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Protective effects of ginseng and ginsenosides in the development of osteoarthritis (Review)

  • Authors:
    • Jincai Chen
    • Lin Huang
    • Xiaofei Liao
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi 341000, P.R. China, Department of Internal Medicine, Ganzhou Hospital of Traditional Chinese Medicine, Ganzhou, Jiangxi 341000, P.R. China, Department of Pharmacy, Ganzhou People's Hospital, Ganzhou, Jiangxi 341000, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 465
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    Published online on: August 11, 2023
       https://doi.org/10.3892/etm.2023.12164
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Abstract

Osteoarthritis (OA) is a chronic inflammatory joint disease. Traditional chinese medicine provides a resource for drug screening for OA treatment. Ginseng and the associated bioactive compound, ginsenosides, may reduce inflammation, which is considered a risk factor for the development of OA. Specifically, ginsenosides may exhibit anti‑inflammatory and anti‑oxidative stress activities, and inhibit extracellular matrix degradation by suppressing the NF‑κB and MAPK signaling pathways. Notably, specific ginsenosides, such as compound K and Rk1, may physically interact with IκB kinase and inhibit the associated phosphorylation. Thus, ginsenosides exhibit potential as therapeutic candidates in the management of OA. However, the low water solubility limits the clinical applications of ginsenosides. Numerous effective strategies have been explored to improve bioavailability; however, further investigations are still required.
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Copy and paste a formatted citation
Spandidos Publications style
Chen J, Huang L and Liao X: Protective effects of ginseng and ginsenosides in the development of osteoarthritis (Review). Exp Ther Med 26: 465, 2023.
APA
Chen, J., Huang, L., & Liao, X. (2023). Protective effects of ginseng and ginsenosides in the development of osteoarthritis (Review). Experimental and Therapeutic Medicine, 26, 465. https://doi.org/10.3892/etm.2023.12164
MLA
Chen, J., Huang, L., Liao, X."Protective effects of ginseng and ginsenosides in the development of osteoarthritis (Review)". Experimental and Therapeutic Medicine 26.4 (2023): 465.
Chicago
Chen, J., Huang, L., Liao, X."Protective effects of ginseng and ginsenosides in the development of osteoarthritis (Review)". Experimental and Therapeutic Medicine 26, no. 4 (2023): 465. https://doi.org/10.3892/etm.2023.12164
Copy and paste a formatted citation
x
Spandidos Publications style
Chen J, Huang L and Liao X: Protective effects of ginseng and ginsenosides in the development of osteoarthritis (Review). Exp Ther Med 26: 465, 2023.
APA
Chen, J., Huang, L., & Liao, X. (2023). Protective effects of ginseng and ginsenosides in the development of osteoarthritis (Review). Experimental and Therapeutic Medicine, 26, 465. https://doi.org/10.3892/etm.2023.12164
MLA
Chen, J., Huang, L., Liao, X."Protective effects of ginseng and ginsenosides in the development of osteoarthritis (Review)". Experimental and Therapeutic Medicine 26.4 (2023): 465.
Chicago
Chen, J., Huang, L., Liao, X."Protective effects of ginseng and ginsenosides in the development of osteoarthritis (Review)". Experimental and Therapeutic Medicine 26, no. 4 (2023): 465. https://doi.org/10.3892/etm.2023.12164
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