Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
June-2023 Volume 25 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2023 Volume 25 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

CKLF1 interference alleviates IL‑1β‑induced inflammation, apoptosis and degradation of the extracellular matrix in chondrocytes via CCR5

  • Authors:
    • Haoran Wang
    • Zhongqing Wu
    • Kanna Xu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Hangzhou Children's Hospital, Hangzhou, Zhejiang 310014, P.R. China, Department of Orthopedics, The First People's Hospital of Huzhou, Huzhou, Zhejiang 313000, P.R. China, Emergency Department, The First People's Hospital of Huzhou, Huzhou, Zhejiang 313000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 303
    |
    Published online on: May 9, 2023
       https://doi.org/10.3892/etm.2023.12002
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Osteoarthritis (OA) is a type of joint disease with a rising prevalence and incidence among the elderly across the global population. Chemokine‑like factor 1 (CKLF1) is a human cytokine, which has been demonstrated to be involved in the progression of multiple human diseases. However, little attention has been paid to the impact of CKLF1 on OA. The present study was designed to identify the role of CKLF1 in OA and to clarify the regulatory mechanism. The expression levels of CKLF1 and its receptor CC chemokine receptor 5 (CCR5) were examined by reverse transcription‑quantitative PCR (RT‑qPCR) and western blotting. A Cell Counting Kit‑8 assay was used to estimate cell viability. The levels and expression of inflammatory factors were determined by ELISA and RT‑qPCR, respectively. Apoptosis was investigated by TUNEL assays and the protein levels of apoptosis‑related factors were analyzed by western blotting. RT‑qPCR and western blotting were used to examine the expression of extracellular matrix (ECM) degradation‑associated proteins and ECM components. Dimethylmethylene blue analysis was used to analyze the production of soluble glycosamine sulfate additive. A co‑immunoprecipitation assay was used to confirm the protein interaction between CKLF1 and CCR5. The results revealed that CKLF1 expression was increased in IL‑1β‑exposed murine chondrogenic ATDC5 cells. Furthermore, CKLF1 silencing enhanced the viability of IL‑1β‑induced ATDC5 cells, while inflammation, apoptosis and degradation of the ECM were reduced. Additionally, CKLF1 knockdown led to decreased CCR5 expression in IL‑1β‑challenged ATDC5 cells, and CKLF1 bound with CCR5. The enhanced viability, as well as the suppressed inflammation, apoptosis and degradation of the ECM, following CKLF1 knockdown in the IL‑1β‑induced ATDC5 cells were all restored after CCR5 was overexpressed. In conclusion, CKLF1 might serve a detrimental role in the development of OA by targeting its receptor CCR5.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

O'Neill TW, McCabe PS and McBeth J: Update on the epidemiology, risk factors and disease outcomes of osteoarthritis. Best Pract Res Clin Rheumatol. 32:312–326. 2018.PubMed/NCBI View Article : Google Scholar

2 

Litwic A, Edwards MH, Dennison EM and Cooper C: Epidemiology and burden of osteoarthritis. Br Med Bull. 105:185–199. 2013.PubMed/NCBI View Article : Google Scholar

3 

Pereira D, Ramos E and Branco J: Osteoarthritis. Acta Med Port. 28:99–106. 2015.PubMed/NCBI View Article : Google Scholar

4 

Martel-Pelletier J, Barr AJ, Cicuttini FM, Conaghan PG, Cooper C, Goldring MB, Goldring SR, Jones G, Teichtahl AJ and Pelletier JP: Osteoarthritis. Nat Rev Dis Primers. 2(16072)2016.PubMed/NCBI View Article : Google Scholar

5 

Palazzo C, Nguyen C, Lefevre-Colau MM, Rannou F and Poiraudeau S: Risk factors and burden of osteoarthritis. Ann Phys Rehabil Med. 59:134–138. 2016.PubMed/NCBI View Article : Google Scholar

6 

Rahmati M, Nalesso G, Mobasheri A and Mozafari M: Aging and osteoarthritis: Central role of the extracellular matrix. Ageing Res Rev. 40:20–30. 2017.PubMed/NCBI View Article : Google Scholar

7 

Theocharis AD, Skandalis SS, Gialeli C and Karamanos NK: Extracellular matrix structure. Adv Drug Deliv Rev. 97:4–27. 2016.PubMed/NCBI View Article : Google Scholar

8 

Shen J, Abu-Amer Y, O'Keefe RJ and McAlinden A: Inflammation and epigenetic regulation in osteoarthritis. Connect Tissue Res. 58:49–63. 2017.PubMed/NCBI View Article : Google Scholar

