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CX3CL1/CX3CR1 axis alleviates inflammation and apoptosis in human nucleus pulpous cells via M2 macrophage polarization

  • Authors:
    • Xiao-Wen Gao
    • Han-Lin Hu
    • Ming-Hua Xie
    • Cai-Xia Tang
    • Jun Ou
    • Zheng-Hao Lu
  • View Affiliations / Copyright

    Affiliations: The Department of Spinal Surgery, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, P.R. China, The Department of Obstetrics and Gynecology, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 359
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    Published online on: June 7, 2023
       https://doi.org/10.3892/etm.2023.12058
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Abstract

CX3C chemokine ligand 1 (CX3CL1) belongs to the CX3C chemokine family and is involved in various disease processes. However, its role in intervertebral disc degeneration (IDD) remains to be elucidated. In the present study, western blotting, reverse transcription‑quantitative PCR and ELISA assays were used to assess target gene expression. In addition, immunofluorescence and TUNEL staining were used to assess macrophage infiltration, monocyte migration and apoptosis. The present study aimed to reveal if and how CX3CL1 regulates IDD progression by exploring its effect on macrophage polarization and apoptosis of human nucleus pulposus cells (HNPCs). The data showed that CX3CL1 bound to CX3C motif chemokine receptor 1 (CX3CR1) promoted the M2 phenotype polarization via JAK2/STAT3 signaling, followed by increasing the secretion of anti‑inflammatory cytokines from HNPCs. In addition, HNPC‑derived CX3CL1 promoted M2 macrophage‑derived C‑C motif chemokine ligand 17 release thereby reducing the apoptosis of HNPCs. In clinic, the reduction of mRNA and protein levels CX3CL1 in degenerative nucleus pulposus tissues (NPs) was measured. Increased M1 macrophages and pro‑inflammatory cytokines were found in NPs of IDD patients with low CX3CL1 expression. Collectively, these findings suggested that the CX3CL1/CX3CR1 axis alleviates IDD by reducing inflammation and apoptosis of HNPCs via macrophages. Therefore, targeting CX3CL1/CX3CR1 axis is expected to produce a new therapeutic approach for IDD.
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1 

Peng B, Hao J, Hou S, Wu W, Jiang D, Fu X and Yang Y: Possible pathogenesis of painful intervertebral disc degeneration. Spine. 31:560–566. 2006.PubMed/NCBI View Article : Google Scholar

2 

Adams MA, Freeman BJ, Morrison HP, Nelson IW and Dolan P: Mechanical initiation of intervertebral disc degeneration. Spine (Phila Pa 1976). 25:1625–1636. 2000.PubMed/NCBI View Article : Google Scholar

3 

Freemont AJ, Watkins A, Le Maitre C, Jeziorska M and Hoyland JA: Current understanding of cellular and molecular events in intervertebral disc degeneration: Implications for therapy. J Pathol. 196:374–379. 2002.PubMed/NCBI View Article : Google Scholar

4 

Jia J, Nie L and Liu Y: Butyrate alleviates inflammatory response and NF-κB activation in human degenerated intervertebral disc tissues. Int Immunopharmacol. 78(106004)2020.PubMed/NCBI View Article : Google Scholar

5 

Yu H, Liu Y, Xie W, Xie Q, Liu Q and Cheng L: IL-38 alleviates the inflammatory response and the degeneration of nucleus pulposus cells via inhibition of the NF-κB signaling pathway in vitro. Int Immunopharmacol. 85(106592)2020.PubMed/NCBI View Article : Google Scholar

6 

Risbud MV, Fertala J, Vresilovic EJ, Albert TJ and Shapiro IM: Nucleus pulposus cells upregulate PI3K/Akt and MEK/ERK signaling pathways under hypoxic conditions and resist apoptosis induced by serum withdrawal. Spine (Phila Pa 1976). 30:882–889. 2005.PubMed/NCBI View Article : Google Scholar

7 

Erwin WM, Islam D, Inman RD, Fehlings MG and Tsui FW: Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: Implications for the mechanisms of intervertebral disc degeneration. Arthritis Res Ther. 13(R215)2011.PubMed/NCBI View Article : Google Scholar

8 

Apostolakis S and Spandidos D: Chemokines and atherosclerosis: focus on the CX3CL1/CX3CR1 pathway. Acta Pharmacol Sin. 34:1251–1256. 2013.PubMed/NCBI View Article : Google Scholar

