Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July-2023 Volume 26 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2023 Volume 26 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Pachymic acid modulates sirtuin 6 activity to alleviate lipid metabolism disorders

  • Authors:
    • Zhi-Sen Pan
    • Yan-Ling Chen
    • Kai-Jia Tang
    • Zhang-Zhou Liu
    • Jia-Li Liang
    • Yan-Hao Guan
    • Xiao-Yi Xin
    • Chang-Hui Liu
    • Chuang-Peng Shen
  • View Affiliations / Copyright

    Affiliations: Department of Traditional Chinese Medicine, The First People's Hospital of Kashgar Prefecture, Kashgar, Xinjiang Uyghur Autonomous Region 844000, P.R. China, Department of Endocrinology, The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, P.R. China, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, P.R. China, Department of Endocrinology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, P.R. China, Department of Traditional Chinese Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uyghur Autonomous Region 830011, P.R. China, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, P.R. China, Department of Traditional Chinese Medicine, The First People's Hospital of Kashgar Prefecture, Kashgar, Xinjiang Uyghur Autonomous Region 844000, P.R. China
    Copyright: © Pan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 320
    |
    Published online on: May 15, 2023
       https://doi.org/10.3892/etm.2023.12019
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Pachymic acid (Pac), a major bioactive constituent of Poria cocos, is an antioxidant that inhibits triglyceride (TG) accumulation. To the best of our knowledge, the present study investigated for the first time whether Pac activated sirtuin 6 (SIRT6) signaling to alleviate oleic acid (OA)‑palmitic acid (PA)‑induced lipid metabolism disorders in mouse primary hepatocytes (MPHs). In the present study, MPHs challenged with Pac were used to test the effects of Pac on intracellular lipid metabolism. Molecular docking studies were performed to explore the potential targets of Pac in defending against lipid deposition. MPHs isolated from liver‑specific SIRT6‑deficient mice were subjected to OA + PA incubation and treated with Pac to determine the function and detailed mechanism. It was revealed that Pac activated SIRT6 by increasing its expression and deacetylase activity. Pa prevented OA + PA‑induced lipid deposition in MPHs in a dose‑dependent manner. Pac (50 µM) administration significantly reduced TG accumulation and increased fatty acid oxidation rate in OA + PA‑incubated MPHs. Meanwhile, as per the results of molecular docking and relative mRNA levels, Pac activated SIRT6 and increased SIRT6 deacetylation levels. Furthermore, SIRT6 deletions in MPHs abolished the protective effects of Pac against OA + PA‑induced hepatocyte lipid metabolism disorders. The present study demonstrated that Pac alleviates OA + PA‑induced hepatocyte lipid metabolism disorders by activating SIRT6 signaling. Overall, SIRT6 signaling increases oxidative stress burden and promotes hepatocyte lipolysis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Juanola O, Martinez-Lopez S, Frances R and Gomez-Hurtado I: Non-Alcoholic fatty liver disease: Metabolic, genetic, epigenetic and environmental risk factors. Int J Environ Res Public Health. 18(5227)2021.PubMed/NCBI View Article : Google Scholar

2 

Byun S, Seok S, Kim YC, Zhang Y, Yau P, Iwamori N, Xu HE, Ma J, Kemper B and Kemper JK: Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase. Nat Commun. 11(807)2020.PubMed/NCBI View Article : Google Scholar

3 

Alves-Bezerra M and Cohen DE: Triglyceride metabolism in the liver. Compr Physiol. 8:1–8. 2017.PubMed/NCBI View Article : Google Scholar

4 

Secor JD, Fligor SC, Tsikis ST, Yu LJ and Puder M: Free fatty acid receptors as mediators and therapeutic targets in liver disease. Front Physiol. 12(656441)2021.PubMed/NCBI View Article : Google Scholar

5 

Jiang G, Chen D, Li W, Liu C, Liu J and Guo Y: Effects of wogonoside on the inflammatory response and oxidative stress in mice with nonalcoholic fatty liver disease. Pharm Biol. 58:1177–1183. 2020.PubMed/NCBI View Article : Google Scholar

6 

Kersten S and Stienstra R: The role and regulation of the peroxisome proliferator activated receptor alpha in human liver. Biochimie. 136:75–84. 2017.PubMed/NCBI View Article : Google Scholar

7 

Sun N, Shen C, Zhang L, Wu X, Yu Y, Yang X, Yang C, Zhong C, Gao Z, Miao W, et al: Hepatic Kruppel-like factor 16 (KLF16) targets PPARα to improve steatohepatitis and insulin resistance. Gut. 70:2183–2195. 2021.PubMed/NCBI View Article : Google Scholar

8 

Wahli W and Michalik L: PPARs at the crossroads of lipid signaling and inflammation. Trends Endocrinol Metab. 23:351–363. 2012.PubMed/NCBI View Article : Google Scholar

9 

Montagner A, Polizzi A, Fouche E, Ducheix S, Lippi Y, Lasserre F, Barquissau V, Régnier M, Lukowicz C, Benhamed F, et al: Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD. Gut. 65:1202–1214. 2016.PubMed/NCBI View Article : Google Scholar

