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Review

Pharmacological properties and underlying mechanisms of aurantio‑obtusin (Review)

  • Authors:
    • Yao Liu
    • Xuemei Sun
    • Xinpei Hu
    • Yitian Xu
    • Teng Li
    • Zhigui Wu
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China
  • Article Number: 380
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    Published online on: June 26, 2023
       https://doi.org/10.3892/etm.2023.12079
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Abstract

Herbal medicine has been widely applied for a range of diseases in China since antiquity. Cassia obtusifolia L. and Cassia tora L. are plants whose seeds have high reported medicinal values and have been documented to function as a laxative, to lower lipid level and to lower blood pressure. The main active ingredient in Cassia seeds is aurantio‑obtusin (AO), which is an anthraquinone monomer compound. Currently, AO is listed in China as a quality control index component of Cassia seeds. In clinical practice in China, AO is typically used to treat obesity, diabetes and its complications, non‑alcoholic fatty liver disease and allergic reactions. In addition, AO has been reported to confer insecticidal activities and antimalarial effects. Previous studies have even suggested that AO is a potential therapeutic candidate for a variety of diseases with research value. Therefore, the present review summarizes and discuss the existing literature on AO to provide a review of its pharmacological activity and mechanism of action, with the aim of providing a basis for its development and utilization in a clinical setting.
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1 

Lee GY, Cho BO, Shin JY, Jang SI, Cho IS, Kim HY, Park JS, Cho CW, Kang JS, Kim JH and Kim YH: Tyrosinase inhibitory components from the seeds of Cassia tora. Arch Pharm Res. 41:490–496. 2018.PubMed/NCBI View Article : Google Scholar

2 

Luo H, Wu H, Wang L, Xiao S, Lu Y, Liu C, Yu X, Zhang X, Wang Z and Tang L: Hepatoprotective effects of Cassiae Semen on mice with non-alcoholic fatty liver disease based on gut microbiota. Commun Biol. 4(1357)2021.PubMed/NCBI View Article : Google Scholar

3 

Kim YJ, Lee S, Jin J, Woo H, Choi YK and Park KG: Cassiaside C Inhibits M1 polarization of macrophages by downregulating glycolysis. Int J Mol Sci. 23(1696)2022.PubMed/NCBI View Article : Google Scholar

4 

Yang B, Xie L, Peng S, Sun K, Jin J, Zhen Y, Qin K and Cai B: Nine components pharmacokinetic study of rat plasma after oral administration raw and prepared Semen Cassiae in normal and acute liver injury rats. J Sep Sci. 42:2341–2350. 2019.PubMed/NCBI View Article : Google Scholar

5 

Xu L, Li J, Tang X, Wang Y, Ma Z and Gao Y: Metabolomics of aurantio-obtusin-induced hepatotoxicity in rats for discovery of potential biomarkers. Molecules. 24(3452)2019.PubMed/NCBI View Article : Google Scholar

6 

Mugas ML, Calvo G, Marioni J, Céspedes M, Martinez F, Vanzulli S, Sáenz D, Di Venosa G, Nuñez Montoya S and Casas A: Photosensitization of a subcutaneous tumour by the natural anthraquinone parietin and blue light. Sci Rep. 11(23820)2021.PubMed/NCBI View Article : Google Scholar

7 

Zou Y, Cao Z, Wang J, Chen X, Chen YQ, Li Y, Liu J, Zhao Y, Wang A and He B: A Series of Novel HDAC inhibitors with anthraquinone as a cap group. Chem Pharm Bull (Tokyo). 68:613–617. 2020.PubMed/NCBI View Article : Google Scholar

8 

Watroly MN, Sekar M, Fuloria S, Gan SH, Jeyabalan S, Wu YS, Subramaniyan V, Sathasivam KV, Ravi S, Mat Rani NNI, et al: Chemistry, biosynthesis, physicochemical and biological properties of rubiadin: A promising natural anthraquinone for new drug discovery and development. Drug Des Devel Ther. 15:4527–4549. 2021.PubMed/NCBI View Article : Google Scholar

9 

Li Y, Guo F, Guan Y, Chen T, Ma K, Zhang L, Wang Z, Su Q, Feng L, Liu Y and Zhou Y: Novel anthraquinone compounds inhibit colon cancer cell proliferation via the reactive oxygen Species/JNK Pathway. Molecules. 25(1672)2020.PubMed/NCBI View Article : Google Scholar

