|
1
|
McDonald SD, Walker WC, Cusack SE,
Yoash-Gantz RE, Pickett TC, Cifu DX, Mid-Atlantic Mirecc Workgroup
V and Tupler LA: Health symptoms after war zone deployment-related
mild traumatic brain injury: Contributions of mental disorders and
lifetime brain injuries. Brain Inj. 35:1338–1348. 2021.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Otero MC, Rau HK, Shofer JB, Peskin ER and
Pagulayan KF: Self-perceived irritability among OEF/OIF/OND
veterans with a history of deployment-related mTBI: Associations
with prospective memory and quality of life. Clin Neuropsychol.
36:1384–1404. 2022.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Alam A, Thelin EP, Tajsic T, Khan DZ,
Khellaf A, Patani R and Helmy A: Cellular infiltration in traumatic
brain injury. J neuroinflammation. 17(328)2020.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Abrahamson EE and Ikonomovic MD: Brain
injury-induced dysfunction of the blood brain barrier as a risk for
dementia. Exp Neurol. 328(113257)2020.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Campbell M, Hanrahan F, Gobbo OL, Kelly
ME, Kiang AS, Humphries MM, Nguyen AT, Ozaki E, Keaney J, Blau CW,
et al: Targeted suppression of claudin-5 decreases cerebral oedema
and improves cognitive outcome following traumatic brain injury.
Nat Commun. 3(849)2012.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Jha RM, Kochanek PM and Simard JM:
Pathophysiology and treatment of cerebral edema in traumatic brain
injury. Neuropharmacology. 145:230–246. 2019.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Cash A and Theus MH: Mechanisms of
blood-brain barrier dysfunction in traumatic brain injury. Int J
Mol Sci. 21(3344)2020.PubMed/NCBI View Article : Google Scholar
|
|
8
|
O'Keeffe E, Kelly E, Liu Y, Giordano C,
Wallace E, Hynes M, Tiernan S, Meagher A, Greene C, Hughes S, et
al: dynamic blood-brain barrier regulation in mild traumatic brain
injury. J Neurotrauma. 37:347–356. 2020.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Delaney C and Campbell M: The blood brain
barrier: Insights from development and ageing. Tissue Barriers.
5(e1373897)2017.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Muoio V, Persson PB and Sendeski MM: The
neurovascular unit-concept review. Acta Physiool (Oxf). 10:790–798.
2014.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Prakash R and Carmichael ST: Blood-brain
barrier breakdown and neovascularization processes after stroke and
traumatic brain injury. Curr Opin Neurol. 28:556–564.
2015.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Logsdon AF, Lucke-Wold BP, Turner RC,
Huber JD, Rosen CL and Simpkins JW: Role of microvascular
disruption in brain damage from traumatic brain injury. Compr
Physiol. 5:1147–1160. 2015.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Xu L, Nirwane A and Yao Y: Basement
membrane and blood-brain barrier. Stroke Vasc Neurol. 4:78–82.
2018.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Toyama K, Spin JM and Tsao PS: Role of
microRNAs on blood brain barrier dysfunction in vascular cognitive
impairment. Curr Drug Deliv. 14:744–757. 2017.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Ballabh P, Braun A and Nedergaard M: The
blood-brain barrier: An overview: Structure, regulation, and
clinical implications. Neurobiol Dis. 16:1–13. 2004.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Varatharaj A and Galea I: The blood-brain
barrier in systemic inflammation. Brain Behav Immun. 60:1–12.
2017.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Banks WA, Gray AM, Erickson MA, Salameh
TS, Damodarasamy M, Sheibani N, Meabon JS, Wing EE, Morofuji Y,
Cook DG and Reed MJ: Lipopolysaccharide-induced blood-brain barrier
disruption: Roles of cyclooxygenase, oxidative stress,
neuroinflammation, and elements of the neurovascular unit. J
Neuroinflammation. 12(223)2015.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Corrigan F, Mander KA, Leonard AV and Vink
R: Neurogenic inflammation after traumatic brain injury and its
potentiation of classical inflammation. J Neuroinflammation.
