Open Access

Autophagy in the pharmacological activities of celastrol (Review)

  • Authors:
    • Caixia Zhang
    • Weiyan Wang
    • Chenhui Du
    • Huifang Li
    • Kun Zhou
    • Zhihua Luan
    • Yinxia Chang
    • Shan Liu
    • Yanming Wei
  • View Affiliations

  • Published online on: April 20, 2023     https://doi.org/10.3892/etm.2023.11967
  • Article Number: 268
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Celastrol, a natural compound extracted from the traditional Chinese medicinal herb Tripterygium wilfordii Hook F, possesses broad‑spectrum pharmacological properties. Autophagy is an evolutionarily conserved catabolic process through which cytoplasmic cargo is delivered to the lysosomes for degradation. Autophagy dysregulation contributes to multiple pathological processes. Therefore, targeting autophagic activity is a promising therapy for various diseases, as well as a drug‑development strategy. According to previous studies, autophagy is specifically targeted and may be altered in response to celastrol treatment, highlighting that autophagy modulation is an important mechanism underlying the therapeutic efficacy of celastrol for the treatment of various diseases. The present study summarizes the currently available information regarding the role of autophagy in the effect of celastrol to exert anti‑tumor, anti‑inflammatory, immunomodulatory, neuroprotective, anti‑atherosclerosis, anti‑pulmonary fibrosis and anti‑macular degeneration activities. The diverse signaling pathways involved are also analyzed to provide insight into the mechanisms of action of celastrol and thereby pave the way for establishing celastrol as an efficacious autophagy modulator in clinical practice.
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June-2023
Volume 25 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang C, Wang W, Du C, Li H, Zhou K, Luan Z, Chang Y, Liu S and Wei Y: Autophagy in the pharmacological activities of celastrol (Review). Exp Ther Med 25: 268, 2023
APA
Zhang, C., Wang, W., Du, C., Li, H., Zhou, K., Luan, Z. ... Wei, Y. (2023). Autophagy in the pharmacological activities of celastrol (Review). Experimental and Therapeutic Medicine, 25, 268. https://doi.org/10.3892/etm.2023.11967
MLA
Zhang, C., Wang, W., Du, C., Li, H., Zhou, K., Luan, Z., Chang, Y., Liu, S., Wei, Y."Autophagy in the pharmacological activities of celastrol (Review)". Experimental and Therapeutic Medicine 25.6 (2023): 268.
Chicago
Zhang, C., Wang, W., Du, C., Li, H., Zhou, K., Luan, Z., Chang, Y., Liu, S., Wei, Y."Autophagy in the pharmacological activities of celastrol (Review)". Experimental and Therapeutic Medicine 25, no. 6 (2023): 268. https://doi.org/10.3892/etm.2023.11967