10 

Szymańska M and Majerz I: Effect of substitution of hydrogen atoms in the molecules of anthrone and anthraquinone. Molecules. 26(502)2021.PubMed/NCBI View Article : Google Scholar

11 

Panigrahi GK, Verma N, Singh N, Asthana S, Gupta SK, Tripathi A and Das M: Interaction of anthraquinones of Cassia occidentalis seeds with DNA and Glutathione. Toxicol Rep. 5:164–172. 2018.PubMed/NCBI View Article : Google Scholar

12 

Zhang N, Dong N, Pang L, Xu H and Ji H: Quantitative determination and pharmacokinetic study of aurantio-obtusin in rat plasma by liquid chromatography-mass spectrometry. J Chromatogr Sci. 52:1059–1064. 2014.PubMed/NCBI View Article : Google Scholar

13 

Nie C, Zhang F, Ma X, Guo R, Zhou S, Zhao L, Xu H, Xiao X and Wang Z: Determination of quality markers of Xuezhiling tablet for hyperlipidemia treatment. Phytomedicine. 44:231–238. 2018.PubMed/NCBI View Article : Google Scholar

14 

Kwon KS, Lee JH, So KS, Park BK, Lim H, Choi JS and Kim HP: Aurantio-obtusin, an anthraquinone from cassiae semen, ameliorates lung inflammatory responses. Phytother Res. 32:1537–1545. 2018.PubMed/NCBI View Article : Google Scholar

15 

He YQ, Zhou CC, Yu LY, Wang L, Deng JL, Tao YL, Zhang F and Chen WS: Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms. Pharmacol Res. 163(105224)2021.PubMed/NCBI View Article : Google Scholar

16 

Ahmed B, Sultana R and Greene MW: Adipose tissue and insulin resistance in obese. Biomed Pharmacother. 137(111315)2021.PubMed/NCBI View Article : Google Scholar

17 

Munafò A, Frara S, Perico N, Di Mauro R, Cortinovis M, Burgaletto C, Cantarella G, Remuzzi G, Giustina A and Bernardini R: In search of an ideal drug for safer treatment of obesity: The false promise of pseudoephedrine. Rev Endocr Metab Disord. 22:1013–1025. 2021.PubMed/NCBI View Article : Google Scholar

18 

Stadler JT and Marsche G: Obesity-Related changes in high-density lipoprotein metabolism and function. Int J Mol Sci. 21(8985)2020.PubMed/NCBI View Article : Google Scholar

19 

Mongioì LM, La Vignera S, Cannarella R, Cimino L, Compagnone M, Condorelli RA and Calogero AE: The role of resveratrol administration in human obesity. Int J Mol Sci. 22(4362)2021.PubMed/NCBI View Article : Google Scholar

20 

Mayoral LP, Andrade GM, Mayoral EP, Huerta TH, Canseco SP, Rodal Canales FJ, Cabrera-Fuentes HA, Cruz MM, Pérez Santiago AD, Alpuche JJ, et al: Obesity subtypes, related biomarkers & heterogeneity. Indian J Med Res. 151:11–21. 2020.PubMed/NCBI View Article : Google Scholar

21 

Kuder MM and Nyenhuis SM: Optimizing lifestyle interventions in adult patients with comorbid asthma and obesity. Ther Adv Respir Dis. 14(1753466620906323)2020.PubMed/NCBI View Article : Google Scholar

22 

Purdy JC and Shatzel JJ: The hematologic consequences of obesity. Eur J Haematol. 106:306–319. 2021.PubMed/NCBI View Article : Google Scholar

23 

Ganesan SM, Vazana S and Stuhr S: Waistline to the gumline: Relationship between obesity and periodontal disease-biological and management considerations. Periodontol 2000. 87:299–314. 2021.PubMed/NCBI View Article : Google Scholar

24 

Landecho MF, Marin-Oto M, Recalde-Zamacona B, Bilbao I and Frühbeck G: Obesity as an adipose tissue dysfunction disease and a risk factor for infections-Covid-19 as a case study. Eur J Intern Med. 91:3–9. 2021.PubMed/NCBI View Article : Google Scholar

25 

Gammone MA and D'Orazio N: COVID-19 and Obesity: Overlapping of two pandemics. Obes Facts. 14:579–585. 2021.PubMed/NCBI View Article : Google Scholar