13(264)2016.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Thal S and Neuhaus W: The blood-brain
barrier as a target in traumatic brain injury treatment. Arch Med
Res. 45:698–710. 2014.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Menge T, Zhao Y, Zhao J, Wataha K, Gerber
M, Zhang J, Letourmeau P, Redell J, Shen L, Wang J, et al:
Mesenchymal stem cells regulate blood-brain barrier integrity
through TIMP3 release after traumatic brain injury. Sci Transl Med.
4(161ra150)2012.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Tang G, Liu Y, Zhang Z, Lu Y, Wang Y,
Huang J, Li Y, Chen X, Gu X, Wang Y and Yang GY: Mesenchymal stem
cells maintain blood-brain barrier integrity by inhibiting
aquaporin-4 upregulation after cerebral ischemia. Stem Cells.
32:3150–3162. 2014.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Lok J, Sardi SP, Guo S, Besancon E, Ha DM,
Rosell A, Kim WJ, Corfas G and Lo EH: Neuregulin-1 signaling in
brain endothelial cells. J Cereb Blood Flow Metab. 29:39–43.
2009.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Xu Z, Ford GD, Croslan DR, Jiang J, Gates
A, Allen R and Ford BD: Neuroprotection by neuregulin-1 following
focal stroke is associated with the attenuation of ischemia-induced
pro-inflammatory and stress gene expression. Neurobiol Dis.
19:461–470. 2005.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Guo WP, Wang J, Li RX and Peng YW:
Neuroprotective effects of neuregulin-1 in rat models of focal
cerebral ischemia. Brain Res. 1087:180–185. 2006.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Simmons LJ, Surles-Zeigler MC, Li Y, Ford
GD, Newman GD and Ford BD: Regulation of inflammatory responses by
neuregulin-1 in brain ischemia and microglial cells in vitro
involves the NF-kappa B pathway J. Neuroinflammation.
13(237)2016.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Citri A and Yarden Y: EGF-ERBB signaling:
Towards the systems level. Nat Rev Mol Cell Biol. 7:505–516.
2006.PubMed/NCBI View
Article : Google Scholar
|
|
27
|
Sun Y, Ikrar T, Davis MF, Gong N, Zheng X,
Luo ZD, Lai C, Mei L, Holmes TC, Gandhi SP and Xu X: Neuregulin-1
(NRG1)/ErbB4 signaling regulates visual cortical plasticity.
Neuron. 92:160–173. 2016.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Lemmens K, Doggen K and De Keulenaer GW:
Role of neuregulin-1/ErbB signaling in cardiovascular physiology
and disease: Implications for therapy of heart failure.
Circulation. 116:954–960. 2007.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Goldstein AL, Hannappel E and Kleinman HK:
Thymosin beta4: Actin-sequestering protein moonlights to repair
injured tissues. Trends Mol Med. 11:421–429. 2005.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Crockford D, Turjman N, Allan C and Angel
J: Thymosin beta4: Structure, function, and biological properties
supporting current and future clinical applications. Ann N Y Acad
Sci. 1194:179–189. 2010.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Bock-Marquette I, Saxena A, White MD,
Dimaio JM and Srivastava D: Thymosin beta4 activates
integrin-linked kinase and promotes cardiac cell migration,
survival and cardiac repair. Nature. 432:466–472. 2004.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Sopko N, Qin Y, Finan A, Dadabayev A,
Chigurupati S, Qin J, Penn MS and Gupta S: Significance of Thymosin
β4 and Implication of PINCH-1-ILK-α-Parvin (PIP) complex in human
dilated cardiomyopathy. PLoS One. 6(e20184)2011.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Sosne G, Szliter EA, Barrett R, Kernacki
KA, Kleinman H and Hazlett LD: Thymosin beta 4 promotes corneal
wound healing and decreases inflammation in vivo following alkali
injury. Exp Eye Res. 74:293–299. 2002.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Chiu LL, Reis LA, Momen A and Radisic M:
Controlled release of thymosin β4 from injected collagen-chitosan
hydrogels promotes angiogenesis and prevents tissue loss after
myocardial infarction. Regen Med. 7:523–533. 2012.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Yuan H, Ma C, Moinet L, Sato N and
Martins-Green M: Reversal of second-hand cigarette smoke-induced
impairment of corneal wound healing by thymosin beta4 combined with
anti-inflammatory agents. Invest Ophthalmol Vis Sci. 51:2424–2435.
