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Predicting reflux symptom recurrence: The impact of gastroesophageal junction indicators and body mass index among outpatients

  • Authors:
    • Qing Wang
    • Junhui Lu
    • Yue Sui
    • Jing Fan
    • Jinnan Ren
    • Zhenzhen Wang
    • Xing Chen
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Shanxi Medical University, Taiyuan, Shanxi 030000, P.R. China, Department of Gastroenterology, Shanxi Datong University Affiliated Cancer Hospital, Datong, Shanxi 037000, P.R. China, Department of Gastroenterology, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 351
    |
    Published online on: May 31, 2023
       https://doi.org/10.3892/etm.2023.12050
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Abstract

The present study aimed to evaluate the efficacy of the prediction model in predicting reflux symptom recurrence among outpatients with reflux esophagitis (RE). A total of 261 outpatients diagnosed with RE complicated by anatomical alterations at the gastroesophageal junction and reflux symptoms were included in the study. Through follow‑up, patients were divided into a General group (149 cases) and a Recurrent group (112 cases). Receiver operating characteristic curves of the related factors and prediction model were analyzed to compare the efficacy of each element in predicting reflux recurrence. A prediction model was constructed for predicting reflux recurrence using the axial length of the hiatal hernia (HH), the diameter of the esophageal hiatus, Hill classification, and body mass index (BMI) as risk factors. The cutoff values of the aforementioned factors for predicting reflux recurrence were: an axial length of HH >2 cm, esophageal hiatus diameter ≥3 cm, Hill grade >III, and BMI >25.1 kg/m2. The multivariate prediction model constructed using the aforementioned four indicators together with chronic atrophic gastritis and Helicobacter pylori infection had the area under the curve of 0.801 (95% confidence interval: 0.748‑0.854), and the cutoff value of 46.8 had a sensitivity and specificity of 71.4% and 75.8%, respectively. The predictive model in the present study can be used for the primary assessment of reflux recurrence in patients with RE.
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1 

Fuchs KH, DeMeester TR, Otte F, Broderick RC, Breithaupt W, Varga G and Musial F: Severity of GERD and disease progression. Dis Esophagus. 34(doab006)2021.PubMed/NCBI View Article : Google Scholar

2 

Li L, Gao H, Zhang C, Tu J, Geng X, Wang J, Zhou X, Pan W and Jing J: Diagnostic value of X-ray, endoscopy, and high-resolution manometry for hiatal hernia: A systematic review and meta-analysis. J Gastroenterol Hepatol. 35:13–18. 2020.PubMed/NCBI View Article : Google Scholar

3 

Asaoka D, Takeda T, Sasaki H, Shimada Y, Matsumoto K, Ueyama H, Matsumoto K, Izumi K, Komori H, Akazawa Y, et al: Evaluation of symptomatic reflux esophagitis in proton pump inhibitor users. Biomed Rep. 10:277–282. 2019.PubMed/NCBI View Article : Google Scholar

4 

El-Serag H, Becher A and Jones R: Systematic review: Persistent reflux symptoms on proton pump inhibitor therapy in primary care and community studies. Aliment Pharmacol Ther. 32:720–737. 2010.PubMed/NCBI View Article : Google Scholar

5 

Katz PO, Dunbar KB, Schnoll-Sussman FH, Greer KB, Yadlapati R and Spechler SJ: ACG clinical guideline for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 117:27–56. 2022.PubMed/NCBI View Article : Google Scholar

6 

Gyawali CP, Kahrilas PJ, Savarino E, Zerbib F, Mion F, Smout AJPM, Vaezi M, Sifrim D, Fox MR, Vela MF, et al: Modern diagnosis of GERD: The Lyon Consensus. Gut. 67:1351–1362. 2018.PubMed/NCBI View Article : Google Scholar

7 

Multidisciplinary Branch of Gastroesophageal Reflux of China International Exchange and Promotion Association for Medical and Healthcare. Consensus on multidisciplinary diagnosis and treatment of gastroesophageal reflux disease in China. Chin J Gastroesophagol Reflux Dis (Electronic Edition). 7:1–28. 2020.(In Chinese).