9 

Chow YY and Chin KY: The role of inflammation in the pathogenesis of osteoarthritis. Mediators Inflamm. 2020(8293921)2020.PubMed/NCBI View Article : Google Scholar

10 

Hwang HS and Kim HA: Chondrocyte apoptosis in the pathogenesis of osteoarthritis. Int J Mol Sci. 16:26035–26054. 2015.PubMed/NCBI View Article : Google Scholar

11 

Xia B, Di C, Zhang J, Hu S, Jin H and Tong P: Osteoarthritis pathogenesis: A review of molecular mechanisms. Calcif Tissue Int. 95:495–505. 2014.PubMed/NCBI View Article : Google Scholar

12 

Geyer M and Schönfeld C: Novel insights into the pathogenesis of osteoarthritis. Current Rheumatol Rev. 14:98–107. 2018.PubMed/NCBI View Article : Google Scholar

13 

Liu DD, Song XY, Yang PF, Ai QD, Wang YY, Feng XY, He X and Chen NH: Progress in pharmacological research of chemokine like factor 1 (CKLF1). Cytokine. 102:41–50. 2018.PubMed/NCBI View Article : Google Scholar

14 

Han W, Lou Y, Tang J, Zhang Y, Chen Y, Li Y, Gu W, Huang J, Gui L, Tang Y, et al: Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity. Biochem J. 357:127–135. 2001.PubMed/NCBI View Article : Google Scholar

15 

Cai X, Deng J, Ming Q, Cai H and Chen Z: Chemokine-like factor 1: A promising therapeutic target in human diseases. Exp Biol Med (Maywood). 245:1518–1528. 2020.PubMed/NCBI View Article : Google Scholar

16 

Li Y, Yu H and Feng J: Role of chemokine-like factor 1 as an inflammatory marker in diseases. Front Immunol. 14(1085154)2023.PubMed/NCBI View Article : Google Scholar

17 

Liu Y, Liu L, Zhou Y, Zhou P, Yan Q, Chen X, Ding S and Zhu F: CKLF1 enhances inflammation-mediated carcinogenesis and prevents doxorubicin-induced apoptosis via IL6/STAT3 signaling in HCC. Clin Cancer Res. 25:4141–4154. 2019.PubMed/NCBI View Article : Google Scholar

18 

Liu X, Qu C, Zhang Y, Fang J, Teng L, Zhang R, Zhang X and Shen C: Chemokine-like factor 1 (CKLF1) aggravates neointimal hyperplasia through activating the NF-κB/VCAM-1 pathway. FEBS Open Bio. 10:1880–1890. 2020.PubMed/NCBI View Article : Google Scholar

19 

Pan Z, Yin H, Wang S, Xiong G and Yin Z: Bcl-xL expression following articular cartilage injury and its effects on the biological function of chondrocytes. Eng Life Sci. 20:571–579. 2020.PubMed/NCBI View Article : Google Scholar

20 

Chen C, Chu SF, Ai QD, Zhang Z and Chen NH: CKLF1/CCR5 axis is involved in neutrophils migration of rats with transient cerebral ischemia. Int Immunopharmacol. 85(106577)2020.PubMed/NCBI View Article : Google Scholar

21 

González-Martin A, Mira E and Mañes S: CCR5 as a potential target in cancer therapy: Inhibition or stimulation? Anticancer Agents Med Chem. 12:1045–1057. 2012.PubMed/NCBI View Article : Google Scholar

22 

Velasco-Velázquez M, Xolalpa W and Pestell RG: The potential to target CCL5/CCR5 in breast cancer. Expert Opin Ther Targets. 18:1265–1275. 2014.PubMed/NCBI View Article : Google Scholar

23 

Aldinucci D and Casagrande N: Inhibition of the CCL5/CCR5 axis against the progression of gastric cancer. Int J Mol Sci. 19(1477)2018.PubMed/NCBI View Article : Google Scholar

24 

Pervaiz A, Zepp M, Georges R, Bergmann F, Mahmood S, Faiza S, Berger MR and Adwan H: Antineoplastic effects of targeting CCR5 and its therapeutic potential for colorectal cancer liver metastasis. J Cancer Res Clin Oncol. 147:73–91. 2021.PubMed/NCBI View Article : Google Scholar