2010.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Malinda KM, Sidhu GS, Mani H, Banaudha K,
Maheshwari RK, Goldstein AL and Kleinman H: Thymosin beta4
accelerates wound healing. J Invest Dermatol. 113:364–368.
1999.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Kumar S and Gupta S: Thymosin beta 4
prevents oxidative stress by targeting antioxidant and
anti-apoptotic genes in cardiac fibroblasts. PLoS One.
6(e26912)2011.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Osei J, Kelly W, Toffolo K, Donahue K,
Levy B, Bard J, Wang J, Levy E, Nowak N and Poulsen D: Thymosin
beta 4 induces significant changes in the plasma miRNA profile
following severe traumatic brain injury in the rat lateral fluid
percussion injury model. Expert Opin Biol Ther. 18(sup1):S159–S164.
2018.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Xaio H, Banks WA, Niehoff ML and Morley
JE: Effect of LPS on the permeability of the blood-brain barrier to
insulin. Brain Res. 896:36–42. 2001.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Al-Nedawi KN, Czyz M, Bednarek R, Szemraj
J, Swiatkowska M, Cierniewska-Cieslak A, Wyczolkowska J and
Cierniewski CS: Thymosin beta 4 induces the synthesis of
plasminogen activator inhibitor 1 in cultured endothelial cells and
increases its extracellular expression. Blood. 103:1319–1324.
2004.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Su L, Kong X, Loo S, Gao Y, Liu B, Su Z,
Dalan R, Ma J and Ye L: Thymosin beta-4 improves endothelial
function and reparative potency of diabetic endothelial cells
differentiated from patient induced pluripotent stem cells. Stem
Cell Res Ther. 13(13)2022.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Liu M, Solomon W, Cespedes JC, Wilson NO,
Ford B and Stiles JK: Neuregulin-1 attenuates experimental cerebral
malaria (ECM) pathogenesis by regulating ErbB4/AKT/STAT3 signaling.
J Neuroinflammation. 15(104)2018.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408.
2001.PubMed/NCBI View Article : Google Scholar
|
|
44
|
van Vliet EA, Ndode-Ekane XE, Lehto LJ,
Gorter JA, Andrade P, Aronica E, Gröhn O and Pitkänen A:
Long-lasting blood-brain barrier dysfunction and neuroinflammation
after traumatic brain injury. Neurobiol. Dis.
145(105080)2020.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Abbott NJ, Patabendige AK, Dolman DE,
Yusof SR and Begley DJ: Structure and function of the blood-brain
barrier Neurobiol. Dis. 37:13–25. 2020.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Harhaj NS and Antonett DA: Regulation of
tight junctions and loss of barrier function in pathophysiology.
Int J Biochem Cell Biol. 36:1206–1237. 2004.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Jiao H, Wang Z, Liu Y, Wang P and Xue Y:
Specific role of tight junction proteins claudin-5, occludin, and
ZO-1 of the blood-brain barrier in a focal cerebral ischemic
insult. J Mol Neurosci. 44:130–139. 2011.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Huff T, Rosorius O, Otto AM, Muller CS,
Ballweber E, Hannappel E and Mannherz HG: Nuclear localisation of
the G-actin sequestering peptide thymosin beta4. J Cell Sci. 117(Pt
22):5333–5341. 2004.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Percipalle P, Zhao J, Pope B, Weeds A,
Lindberg U and Daneholt B: Actin bound to the heterogeneous nuclear
ribonucleoprotein hrp36 is associated with Balbiani ring mRNA from
the gene to polysomes. Cell Biol. 153:229–236. 2001.PubMed/NCBI View Article : Google Scholar
|
|
50
|
Takata F, Nakagawa S, Matsumoto J and
Dohgu S: Blood-Brain barrier dysfunction amplifies the development
of neuroinflammation: Understanding of cellular events in brain
microvascular endothelial cells for prevention and treatment of BBB
dysfunction. Front Cell Neurosci. 15(661838)2021.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Dri E, Lampas E, Lazaros G, Lazarou E,
Theofilis P, Tsioufis C and Tousoulis D: Inflammatory mediators of
endothelial dysfunction. Life (Basel). 13(1420)2023.PubMed/NCBI View Article : Google Scholar
|
|
52
|
Xiong Y, Zhang Y, Mahmood A, Meng Y, Zhang
ZG, Morris DC and Chopp M: Neuroprotective and neurorestorative
effects of thymosin β4 treatment initiated 6 hours after traumatic
brain injury in rats. J Neurosurg. 116:1081–1092. 2012.PubMed/NCBI View Article : Google Scholar
|
|
53
|
Xiong Y, Mahmood A, Meng Y, Zhang Y, Zhang
ZG, Morris DC and Chopp M: Treatment of traumatic brain injury with
thymosin β4 in rats. J Neurosurg. 114:102–115.
