Open Access

Lactate dehydrogenase and aspartate aminotransferase levels associated with the severity of COVID‑19: A systematic review and meta‑analysis

  • Authors:
    • Ziyun He
    • Rengqin Yan
    • Jinsong Liu
    • Haibing Dai
    • Yonglin Zhu
    • Feng Zhang
    • Lin Zhang
    • Shengkai Yan
  • View Affiliations

  • Published online on: March 29, 2023     https://doi.org/10.3892/etm.2023.11920
  • Article Number: 221
  • Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) are important indicators of cardiovascular, muscle and liver lesions, and can be used as prognostic indicators for infectious diseases, such as coronavirus disease 2019 (COVID‑19). The present systematic review and meta‑analysis assessed the prognostic value of LDH and AST levels for COVID‑19 severity. Ovid‑Medline, PubMed, Embase and The Cochrane Library were used to search for articles, according to the inclusion and exclusion criteria, until July 2022. The meta‑analysis was performed using Revman5.3 and Stata15.1. Standardized mean difference (SMD) and 95% confidence intervals (CIs) of LDH and AST concentrations were analyzed using a random‑effects model. Heterogeneity was investigated using meta‑regression and subgroup methods. A total of 4,342 patients with COVID‑19 in 23 articles were included in the present study. LDH (SMD=1.21; 95% CI: 0.98, 1.44) and AST (SMD=0.68; 95% CI: 0.54, 0.81) were significantly higher in patients with severe COVID‑19 compared with in those with non‑severe COVID‑19. Serum LDH and AST levels in critically ill patients with COVID‑19 were increased, suggesting a correlation between the levels of LDH and AST and the severity of COVID‑19. These findings may help to develop a risk‑stratified approach to the care of patients with this disease.
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May-2023
Volume 25 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
He Z, Yan R, Liu J, Dai H, Zhu Y, Zhang F, Zhang L and Yan S: Lactate dehydrogenase and aspartate aminotransferase levels associated with the severity of COVID‑19: A systematic review and meta‑analysis. Exp Ther Med 25: 221, 2023
APA
He, Z., Yan, R., Liu, J., Dai, H., Zhu, Y., Zhang, F. ... Yan, S. (2023). Lactate dehydrogenase and aspartate aminotransferase levels associated with the severity of COVID‑19: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 25, 221. https://doi.org/10.3892/etm.2023.11920
MLA
He, Z., Yan, R., Liu, J., Dai, H., Zhu, Y., Zhang, F., Zhang, L., Yan, S."Lactate dehydrogenase and aspartate aminotransferase levels associated with the severity of COVID‑19: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 25.5 (2023): 221.
Chicago
He, Z., Yan, R., Liu, J., Dai, H., Zhu, Y., Zhang, F., Zhang, L., Yan, S."Lactate dehydrogenase and aspartate aminotransferase levels associated with the severity of COVID‑19: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 25, no. 5 (2023): 221. https://doi.org/10.3892/etm.2023.11920