26 

Guo CY, Liao WT, Qiu RJ, Zhou DS, Ni WJ, Yu CP and Zeng Y: Aurantio-obtusin improves obesity and insulin resistance induced by high-fat diet in obese mice. Phytother Res. 35:346–360. 2021.PubMed/NCBI View Article : Google Scholar

27 

Yamashita S, Masuda D and Matsuzawa Y: Pemafibrate, a new selective PPARα modulator: Drug concept and its clinical applications for dyslipidemia and metabolic diseases. Curr Atheroscler Rep. 22(5)2020.PubMed/NCBI View Article : Google Scholar

28 

Ciavarella C, Motta I, Valente S and Pasquinelli G: Pharmacological (or Synthetic) and nutritional agonists of PPAR-γ as candidates for cytokine storm modulation in COVID-19 disease. Molecules. 25(2076)2020.PubMed/NCBI View Article : Google Scholar

29 

Prabhakar PK: Pathophysiology of diabetic secondary complication and their management. Curr Diabetes Rev. 17:395–396. 2021.PubMed/NCBI View Article : Google Scholar

30 

Wang Z, Shen S, Cui Z, Nie H, Han D and Yan H: Screening and isolating major aldose reductase inhibitors from the seeds of evening primrose (Oenothera biennis). Molecules. 24(2709)2019.PubMed/NCBI View Article : Google Scholar

31 

Julius A, Renuka RR, Hopper W, Babu Raghu P, Rajendran S, Srinivasan S, Dharmalingam K, Alanazi AM, Arokiyaraj S and Prasath S: Inhibition of aldose reductase by novel phytocompounds: A heuristic approach to treating diabetic retinopathy. Evid Based Complement Alternat Med. 2022(9624118)2022.PubMed/NCBI View Article : Google Scholar

32 

Thakur S, Gupta SK, Ali V, Singh P and Verma M: Aldose Reductase: A cause and a potential target for the treatment of diabetic complications. Arch Pharm Res. 44:655–667. 2021.PubMed/NCBI View Article : Google Scholar

33 

Zhou Y, Chi J, Lv W and Wang Y: Obesity and diabetes as high-risk factors for severe coronavirus disease 2019 (Covid-19). Diabetes Metab Res Rev. 37(e3377)2021.PubMed/NCBI View Article : Google Scholar

34 

Dodda D, Rama Rao A and Veeresham C: In vitro and in vivo evaluation of pterostilbene for the management of diabetic complications. J Ayurveda Integr Med. 11:369–375. 2020.PubMed/NCBI View Article : Google Scholar

35 

Jang DS, Lee GY, Kim YS, Lee YM, Kim CS, Yoo JL and Kim JS: Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase. Biol Pharm Bull. 30:2207–2210. 2007.PubMed/NCBI View Article : Google Scholar

36 

Younossi ZM, Marchesini G, Pinto-Cortez H and Petta S: Epidemiology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Implications for liver transplantation. Transplantation. 103:22–27. 2019.PubMed/NCBI View Article : Google Scholar

37 

Arrese M, Arab JP, Barrera F, Kaufmann B, Valenti L and Feldstein AE: Insights into nonalcoholic fatty-liver disease heterogeneity. Semin Liver Dis. 41:421–434. 2021.PubMed/NCBI View Article : Google Scholar

38 

American Family Physician: Nonalcoholic Fatty Liver Disease. https://www.aafp.org/pubs/afp/issues/2020/1115/p603-s1.html. Accessed April 2, 2023.

39 

Makri E, Goulas A and Polyzos SA: Epidemiology, pathogenesis, diagnosis and emerging treatment of nonalcoholic fatty liver disease. Arch Med Res. 52:25–37. 2021.PubMed/NCBI View Article : Google Scholar

40 

Friedman SL, Neuschwander-Tetri BA, Rinella M and Sanyal AJ: Mechanisms of NAFLD development and therapeutic strategies. Nat Med. 24:908–922. 2018.PubMed/NCBI View Article : Google Scholar

41 

Zhou F, Ding M, Gu Y, Fan G, Liu C, Li Y, Sun R, Wu J, Li J, Xue X, et al: Aurantio-Obtusin attenuates non-alcoholic fatty liver disease through AMPK-Mediated autophagy and fatty acid oxidation pathways. Front Pharmacol. 12(826628)2021.PubMed/NCBI View Article : Google Scholar

42 

Galli SJ, Tsai M and Piliponsky AM: The development of allergic inflammation. Nature. 454:445–454. 2008.PubMed/NCBI View Article : Google Scholar