2011.PubMed/NCBI View Article : Google Scholar
|
|
54
|
Zhang Y, Zhang ZG, Chopp M, Meng Y, Zhang
L, Mahmood A and Xiong Y: Treatment of traumatic brain injury in
rats with N-acetyl-seryl-aspartyl-lysyl-proline. J Neurosurg.
126:782–795. 2017.PubMed/NCBI View Article : Google Scholar
|
|
55
|
Shah R, Reyes-Gordillo K, Cheng Y,
Varatharajalu R, Ibrahim J and Lakshman MR: Thymosin β4 prevents
oxidative stress, inflammation, and fibrosis in Ethanol- and
LPS-Induced liver injury in mice. Oxid Med Cell Longev.
2018(9630175)2018.PubMed/NCBI View Article : Google Scholar
|
|
56
|
Pardon MC: Anti-inflammatory potential of
thymosin β4 in the central nervous system: Implications for
progressive neurodegenerative diseases. Expert Opin Biol Ther.
18(sup1):S165–S169. 2018.PubMed/NCBI View Article : Google Scholar
|
|
57
|
Gupta S, Kumar S, Sopko N, Qin Y, Wei C
and Kim IK: Thymosin β4 and cardiac protection: Implication in
inflammation and fibrosis. Ann N Y Acad Sci. 1269:84–91.
2012.PubMed/NCBI View Article : Google Scholar
|
|
58
|
Abdullahi W, Tripathi D and Ronaldson PT:
Blood-brain barrier dysfunction in ischemic stroke: Targeting tight
junctions and transporters for vascular protection. Am J Physiol
Cell Physiol. 315:C343–C356. 2018.PubMed/NCBI View Article : Google Scholar
|
|
59
|
Li Y, Xu Z, Ford GD, Croslan DR, Cairobe
T, Li Z and Ford BD: Neuroprotection by neuregulin-1 in a rat model
of permanent focal cerebral ischemia. Brain Res. 1184:277–283.
2007.PubMed/NCBI View Article : Google Scholar
|
|
60
|
Mei L and Nave KA: Neuregulin-ERBB
signaling in the nervous system and neuropsychiatric diseases.
Neuron. 83:27–49. 2014.PubMed/NCBI View Article : Google Scholar
|
|
61
|
Chen YJ, Zhang M, Yin DM, Wen L, Ting A,
Wang P, Lu YS, Zhu XH, Li SJ, Wu CY, et al: ErbB4 in
parvalbumin-positive interneurons is critical for neuregulin 1
regulation of long-term potentiation. Proc Natl Acad Sci USA.
107:21818–21823. 2010.PubMed/NCBI View Article : Google Scholar
|
|
62
|
Xu Z, Jiang J, Ford G and Ford BD:
Neuregulin-1 is neuroprotective and attenuates inflammatory
responses induced by ischemic stroke. Biochem Biophys Res Commun.
322:440–446. 2004.PubMed/NCBI View Article : Google Scholar
|
|
63
|
Noll JM, Li Y, Distel TJ, Ford GD and Ford
BD: Neuroprotection by exogenous and endogenous neuregulin-1 in
mouse models of focal ischemic stroke. J Mol Neurosci. 69:333–342.
2019.PubMed/NCBI View Article : Google Scholar
|
