with acute promyelocytic leukemia delivers healthy twins and is cured successfully: A case report. Exp Ther Med 25: 206, 2023
APA
Ni, W., Deng, K., Chen, Y., Li, L., Liu, J., Ju, W., & Wang, L. (2023). Pregnant woman with acute promyelocytic leukemia delivers healthy twins and is cured successfully: A case report. Experimental and Therapeutic Medicine, 25, 206. https://doi.org/10.3892/etm.2023.11905
MLA
Ni, W., Deng, K., Chen, Y., Li, L., Liu, J., Ju, W., Wang, L."Pregnant woman with acute promyelocytic leukemia delivers healthy twins and is cured successfully: A case report". Experimental and Therapeutic Medicine 25.5 (2023): 206.
Chicago
Ni, W., Deng, K., Chen, Y., Li, L., Liu, J., Ju, W., Wang, L."Pregnant woman with acute promyelocytic leukemia delivers healthy twins and is cured successfully: A case report". Experimental and Therapeutic Medicine 25, no. 5 (2023): 206. https://doi.org/10.3892/etm.2023.11905