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Axons of retinal ganglion cells on the optic nerve disc following vessel density correction at different IOP values

  • Authors:
    • Ján Lešták
    • Martin Fůs
    • Jakub Král
  • View Affiliations / Copyright

    Affiliations: Department of Natural Sciences, Faculty of Biomedical Engineering, Czech Technical University in Prague, 27201 Kladno 2, Czech Republic
    Copyright: © Lešták et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 261
    |
    Published online on: April 19, 2023
       https://doi.org/10.3892/etm.2023.11960
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Abstract

The present study aimed to determine how the vascular density (VD) in each segment peripapillary influences the retinal nerve fiber layer (RNFL) and to eliminate its contribution to RNFL in pathological intraocular pressure (IOP). In a cohort of 69 subjects (mean age, 45±6 years old) with untreated ocular hypertension (122 eyes in total) enrolled in this study, Ocular Response Analyser IOP was measured during routine outpatient care. Its value was >21 (range, 21‑36) mmHg in all eyes. Furthermore, peripapillary VD and RNFL were measured using optical coherence tomography in the following eight segments: Inferior temporal (segment 1); temporal inferior (segment 2); temporal superior (segment 3); superior temporal (segment 4); superior nasal (segment 5); nasal superior (segment 6); nasal inferior (segment 7); and inferior nasal (segment 8). The visual field examination was performed with the fast threshold glaucoma program using the Medmont M 700. The overall defect was evaluated. Person's correlation coefficient was used to assess the correlation between VD and IOP. The largest changes were observed in peripapillary segments 1, 4, 5, 6, 7 and 8. The second part of the work was to eliminate the contribution of VD to RNFL. The partial correlation coefficient r was used to adjust RNFL from VD to assess the dependence between the selected parameters. The largest changes in RNFL were in segments 5 and 8 after they had been ‘cleaned’ of peripapillary VD. In conclusion, the present study revealed that the largest changes in RNFL after VD adjustment were observed for the incipient hypertensive glaucoma in segments 5 and 8.
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Copy and paste a formatted citation
Spandidos Publications style
Lešták J, Fůs M and Král J: Axons of retinal ganglion cells on the optic nerve disc following vessel density correction at different IOP values. Exp Ther Med 25: 261, 2023.
APA
Lešták, J., Fůs, M., & Král, J. (2023). Axons of retinal ganglion cells on the optic nerve disc following vessel density correction at different IOP values. Experimental and Therapeutic Medicine, 25, 261. https://doi.org/10.3892/etm.2023.11960
MLA
Lešták, J., Fůs, M., Král, J."Axons of retinal ganglion cells on the optic nerve disc following vessel density correction at different IOP values". Experimental and Therapeutic Medicine 25.6 (2023): 261.
Chicago
Lešták, J., Fůs, M., Král, J."Axons of retinal ganglion cells on the optic nerve disc following vessel density correction at different IOP values". Experimental and Therapeutic Medicine 25, no. 6 (2023): 261. https://doi.org/10.3892/etm.2023.11960
Copy and paste a formatted citation
x
Spandidos Publications style
Lešták J, Fůs M and Král J: Axons of retinal ganglion cells on the optic nerve disc following vessel density correction at different IOP values. Exp Ther Med 25: 261, 2023.
APA
Lešták, J., Fůs, M., & Král, J. (2023). Axons of retinal ganglion cells on the optic nerve disc following vessel density correction at different IOP values. Experimental and Therapeutic Medicine, 25, 261. https://doi.org/10.3892/etm.2023.11960
MLA
Lešták, J., Fůs, M., Král, J."Axons of retinal ganglion cells on the optic nerve disc following vessel density correction at different IOP values". Experimental and Therapeutic Medicine 25.6 (2023): 261.
Chicago
Lešták, J., Fůs, M., Král, J."Axons of retinal ganglion cells on the optic nerve disc following vessel density correction at different IOP values". Experimental and Therapeutic Medicine 25, no. 6 (2023): 261. https://doi.org/10.3892/etm.2023.11960
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