8 

Dent J, Vakil N, Jones R, Bytzer P, Schöning U, Halling K, Junghard O and Lind T: Accuracy of the diagnosis of GORD by questionnaire, physicians and a trial of proton pump inhibitor treatment: The Diamond Study. Gut. 59:714–721. 2010.PubMed/NCBI View Article : Google Scholar

9 

Value of reflux diagnostic questionnaire in the diagnosis of gastroesophageal reflux disease. Chin J Dig Dis. 5:51–55. 2004.PubMed/NCBI View Article : Google Scholar

10 

Shaw MJ, Talley NJ, Beebe TJ, Rockwood T, Carlsson R, Adlis S, Fendrick AM, Jones R, Dent J and Bytzer P: Initial validation of a diagnostic questionnaire for gastroesophageal reflux disease. Am J Gastroenterol. 96:52–57. 2001.PubMed/NCBI View Article : Google Scholar

11 

Lundell LR, Dent J, Bennett JR, Blum AL, Armstrong D, Galmiche JP, Johnson F, Hongo M, Richter JE, Spechler SJ, et al: Endoscopic assessment of oesophagitis: Clinical and functional correlates and further validation of the Los Angeles classification. Gut. 45:172–180. 1999.PubMed/NCBI View Article : Google Scholar

12 

Quach DT and Hiyama T: Assessment of endoscopic gastric atrophy according to the kimura-takemoto classification and its potential application in daily practice. Clin Endosc. 52:321–327. 2019.PubMed/NCBI View Article : Google Scholar

13 

Sgouros SN, Mpakos D, Rodias M, Vassiliades K, Karakoidas C, Andrikopoulos E, Stefanidis G and Mantides A: Prevalence and axial length of hiatus hernia in patients, with nonerosive reflux disease: A prospective study. J Clin Gastroenterol. 41:814–818. 2007.PubMed/NCBI View Article : Google Scholar

14 

Wallner B, Björ O, Andreasson A, Hellström PM, Forsberg AM, Talley NJ and Agreus L: Identifying clinically relevant sliding hiatal hernias: A population-based endoscopy study. Scand J Gastroenterol. 53:657–660. 2018.PubMed/NCBI View Article : Google Scholar

15 

Kaneyama H, Kaise M, Arakawa H, Arai Y, Kanazawa K and Tajiri H: Gastroesophageal flap valve status distinguishes clinical phenotypes of large hiatal hernia. World J Gastroenterol. 16:6010–6015. 2010.PubMed/NCBI View Article : Google Scholar

16 

Peng S, Xiao YL, Cui Y, Lin JK, Zhang N, Hu PJ and Chen MH: High-dose esomeprazole is required for intraesophageal acid control in gastroesophageal reflux disease patients with hiatus hernia. J Gastroenterol Hepatol. 27:893–898. 2012.PubMed/NCBI View Article : Google Scholar

17 

Cheong JH, Kim GH, Lee BE, Choi MK, Moon JY, Ryu DY, Kim DU and Song GA: Endoscopic grading of gastroesophageal flap valve helps predict proton pump inhibitor response in patients with gastroesophageal reflux disease. Scand J Gastroenterol. 46:789–796. 2011.PubMed/NCBI View Article : Google Scholar

18 

Watanabe A, Iwakiri R, Yamaguchi D, Higuchi T, Tsuruoka N, Miyahara K, Akutagawa K, Sakata Y, Fujise T, Oda Y, et al: Risk factors for resistance to proton pump inhibitor maintenance therapy for reflux esophagitis in Japanese women over 60 years. Digestion. 86:323–331. 2012.PubMed/NCBI View Article : Google Scholar

19 

Pandolfino JE, El-Serag HB, Zhang Q, Shah N, Ghosh SK and Kahrilas PJ: Obesity: A challenge to esophagogastric junction integrity. Gastroenterology. 130:639–649. 2006.PubMed/NCBI View Article : Google Scholar

20 

Hill LD, Kozarek RA, Kraemer SJ, Aye RW, Mercer CD, Low DE and Pope CE II: The gastroesophageal flap valve: In vitro and in vivo observations. Gastrointest Endosc. 44:541–547. 1996.PubMed/NCBI View Article : Google Scholar

21 

Osman A, Albashir MM, Nandipati K, Walters RW and Chandra S: Esophagogastric junction morphology on Hill's classification predicts gastroesophageal reflux with good accuracy and consistency. Dig Dis Sci. 66:151–159. 2021.PubMed/NCBI View Article : Google Scholar

22 

Duranceau A: Massive hiatal hernia: A review. Dis Esophagus. 29:350–366. 2016.PubMed/NCBI View Article : Google Scholar