43 

Hu T, Dong Y, Yang C, Zhao M and He Q: Pathogenesis of children's allergic diseases: Refocusing the role of the gut microbiota. Front Physiol. 12(749544)2021.PubMed/NCBI View Article : Google Scholar

44 

Yao Y, Chen CL, Yu D and Liu Z: Roles of follicular helper and regulatory T cells in allergic diseases and allergen immunotherapy. Allergy. 76:456–470. 2021.PubMed/NCBI View Article : Google Scholar

45 

Nguyen SMT, Rupprecht CP, Haque A, Pattanaik D, Yusin J and Krishnaswamy G: Mechanisms governing anaphylaxis: Inflammatory cells, mediators, endothelial gap junctions and beyond. Int J Mol Sci. 22(7785)2021.PubMed/NCBI View Article : Google Scholar

46 

Xu-De Z, Bei-Bei G, Xi-Juan W, Hai-Bo L, Li-Li Z and Feng-Xia L: Serum IgE Predicts difference of population and allergens in allergic diseases: Data from Weifang City, China. Mediators Inflamm. 2021(6627087)2021.PubMed/NCBI View Article : Google Scholar

47 

Zellweger F and Eggel A: IgE-associated allergic disorders: Recent advances in etiology, diagnosis, and treatment. Allergy. 71:1652–1661. 2016.PubMed/NCBI View Article : Google Scholar

48 

Kim M, Lim SJ, Lee HJ and Nho CW: Cassia tora seed extract and its active compound aurantio-obtusin inhibit allergic responses in IgE-Mediated mast cells and anaphylactic models. J Agric Food Chem. 63:9037–9046. 2015.PubMed/NCBI View Article : Google Scholar

49 

Hou J, Gu Y, Zhao S, Huo M, Wang S, Zhang Y, Qiao Y and Li X: Anti-Inflammatory effects of aurantio-obtusin from seed of cassia obtusifolia L. through Modulation of the NF-κB pathway. Molecules. 23(3093)2018.PubMed/NCBI View Article : Google Scholar

50 

Song JY, Casanova-Nakayama A, Möller AM, Kitamura SI, Nakayama K and Segner H: Aryl hydrocarbon receptor signaling is functional in immune cells of rainbow trout (Oncorhynchus mykiss). Int J Mol Sci. 21(6323)2020.PubMed/NCBI View Article : Google Scholar

51 

Disner GR, Lopes-Ferreira M and Lima C: Where the Aryl hydrocarbon receptor meets the microRNAs: Literature review of the last 10 years. Front Mol Biosci. 8(725044)2021.PubMed/NCBI View Article : Google Scholar

52 

Yamashita N, Kanno Y, Yoshikawa M, Ozawa M, Sanada N, Nemoto K and Kizu R: Polycyclic aromatic hydrocarbons induce CYP3A5 gene expression via aryl hydrocarbon receptor in HepG2 cells. J Toxicol Sci. 46:25–29. 2021.PubMed/NCBI View Article : Google Scholar

53 

Vogel CFA, Van Winkle LS, Esser C and Haarmann-Stemmann T: The aryl hydrocarbon receptor as a target of environmental stressors-Implications for pollution mediated stress and inflammatory responses. Redox Biol. 34(101530)2020.PubMed/NCBI View Article : Google Scholar

54 

Amakura Y, Yoshimura M, Takaoka M, Toda H, Tsutsumi T, Matsuda R, Teshima R, Nakamura M, Handa H and Yoshida T: Characterization of natural aryl hydrocarbon receptor agonists from cassia seed and rosemary. Molecules. 19:4956–4966. 2014.PubMed/NCBI View Article : Google Scholar

55 

Xu H, Bin NR and Sugita S: Diverse exocytic pathways for mast cell mediators. Biochem Soc Trans. 46:235–247. 2018.PubMed/NCBI View Article : Google Scholar

56 

Lee EK, Song J, Seo Y, Koh EM, Kim SH and Jung KJ: Inhibitory Effects of AF-343, a Mixture of Cassia tora L., Ulmus pumila L., and Taraxacum officinale, on Compound 48/80-Mediated Allergic Responses in RBL-2H3 Cells. Molecules. 25(2434)2020.PubMed/NCBI View Article : Google Scholar

57 

WHO: Global health estimates:leading causes of death. Cause specific mortality 2000-2019. WHO, Genova, Switzerland, 2019.