25 

Singh SK, Mishra MK, Eltoum IA, Bae S, Lillard JW Jr and Singh R: CCR5/CCL5 axis interaction promotes migratory and invasiveness of pancreatic cancer cells. Sci Rep. 8(1323)2018.PubMed/NCBI View Article : Google Scholar

26 

Xie P, Dan F, Yu G, Ruan W and Yu H: Laquinimod mitigated IL-1β-induced impairment of the cartilage extracellular matrix in human ATDC5 chondrocytes. Chem Res Toxicol. 33:933–939. 2020.PubMed/NCBI View Article : Google Scholar

27 

Ladner YD, Alini M and Armiento AR: The dimethylmethylene blue assay (DMMB) for the quantification of sulfated glycosaminoglycans. Methods Mol Biol. 2598:115–121. 2023.PubMed/NCBI View Article : Google Scholar

28 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

29 

Landskron G, De la Fuente M, Thuwajit P, Thuwajit C and Hermoso MA: Chronic inflammation and cytokines in the tumor microenvironment. J Immunol Res. 2014(149185)2014.PubMed/NCBI View Article : Google Scholar

30 

Luo Y, Sinkeviciute D, He Y, Karsdal M, Henrotin Y, Mobasheri A, Önnerfjord P and Bay-Jensen A: The minor collagens in articular cartilage. Protein Cell. 8:560–572. 2017.PubMed/NCBI View Article : Google Scholar

31 

Malemud CJ: Inhibition of MMPs and ADAM/ADAMTS. Biochem Pharmacol. 165:33–40. 2019.PubMed/NCBI View Article : Google Scholar

32 

Mathiessen A and Conaghan PG: Synovitis in osteoarthritis: Current understanding with therapeutic implications. Arthritis Res Ther. 19(18)2017.PubMed/NCBI View Article : Google Scholar

33 

Vilá S: Inflammation in osteoarthritis. P R Health Sci J. 36:123–129. 2017.PubMed/NCBI

34 

Jenei-Lanzl Z, Meurer A and Zaucke F: Interleukin-1β signaling in osteoarthritis-chondrocytes in focus. Cell Signal. 53:212–223. 2019.PubMed/NCBI View Article : Google Scholar

35 

Blasioli DJ and Kaplan DL: The roles of catabolic factors in the development of osteoarthritis. Tissue Eng Part B Rev. 20:355–363. 2014.PubMed/NCBI View Article : Google Scholar

36 

Tao K, Tang X, Wang B, Li RJ, Zhang BQ, Lin JH, Zhang BQ, Lin JH and Li H: Distinct expression of chemokine-like factor 1 in synovium of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. J Huazhong Univ Sci Technolog Med Sci. 36:70–76. 2016.PubMed/NCBI View Article : Google Scholar

37 

Ai Q, Chen C, Chu S, Luo Y, Zhang Z, Zhang S, Yang P, Gao Y, Zhang X and Chen N: IMM-H004 protects against cerebral ischemia injury and cardiopulmonary complications via CKLF1 mediated inflammation pathway in adult and aged rats. Int J Mol Sci. 20(1661)2019.PubMed/NCBI View Article : Google Scholar

38 

Zheng Y, Wang Y, Zhang X, Tan Y, Peng S, Chen L and He Y: C19, a C-terminal peptide of CKLF1, decreases inflammation and proliferation of dermal capillaries in psoriasis. Sci Rep. 7(13890)2017.PubMed/NCBI View Article : Google Scholar

39 

Chen C, Ai Q and Wei Y: Hydroxytyrosol protects against cisplatin-induced nephrotoxicity via attenuating CKLF1 mediated inflammation, and inhibiting oxidative stress and apoptosis. Int Immunopharmacol. 96(107805)2021.PubMed/NCBI View Article : Google Scholar

40 

Li J, Bao X, Li Y, Wang Y, Zhao Z and Jin X: Study of the functional mechanisms of osteopontin and chemokine-like factor 1 in the development and progression of abdominal aortic aneurysms in rats. Exp Ther Med. 12:4007–4011. 2016.PubMed/NCBI View Article : Google Scholar

41 

Risbud MV and Shapiro IM: Role of cytokines in intervertebral disc degeneration: Pain and disc content. Nat Rev Rheumatol. 10:44–56. 2014.PubMed/NCBI View Article : Google Scholar

42 

Cui N, Hu M and Khalil RA: Biochemical and biological attributes of matrix metalloproteinases. Prog Mol Biol Transl Sci. 147:1–73. 2017.PubMed/NCBI View Article : Google Scholar

