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Article Open Access

Lactate dehydrogenase and aspartate aminotransferase levels associated with the severity of COVID‑19: A systematic review and meta‑analysis

  • Authors:
    • Ziyun He
    • Rengqin Yan
    • Jinsong Liu
    • Haibing Dai
    • Yonglin Zhu
    • Feng Zhang
    • Lin Zhang
    • Shengkai Yan
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563009, P.R. China, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 221
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    Published online on: March 29, 2023
       https://doi.org/10.3892/etm.2023.11920
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Abstract

Lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) are important indicators of cardiovascular, muscle and liver lesions, and can be used as prognostic indicators for infectious diseases, such as coronavirus disease 2019 (COVID‑19). The present systematic review and meta‑analysis assessed the prognostic value of LDH and AST levels for COVID‑19 severity. Ovid‑Medline, PubMed, Embase and The Cochrane Library were used to search for articles, according to the inclusion and exclusion criteria, until July 2022. The meta‑analysis was performed using Revman5.3 and Stata15.1. Standardized mean difference (SMD) and 95% confidence intervals (CIs) of LDH and AST concentrations were analyzed using a random‑effects model. Heterogeneity was investigated using meta‑regression and subgroup methods. A total of 4,342 patients with COVID‑19 in 23 articles were included in the present study. LDH (SMD=1.21; 95% CI: 0.98, 1.44) and AST (SMD=0.68; 95% CI: 0.54, 0.81) were significantly higher in patients with severe COVID‑19 compared with in those with non‑severe COVID‑19. Serum LDH and AST levels in critically ill patients with COVID‑19 were increased, suggesting a correlation between the levels of LDH and AST and the severity of COVID‑19. These findings may help to develop a risk‑stratified approach to the care of patients with this disease.
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1 

Parasher A: COVID-19: Current understanding of its pathophysiology, clinical presentation and treatment. Postgrad Med J. 97:312–320. 2021.PubMed/NCBI View Article : Google Scholar

2 

Abobaker A, Raba A and Alzwi A: Extrapulmonary and atypical clinical presentations of COVID-19. J Med Virol. 92:2458–2464. 2021.PubMed/NCBI View Article : Google Scholar

3 

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, et al: Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 323:1061–1069. 2020.PubMed/NCBI View Article : Google Scholar

4 

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, et al: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 395:497–506. 2020.PubMed/NCBI View Article : Google Scholar

5 

Liu J, Deswal A and Khalid U: COVID-19 myocarditis and long-term heart failure sequelae. Curr Opin Cardiol. 36:234–240. 2021.PubMed/NCBI View Article : Google Scholar

6 

Islam MT, Nasiruddin M, Khan IN, Mishra SK, Kudrat-E-Zahan M, Riaz TA, Ali ES, Rahman MS, Mubarak MS, Martorell M, et al: A perspective on emerging therapeutic interventions for COVID-19. Front Public Health. 8(281)2020.PubMed/NCBI View Article : Google Scholar

7 

Kmietowicz Z: Covid-19: WHO recommends baricitinib and sotrovimab to treat patients. BMJ. 376(097)2022.PubMed/NCBI View Article : Google Scholar

8 

Wu X, Deng KD, Li C, Yang Z, Hu H, Cai H, Zhang C, He T, Zheng F, Wang H, et al: Cardiac involvement in recovered patients from COVID-19: A preliminary 6-month follow-up study. Front Cardiovasc Med. 8(654405)2021.PubMed/NCBI View Article : Google Scholar

9 

Fialek B, Pruc M, Smereka J, Jas R, Rahnama-Hezavah M, Denegri A, Szarpak A, Jaguszewski MJ, Peacock FW and Szarpak L: Diagnostic value of lactate dehydrogenase in COVID-19: A systematic review and meta-analysis. Cardiol J. 29:751–758. 2022.PubMed/NCBI View Article : Google Scholar

10 

Malik P, Patel U, Mehta D, Patel N, Kelkar R, Akrmah M, Gabrilove JL and Sacks H: Biomarkers and outcomes of COVID-19 hospitalisations: Systematic review and meta-analysis. BMJ Evid Based Med. 26:107–108. 2021.PubMed/NCBI View Article : Google Scholar

11 

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J and Moher D: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: Explanation and elaboration. BMJ. 339(b2700)2009.PubMed/NCBI View Article : Google Scholar

12 

Stang A: Critical evaluation of the Newcastle-Ottawa scale for the assessment of thequality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 25:603–605. 2010.PubMed/NCBI View Article : Google Scholar

13 

Wan X, Wang W, Liu J and Tong T: Estimating the sample mean and standard deviation from the samplesize, median, range and/or interquartile range. BMC Med Res Methodol. 14(135)2014.PubMed/NCBI View Article : Google Scholar