9 

Limatola C and Ransohoff RM: Modulating neurotoxicity through CX3CL1/CX3CR1 signaling. Front Cell Neurosci. 8(229)2014.PubMed/NCBI View Article : Google Scholar

10 

Wojdasiewicz P, Poniatowski LA, Kotela A, Deszczyński J, Kotela I and Szukiewicz D: The chemokine CX3CL1 (fractalkine) and its receptor CX3CR1: Occurrence and potential role in osteoarthritis. Arch Immunol Ther Exp (Warsz). 62:395–403. 2014.PubMed/NCBI View Article : Google Scholar

11 

Aoyama T, Inokuchi S, Brenner DA and Seki E: CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. Hepatology. 52:1390–1400. 2010.PubMed/NCBI View Article : Google Scholar

12 

Huang ZZ, Li D, Liu CC, Cui Y, Zhu HQ, Zhang WW, Li YY and Xin WJ: CX3CL1-mediated macrophage activation contributed to paclitaxel-induced DRG neuronal apoptosis and painful peripheral neuropathy. Brain Behav Immun. 40:155–165. 2014.PubMed/NCBI View Article : Google Scholar

13 

Oh IS, Suh DW and Ha KY: Hypertrophy of the ligament flavum in degenerative lumbar stenosis associated with the increased expression of fractalkine (CX3CL1)/CX3CR1. chemokine. 54:380–385. 2013.PubMed/NCBI View Article : Google Scholar

14 

Yang C, Cao P, Gao Y, Wu M, Lin Y, Tian Y and Yuan W: Differential expression of p38 MAPK α, β, γ, δ isoforms in nucleus pulposus modulates macrophage polarization in intervertebral disc degeneration. Sci Rep. 6(22182)2016.PubMed/NCBI View Article : Google Scholar

15 

Liu ZH, Sun Z, Wang HQ, Ge J, Jiang TS, Chen YF, Ma Y, Wang C, Hu S, Samartzis D and Luo ZJ: FasL expression on human nucleus pulposus cells contributes to the immune privilege of intervertebral disc by interacting with immunocytes. Int J Med Sci. 10:1053–1060. 2013.PubMed/NCBI View Article : Google Scholar

16 

Kim JH, Moon HJ, Lee JH, Kim JH, Kwon TH and Park YK: Rabbit notochordal cells modulate the expression of inflammatory mediators by human annulus fibrosus cells cocultured with activated macrophage-like THP-1 cells. Spine (Phila Pa 1976). 37:1856–1864. 2012.PubMed/NCBI View Article : Google Scholar

17 

Park JJ, Moon HJ, Park JH, Kwon TH, Park YK and Kim JH: Induction of proinflammatory cytokine production in intervertebral disc cells by macrophage-like THP-1 cells requires mitogen-activated protein kinase activity. J Neurosurg Spine. 24:167–175. 2016.PubMed/NCBI View Article : Google Scholar

18 

Ni L, Zheng Y, Gong T, Xiu C, Li K, Saijilafu Li B, Yang H and Chen J: Proinflammatory macrophages promote degenerative phenotypes in rat nucleus pulpous cells partly through ERK and JNK signaling. J Cell Physiol. 234:5362–5371. 2019.PubMed/NCBI View Article : Google Scholar

19 

Ling Z, Liu Y, Wang Z, Zhang Z, Chen B, Yang J, Zeng B, Gao Y, Jiang C, Huang Y, et al: Single-cell RNA-Seq analysis reveals macrophage involved in the progression of human intervertebral disc degeneration. Front Cell Dev Biol. 9(833420)2021.PubMed/NCBI View Article : Google Scholar

20 

Yamagishi A, Nakajima H, Kokubo Y, Yamamoto Y and Matsumine A: Polarization of infiltrating macrophages in the outer annulus fibrosus layer associated with the process of intervertebral disc degeneration and neural ingrowth in the human cervical spine. Spine J. 22:877–886. 2022.PubMed/NCBI View Article : Google Scholar

21 

Yamamoto Y, Kokubo Y, Nakajima H, Honjoh K, Watanabe S and Matsumine A: Distribution and polarization of hematogenous macrophages associated with the progression of intervertebral disc degeneration. Spine (Phila Pa 1976). 47:E149–E158. 2022.PubMed/NCBI View Article : Google Scholar

22 

Li C, Xu MM, Wang K, Adler AJ, Vella AT and Zhou B: Macrophage polarization and meta-inflammation. Transl Res. 191:29–44. 2018.PubMed/NCBI View Article : Google Scholar