10 

Yang DK and Jo DG: Mulberry fruit extract ameliorates nonalcoholic fatty liver disease (NAFLD) through inhibition of mitochondrial oxidative stress in rats. Evid Based Complement Alternat Med. 2018(8165716)2018.PubMed/NCBI View Article : Google Scholar

11 

Wu W, Peng G, Yang F, Zhang Y, Mu Z and Han X: Sulforaphane has a therapeutic effect in an atopic dermatitis murine model and activates the Nrf2/HO1 axis. Mol Med Rep. 20:1761–1771. 2019.PubMed/NCBI View Article : Google Scholar

12 

Yan C, Sun W, Wang X, Long J, Liu X, Feng Z and Liu J: Punicalagin attenuates palmitate-induced lipotoxicity in HepG2 cells by activating the Keap1-Nrf2 antioxidant defense system. Mol Nutr Food Res. 60:1139–1149. 2016.PubMed/NCBI View Article : Google Scholar

13 

Van Gool F, Galli M, Gueydan C, Kruys V, Prevot PP, Bedalov A, Mostoslavsky R, Alt FW, De Smedt T and Leo O: Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nat Med. 15:206–210. 2009.PubMed/NCBI View Article : Google Scholar

14 

Naiman S, Huynh FK, Gil R, Glick Y, Shahar Y, Touitou N, Nahum L, Avivi MY, Roichman A, Kanfi Y, et al: SIRT6 promotes hepatic beta-oxidation via activation of PPARα. Cell Rep. 29:4127–4143 e8. 2019.PubMed/NCBI View Article : Google Scholar

15 

Kim HS, Xiao C, Wang RH, Lahusen T, Xu X, Vassilopoulos A, Vazquez-Ortiz G, Jeong WI, Park O, Ki SH, et al: Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab. 12:224–236. 2010.PubMed/NCBI View Article : Google Scholar

16 

Kuang J, Chen L, Tang Q, Zhang J, Li Y and He J: The role of Sirt6 in obesity and diabetes. Front Physiol. 9(135)2018.PubMed/NCBI View Article : Google Scholar

17 

Kanfi Y, Peshti V, Gil R, Naiman S, Nahum L, Levin E, Kronfeld-Schor N and Cohen HY: SIRT6 protects against pathological damage caused by diet-induced obesity. Aging Cell. 9:162–173. 2010.PubMed/NCBI View Article : Google Scholar

18 

Ding B, Ji X, Sun X, Zhang T and Mu S: In vitro effect of pachymic acid on the activity of Cytochrome P450 enzymes. Xenobiotica. 50:913–918. 2020.PubMed/NCBI View Article : Google Scholar

19 

Akihisa T, Nakamura Y, Tokuda H, Uchiyama E, Suzuki T, Kimura Y, Uchikura K and Nishino H: Triterpene acids from Poria cocos and their anti-tumor-promoting effects. J Nat Prod. 70:948–953. 2007.PubMed/NCBI View Article : Google Scholar

20 

Kim TG, Lee YH, Lee NH, Bhattarai G, Lee IK, Yun BS and Yi HK: The antioxidant property of pachymic acid improves bone disturbance against AH plus-induced inflammation in MC-3T3 E1 cells. J Endod. 39:461–466. 2013.PubMed/NCBI View Article : Google Scholar

21 

Lee YH, Lee NH, Bhattarai G, Kim GE, Lee IK, Yun BS, Hwang PH and Yi HK: Anti-inflammatory effect of pachymic acid promotes odontoblastic differentiation via HO-1 in dental pulp cells. Oral Dis. 19:193–199. 2013.PubMed/NCBI View Article : Google Scholar

22 

Lu C, Ma J and Cai D: Pachymic acid inhibits the tumorigenicity of gastric cancer cells by the mitochondrial pathway. Anticancer Drugs. 28:170–179. 2017.PubMed/NCBI View Article : Google Scholar

23 

Kim JH, Sim HA, Jung DY, Lim EY, Kim YT, Kim BJ and Jung MH: Poria cocus Wolf extract ameliorates hepatic steatosis through regulation of lipid metabolism, inhibition of ER stress, and activation of autophagy via AMPK activation. Int J Mol Sci. 20(4801)2019.PubMed/NCBI View Article : Google Scholar

24 

Chen L, Liu Q, Tang Q, Kuang J, Li H, Pu S, Wu T, Yang X, Li R, Zhang J, et al: Hepatocyte-specific Sirt6 deficiency impairs ketogenesis. J Biol Chem. 294:1579–1589. 2019.PubMed/NCBI View Article : Google Scholar

25 

Friesner RA, Banks JL, Murphy RB, Halgren TA, Klicic JJ, Mainz DT, Repasky MP, Knoll EH, Shelley M, Perry JK, et al: Glide: A new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. J Med Chem. 47:1739–1749. 2004.PubMed/NCBI View Article : Google Scholar