14 

Bowden J, Tierney JF, Copas AJ and Burdett S: Quantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Q statistics. BMC Med Res Methodol. 11(41)2011.PubMed/NCBI View Article : Google Scholar

15 

Pan F, Yang L, Li Y, Liang B, Li L, Ye T, Li L, Liu D, Gui S, Hu Y and Zheng C: Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): A case-control study. Int J Med Sci. 17:1281–1292. 2020.PubMed/NCBI View Article : Google Scholar

16 

Ayten O and Saylan B: Retrospective analysis of severe COVID-19 pneumonia patients treated with lopinavir/ritonavir: A comparison with survivor and non-survivor patients. S Afr J Infect Dis. 35(233)2020.PubMed/NCBI View Article : Google Scholar

17 

Sepulchre E, Pittie G, Stojkovic V, Haesbroek G, Crama Y, Schyns M, Paridaens H, de Marchin J, Degesves S, Biemar C, et al: Covid-19: Contribution of clinical characteristics and laboratory features for early detection of patients with high risk of severe evolution. Acta Clin Belg. 77:261–267. 2022.PubMed/NCBI View Article : Google Scholar

18 

Bonetti G, Manelli F, Patroni A, Bettinardi A, Borrelli G, Fiordalisi G, Marino A, Menolfi A, Saggini S, Volpi R, et al: Laboratory predictors of death from coronavirus disease 2019 (COVID-19) in the area of Valcamonica, Italy. Clin Chem Lab Med. 58:1100–1105. 2020.PubMed/NCBI View Article : Google Scholar

19 

Kumar H, Gupta P and Shakya S: Predictors of mortality in patients of COVID-19 pneumonia in intensive care unit: An observational study in a tertiary care hospital, Lucknow, India. J Clin Diagnostic Res. 15:C11–C15. 2021.

20 

Vidal-Cevallos P, Higuera-De-La-Tijera F, Chávez-Tapia NC, Sanchez-Giron F, Cerda-Reyes E, Rosales-Salyano VH, Servin-Caamaño A, Vázquez-Medina MU and Méndez-Sánchez N: Lactate-dehydrogenase associated with mortality in hospitalized patients with COVID-19 in Mexico: A multi-centre retrospective cohort study. Ann Hepatol. 24(100338)2021.PubMed/NCBI View Article : Google Scholar

21 

Snipelisky D, Johnson R, Prasad R, Lakhani B and Ellington J: Characteristics and outcomes based on perceived illness severity in SARS-CoV-2. South Med J. 113:618–622. 2020.PubMed/NCBI View Article : Google Scholar

22 

Qin W, Bai W, Liu K, Liu Y, Meng X, Zhang K and Zhang M: Clinical course and risk factors of disease deterioration in critically Ill patients with COVID-19. Hum Gene Ther. 32:310–315. 2021.PubMed/NCBI View Article : Google Scholar

23 

Zhu Y, Du Z, Zhu Y, Li W, Miao H and Li Z: Evaluation of organ function in patients with severe COVID-19 infections. Med Clin (Barc). 155:191–196. 2020.PubMed/NCBI View Article : Google Scholar : (In English, Spanish).

24 

Yousaf MN, Sarwar S, Tarique S, Ahmed M and Tahir H: Mortality in patients of COVID-19 infection: Biochemical markers and its cut-off values for predicting outcome. J Coll Physicians Surg Pak. 32:37–41. 2022.PubMed/NCBI View Article : Google Scholar

25 

Wang Z, Ye D, Wang M, Zhao M, Li D, Ye J, Liu J, Xu Y, Zhang J, Pan W, et al: Clinical features of COVID-19 patients with different outcomes in Wuhan: A retrospective observational study. Biomed Res Int. 2020(2138387)2020.PubMed/NCBI View Article : Google Scholar

26 

Akdogan D, Guzel M, Tosun D and Akpinar O: Diagnostic and early prognostic value of serum CRP and LDH levels in patients with possible COVID-19 at the first admission. J Infect Dev Ctries. 15:766–772. 2021.PubMed/NCBI View Article : Google Scholar

27 

Kantri A, Ziati J, Khalis M, Haoudar A, El Aidaoui K, Daoudi Y, Chikhaoui I, El Yamani K, Mouhaoui M, El Bakkouri J, et al: Hematological and biochemical abnormalities associated with severe forms of COVID-19: A retrospective single-centre study from Morocco. PLoS One. 16(e246295)2021.PubMed/NCBI View Article : Google Scholar

28 

Azizmohammadi S, Azizmohammadi S, Dahmardeh S, Azargashb H, Shokouh SJH, Mohajeri-Iravani M, Mobasher M, Soleiman-Meigooni S and Zabihi M: Analysis of 239 ordinary and severe cases of COVID-19:Clinical features and treatment. Eur J Transl Myol. 31(9579)2021.PubMed/NCBI View Article : Google Scholar