58 

Dumitrache MD, Jieanu AS, Scheau C, Badarau IA, Popescu GDA, Caruntu A, Costache DO, Costache RS, Constantin C, Neagu M and Caruntu C: Comparative effects of capsaicin in chronic obstructive pulmonary disease and asthma (Review). Exp Ther Med. 22(917)2021.PubMed/NCBI View Article : Google Scholar

59 

Chen YY, Yu MF, Zhao XX, Shen J, Peng YB, Zhao P, Xue L, Chen W, Ma LQ, Qin G, et al: Paracetamol inhibits Ca2+ permeant ion channels and Ca(2+) sensitization resulting in relaxation of precontracted airway smooth muscle. J Pharmacol Sci. 142:60–68. 2020.PubMed/NCBI View Article : Google Scholar

60 

She YS, Ma LQ, Liu BB, Zhang WJ, Qiu JY, Chen YY, Li MY, Xue L, Luo X, Wang Q, et al: Semen cassiae extract inhibits contraction of airway smooth muscle. Front Pharmacol. 9(1389)2018.PubMed/NCBI View Article : Google Scholar

61 

Duong V, Lambrechts L, Paul RE, Ly S, Lay RS, Long KC, Huy R, Tarantola A, Scott TW, Sakuntabhai A and Buchy P: Asymptomatic humans transmit dengue virus to mosquitoes. Proc Natl Acad Sci USA. 112:14688–14693. 2015.PubMed/NCBI View Article : Google Scholar

62 

Lee H, Halverson S and Ezinwa N: Mosquito-Borne Diseases. Prim Care. 45:393–407. 2018.PubMed/NCBI View Article : Google Scholar

63 

Gan SJ, Leong YQ, Bin Barhanuddin MFH, Wong ST, Wong SF, Mak JW and Ahmad RB: Dengue fever and insecticide resistance in Aedes mosquitoes in Southeast Asia: A review. Parasit Vectors. 14(315)2021.PubMed/NCBI View Article : Google Scholar

64 

Fillinger U and Lindsay SW: Larval source management for malaria control in Africa: Myths and reality. Malar J. 10(353)2011.PubMed/NCBI View Article : Google Scholar

65 

Raman Ibrahim NBB, Puchooa D, Govinden-Soulange J and Facknath S: Cassia species: a potential source of biopesticides. Journal of Plant Diseases and Protection. 128:339–351. 2021.

66 

Mbatchou VC, Tchouassi DP, Dickson RA, Annan K, Mensah AY, Amponsah IK, Jacob JW, Cheseto X, Habtemariam S and Torto B: Mosquito larvicidal activity of Cassia tora seed extract and its key anthraquinones aurantio-obtusin and obtusin. Parasit Vectors. 10(562)2017.PubMed/NCBI View Article : Google Scholar

67 

Mbatchou VC, Dickson RA, Amponsah IK, Mensah AY and Habtemariam S: Protection effect of the anthraquinones, cassiatorin and aurantio-obtusin from seeds of Senna tora against cowpea weevil attack. Asian Pac J Trop Biomed. 8:98–105. 2018.

68 

Piplani M, Bhagwat DP, Singhvi G, Sankaranarayanan M, Balana-Fouce R, Vats T and Chander S: Plant-based larvicidal agents: An overview from 2000 to 2018. Exp Parasitol. 199:92–103. 2019.PubMed/NCBI View Article : Google Scholar

69 

Lim H, Park BK, Shin SY, Kwon YS and Kim HP: Methyl caffeate and some plant constituents inhibit age-related inflammation: Effects on senescence-associated secretory phenotype (SASP) formation. Arch Pharm Res. 40:524–535. 2017.PubMed/NCBI View Article : Google Scholar

70 

Birch J and Gil J: Senescence and the SASP: Many therapeutic avenues. Genes Dev. 34:1565–1576. 2020.PubMed/NCBI View Article : Google Scholar

71 

Ohtani N: The roles and mechanisms of senescence-associated secretory phenotype (SASP): Can it be controlled by senolysis? Inflamm Regen. 42(11)2022.PubMed/NCBI View Article : Google Scholar

72 

Scheltens P, De trooper B, Kivipelto M, Holstege H, Chételat G, Teunissen CE, Cummings J and van der Flier WM: Alzheimer's disease. Lancet. 397:1577–1590. 2021.PubMed/NCBI View Article : Google Scholar

