Pharmacological properties and underlying mechanisms of aurantio‑obtusin (Review)

Liu,Yao; Sun,Xuemei; Hu,Xinpei; Xu,Yitian; Li,Teng; Wu,Zhigui

doi:10.3892/etm.2023.12079

Pharmacological properties and underlying mechanisms of aurantio‑obtusin (Review)

Authors:
- Yao Liu
- Xuemei Sun
- Xinpei Hu
- Yitian Xu
- Teng Li
- Zhigui Wu
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Affiliations: Department of Pharmacy, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China
Published online on: June 26, 2023 https://doi.org/10.3892/etm.2023.12079
Article Number: 380

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Abstract

Herbal medicine has been widely applied for a range of diseases in China since antiquity. Cassia obtusifolia L. and Cassia tora L. are plants whose seeds have high reported medicinal values and have been documented to function as a laxative, to lower lipid level and to lower blood pressure. The main active ingredient in Cassia seeds is aurantio‑obtusin (AO), which is an anthraquinone monomer compound. Currently, AO is listed in China as a quality control index component of Cassia seeds. In clinical practice in China, AO is typically used to treat obesity, diabetes and its complications, non‑alcoholic fatty liver disease and allergic reactions. In addition, AO has been reported to confer insecticidal activities and antimalarial effects. Previous studies have even suggested that AO is a potential therapeutic candidate for a variety of diseases with research value. Therefore, the present review summarizes and discuss the existing literature on AO to provide a review of its pharmacological activity and mechanism of action, with the aim of providing a basis for its development and utilization in a clinical setting.

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