29 

Wang D, Li R, Wang J, Jiang Q, Gao C, Yang J, Ge L and Hu Q: Correlation analysis between disease severity and clinical and biochemical characteristics of 143 cases of COVID-19 in Wuhan, China: A descriptive study. BMC Infect Dis. 20(519)2020.PubMed/NCBI View Article : Google Scholar

30 

Zheng F, Tang W, Li H, Huang YX, Xie YL and Zhou ZG: Clinical characteristics of 161 cases of corona virus disease 2019 (COVID-19) in Changsha. Eur Rev Med Pharmacol Sci. 24:3404–3410. 2020.PubMed/NCBI View Article : Google Scholar

31 

Fukushima K, Yamada Y, Fujiwara S, Tanaka M, Kobayashi T, Yajima K, Tanaka K, Sekiya N and Imamura A: Development of a risk prediction score to identify high-risk groups for the critical coronavirus disease 2019 (COVID-19) in Japan. Jpn J Infect Dis. 74:344–351. 2021.PubMed/NCBI View Article : Google Scholar

32 

Wang H, Xing Y, Yao X, Li Y, Huang J, Tang J, Zhu S, Zhang Y and Xiao J: Retrospective study of clinical features of COVID-19 in inpatients and their association with disease severity. Med Sci Monit. 26(e927674)2020.PubMed/NCBI View Article : Google Scholar

33 

Huang H, Song B, Xu Z, Jiao Y, Huang L, Zhao P, Huang J, Zhou Z, Zhao Z, Tian J, et al: Predictors of coronavirus disease 2019 severity: A retrospective study of 64 cases. Jpn J Infect Dis. 74:54–60. 2021.PubMed/NCBI View Article : Google Scholar

34 

Gómez LC, Curto SV, Sebastian MBP, Jiménez BF and Duniol MD: Predictive model of severity in SARS CoV-2 patients at hospital admission using blood-related parameters. EJIFCC. 32:255–264. 2021.PubMed/NCBI

35 

Mo P, Xing Y, Xiao Y, Deng L, Zhao Q, Wang H, Xiong Y, Cheng Z, Gao S, Liang K, et al: Clinical characteristics of refractory coronavirus disease 2019 in Wuhan, China. Clin Infect Dis. 73:e4208–e4213. 2021.PubMed/NCBI View Article : Google Scholar

36 

Zhang W, Ban Y, Wu YH, Liu JY, Li XH, Wu H, Li H, Chen R, Yu XX and Zheng R: Epidemiological and clinical characteristics of 65 hospitalized patients with COVID-19 in Liaoning, China. World J Clin Cases. 9:2205–2217. 2021.PubMed/NCBI View Article : Google Scholar

37 

Feng X, Li P, Ma L, Liang H, Lei J, Li W, Wang K, Song Y, Li S, Yang W and Yang C: Clinical characteristics and short-term outcomes of severe patients with COVID-19 in Wuhan, China. Front Med (Lausanne). 7(491)2020.PubMed/NCBI View Article : Google Scholar

38 

Wu Y, Lu C, Pan N, Zhang M, An Y, Xu M, Zhang L, Guo Y and Tan L: Serum lactate dehydrogenase activities as systems biomarkers for 48 types of human diseases. Sci Rep. 11(12997)2021.PubMed/NCBI View Article : Google Scholar

39 

Chen XY, Huang MY, Xiao ZW, Yang S and Chen XQ: Lactate dehydrogenase elevations is associated with severity of COVID-19: A meta-analysis. Crit Care. 24(459)2020.PubMed/NCBI View Article : Google Scholar

40 

Henry BM, Aggarwal G, Wong J, Benoit S, Vikse J, Plebani M and Lippi G: Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis. Am J Emerg Med. 38:1722–1726. 2020.PubMed/NCBI View Article : Google Scholar

41 

Poggiali E, Zaino D, Immovilli P, Rovero L, Losi G, Dacrema A, Nuccetelli M, Vadacca GB, Guidetti D, Vercelli A, et al: Lactate dehydrogenase and C-reactive protein as predictors of respiratory failure in CoVID-19 patients. Clin Chim Acta. 509:135–138. 2020.PubMed/NCBI View Article : Google Scholar

42 

Lei F, Liu YM, Zhou F, Qin JJ, Zhang P, Zhu L, Zhang XJ, Cai J, Lin L, Ouyang S, et al: Longitudinal association between markers of liver injury and mortality in COVID-19 in China. Hepatology. 72:389–398. 2020.PubMed/NCBI View Article : Google Scholar

43 

Aloisio E and Panteghini M: Aspartate aminotransferase in COVID-19: A probably overrated marker. Liver Int. 41:2809–2810. 2021.PubMed/NCBI View Article : Google Scholar