73 

Jung HA, Ali MY, Jung HJ, Jeong HO, Chung HY and Choi JS: Inhibitory activities of major anthraquinones and other constituents from Cassia obtusifolia against β-secretase and cholinesterases. J Ethnopharmacol. 191:152–160. 2016.PubMed/NCBI View Article : Google Scholar

74 

Török B, Fazekas CL, Szabó A and Zelena D: Epigenetic modulation of vasopressin expression in health and disease. Int J Mol Sci. 22(9415)2021.PubMed/NCBI View Article : Google Scholar

75 

Watanabe J, Takayanagi Y, Yoshida M, Hattori T, Saito M, Kohno K, Kobayashi E and Onaka T: Conditional ablation of vasopressin-synthesizing neurons in transgenic rats. J Neuroendocrinol. 33(e13057)2021.PubMed/NCBI View Article : Google Scholar

76 

Glavaš M, Gitlin-Domagalska A, Dębowski D, Ptaszyńska N, Łęgowska A and Rolka K: Vasopressin and its analogues: From natural hormones to multitasking peptides. Int J Mol Sci. 23(3068)2022.PubMed/NCBI View Article : Google Scholar

77 

Al-Kuraishy HM, Al-Gareeb AI, Qusti S, Alshammari EM, Atanu FO and Batiha GE: Arginine vasopressin and pathophysiology of COVID-19: An innovative perspective. Biomed Pharmacother. 143(112193)2021.PubMed/NCBI View Article : Google Scholar

78 

Mondritzki T, Mai TA, Vogel J, Pook E, Wasnaire P, Schmeck C, Hüser J, Dinh W, Truebel H and Kolkhof P: Cardiac output improvement by pecavaptan: A novel dual-acting vasopressin V1a/V2 receptor antagonist in experimental heart failure. Eur J Heart Fail. 23:743–750. 2021.PubMed/NCBI View Article : Google Scholar

79 

Szczepanska-Sadowska E, Wsol A, Cudnoch-Jedrzejewska A and Żera T: Complementary role of oxytocin and vasopressin in cardiovascular regulation. Int J Mol Sci. 22(11465)2021.PubMed/NCBI View Article : Google Scholar

80 

Che K, Muttenthaler M and Kurzbach D: Conformational selection of vasopressin upon V1a receptor binding. Comput Struct Biotechnol J. 19:5826–5833. 2021.PubMed/NCBI View Article : Google Scholar

81 

Sparapani S, Millet-Boureima C, Oliver J, Mu K, Hadavi P, Kalostian T, Ali N, Avelar CM, Bardies M, Barrow B, et al: The biology of vasopressin. Biomedicines. 9(89)2021.PubMed/NCBI View Article : Google Scholar

82 

Lago TR, Brownstein MJ, Page E, Beydler E, Manbeck A, Beale A, Roberts C, Balderston N, Damiano E, Pineles SL, et al: The novel vasopressin receptor (V1aR) antagonist SRX246 reduces anxiety in an experimental model in humans: A randomized proof-of-concept study. Psychopharmacology (Berl). 238:2393–2403. 2021.PubMed/NCBI View Article : Google Scholar

83 

Paudel P, Kim DH, Jeon J, Park SE, Seong SH, Jung HA and Choi JS: Neuroprotective effect of aurantio-obtusin, a putative vasopressin V(1A) receptor antagonist, on transient forebrain ischemia mice model. Int J Mol Sci. 22(3335)2021.PubMed/NCBI View Article : Google Scholar

84 

Lemmens-Gruber R and Kamyar M: Vasopressin antagonists. Cell Mol Life Sci. 63:1766–1779. 2006.PubMed/NCBI View Article : Google Scholar

85 

Lemmens-Gruber R and Kamyar M: Pharmacology and clinical relevance of vasopressin antagonists. Internist (Berl). 49:628. 629–630, 632-4. 2008.PubMed/NCBI View Article : Google Scholar

86 

Ripoll GV, Pifano M, Garona J and Alonso DF: Commentary: Arginine vasopressin receptor 1a is a therapeutic target for castration-resistant prostate cancer. Front Oncol. 9(1490)2020.PubMed/NCBI View Article : Google Scholar

87 

Hu Y, Tao R, Chen L, Xiong Y, Xue H, Hu L, Yan C, Xie X, Lin Z, Panayi AC, et al: Exosomes derived from pioglitazone-pretreated MSCs accelerate diabetic wound healing through enhancing angiogenesis. J Nanobiotechnology. 19(150)2021.PubMed/NCBI View Article : Google Scholar