23 

Schlottmann F, Andolfi C, Herbella FA, Rebecchi F, Allaix ME and Patti MG: GERD: Presence and size of hiatal hernia influence clinical presentation, esophageal function, reflux profile, and degree of mucosal injury. Am Surg. 84:978–982. 2018.PubMed/NCBI

24 

Hansdotter I, Björ O, Andreasson A, Agreus L, Hellström P, Forsberg A, Talley NJ, Vieth M and Wallner B: Hill classification is superior to the axial length of a hiatal hernia for assessment of the mechanical anti-reflux barrier at the gastroesophageal junction. Endosc Int Open. 4:E311–E317. 2016.PubMed/NCBI View Article : Google Scholar

25 

Richter JE and Rubenstein JH: Presentation and epidemiology of gastroesophageal reflux disease. Gastroenterology. 154:267–276. 2018.PubMed/NCBI View Article : Google Scholar

26 

Eusebi LH, Ratnakumaran R, Yuan Y, Solaymani-Dodaran M, Bazzoli F and Ford AC: Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: A meta-analysis. Gut. 67:430–440. 2018.PubMed/NCBI View Article : Google Scholar

27 

Han YM, Chung SJ, Yoo S, Yang JI, Choi JM, Lee J and Kim JS: Inverse correlation between gastroesophageal reflux disease and atrophic gastritis assessed by endoscopy and serology. World J Gastroenterol. 28:853–867. 2022.PubMed/NCBI View Article : Google Scholar

28 

Kim JY, Shin IS, Min YW, Kim K, Lee H, Min BH, Lee JH, Kim JJ and Rhee PL: Endoscopic prediction for acid reflux in patients without Hiatus Hernia. Korean J Gastroenterol. 76:134–141. 2020.PubMed/NCBI View Article : Google Scholar

29 

Xiao YL, Zhou LY, Hou XH, Li YQ, Zou DW and Chen MH: Chinese Society of Gastroenterology. Chinese expert consensus on gastroesophageal reflux disease in 2020. J Dig Dis. 22:376–389. 2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang Q, Lu J, Sui Y, Fan J, Ren J, Wang Z and Chen X: Predicting reflux symptom recurrence: The impact of gastroesophageal junction indicators and body mass index among outpatients. Exp Ther Med 26: 351, 2023.
APA
Wang, Q., Lu, J., Sui, Y., Fan, J., Ren, J., Wang, Z., & Chen, X. (2023). Predicting reflux symptom recurrence: The impact of gastroesophageal junction indicators and body mass index among outpatients. Experimental and Therapeutic Medicine, 26, 351. https://doi.org/10.3892/etm.2023.12050
MLA
Wang, Q., Lu, J., Sui, Y., Fan, J., Ren, J., Wang, Z., Chen, X."Predicting reflux symptom recurrence: The impact of gastroesophageal junction indicators and body mass index among outpatients". Experimental and Therapeutic Medicine 26.1 (2023): 351.
Chicago
Wang, Q., Lu, J., Sui, Y., Fan, J., Ren, J., Wang, Z., Chen, X."Predicting reflux symptom recurrence: The impact of gastroesophageal junction indicators and body mass index among outpatients". Experimental and Therapeutic Medicine 26, no. 1 (2023): 351. https://doi.org/10.3892/etm.2023.12050
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Q, Lu J, Sui Y, Fan J, Ren J, Wang Z and Chen X: Predicting reflux symptom recurrence: The impact of gastroesophageal junction indicators and body mass index among outpatients. Exp Ther Med 26: 351, 2023.
APA
Wang, Q., Lu, J., Sui, Y., Fan, J., Ren, J., Wang, Z., & Chen, X. (2023). Predicting reflux symptom recurrence: The impact of gastroesophageal junction indicators and body mass index among outpatients. Experimental and Therapeutic Medicine, 26, 351. https://doi.org/10.3892/etm.2023.12050
MLA
Wang, Q., Lu, J., Sui, Y., Fan, J., Ren, J., Wang, Z., Chen, X."Predicting reflux symptom recurrence: The impact of gastroesophageal junction indicators and body mass index among outpatients". Experimental and Therapeutic Medicine 26.1 (2023): 351.
Chicago
Wang, Q., Lu, J., Sui, Y., Fan, J., Ren, J., Wang, Z., Chen, X."Predicting reflux symptom recurrence: The impact of gastroesophageal junction indicators and body mass index among outpatients". Experimental and Therapeutic Medicine 26, no. 1 (2023): 351. https://doi.org/10.3892/etm.2023.12050
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