23 

Bashir S, Sharma Y, Elahi A and Khan F: Macrophage polarization: The link between inflammation and related diseases. Inflamm Res. 65:1–11. 2016.PubMed/NCBI View Article : Google Scholar

24 

Nakazawa KR, Walter BA, Laudier DM, Krishnamoorthy D, Mosley GE, Spiller KL and Iatridis JC: Accumulation and localization of macrophage phenotypes with human intervertebral disc degeneration. Spine J. 18:343–356. 2018.PubMed/NCBI View Article : Google Scholar

25 

Li XC, Luo SJ, Fan W, Zhou TL, Huang CM and Wang MS: M2 macrophage-conditioned medium inhibits intervertebral disc degeneration in a tumor necrosis factor-α-rich environment. J Orthop Res. 40:2488–2501. 2022.PubMed/NCBI View Article : Google Scholar

26 

Mondragon AA, Betts-Obregon BS, Moritz RJ, Parvathaneni K, Navarro MM, Kim HS, Lee CF, LeBaron RG, Asmis R and Tsin AT: BIGH3 protein and macrophages in retinal endothelial cell apoptosis. Apoptosis. 20:29–37. 2015.PubMed/NCBI View Article : Google Scholar

27 

Ing DJ, Zang J, Dzau VJ, Webster KA and Bishopric NH: Modulation of cytokine-induced cardiac myocyte apoptosis by nitric oxide, Bak, and Bcl-x. Circ Res. 84:21–33. 1999.PubMed/NCBI View Article : Google Scholar

28 

Truman LA, Ford CA, Pasikowska M, Pound JD, Wilkinson SJ, Dumitriu IE, Melville L, Melrose LA, Ogden CA, Nibbs R, et al: CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis. Blood. 112:5026–5036. 2008.PubMed/NCBI View Article : Google Scholar

29 

Gevrey JC, Isaac BM and Cox D: Syk is required for monocyte/macrophage chemotaxis to CX3CL1 (Fractalkine). J Immunol. 175:3737–3745. 2005.PubMed/NCBI View Article : Google Scholar

30 

Li XC, Luo SJ, Fan W, Zhou TL, Tan DQ, Tan RX, Xian QZ, Li J, Huang CM and Wang MS: Macrophage polarization regulates intervertebral disc degeneration by modulating cell proliferation, inflammation mediator secretion, and extracellular matrix metabolism. Front Immunol. 13(922173)2022.PubMed/NCBI View Article : Google Scholar

31 

Liu B, Jiang Q, Chen R, Gao S, Xia Q, Zhu J, Zhang F, Shao C, Liu X, Li X, et al: Tacrolimus ameliorates bleomycin-induced pulmonary fibrosis by inhibiting M2 macrophage polarization via JAK2/STAT3 signaling. Int Immunopharmacol. 113(109424)2022.PubMed/NCBI View Article : Google Scholar

32 

Li X, Luo J, Li Y, Jia L, Li Y, Ye S, Liu L, Yu Y, Lu Y and Luan Y: Macrophage-derived exosomes in TLR9-/- mice ameliorate sepsis-induced mitochondrial oxidative stress and apoptosis in cardiomyocytes. Oxid Med Cell Longev. 2022(5719974)2022.PubMed/NCBI View Article : Google Scholar

33 

Zhang S, Wang P, Hu B, Liu W, Lv X, Chen S and Shao Z: HSP90 inhibitor 17-AAG attenuates nucleus pulposus inflammation and catabolism induced by M1-polarized macrophages. Front Cell Dev Biol. 9(796974)2021.PubMed/NCBI View Article : Google Scholar

34 

Zhao F, Guo Z, Hou F, Fan W, Wu B and Qian Z: Magnoflorine alleviates ‘M1’ polarized macrophage-induced intervertebral disc degeneration through repressing the HMGB1/Myd88/NF-κB pathway and NLRP3 inflammasome. Front Pharmacol. 12(701087)2021.PubMed/NCBI View Article : Google Scholar

35 

Phillips KL, Cullen K, Chiverton N, Michael AL, Cole AA, Breakwell LM, Haddock G, Bunning RA, Cross AK and Le Maitre CL: Potential roles of cytokines and chemokines in human intervertebral disc degeneration: Interleukin-1 is a master regulator of catabolic processes. Osteoarthritis Cartilage. 23:1165–1177. 2015.PubMed/NCBI View Article : Google Scholar