88 

Li S, Wang Y, Wang Z, Chen L, Zuo B, Liu C and Sun D: Enhanced renoprotective effect of GDNF-modified adipose-derived mesenchymal stem cells on renal interstitial fibrosis. Stem Cell Res Ther. 12(27)2021.PubMed/NCBI View Article : Google Scholar

89 

Chen C, Sun L, Zhang W, Tang Y, Li X, Jing R and Liu T: Limb ischemic preconditioning ameliorates renal microcirculation through activation of PI3K/Akt/eNOS signaling pathway after acute kidney injury. Eur J Med Res. 25(10)2020.PubMed/NCBI View Article : Google Scholar

90 

Chen J, Huang Y, Hu X, Bian X and Nian S: Gastrodin prevents homocysteine-induced human umbilical vein endothelial cells injury via PI3K/Akt/eNOS and Nrf2/ARE pathway. J Cell Mol Med. 25:345–357. 2021.PubMed/NCBI View Article : Google Scholar

91 

Xue X, Ling X, Xi W, Wang P, Sun J, Yang Q and Xiao J: Exogenous hydrogen sulfide reduces atrial remodeling and atrial fibrillation induced by diabetes mellitus via activation of the PI3K/Akt/eNOS pathway. Mol Med Rep. 22:1759–1766. 2020.PubMed/NCBI View Article : Google Scholar

92 

Song W, Liang Q, Cai M and Tian Z: HIF-1α-induced up-regulation of microRNA-126 contributes to the effectiveness of exercise training on myocardial angiogenesis in myocardial infarction rats. J Cell Mol Med. 24:12970–12979. 2020.PubMed/NCBI View Article : Google Scholar

93 

Li S, Li Q, Lv X, Liao L, Yang W, Li S, Lu P and Zhu D: Aurantio-obtusin relaxes systemic arteries through endothelial PI3K/AKT/eNOS-dependent signaling pathway in rats. J Pharmacol Sci. 128:108–115. 2015.PubMed/NCBI View Article : Google Scholar

94 

Yu X, Wei LH, Zhang JK, Chen TR, Jin Q, Wang YN, Zhang SJ, Dou TY, Cao YF, Guo WZ, et al: Anthraquinones from Cassiae semen as thrombin inhibitors: In vitro and in silico studies. Phytochemistry. 165(112025)2019.PubMed/NCBI View Article : Google Scholar

95 

Tarandovskiy ID, Artemenko EO, Panteleev MA, Sinauridze EI and Ataullakhanov FI: Antiplatelet agents can promote two-peaked thrombin generation in platelet rich plasma: Mechanism and possible applications. PLoS One. 8(e55688)2013.PubMed/NCBI View Article : Google Scholar

96 

Varghese R, George Priya Doss C, Kumar RS, Almansour AI, Arumugam N, Efferth T and Ramamoorthy S: Cardioprotective effects of phytopigments via multiple signaling pathways. Phytomedicine. 95(153859)2022.PubMed/NCBI View Article : Google Scholar

97 

Alkarithi G, Duval C, Shi Y, Macrae FL and Ariëns RAS: Thrombus structural composition in cardiovascular disease. Arterioscler Thromb Vasc Biol. 41:2370–2383. 2021.PubMed/NCBI View Article : Google Scholar

98 

Wu H, Wang Y, Zhang Y, Xu F, Chen J, Duan L, Zhang T, Wang J and Zhang F: Breaking the vicious loop between inflammation, oxidative stress and coagulation, a novel anti-thrombus insight of nattokinase by inhibiting LPS-induced inflammation and oxidative stress. Redox Biol. 32(101500)2020.PubMed/NCBI View Article : Google Scholar

99 

Zhao Y, Xie R, Yodsanit N, Ye M, Wang Y, Wang B, Guo LW, Kent KC and Gong S: Hydrogen peroxide-responsive platelet membrane-coated nanoparticles for thrombus therapy. Biomater Sci. 9:2696–2708. 2021.PubMed/NCBI View Article : Google Scholar

100 

Williams LM and Gilmore TD: Looking Down on NF-κB. Mol Cell Biol. 40:e00104–20. 2020.PubMed/NCBI View Article : Google Scholar