26 

Fazi R, Tintori C, Brai A, Botta L, Selvaraj M, Garbelli A, Maga G and Botta M: Homology model-based virtual screening for the identification of human helicase DDX3 inhibitors. J Chem Inf Model. 55:2443–2454. 2015.PubMed/NCBI View Article : Google Scholar

27 

Chen Z, Tian R, She Z, Cai J and Li H: Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease. Free Radic Biol Med. 152:116–141. 2020.PubMed/NCBI View Article : Google Scholar

28 

Zhou Y, Fan X, Jiao T, Li W, Chen P, Jiang Y, Sun J, Chen Y, Chen P, Guan L, et al: SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation. Acta Pharm Sin B. 11:89–99. 2021.PubMed/NCBI View Article : Google Scholar

29 

Rives C, Fougerat A, Ellero-Simatos S, Loiseau N, Guillou H, Gamet-Payrastre L and Wahli W: Oxidative stress in NAFLD: Role of nutrients and food contaminants. Biomolecules. 10(1702)2020.PubMed/NCBI View Article : Google Scholar

30 

Fang YL, Chen H, Wang CL and Liang L: Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From ‘two hit theory’ to ‘multiple hit model’. World J Gastroenterol. 24:2974–2983. 2018.PubMed/NCBI View Article : Google Scholar

31 

Buzzetti E, Pinzani M and Tsochatzis EA: The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). Metabolism. 65:1038–1048. 2016.PubMed/NCBI View Article : Google Scholar

32 

Pawlak M, Lefebvre P and Staels B: Molecular mechanism of PPARalpha action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease. J Hepatol. 62:720–733. 2015.PubMed/NCBI View Article : Google Scholar

33 

Ferramosca A and Zara V: Modulation of hepatic steatosis by dietary fatty acids. World J Gastroenterol. 20:1746–1755. 2014.PubMed/NCBI View Article : Google Scholar

34 

Kawahara TL, Michishita E, Adler AS, Damian M, Berber E, Lin M, McCord RA, Ongaigui KC, Boxer LD, Chang HY and Chua KF: SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life Span. Cell. 136:62–74. 2009.PubMed/NCBI View Article : Google Scholar

35 

Li Z, Xu K, Guo Y, Ping L, Gao Y, Qiu Y, Ni J, Liu Q and Wang Z: A high-fat diet reverses metabolic disorders and premature aging by modulating insulin and IGF1 signaling in SIRT6 knockout mice. Aging Cell. 19(e13104)2020.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Pan Z, Chen Y, Tang K, Liu Z, Liang J, Guan Y, Xin X, Liu C and Shen C: Pachymic acid modulates sirtuin 6 activity to alleviate lipid metabolism disorders. Exp Ther Med 26: 320, 2023.
APA
Pan, Z., Chen, Y., Tang, K., Liu, Z., Liang, J., Guan, Y. ... Shen, C. (2023). Pachymic acid modulates sirtuin 6 activity to alleviate lipid metabolism disorders. Experimental and Therapeutic Medicine, 26, 320. https://doi.org/10.3892/etm.2023.12019
MLA
Pan, Z., Chen, Y., Tang, K., Liu, Z., Liang, J., Guan, Y., Xin, X., Liu, C., Shen, C."Pachymic acid modulates sirtuin 6 activity to alleviate lipid metabolism disorders". Experimental and Therapeutic Medicine 26.1 (2023): 320.
Chicago
Pan, Z., Chen, Y., Tang, K., Liu, Z., Liang, J., Guan, Y., Xin, X., Liu, C., Shen, C."Pachymic acid modulates sirtuin 6 activity to alleviate lipid metabolism disorders". Experimental and Therapeutic Medicine 26, no. 1 (2023): 320. https://doi.org/10.3892/etm.2023.12019
Copy and paste a formatted citation
x
Spandidos Publications style
Pan Z, Chen Y, Tang K, Liu Z, Liang J, Guan Y, Xin X, Liu C and Shen C: Pachymic acid modulates sirtuin 6 activity to alleviate lipid metabolism disorders. Exp Ther Med 26: 320, 2023.
APA
Pan, Z., Chen, Y., Tang, K., Liu, Z., Liang, J., Guan, Y. ... Shen, C. (2023). Pachymic acid modulates sirtuin 6 activity to alleviate lipid metabolism disorders. Experimental and Therapeutic Medicine, 26, 320. https://doi.org/10.3892/etm.2023.12019
MLA
Pan, Z., Chen, Y., Tang, K., Liu, Z., Liang, J., Guan, Y., Xin, X., Liu, C., Shen, C."Pachymic acid modulates sirtuin 6 activity to alleviate lipid metabolism disorders". Experimental and Therapeutic Medicine 26.1 (2023): 320.
Chicago
Pan, Z., Chen, Y., Tang, K., Liu, Z., Liang, J., Guan, Y., Xin, X., Liu, C., Shen, C."Pachymic acid modulates sirtuin 6 activity to alleviate lipid metabolism disorders". Experimental and Therapeutic Medicine 26, no. 1 (2023): 320. https://doi.org/10.3892/etm.2023.12019
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team