36 

Stich S, Möller A, Cabraja M, Krüger JP, Hondke S, Endres M, Ringe J and Sittinger M: Chemokine CCL25 induces migration and extracellular matrix production of anulus fibrosus-derived cells. Int J Mol Sci. 19(2207)2018.PubMed/NCBI View Article : Google Scholar

37 

Ying JW, Wen TY, Pei SS, Su LH and Ruan DK: Stromal cell-derived factor-1α promotes recruitment and differentiation of nucleus pulposus-derived stem cells. World J Stem Cells. 11:196–211. 2019.PubMed/NCBI View Article : Google Scholar

38 

Klapproth E, Witt A, Klose P, Wiedemann J, Vavilthota N, Künzel SR, Kämmerer S, Günscht M, Sprott D, Lesche M, et al: Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction. Nat Commun. 13(7648)2022.PubMed/NCBI View Article : Google Scholar

39 

Komissarov A, Potashnikova D, Freeman ML, Gontarenko V, Maytesyan D, Lederman MM, Vasilieva E and Margolis L: Driving T cells to human atherosclerotic plaques: CCL3/CCR5 and CX3CL1/CX3CR1 migration axes. Eur J Immunol. 51:1857–1859. 2021.PubMed/NCBI View Article : Google Scholar

40 

Hsu AT, Lupancu TJ, Lee MC, Fleetwood AJ, Cook AD, Hamilton JA and Achuthan A: Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages. J Biol Chem. 293:11415–11423. 2018.PubMed/NCBI View Article : Google Scholar

41 

Zhang A, Liu Y, Xu H, Zhang Z, Wang X, Yuan L, Lenahan C, Zhang C, Jiang J, Fang C, et al: CCL17 exerts neuroprotection through activation of CCR4/mTORC2 axis in microglia after subarachnoid haemorrhage in rats. Stroke Vasc Neurol. 8:4–16. 2022.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Gao X, Hu H, Xie M, Tang C, Ou J and Lu Z: CX3CL1/CX3CR1 axis alleviates inflammation and apoptosis in human nucleus pulpous cells via M2 macrophage polarization. Exp Ther Med 26: 359, 2023.
APA
Gao, X., Hu, H., Xie, M., Tang, C., Ou, J., & Lu, Z. (2023). CX3CL1/CX3CR1 axis alleviates inflammation and apoptosis in human nucleus pulpous cells via M2 macrophage polarization. Experimental and Therapeutic Medicine, 26, 359. https://doi.org/10.3892/etm.2023.12058
MLA
Gao, X., Hu, H., Xie, M., Tang, C., Ou, J., Lu, Z."CX3CL1/CX3CR1 axis alleviates inflammation and apoptosis in human nucleus pulpous cells via M2 macrophage polarization". Experimental and Therapeutic Medicine 26.1 (2023): 359.
Chicago
Gao, X., Hu, H., Xie, M., Tang, C., Ou, J., Lu, Z."CX3CL1/CX3CR1 axis alleviates inflammation and apoptosis in human nucleus pulpous cells via M2 macrophage polarization". Experimental and Therapeutic Medicine 26, no. 1 (2023): 359. https://doi.org/10.3892/etm.2023.12058
Copy and paste a formatted citation
x
Spandidos Publications style
Gao X, Hu H, Xie M, Tang C, Ou J and Lu Z: CX3CL1/CX3CR1 axis alleviates inflammation and apoptosis in human nucleus pulpous cells via M2 macrophage polarization. Exp Ther Med 26: 359, 2023.
APA
Gao, X., Hu, H., Xie, M., Tang, C., Ou, J., & Lu, Z. (2023). CX3CL1/CX3CR1 axis alleviates inflammation and apoptosis in human nucleus pulpous cells via M2 macrophage polarization. Experimental and Therapeutic Medicine, 26, 359. https://doi.org/10.3892/etm.2023.12058
MLA
Gao, X., Hu, H., Xie, M., Tang, C., Ou, J., Lu, Z."CX3CL1/CX3CR1 axis alleviates inflammation and apoptosis in human nucleus pulpous cells via M2 macrophage polarization". Experimental and Therapeutic Medicine 26.1 (2023): 359.
Chicago
Gao, X., Hu, H., Xie, M., Tang, C., Ou, J., Lu, Z."CX3CL1/CX3CR1 axis alleviates inflammation and apoptosis in human nucleus pulpous cells via M2 macrophage polarization". Experimental and Therapeutic Medicine 26, no. 1 (2023): 359. https://doi.org/10.3892/etm.2023.12058
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