43 

Mead TJ and Apte SS: ADAMTS proteins in human disorders. Matrix Biol. 71-72:225–239. 2018.PubMed/NCBI View Article : Google Scholar

44 

Santamaria S and Yamamoto K: Analysis of aggrecanase activity using neoepitope antibodies. Methods Mol Biol. 2043:125–136. 2020.PubMed/NCBI View Article : Google Scholar

45 

Wang T and He C: Pro-inflammatory cytokines: The link between obesity and osteoarthritis. Cytokine Growth Factor Rev. 44:38–50. 2018.PubMed/NCBI View Article : Google Scholar

46 

Hintze V, Samsonov SA, Anselmi M, Moeller S, Becher J, Schnabelrauch M, Scharnweber D and Pisabarro MT: Sulfated glycosaminoglycans exploit the conformational plasticity of bone morphogenetic protein-2 (BMP-2) and alter the interaction profile with its receptor. Biomacromolecules. 15:3083–3092. 2014.PubMed/NCBI View Article : Google Scholar

47 

Maeda K, Das D, Nakata H and Mitsuya H: CCR5 inhibitors: Emergence, success, and challenges. Exp Opin Emerg Drugs. 17:135–145. 2012.PubMed/NCBI View Article : Google Scholar

48 

Hsu YH, Hsieh MS, Liang YC, Li CY, Sheu MT, Chou DT, Chen TF and Chen CH: Production of the chemokine eotaxin-1 in osteoarthritis and its role in cartilage degradation. J Cell Biochem. 93:929–939. 2004.PubMed/NCBI View Article : Google Scholar

49 

Yuan GH, Masuko-Hongo K, Sakata M, Tsuruha J, Onuma H, Nakamura H, Aoki H, Kato T and Nishioka K: The role of C-C chemokines and their receptors in osteoarthritis. Arthritis Rheum. 44:1056–1070. 2001.PubMed/NCBI View Article : Google Scholar

50 

Alblowi J, Tian C, Siqueira MF, Kayal RA, McKenzie E, Behl Y, Gerstenfeld L, Einhorn TA and Graves DT: Chemokine expression is upregulated in chondrocytes in diabetic fracture healing. Bone. 53:294–300. 2013.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang H, Wu Z and Xu K: CKLF1 interference alleviates IL‑1β‑induced inflammation, apoptosis and degradation of the extracellular matrix in chondrocytes via CCR5. Exp Ther Med 25: 303, 2023.
APA
Wang, H., Wu, Z., & Xu, K. (2023). CKLF1 interference alleviates IL‑1β‑induced inflammation, apoptosis and degradation of the extracellular matrix in chondrocytes via CCR5. Experimental and Therapeutic Medicine, 25, 303. https://doi.org/10.3892/etm.2023.12002
MLA
Wang, H., Wu, Z., Xu, K."CKLF1 interference alleviates IL‑1β‑induced inflammation, apoptosis and degradation of the extracellular matrix in chondrocytes via CCR5". Experimental and Therapeutic Medicine 25.6 (2023): 303.
Chicago
Wang, H., Wu, Z., Xu, K."CKLF1 interference alleviates IL‑1β‑induced inflammation, apoptosis and degradation of the extracellular matrix in chondrocytes via CCR5". Experimental and Therapeutic Medicine 25, no. 6 (2023): 303. https://doi.org/10.3892/etm.2023.12002
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Wu Z and Xu K: CKLF1 interference alleviates IL‑1β‑induced inflammation, apoptosis and degradation of the extracellular matrix in chondrocytes via CCR5. Exp Ther Med 25: 303, 2023.
APA
Wang, H., Wu, Z., & Xu, K. (2023). CKLF1 interference alleviates IL‑1β‑induced inflammation, apoptosis and degradation of the extracellular matrix in chondrocytes via CCR5. Experimental and Therapeutic Medicine, 25, 303. https://doi.org/10.3892/etm.2023.12002
MLA
Wang, H., Wu, Z., Xu, K."CKLF1 interference alleviates IL‑1β‑induced inflammation, apoptosis and degradation of the extracellular matrix in chondrocytes via CCR5". Experimental and Therapeutic Medicine 25.6 (2023): 303.
Chicago
Wang, H., Wu, Z., Xu, K."CKLF1 interference alleviates IL‑1β‑induced inflammation, apoptosis and degradation of the extracellular matrix in chondrocytes via CCR5". Experimental and Therapeutic Medicine 25, no. 6 (2023): 303. https://doi.org/10.3892/etm.2023.12002
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team