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Macroscopic on‑site quality evaluation of biopsy specimens to improve the diagnostic accuracy of endoscopic ultrasound‑guided fine needle aspiration using a 22‑gauge needle for solid lesions: A single‑center retrospective study

  • Authors:
    • Chengqi Guan
    • Mengyu Wu
    • Jingxin Ye
    • Zhaoxiu Liu
    • Zhenbiao Mao
    • Cuihua Lu
    • Jianfeng Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China
    Copyright: © Guan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 338
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    Published online on: May 22, 2023
       https://doi.org/10.3892/etm.2023.12037
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Abstract

The present study aimed to evaluate the clinical value of macroscopic on‑site evaluation (MOSE) of solid masses by endoscopic ultrasound (EUS)‑guided fine needle aspiration (FNA) using a standard 22‑gauge needle and to explore the cut‑off length of macroscopic visible core (MVC) required to obtain an accurate histopathological diagnosis. In total, 119 patients who satisfied the inclusion and exclusion criteria and underwent EUS‑FNA were divided into conventional FNA and FNA combined with MOSE groups. In the MOSE group, the presence of MVC was examined and its total length measured, after which the pathological results of FNA were compared with the final diagnosis. The diagnostic sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of FNA in the two groups were calculated and the effect of MOSE on the FNA result was analyzed. The MOSE group had a higher diagnostic sensitivity (75.0% vs. 89.8%; P=0.038) and accuracy (74.5% vs. 90.6%; P=0.026). MVC was observed in 98.4% (63/64) of patients in the MOSE group. The median length of MVC was 15 mm. The optimal cut‑off length of MVC for obtaining an accurate histological diagnosis was 13 mm, with a sensitivity of 90.2%. No statistically significant significance was observed in the specificity, PPV and NPV between the groups. Thus, MOSE helps to improve the diagnostic ability of FNA for solid masses and may be a useful alternative to assess the adequacy of puncture specimens in units where rapid on‑site evaluation cannot be performed.
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Copy and paste a formatted citation
Spandidos Publications style
Guan C, Wu M, Ye J, Liu Z, Mao Z, Lu C and Zhang J: Macroscopic on‑site quality evaluation of biopsy specimens to improve the diagnostic accuracy of endoscopic ultrasound‑guided fine needle aspiration using a 22‑gauge needle for solid lesions: A single‑center retrospective study. Exp Ther Med 26: 338, 2023.
APA
Guan, C., Wu, M., Ye, J., Liu, Z., Mao, Z., Lu, C., & Zhang, J. (2023). Macroscopic on‑site quality evaluation of biopsy specimens to improve the diagnostic accuracy of endoscopic ultrasound‑guided fine needle aspiration using a 22‑gauge needle for solid lesions: A single‑center retrospective study. Experimental and Therapeutic Medicine, 26, 338. https://doi.org/10.3892/etm.2023.12037
MLA
Guan, C., Wu, M., Ye, J., Liu, Z., Mao, Z., Lu, C., Zhang, J."Macroscopic on‑site quality evaluation of biopsy specimens to improve the diagnostic accuracy of endoscopic ultrasound‑guided fine needle aspiration using a 22‑gauge needle for solid lesions: A single‑center retrospective study". Experimental and Therapeutic Medicine 26.1 (2023): 338.
Chicago
Guan, C., Wu, M., Ye, J., Liu, Z., Mao, Z., Lu, C., Zhang, J."Macroscopic on‑site quality evaluation of biopsy specimens to improve the diagnostic accuracy of endoscopic ultrasound‑guided fine needle aspiration using a 22‑gauge needle for solid lesions: A single‑center retrospective study". Experimental and Therapeutic Medicine 26, no. 1 (2023): 338. https://doi.org/10.3892/etm.2023.12037
Copy and paste a formatted citation
x
Spandidos Publications style
Guan C, Wu M, Ye J, Liu Z, Mao Z, Lu C and Zhang J: Macroscopic on‑site quality evaluation of biopsy specimens to improve the diagnostic accuracy of endoscopic ultrasound‑guided fine needle aspiration using a 22‑gauge needle for solid lesions: A single‑center retrospective study. Exp Ther Med 26: 338, 2023.
APA
Guan, C., Wu, M., Ye, J., Liu, Z., Mao, Z., Lu, C., & Zhang, J. (2023). Macroscopic on‑site quality evaluation of biopsy specimens to improve the diagnostic accuracy of endoscopic ultrasound‑guided fine needle aspiration using a 22‑gauge needle for solid lesions: A single‑center retrospective study. Experimental and Therapeutic Medicine, 26, 338. https://doi.org/10.3892/etm.2023.12037
MLA
Guan, C., Wu, M., Ye, J., Liu, Z., Mao, Z., Lu, C., Zhang, J."Macroscopic on‑site quality evaluation of biopsy specimens to improve the diagnostic accuracy of endoscopic ultrasound‑guided fine needle aspiration using a 22‑gauge needle for solid lesions: A single‑center retrospective study". Experimental and Therapeutic Medicine 26.1 (2023): 338.
Chicago
Guan, C., Wu, M., Ye, J., Liu, Z., Mao, Z., Lu, C., Zhang, J."Macroscopic on‑site quality evaluation of biopsy specimens to improve the diagnostic accuracy of endoscopic ultrasound‑guided fine needle aspiration using a 22‑gauge needle for solid lesions: A single‑center retrospective study". Experimental and Therapeutic Medicine 26, no. 1 (2023): 338. https://doi.org/10.3892/etm.2023.12037
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