44 

Zhang C, Shi L and Wang FS: Liver injury in COVID-19: Management and challenges. Lancet Gastroenterol Hepatol. 5:428–430. 2020.PubMed/NCBI View Article : Google Scholar

45 

Battaglini D, Lopes-Pacheco M, Castro-Faria-Neto HC, Pelosi P and Rocco PRM: Laboratory biomarkers for diagnosis and prognosis in COVID-19. Front Immunol. 13(857573)2022.PubMed/NCBI View Article : Google Scholar

46 

Stegeman I, Ochodo EA, Guleid F, Holtman GA, Yang B, Davenport C, Deeks JJ, Dinnes J, Dittrich S, Emperador D, et al: Routine laboratory testing to determine if a patient has COVID-19. Cochrane Database Syst Rev. 11(CD013787)2020.PubMed/NCBI View Article : Google Scholar

47 

Babapoor-Farrokhran S, Gill D, Walker J, Rasekhi RT, Bozorgnia B and Amanullah A: Myocardial injury and COVID-19: Possible mechanisms. Life Sci. 253(117723)2020.PubMed/NCBI View Article : Google Scholar

48 

Evans PC, Rainger GE, Mason JC, Guzik TJ, Osto E, Stamataki Z, Neil D, Hoefer IE, Fragiadaki M, Waltenberger J, et al: Endothelial dysfunction in COVID-19: A position paper of the ESC working group for atherosclerosis and vascular biology, and the ESC council of basic cardiovascular science. Cardiovasc Res. 116:2177–2184. 2020.PubMed/NCBI View Article : Google Scholar

49 

Chung MK, Zidar DA, Bristow MR, Cameron SJ, Chan T, Harding CV III, Kwon DH, Singh T, Tilton JC, Tsai EJ, et al: COVID-19 and cardiovascular disease: From bench to bedside. Circ Res. 128:1214–1236. 2021.PubMed/NCBI View Article : Google Scholar

50 

Weckbach LT, Curta A, Bieber S, Kraechan A, Brado J, Hellmuth JC, Muenchhoff M, Scherer C, Schroeder I, Irlbeck M, et al: Myocardial inflammation and dysfunction in COVID-19-associated myocardial injury. Circ Cardiovasc Imaging. 14(e12220)2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
He Z, Yan R, Liu J, Dai H, Zhu Y, Zhang F, Zhang L and Yan S: Lactate dehydrogenase and aspartate aminotransferase levels associated with the severity of COVID‑19: A systematic review and meta‑analysis. Exp Ther Med 25: 221, 2023.
APA
He, Z., Yan, R., Liu, J., Dai, H., Zhu, Y., Zhang, F. ... Yan, S. (2023). Lactate dehydrogenase and aspartate aminotransferase levels associated with the severity of COVID‑19: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 25, 221. https://doi.org/10.3892/etm.2023.11920
MLA
He, Z., Yan, R., Liu, J., Dai, H., Zhu, Y., Zhang, F., Zhang, L., Yan, S."Lactate dehydrogenase and aspartate aminotransferase levels associated with the severity of COVID‑19: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 25.5 (2023): 221.
Chicago
He, Z., Yan, R., Liu, J., Dai, H., Zhu, Y., Zhang, F., Zhang, L., Yan, S."Lactate dehydrogenase and aspartate aminotransferase levels associated with the severity of COVID‑19: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 25, no. 5 (2023): 221. https://doi.org/10.3892/etm.2023.11920
Copy and paste a formatted citation
x
Spandidos Publications style
He Z, Yan R, Liu J, Dai H, Zhu Y, Zhang F, Zhang L and Yan S: Lactate dehydrogenase and aspartate aminotransferase levels associated with the severity of COVID‑19: A systematic review and meta‑analysis. Exp Ther Med 25: 221, 2023.
APA
He, Z., Yan, R., Liu, J., Dai, H., Zhu, Y., Zhang, F. ... Yan, S. (2023). Lactate dehydrogenase and aspartate aminotransferase levels associated with the severity of COVID‑19: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 25, 221. https://doi.org/10.3892/etm.2023.11920
MLA
He, Z., Yan, R., Liu, J., Dai, H., Zhu, Y., Zhang, F., Zhang, L., Yan, S."Lactate dehydrogenase and aspartate aminotransferase levels associated with the severity of COVID‑19: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 25.5 (2023): 221.
Chicago
He, Z., Yan, R., Liu, J., Dai, H., Zhu, Y., Zhang, F., Zhang, L., Yan, S."Lactate dehydrogenase and aspartate aminotransferase levels associated with the severity of COVID‑19: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 25, no. 5 (2023): 221. https://doi.org/10.3892/etm.2023.11920
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