101 

Harrold AP, Cleary MM, Bharathy N, Lathara M, Berlow NE, Foreman NK, Donson AM, Amani V, Zuercher WJ and Keller C: In vitro benchmarking of NF-κB inhibitors. Eur J Pharmacol. 873(172981)2020.PubMed/NCBI View Article : Google Scholar

102 

Son M, Wang AG, Tu HL, Metzig MO, Patel P, Husain K, Lin J, Murugan A, Hoffmann A and Tay S: NF-κB responds to absolute differences in cytokine concentrations. Sci Signal. 14(eaaz4382)2021.PubMed/NCBI View Article : Google Scholar

103 

Yang B, Xie Y, Guo M, Rosner MH, Yang H and Ronco C: Nephrotoxicity and Chinese Herbal Medicine. Clin J Am Soc Nephrol. 13:1605–1611. 2018.PubMed/NCBI View Article : Google Scholar

104 

Liu Y, Mapa MST and Sprando RL: Liver toxicity of anthraquinones: A combined in vitro cytotoxicity and in silico reverse dosimetry evaluation. Food Chem Toxicol. 140(111313)2020.PubMed/NCBI View Article : Google Scholar

105 

Yang J, Zhu A, Xiao S, Zhang T, Wang L, Wang Q and Han L: Anthraquinones in the aqueous extract of Cassiae semen cause liver injury in rats through lipid metabolism disorder. Phytomedicine. 64(153059)2019.PubMed/NCBI View Article : Google Scholar

106 

Hu M, Lin L, Liu J, Zhong Y, Liang B, Huang Y, Li Z, Lin X, Wang B, Zhang B, et al: Aurantio-obtusin induces hepatotoxicity through activation of NLRP3 inflammasome signaling. Toxicol Lett. 354:1–13. 2022.PubMed/NCBI View Article : Google Scholar

107 

Wang J, Zhao Y, Xiao X, Li H, Zhao H, Zhang P and Jin C: Assessment of the renal protection and hepatotoxicity of rhubarb extract in rats. J Ethnopharmacol. 124:18–25. 2009.PubMed/NCBI View Article : Google Scholar

108 

Yu J, Han JC and Gao YJ: Biotransformation of glucoaurantio-obtusin towards aurantio-obtusin increases the toxicity of irinotecan through increased inhibition towards SN-38 glucuronidation. Phytother Res. 28:1577–1580. 2014.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Sun X, Hu X, Xu Y, Li T and Wu Z: Pharmacological properties and underlying mechanisms of aurantio‑obtusin (Review). Exp Ther Med 26: 380, 2023.
APA
Liu, Y., Sun, X., Hu, X., Xu, Y., Li, T., & Wu, Z. (2023). Pharmacological properties and underlying mechanisms of aurantio‑obtusin (Review). Experimental and Therapeutic Medicine, 26, 380. https://doi.org/10.3892/etm.2023.12079
MLA
Liu, Y., Sun, X., Hu, X., Xu, Y., Li, T., Wu, Z."Pharmacological properties and underlying mechanisms of aurantio‑obtusin (Review)". Experimental and Therapeutic Medicine 26.2 (2023): 380.
Chicago
Liu, Y., Sun, X., Hu, X., Xu, Y., Li, T., Wu, Z."Pharmacological properties and underlying mechanisms of aurantio‑obtusin (Review)". Experimental and Therapeutic Medicine 26, no. 2 (2023): 380. https://doi.org/10.3892/etm.2023.12079
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Sun X, Hu X, Xu Y, Li T and Wu Z: Pharmacological properties and underlying mechanisms of aurantio‑obtusin (Review). Exp Ther Med 26: 380, 2023.
APA
Liu, Y., Sun, X., Hu, X., Xu, Y., Li, T., & Wu, Z. (2023). Pharmacological properties and underlying mechanisms of aurantio‑obtusin (Review). Experimental and Therapeutic Medicine, 26, 380. https://doi.org/10.3892/etm.2023.12079
MLA
Liu, Y., Sun, X., Hu, X., Xu, Y., Li, T., Wu, Z."Pharmacological properties and underlying mechanisms of aurantio‑obtusin (Review)". Experimental and Therapeutic Medicine 26.2 (2023): 380.
Chicago
Liu, Y., Sun, X., Hu, X., Xu, Y., Li, T., Wu, Z."Pharmacological properties and underlying mechanisms of aurantio‑obtusin (Review)". Experimental and Therapeutic Medicine 26, no. 2 (2023): 380. https://doi.org/10.3892/etm.2023.12079
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